Cytotoxic CD8+ T cells in cancer and cancer immunotherapy DOI Creative Commons
Hans Raskov, Adile Orhan, Jan Pravsgaard Christensen

и другие.

British Journal of Cancer, Год журнала: 2020, Номер 124(2), С. 359 - 367

Опубликована: Сен. 15, 2020

Abstract The functions of, and interactions between, the innate adaptive immune systems are vital for anticancer immunity. Cytotoxic T cells expressing cell-surface CD8 most powerful effectors in response form backbone of current successful cancer immunotherapies. Immune-checkpoint inhibitors designed to target immune-inhibitory receptors that function regulate response, whereas adoptive cell-transfer therapies use + with genetically modified receptors—chimaeric antigen receptors—to specify enhance T-cell functionality. New generations cytotoxic or synthetic being developed evaluated clinical trials. Furthermore, combinatory regimens might optimise treatment effects reduce adverse events. This review summarises advances research on prominent immunotherapy, cells, discusses possible implications future treatment.

Язык: Английский

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients DOI
Roy S. Herbst, Jean‐Charles Soria,

Marcin Kowanetz

и другие.

Nature, Год журнала: 2014, Номер 515(7528), С. 563 - 567

Опубликована: Ноя. 25, 2014

Язык: Английский

Процитировано

4838

Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy DOI Creative Commons
Padmanee Sharma, Siwen Hu‐Lieskovan, Jennifer A. Wargo

и другие.

Cell, Год журнала: 2017, Номер 168(4), С. 707 - 723

Опубликована: Фев. 1, 2017

Язык: Английский

Процитировано

4445

Elements of cancer immunity and the cancer–immune set point DOI
Daniel S. Chen, Ira Mellman

Nature, Год журнала: 2017, Номер 541(7637), С. 321 - 330

Опубликована: Янв. 1, 2017

Язык: Английский

Процитировано

4352

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response DOI
Peng Jiang, Shengqing Gu, Deng Pan

и другие.

Nature Medicine, Год журнала: 2018, Номер 24(10), С. 1550 - 1558

Опубликована: Авг. 13, 2018

Язык: Английский

Процитировано

3973

Tumor-Associated Macrophages: From Mechanisms to Therapy DOI Creative Commons

Roy Noy,

Jeffrey W. Pollard

Immunity, Год журнала: 2014, Номер 41(1), С. 49 - 61

Опубликована: Июль 1, 2014

Язык: Английский

Процитировано

3488

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer DOI
Anushka Dongre, Robert A. Weinberg

Nature Reviews Molecular Cell Biology, Год журнала: 2018, Номер 20(2), С. 69 - 84

Опубликована: Ноя. 20, 2018

Язык: Английский

Процитировано

3118

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies DOI
Jérôme Galon, Daniela Bruni

Nature Reviews Drug Discovery, Год журнала: 2019, Номер 18(3), С. 197 - 218

Опубликована: Янв. 4, 2019

Язык: Английский

Процитировано

2661

The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014 DOI Creative Commons
Roberto Salgado, Carsten Denkert, Sandra Demaria

и другие.

Annals of Oncology, Год журнала: 2014, Номер 26(2), С. 259 - 271

Опубликована: Сен. 12, 2014

Язык: Английский

Процитировано

2647

Macrophage Polarization DOI
Peter J. Murray

Annual Review of Physiology, Год журнала: 2016, Номер 79(1), С. 541 - 566

Опубликована: Ноя. 4, 2016

Macrophage polarization refers to how macrophages have been activated at a given point in space and time. Polarization is not fixed, as are sufficiently plastic integrate multiple signals, such those from microbes, damaged tissues, the normal tissue environment. Three broad pathways control polarization: epigenetic cell survival that prolong or shorten macrophage development viability, microenvironment, extrinsic factors, microbial products cytokines released inflammation. A plethora of advances provided framework for rationally purifying, describing, manipulating polarization. Here, I assess current state knowledge about enumerate major questions regulate physiology tissues.

Язык: Английский

Процитировано

2412

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations DOI Open Access
Weiping Zou, Jedd D. Wolchok, Lieping Chen

и другие.

Science Translational Medicine, Год журнала: 2016, Номер 8(328)

Опубликована: Март 2, 2016

PD-L1 and PD-1 (PD) pathway blockade is a highly promising therapy has elicited durable antitumor responses long-term remissions in subset of patients with broad spectrum cancers. How to improve, widen, predict the clinical response anti-PD central theme field cancer immunology immunotherapy. Oncologic, immunologic, genetic, biological studies focused on human microenvironment have yielded substantial insight into this issue. Here, we focus tumor evaluate several potential therapeutic markers including expression pattern, genetic mutations within cells neoantigens, epigenetics effector T cell landscape, microbiota. We further clarify mechanisms action these their roles shaping, being shaped, and/or predicting responses. also discuss variety combinations PD scientific rationales for treatment.

Язык: Английский

Процитировано

2155