Angewandte Chemie International Edition,
Journal Year:
2021,
Volume and Issue:
60(15), P. 8157 - 8163
Published: Jan. 15, 2021
Abstract
Suffering
from
the
laborious
synthesis
and
undesirable
tumor
microenvironment
response,
exploitation
of
novel
NIR‐II
absorbing
organic
photothermal
agents
is
importance
to
promote
phototherapeutic
efficacy.
Herein,
two
kinds
charge‐transfer
complex
nanoparticles
(TMB‐F4TCNQ
TMB‐TCNQ)
are
prepared
by
supramolecular
assembly.
Because
larger
energy
gap
between
donor
acceptor,
TMB‐F4TCNQ
presents
higher
degree
(72
%)
than
that
TMB‐TCNQ
(48
in
nanoaggregates.
Therefore,
exhibits
stronger
absorption
ability
with
a
mass
extinction
coefficient
15.4
Lg
−1
cm
at
1300
nm
excellent
effect.
Impressively,
specific
cysteine
response
can
make
effectively
inhibit
intracellular
biosynthesis
GSH,
leading
redox
dsyhomeostasis
ROS‐mediated
ferroptosis.
serve
as
contrast
agent
for
photoacoustic
imaging
guide
precise
efficient
therapy
vivo.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
121(4), P. 1981 - 2019
Published: Jan. 25, 2021
Since
the
first
connection
between
Fenton
chemistry
and
biomedicine,
numerous
studies
have
been
presented
in
this
field.
Comprehensive
presentation
of
guidance
from
a
summary
its
representative
applications
cancer
therapy
would
help
us
understand
promote
further
development
This
comprehensive
review
supplies
basic
information
regarding
chemistry,
including
reactions
Fenton-like
reactions.
Subsequently,
current
progress
is
discussed,
with
some
corresponding
examples
presented.
Furthermore,
strategies
for
optimizing
performance
chemodynamic
guided
by
are
highlighted.
Most
importantly,
future
perspectives
on
combination
biomedicine
or
wider
range
catalytic
approaches
We
hope
that
will
attract
positive
attention
materials
science,
fields
tighten
their
connections.
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(10), P. 6013 - 6041
Published: Jan. 1, 2021
In
this
review,
we
systematically
survey
the
most
recent
progress
in
engineering
nanomedicine
for
intracellular
glutathione
consumption-augmented
cancer
therapy.
Small,
Journal Year:
2021,
Volume and Issue:
18(6)
Published: Nov. 2, 2021
Abstract
Chemodynamic
therapy
(CDT),
a
novel
cancer
therapeutic
strategy
defined
as
the
treatment
using
Fenton
or
Fenton‐like
reaction
to
produce
•OH
in
tumor
region,
was
first
proposed
by
Bu,
Shi,
and
co‐workers
2016.
Recently,
with
rapid
development
of
nanomaterials,
CDT
has
attracted
tremendous
attention
because
its
unique
advantages:
1)
It
is
tumor‐selective
low
side
effects;
2)
process
does
not
depend
on
external
field
stimulation;
3)
it
can
modulate
hypoxic
immunosuppressive
microenvironment;
4)
cost
low.
In
addition
Fe‐involved
strategies,
reaction‐mediated
strategies
have
also
been
proposed,
which
are
based
many
other
metal
elements
including
copper,
manganese,
cobalt,
titanium,
vanadium,
palladium,
silver,
molybdenum,
ruthenium,
tungsten,
cerium,
zinc.
Moreover,
combined
therapies
like
chemotherapy,
radiotherapy,
phototherapy,
sonodynamic
therapy,
immunotherapy
for
achieving
enhanced
anticancer
effects.
Besides,
there
studies
that
extend
application
antibacterial
field.
This
review
introduces
latest
advancements
nanomaterials‐involved
from
2018
present
proposes
current
limitations
well
future
research
directions
related
Accounts of Chemical Research,
Journal Year:
2020,
Volume and Issue:
53(7), P. 1389 - 1400
Published: June 29, 2020
ConspectusNanozymes,
which
integrate
the
advantages
of
both
nanomaterials
and
natural
enzymes,
have
accumulated
enormous
research
interest
over
past
decades
because
opportunity
they
provide
to
appreciate
further
cultivate
artificial
enzymes
with
comparable
properties.
By
mimicking
coordination
environments
catalytic
sites
in
nanozymes
confined
nanostructures
can
serve
as
substitutes
many
processes
activity
robust
stability
even
harsh
conditions.
Since
pioneering
report
about
peroxidase-mimicking
ferromagnetic
nanoparticles
2007,
been
developed
specialized
for
intrinsic
enzyme-mimicking
property.
With
rapid
development
nanoscience
nanotechnology,
superior
advantages,
such
large-scale
production,
desired
activity,
stability,
bridge
nanozymes.Metal–organic
frameworks
(MOFs)
their
derivatives
hold
great
promise
direct
surrogates
conventional
enzymatic
reactions.
