Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

Biomaterials, Год журнала: 2021, Номер 277, С. 121110 - 121110

Опубликована: Авг. 30, 2021

Язык: Английский

---

Biomedicine Meets Fenton Chemistry

Chemical Reviews, Год журнала: 2021, Номер 121(4), С. 1981 - 2019

Опубликована: Янв. 25, 2021

Since the first connection between Fenton chemistry and biomedicine, numerous studies have been presented in this field. Comprehensive presentation of guidance from a summary its representative applications cancer therapy would help us understand promote further development This comprehensive review supplies basic information regarding chemistry, including reactions Fenton-like reactions. Subsequently, current progress is discussed, with some corresponding examples presented. Furthermore, strategies for optimizing performance chemodynamic guided by are highlighted. Most importantly, future perspectives on combination biomedicine or wider range catalytic approaches We hope that will attract positive attention materials science, fields tighten their connections.

Язык: Английский

---

Recent progress of chemodynamic therapy-induced combination cancer therapy

Nano Today, Год журнала: 2020, Номер 35, С. 100946 - 100946

Опубликована: Авг. 13, 2020

Язык: Английский

---

Engineering nanomedicine for glutathione depletion-augmented cancer therapy

Chemical Society Reviews, Год журнала: 2021, Номер 50(10), С. 6013 - 6041

Опубликована: Янв. 1, 2021

In this review, we systematically survey the most recent progress in engineering nanomedicine for intracellular glutathione consumption-augmented cancer therapy.

Язык: Английский

---

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Small, Год журнала: 2021, Номер 18(6)

Опубликована: Ноя. 2, 2021

Abstract Chemodynamic therapy (CDT), a novel cancer therapeutic strategy defined as the treatment using Fenton or Fenton‐like reaction to produce •OH in tumor region, was first proposed by Bu, Shi, and co‐workers 2016. Recently, with rapid development of nanomaterials, CDT has attracted tremendous attention because its unique advantages: 1) It is tumor‐selective low side effects; 2) process does not depend on external field stimulation; 3) it can modulate hypoxic immunosuppressive microenvironment; 4) cost low. In addition Fe‐involved strategies, reaction‐mediated strategies have also been proposed, which are based many other metal elements including copper, manganese, cobalt, titanium, vanadium, palladium, silver, molybdenum, ruthenium, tungsten, cerium, zinc. Moreover, combined therapies like chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, immunotherapy for achieving enhanced anticancer effects. Besides, there studies that extend application antibacterial field. This review introduces latest advancements nanomaterials‐involved from 2018 present proposes current limitations well future research directions related

Язык: Английский

---

Metal–Organic Framework Derived Nanozymes in Biomedicine

Accounts of Chemical Research, Год журнала: 2020, Номер 53(7), С. 1389 - 1400

Опубликована: Июнь 29, 2020

ConspectusNanozymes, which integrate the advantages of both nanomaterials and natural enzymes, have accumulated enormous research interest over past decades because opportunity they provide to appreciate further cultivate artificial enzymes with comparable properties. By mimicking coordination environments catalytic sites in nanozymes confined nanostructures can serve as substitutes many processes activity robust stability even harsh conditions. Since pioneering report about peroxidase-mimicking ferromagnetic nanoparticles 2007, been developed specialized for intrinsic enzyme-mimicking property. With rapid development nanoscience nanotechnology, superior advantages, such large-scale production, desired activity, stability, bridge nanozymes.Metal–organic frameworks (MOFs) their derivatives hold great promise direct surrogates conventional enzymatic reactions. According chemical nature, MOF-based be divided into three main categories: pristine MOFs, enzyme-encapsulated MOF composites, derivatives. Due versatility metallic nodes bridging linkers together feasibility postsynthetic engineering modification, MOFs are envisioned one most appropriate this purpose. Using precursors or sacrificial templates, multiple including carbon-based (e.g., heteroatom-doped carbon M–N–C moiety), metal oxide/carbon nanoparticles, metal/carbon rationally synthesized through one-step carbonization/oxidation indirect post-synthesis treatments linker-exchange node-doping). Compared existing nanozymes, open up a new avenue constructing mesoporous nanozymes. In way, properties still maintained, while greatly improved. Account, we highlight some important advances (including moieties (M = single atom), oxide/carbon, metal/carbon, obtained linker exchange doping strategies) activity. We also demonstrate that, integrating physicochemical activities MOF-derived multifunctional platforms biomedical fields antibacterial agents, biosensors, imaging, cancer therapy, environmental protection. Finally, propose future design principles possible approaches deeper understanding mechanisms, thus pointing out directions offer more opportunities enzyme-engineering industry.

