Nanocatalytic Theranostics with Glutathione Depletion and Enhanced Reactive Oxygen Species Generation for Efficient Cancer Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(7)

Published: Jan. 4, 2021

Chemodynamic therapy (CDT) is an emerging method that kills cancer cells by converting intracellular hydrogen peroxide (H2 O2 ) into highly toxic hydroxyl radicals (• OH). To overcome the current limitations of insufficient endogenous H2 and high concentration glutathione (GSH) in tumor cells, intelligent nanocatalytic theranostics (denoted as PGC-DOX) possesses both self-supply GSH-elimination properties for efficient presented. This nanoplatform constructed a facile one-step biomineralization using poly(ethylene glycol)-modified glucose oxidase (GOx) template to form biodegradable copper-doped calcium phosphate nanoparticles, followed loading doxorubicin (DOX). As enzyme catalyst, GOx can effectively catalyze generate , which not only starves but also supplies subsequent Fenton-like reaction. Meanwhile, redox reaction between released Cu2+ ions GSH will induce depletion reduce Fenton agent Cu+ ions, then trigger • OH -mediated reaction, resulting enhanced CDT efficacy. The integration GOx-mediated starvation therapy, CDT, DOX-induced chemotherapy, endow PGC-DOX with effective growth inhibition minimal side effects vivo.

Language: Английский

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Recent progress of chemodynamic therapy-induced combination cancer therapy

Nano Today, Journal Year: 2020, Volume and Issue: 35, P. 100946 - 100946

Published: Aug. 13, 2020

Language: Английский

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Biomedicine Meets Fenton Chemistry

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(4), P. 1981 - 2019

Published: Jan. 25, 2021

Since the first connection between Fenton chemistry and biomedicine, numerous studies have been presented in this field. Comprehensive presentation of guidance from a summary its representative applications cancer therapy would help us understand promote further development This comprehensive review supplies basic information regarding chemistry, including reactions Fenton-like reactions. Subsequently, current progress is discussed, with some corresponding examples presented. Furthermore, strategies for optimizing performance chemodynamic guided by are highlighted. Most importantly, future perspectives on combination biomedicine or wider range catalytic approaches We hope that will attract positive attention materials science, fields tighten their connections.

Language: Английский

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Engineering nanomedicine for glutathione depletion-augmented cancer therapy

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(10), P. 6013 - 6041

Published: Jan. 1, 2021

In this review, we systematically survey the most recent progress in engineering nanomedicine for intracellular glutathione consumption-augmented cancer therapy.

Language: Английский

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Bioinspired Construction of a Nanozyme-Based H₂O₂ Homeostasis Disruptor for Intensive Chemodynamic Therapy

Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 142(11), P. 5177 - 5183

Published: Feb. 26, 2020

The insufficient intracellular H2O2 level in tumor cells is closely associated with the limited efficacy of chemodynamic therapy (CDT). Despite tremendous efforts, engineering CDT agents a straightforward and secure supplying ability remains great challenge. Inspired by balance generation elimination cancer cells, herein, nanozyme-based homeostasis disruptor fabricated to elevate through facilitating production restraining for enhanced CDT. In formulation, superoxide dismutase-mimicking activity can convert O2•– H2O2, promoting H2O2. Simultaneously, suppression catalase depletion glutathione weaken transformation H2O. Thus, well-defined system could perturb give rise accumulation cells. raised would ultimately amplify Fenton-like reaction-based efficiency. Our work not only paves way engineer alternative intensive but also provides new insights into construction bioinspired materials.

Language: Английский

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Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics

Theranostics, Journal Year: 2020, Volume and Issue: 10(10), P. 4557 - 4588

Published: Jan. 1, 2020

In recent years, much progress has been motivated in stimuli-responsive nanocarriers, which could response to the intrinsic physicochemical and pathological factors diseased regions increase specificity of drug delivery. Currently, numerous nanocarriers have engineered with changes responding external stimuli, such as ultrasound, thermal, light magnetic field, well internal including pH, redox potential, hypoxia enzyme, etc. Nanocarriers respond stimuli tumor microenvironments or inside cancer cells for on-demanded delivery accumulation, controlled release, activation bioactive compounds, probes targeting ligands, size, charge conformation conversion, etc., leading sensing signaling, overcoming multidrug resistance, accurate diagnosis precision therapy. This review summarized general strategies developing advances, presented their applications delivery, imaging, therapy theranostics, illustrated clinical translation made prospects.