According
chemical
nature,
MOF-based
be
divided
into
three
main
categories:
pristine
MOFs,
enzyme-encapsulated
MOF
composites,
derivatives.
Due
versatility
metallic
nodes
bridging
linkers
together
feasibility
postsynthetic
engineering
modification,
MOFs
are
envisioned
one
most
appropriate
this
purpose.
Using
precursors
or
sacrificial
templates,
multiple
including
carbon-based
(e.g.,
heteroatom-doped
carbon
M–N–C
moiety),
metal
oxide/carbon
nanoparticles,
metal/carbon
rationally
synthesized
through
one-step
carbonization/oxidation
indirect
post-synthesis
treatments
linker-exchange
node-doping).
Compared
existing
nanozymes,
open
up
a
new
avenue
constructing
mesoporous
nanozymes.
In
way,
properties
still
maintained,
while
greatly
improved.
Account,
we
highlight
some
important
advances
(including
moieties
(M
=
single
atom),
oxide/carbon,
metal/carbon,
obtained
linker
exchange
doping
strategies)
activity.
We
also
demonstrate
that,
integrating
physicochemical
activities
MOF-derived
multifunctional
platforms
biomedical
fields
antibacterial
agents,
biosensors,
imaging,
cancer
therapy,
environmental
protection.
Finally,
propose
future
design
principles
possible
approaches
deeper
understanding
mechanisms,
thus
pointing
out
directions
offer
more
opportunities
enzyme-engineering
industry.
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(48)
Published: Sept. 27, 2021
Chemodynamic
therapy
(CDT)
uses
the
tumor
microenvironment-assisted
intratumoral
Fenton
reaction
for
generating
highly
toxic
hydroxyl
free
radicals
(•OH)
to
achieve
selective
treatment.
However,
limited
efficiency
restricts
therapeutic
efficacy
of
CDT.
Recent
years
have
witnessed
impressive
development
various
strategies
increase
reaction.
The
introduction
these
reinforcement
can
dramatically
improve
treatment
CDT
and
further
promote
enhanced
(ECDT)-based
multimodal
anticancer
treatments.
In
this
review,
authors
systematically
introduce
strategies,
from
their
basic
working
principles,
mechanisms
representative
clinical
applications.
Then,
ECDT-based
is
discussed,
including
how
integrate
emerging
accelerating
therapy,
as
well
synergistic
ECDT
other
methods.
Eventually,
future
direction
challenges
therapies
are
elaborated,
highlighting
key
scientific
problems
unsolved
technical
bottlenecks
facilitate
translation.
Journal of Materials Chemistry B,
Journal Year:
2021,
Volume and Issue:
9(35), P. 6939 - 6957
Published: Jan. 1, 2021
This
review
summarizes
catalytic
mechanisms,
regulatory
factors,
measurement
methods
and
various
applications
of
SOD-like
nanozymes,
as
well
proposes
the
current
challenges
prospects
in
development
nanozymes.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(5), P. 8039 - 8068
Published: May 11, 2021
Cancer
cells
frequently
exhibit
resistance
to
various
molecular
and
nanoscale
drugs,
which
inevitably
affects
the
drugs'
therapeutic
outcomes.
Overexpression
of
glutathione
(GSH)
has
been
observed
in
many
cancer
cells,
solid
evidence
corroborated
resulting
tumor
a
variety
anticancer
therapies,
suggesting
that
this
biochemical
characteristic
can
be
developed
as
potential
target
for
treatments.
The
single
treatment
GSH-depleting
agents
potentiate
responses
different
cell
death
stimuli;
therefore,
an
adjunctive
strategy,
GSH
depletion
is
usually
combined
with
mainstream
therapies
enhancing
Propelled
by
rapid
development
nanotechnology,
readily
constructed
into
nanomedicines,
have
shown
steep
rise
over
past
decade.
Here,
we
review
common
nanomedicines
widely
applied
synergistic
treatments
recent
years.
Some
current
challenges
future
perspectives
depletion-based
are
also
presented.
With
understanding
structure–property
relationship
action
mechanisms
these
biomaterials,
hope
nanotechnology
will
further
realize
more
effective
disease
even
achieve
successful
clinical
translations.
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: Feb. 22, 2022
Nanozyme
is
a
series
of
nanomaterials
with
enzyme-mimetic
activities
that
can
proceed
the
catalytic
reactions
natural
enzymes.
In
field
biomedicine,
nanozymes
are
capturing
tremendous
attention
due
to
their
high
stability
and
low
cost.
Enzyme-mimetic
be
regulated
by
multiple
factors,
such
as
chemical
state
metal
ion,
pH,
hydrogen
peroxide
(H2O2),
glutathione
(GSH)
level,
presenting
great
promise
for
biomedical
applications.
Over
past
decade,
multi-functional
have
been
developed
various
To
promote
understandings
development
novel
multifunctional
nanozymes,
we
herein
provide
comprehensive
review
applications
in
field.
Nanozymes
versatile
enzyme-like
properties
briefly
overviewed,
mechanism
application
discussed
future
research.
Finally,
underlying
challenges
prospects
frontier
this
review.