Язык: Английский

---

Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy

Advanced Materials, Год журнала: 2021, Номер 33(48)

Опубликована: Сен. 27, 2021

Chemodynamic therapy (CDT) uses the tumor microenvironment-assisted intratumoral Fenton reaction for generating highly toxic hydroxyl free radicals (•OH) to achieve selective treatment. However, limited efficiency restricts therapeutic efficacy of CDT. Recent years have witnessed impressive development various strategies increase reaction. The introduction these reinforcement can dramatically improve treatment CDT and further promote enhanced (ECDT)-based multimodal anticancer treatments. In this review, authors systematically introduce strategies, from their basic working principles, mechanisms representative clinical applications. Then, ECDT-based is discussed, including how integrate emerging accelerating therapy, as well synergistic ECDT other methods. Eventually, future direction challenges therapies are elaborated, highlighting key scientific problems unsolved technical bottlenecks facilitate translation.

Язык: Английский

---

Superoxide dismutase nanozymes: an emerging star for anti-oxidation

Journal of Materials Chemistry B, Год журнала: 2021, Номер 9(35), С. 6939 - 6957

Опубликована: Янв. 1, 2021

This review summarizes catalytic mechanisms, regulatory factors, measurement methods and various applications of SOD-like nanozymes, as well proposes the current challenges prospects in development nanozymes.

Язык: Английский

---

Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants

Archives of Toxicology, Год журнала: 2024, Номер 98(5), С. 1323 - 1367

Опубликована: Март 14, 2024

Abstract Reactive oxygen species (ROS) and reactive nitrogen (RNS) are well recognized for playing a dual role, since they can be either deleterious or beneficial to biological systems. An imbalance between ROS production elimination is termed oxidative stress, critical factor common denominator of many chronic diseases such as cancer, cardiovascular diseases, metabolic neurological disorders (Alzheimer’s Parkinson’s diseases), other disorders. To counteract the harmful effects ROS, organisms have evolved complex, three-line antioxidant defense system. The first-line mechanism most efficient involves enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx). This line plays an irreplaceable role in dismutation radicals (O 2 ·− ) hydrogen peroxide (H O ). removal by SOD prevents formation much more damaging peroxynitrite ONOO − + NO · → maintains physiologically relevant level nitric oxide (NO ), important molecule neurotransmission, inflammation, vasodilation. second-line pathway exogenous diet-derived small-molecule antioxidants. third-line ensured repair oxidized proteins biomolecules variety enzyme review briefly discusses endogenous (mitochondria, NADPH, xanthine oxidase (XO), Fenton reaction) (e.g., smoking, radiation, drugs, pollution) sources (superoxide radical, peroxide, hydroxyl peroxyl hypochlorous acid, peroxynitrite). Attention has been given system provided SOD, CAT, GPx. chemical molecular mechanisms enzymes, enzyme-related (cancer, cardiovascular, lung, metabolic, GPx4) cellular processes ferroptosis discussed. Potential therapeutic applications mimics recent progress metal-based (copper, iron, cobalt, molybdenum, cerium) nonmetal (carbon)-based nanomaterials with enzyme-like activities (nanozymes) also Moreover, attention action low-molecular-weight antioxidants (vitamin C (ascorbate), vitamin E (alpha-tocopherol), carotenoids β-carotene, lycopene, lutein), flavonoids quercetin, anthocyanins, epicatechin), (GSH)), activation transcription factors Nrf2, protection against diseases. Given that there discrepancy preclinical clinical studies, approaches may result greater pharmacological success therapies subject discussion.

Язык: Английский

---

Glutathione-Depleting Nanomedicines for Synergistic Cancer Therapy

ACS Nano, Год журнала: 2021, Номер 15(5), С. 8039 - 8068

Опубликована: Май 11, 2021

Cancer cells frequently exhibit resistance to various molecular and nanoscale drugs, which inevitably affects the drugs' therapeutic outcomes. Overexpression of glutathione (GSH) has been observed in many cancer cells, solid evidence corroborated resulting tumor a variety anticancer therapies, suggesting that this biochemical characteristic can be developed as potential target for treatments. The single treatment GSH-depleting agents potentiate responses different cell death stimuli; therefore, an adjunctive strategy, GSH depletion is usually combined with mainstream therapies enhancing Propelled by rapid development nanotechnology, readily constructed into nanomedicines, have shown steep rise over past decade. Here, we review common nanomedicines widely applied synergistic treatments recent years. Some current challenges future perspectives depletion-based are also presented. With understanding structure–property relationship action mechanisms these biomaterials, hope nanotechnology will further realize more effective disease even achieve successful clinical translations.

Язык: Английский

---