Antibacterial Activity of Silver Nanoparticles: Structural Effects

Advanced Healthcare Materials, Год журнала: 2018, Номер 7(13)

Опубликована: Май 29, 2018

Abstract The increase of antibiotic resistance in bacteria has become a major concern for successful diagnosis and treatment infectious diseases. Over the past few decades, significant progress been achieved on development nanotechnology‐based medicines combating multidrug microorganisms. Among this, silver nanoparticles (AgNPs) hold great promise addressing this challenge due to their broad‐spectrum robust antimicrobial properties. This review illustrates antibacterial mechanisms further elucidates how different structural factors including surface chemistry, size, shape, impact activities, which are expected promote future more potent nanoparticle‐based agents.

Язык: Английский

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Natural Products as Platforms To Overcome Antibiotic Resistance

Chemical Reviews, Год журнала: 2017, Номер 117(19), С. 12415 - 12474

Опубликована: Сен. 27, 2017

Natural products have served as powerful therapeutics against pathogenic bacteria since the golden age of antibiotics mid-20th century. However, increasing frequency antibiotic-resistant infections clearly demonstrates that new are critical for modern medicine. Because combinatorial approaches not yielded effective drugs, we propose development around proven natural scaffolds is best short-term solution to rising crisis antibiotic resistance. We analyze herein synthetic aiming reengineer into potent antibiotics. Furthermore, discuss in modulating quorum sensing and biofilm formation a nonlethal method, well narrow-spectrum pathogen-specific antibiotics, which interest given insights implications disrupting microbiome.

Язык: Английский

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Sequencing-based methods and resources to study antimicrobial resistance

Nature Reviews Genetics, Год журнала: 2019, Номер unknown

Опубликована: Март 18, 2019

Язык: Английский

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Antibiotic resistance in Pseudomonas aeruginosa – Mechanisms, epidemiology and evolution

Drug Resistance Updates, Год журнала: 2019, Номер 44, С. 100640 - 100640

Опубликована: Май 1, 2019

Язык: Английский

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Antibiotics and antibiotic resistance from animal manures to soil: a review

European Journal of Soil Science, Год журнала: 2017, Номер 69(1), С. 181 - 195

Опубликована: Ноя. 20, 2017

Summary The overuse of veterinary antibiotics in animal production and the subsequent land applications manures contribute to elevated antibiotic resistance soil environment. To minimize risk resistance, it is important understand fate spread genes (ARGs) from systems soil. In this paper, we review recent studies on use, concentrations abundance diversity AGRs that receives or manure composts. mechanisms ARG dissemination environment are also discussed. Although focus China where around 3 billion tons produced more than 84 000 consumed annually industries, problem worldwide. Approximately 58% excreted into environment, half which end up ARGs can reach 10 −1 16S rRNA genes. Applications composts enrich at least three ways: (i) by direct introduction manure‐derived ARGs, (ii) elevating intrinsic (iii) imposing a selection with manures. We discuss need for stringent regulations use future research directions management. Highlights Soil natural reservoir (ARGs). Manure introduce through different mechanisms. Horizontal gene transfer plays an role More needed reduce sources.

Язык: Английский

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Compositional and functional differences of the mucosal microbiota along the intestine of healthy individuals

Scientific Reports, Год журнала: 2020, Номер 10(1)

Опубликована: Сен. 11, 2020

Abstract Gut mucosal microbes evolved closest to the host, developing specialized local communities. There is, however, insufficient knowledge of these communities as most studies have employed sequencing technologies investigate faecal microbiota only. This work used shotgun metagenomics biopsies explore microbial communities’ compositions terminal ileum and large intestine in 5 healthy individuals. Functional annotations genome-scale metabolic modelling selected species were then identify functional enrichments. While provided a good approximation average gut microbiome composition, allowed detecting subtle variations Given their significant enrichment microbiota, we highlight roles Bacteroides describe antimicrobial resistance biogeography along intestine. We also detail which species, at locations, are involved with tryptophan/indole pathway, whose malfunctioning has been linked pathologies including inflammatory bowel disease. Our study thus provides invaluable resources for investigating mechanisms connecting host pathophysiology.

Язык: Английский

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Rejuvenated Photodynamic Therapy for Bacterial Infections

Advanced Healthcare Materials, Год журнала: 2019, Номер 8(14)

Опубликована: Июнь 26, 2019

Abstract The emergence of multidrug resistant bacterial strains has hastened the exploration advanced microbicides and antibacterial techniques. Photodynamic therapy (PDAT), an old‐fashioned technique, been rejuvenated to combat “superbugs” biofilm‐associated infections owing its excellent characteristics noninvasiveness broad spectrum. More importantly, bacteria are less likely produce drug resistance PDAT because it does not require specific targeting interaction between photosensitizers (PSs) bacteria. This review mainly focuses on recent developments future prospects PDAT. mechanisms against biofilms briefly introduced. In addition classical macrocyclic PSs, several innovative including non‐self‐quenching conjugated polymer–based nano‐PSs, summarized in detail. Numerous multifunctional systems such as situ light‐activated PDAT, stimuli‐responsive oxygen self‐enriching enhanced PDAT‐based multimodal highlighted overcome inherent defects vivo (e.g., limited penetration depth light hypoxic environment infectious sites).

Язык: Английский

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The effect of soil on human health: an overview

European Journal of Soil Science, Год журнала: 2017, Номер 69(1), С. 159 - 171

Опубликована: Июль 17, 2017

Soil has a considerable effect on human health, whether those effects are positive or negative, direct indirect. is an important source of nutrients in our food supply and medicines such as antibiotics. However, nutrient imbalances the presence pathogens soil biological community can cause negative health. There also many locations where various elements chemical compounds found at toxic levels, because either natural conditions anthropogenic activities. The urban environments received increased attention last few years, they too pose number health questions challenges. Concepts security may provide framework within which issues be investigated using interdisciplinary transdisciplinary approaches. It will take contributions experts several different scientific, medical social science fields to address fully issues. Although much progress was made understanding links between over century, there still that we do not know about complex interactions them. Therefore, need for research this area.

Язык: Английский

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Graphene oxide and carbon dots as broad-spectrum antimicrobial agents – a minireview

Nanoscale Horizons, Год журнала: 2018, Номер 4(1), С. 117 - 137

Опубликована: Сен. 5, 2018

Complex antibacterial mechanisms of graphene oxide and carbon dots.

Язык: Английский

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Plant growth promoting bacteria in agriculture: Two sides of a coin

Applied Soil Ecology, Год журнала: 2019, Номер 138, С. 10 - 18

Опубликована: Март 2, 2019

Язык: Английский

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