Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids

Cell Reports, Год журнала: 2019, Номер 26(1), С. 222 - 235.e5

Опубликована: Янв. 1, 2019

Highlights•Parabacteroides distasonis alleviates obesity and obesity-related dysfunctions in mice.•P. generates succinate secondary bile acids the gut.•P. activates intestinal gluconeogenesis (IGN) FXR pathways gut.•Succinate is a ligand of fructose-1,6-bisphosphatase, rate-limiting enzyme IGN.SummaryWe demonstrated metabolic benefits Parabacteroides (PD) on decreasing weight gain, hyperglycemia, hepatic steatosis ob/ob high-fat diet (HFD)-fed mice. Treatment with live P. (LPD) dramatically altered acid profile elevated lithocholic (LCA) ursodeoxycholic (UDCA) increased level gut. In vitro cultivation PD its capacity to transform production succinate. Succinate supplementation decreased hyperglycemia mice via activation (IGN). Gavage mixture LCA UDCA reduced hyperlipidemia by activating pathway repairing gut barrier integrity. Co-treatment LCA/UDCA mirrored LPD. The binding target was identified as IGN. produced played key roles modulation host metabolism.Graphical abstract

Язык: Английский

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Inflammaging and ‘Garb-aging’

Trends in Endocrinology and Metabolism, Год журнала: 2016, Номер 28(3), С. 199 - 212

Опубликована: Окт. 24, 2016

Язык: Английский

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Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases

Journal of Gastroenterology, Год журнала: 2016, Номер 52(1), С. 1 - 8

Опубликована: Июль 23, 2016

Язык: Английский

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The intestinal microbiota fuelling metabolic inflammation

Nature reviews. Immunology, Год журнала: 2019, Номер 20(1), С. 40 - 54

Опубликована: Авг. 6, 2019

Язык: Английский

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The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

Immunity, Год журнала: 2019, Номер 50(2), С. 432 - 445.e7

Опубликована: Янв. 25, 2019

Язык: Английский

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The gut microbiome: Relationships with disease and opportunities for therapy

The Journal of Experimental Medicine, Год журнала: 2018, Номер 216(1), С. 20 - 40

Опубликована: Окт. 15, 2018

Over the past decade, our view of human-associated microbes has expanded beyond that a few species toward an appreciation diverse and niche-specialized microbial communities develop in human host with chronological age. The largest reservoir exists distal gastrointestinal tract, both lumen, where facilitate primary secondary metabolism, on mucosal surfaces, they interact immune cell populations. While local microbial-driven immunomodulation gut is well described, more recent studies have demonstrated role for microbiome influencing remote organs hematopoietic function. Unsurprisingly, therefore, perturbation to composition function microbiota been associated chronic diseases ranging from inflammatory metabolic conditions neurological, cardiovascular, respiratory illnesses. Considerable effort currently focused understanding natural history development humans context health outcomes, parallel improving knowledge microbiome-host molecular interactions. These efforts ultimately aim effective approaches rehabilitate perturbed ecosystems as means restore or prevent disease. This review details modulating focus discusses strategies manipulating management prevention conditions.

Язык: Английский

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Microbes, metabolites, and the gut–lung axis

Mucosal Immunology, Год журнала: 2019, Номер 12(4), С. 843 - 850

Опубликована: Апрель 11, 2019

Язык: Английский

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Intestinal barrier and gut microbiota: Shaping our immune responses throughout life

Tissue Barriers, Год журнала: 2017, Номер 5(4), С. e1373208 - e1373208

Опубликована: Сен. 6, 2017

The gastrointestinal (GI) tract is considered the largest immunological organ in body having a central role regulating immune homeostasis. Contrary to earlier belief, intestinal epithelial barrier not static physical but rather strongly interacts with gut microbiome and cells of system. This intense communication between cells, will shape specific responses antigens, balancing tolerance effector functions. Recent studies indicate that composition affects system development modulates mediators, which turn affect barrier. Moreover, dysbiosis may favor disruption could be related increased susceptibility certain diseases. review focused on its function host defense how throughout life can this role.

Язык: Английский

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Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity

Nature Communications, Год журнала: 2020, Номер 11(1)

Опубликована: Сен. 8, 2020

Innate lymphoid cells (ILCs) and CD4+ T produce IL-22, which is critical for intestinal immunity. The microbiota central to IL-22 production in the intestines; however, factors that regulate by ILCs are not clear. Here, we show microbiota-derived short-chain fatty acids (SCFAs) promote through G-protein receptor 41 (GPR41) inhibiting histone deacetylase (HDAC). SCFAs upregulate promoting aryl hydrocarbon (AhR) hypoxia-inducible factor 1α (HIF1α) expression, differentially regulated mTOR Stat3. HIF1α binds directly Il22 promoter, increase binding promoter modification. SCFA supplementation enhances production, protects intestines from inflammation. human cell production. These findings establish roles of inducing maintain homeostasis.

Язык: Английский

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Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System

Cell Metabolism, Год журнала: 2017, Номер 26(1), С. 110 - 130

Опубликована: Июнь 15, 2017

Язык: Английский

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