Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

Nature, Journal Year: 2014, Volume and Issue: 515(7528), P. 563 - 567

Published: Nov. 25, 2014

Language: Английский

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Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy

Cell, Journal Year: 2017, Volume and Issue: 168(4), P. 707 - 723

Published: Feb. 1, 2017

Language: Английский

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Elements of cancer immunity and the cancer–immune set point

Nature, Journal Year: 2017, Volume and Issue: 541(7637), P. 321 - 330

Published: Jan. 1, 2017

Language: Английский

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Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

Nature Medicine, Journal Year: 2018, Volume and Issue: 24(10), P. 1550 - 1558

Published: Aug. 13, 2018

Language: Английский

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Tumor-Associated Macrophages: From Mechanisms to Therapy

Immunity, Journal Year: 2014, Volume and Issue: 41(1), P. 49 - 61

Published: July 1, 2014

Language: Английский

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New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

Nature Reviews Molecular Cell Biology, Journal Year: 2018, Volume and Issue: 20(2), P. 69 - 84

Published: Nov. 20, 2018

Language: Английский

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Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

Nature Reviews Drug Discovery, Journal Year: 2019, Volume and Issue: 18(3), P. 197 - 218

Published: Jan. 4, 2019

Language: Английский

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The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014

Annals of Oncology, Journal Year: 2014, Volume and Issue: 26(2), P. 259 - 271

Published: Sept. 12, 2014

Language: Английский

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Macrophage Polarization

Annual Review of Physiology, Journal Year: 2016, Volume and Issue: 79(1), P. 541 - 566

Published: Nov. 4, 2016

Macrophage polarization refers to how macrophages have been activated at a given point in space and time. Polarization is not fixed, as are sufficiently plastic integrate multiple signals, such those from microbes, damaged tissues, the normal tissue environment. Three broad pathways control polarization: epigenetic cell survival that prolong or shorten macrophage development viability, microenvironment, extrinsic factors, microbial products cytokines released inflammation. A plethora of advances provided framework for rationally purifying, describing, manipulating polarization. Here, I assess current state knowledge about enumerate major questions regulate physiology tissues.

Language: Английский

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PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

Science Translational Medicine, Journal Year: 2016, Volume and Issue: 8(328)

Published: March 2, 2016

PD-L1 and PD-1 (PD) pathway blockade is a highly promising therapy has elicited durable antitumor responses long-term remissions in subset of patients with broad spectrum cancers. How to improve, widen, predict the clinical response anti-PD central theme field cancer immunology immunotherapy. Oncologic, immunologic, genetic, biological studies focused on human microenvironment have yielded substantial insight into this issue. Here, we focus tumor evaluate several potential therapeutic markers including expression pattern, genetic mutations within cells neoantigens, epigenetics effector T cell landscape, microbiota. We further clarify mechanisms action these their roles shaping, being shaped, and/or predicting responses. also discuss variety combinations PD scientific rationales for treatment.

Language: Английский

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