Language: Английский

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An open source and reduce expenditure ROS generation strategy for chemodynamic/photodynamic synergistic therapy

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: April 8, 2020

Abstract The therapeutic effect of reactive oxygen species (ROS)-involved cancer therapies is significantly limited by shortage oxy-substrates, such as hypoxia in photodynamic therapy (PDT) and insufficient hydrogen peroxide (H 2 O ) chemodynamic (CDT). Here, we report a H /O self-supplying nanoagent, (MSNs@CaO -ICG)@LA, which consists manganese silicate (MSN)-supported calcium (CaO indocyanine green (ICG) with further surface modification phase-change material lauric acid (LA). Under laser irradiation, ICG simultaneously generates singlet emits heat to melt the LA. exposed CaO reacts water produce for hypoxia-relieved ICG-mediated PDT -supplying MSN-based CDT, acting an open source strategy ROS production. Additionally, MSNs-induced glutathione depletion protects from scavenging, termed reduce expenditure. This expenditure effective inhibiting tumor growth both vitro vivo, improves generation efficiency multi-level ROS-involved therapies.

Language: Английский

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Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Small, Journal Year: 2021, Volume and Issue: 18(6)

Published: Nov. 2, 2021

Abstract Chemodynamic therapy (CDT), a novel cancer therapeutic strategy defined as the treatment using Fenton or Fenton‐like reaction to produce •OH in tumor region, was first proposed by Bu, Shi, and co‐workers 2016. Recently, with rapid development of nanomaterials, CDT has attracted tremendous attention because its unique advantages: 1) It is tumor‐selective low side effects; 2) process does not depend on external field stimulation; 3) it can modulate hypoxic immunosuppressive microenvironment; 4) cost low. In addition Fe‐involved strategies, reaction‐mediated strategies have also been proposed, which are based many other metal elements including copper, manganese, cobalt, titanium, vanadium, palladium, silver, molybdenum, ruthenium, tungsten, cerium, zinc. Moreover, combined therapies like chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, immunotherapy for achieving enhanced anticancer effects. Besides, there studies that extend application antibacterial field. This review introduces latest advancements nanomaterials‐involved from 2018 present proposes current limitations well future research directions related

Language: Английский

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Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(10)

Published: Jan. 28, 2020

Abstract Despite the comprehensive applications in bioimaging, biosensing, drug/gene delivery, and tumor therapy of manganese oxide nanomaterials (MONs including MnO 2 , MnO, Mn O 3 4 x ) their derivatives, a review article focusing on MON‐based nanoplatforms has not been reported yet. Herein, representative progresses MONs synthesis, heterogene, properties, surface modification, toxicity, imaging, biodetection, are mainly introduced. First, five kinds primary synthetic methods presented, thermal decomposition method, exfoliation strategy, permanganates reduction adsorption–oxidation hydro/solvothermal. Second, preparations hollow composite materials summarized specially. Then, chemical toxicity discussed. Next, diagnostic imaging sensing outlined. Finally, some rational designs photodynamic therapy, photothermal chemodynamic sonodynamic radiotherapy, magnetic hyperthermia, chemotherapy, gene starvation ferroptosis, immunotherapy, various combination highlighted.

Language: Английский

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A Metal–Polyphenol‐Coordinated Nanomedicine for Synergistic Cascade Cancer Chemotherapy and Chemodynamic Therapy

Advanced Materials, Journal Year: 2019, Volume and Issue: 32(6)

Published: Dec. 13, 2019

The clinical application of chemotherapy is impeded by the unsatisfactory efficacy and severe side effects. Chemodynamic therapy (CDT) has emerged as an efficient strategy for cancer treatment utilizing Fenton chemistry to destroy cells converting endogenous H2 O2 into highly toxic reactive oxygen species. Apart from chemotherapeutic effect, cisplatin able act artificial enzyme produce CDT through cascade reactions, thus remarkably improving anti-tumor outcomes. Herein, organic theranostic nanomedicine (PTCG NPs) constructed with high loading capability using epigallocatechin-3-gallate (EGCG), phenolic platinum(IV) prodrug (Pt-OH), polyphenol modified block copolymer (PEG-b-PPOH) building blocks. stability PTCG NPs during circulation stems their strong metal-polyphenol coordination interactions, drug release realized after cellular internalization. activated elevates intracellular level reactions. This further utilized species catalyzed iron-based reaction. In vitro in vivo investigations demonstrate that combination chemodynamic achieves excellent anticancer efficacy. Meanwhile, systemic toxicity faced platinum-based drugs avoided this nanoformulation. work provides a promising develop advanced therapy.

Language: Английский

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