Abstract
Drug‐resistant
bacterial
infection
impairs
tissue
regeneration
and
is
a
challenging
clinical
problem.
Metal–organic
frameworks
(MOFs)‐based
photodynamic
therapy
(PDT)
opens
up
new
era
for
antibiotic‐free
treatment.
However,
the
MOF‐based
PDT
normally
encounters
limited
photon
absorbance
under
visible
light
notorious
recombination
of
photogenerated
holes
electrons,
which
significantly
impede
their
applications.
Herein,
MOFs‐based
nanosystem
(AgNPs@MOFs)
with
enhanced
response
charge
carrier
separation
developed
by
modifying
MOFs
silver
nanoparticles
(AgNPs)
to
improve
efficiency.
The
AgNPs@MOFs
performance
irradiation
mainly
disrupt
bacteria
translation
process
metabolism
purine
pyrimidine.
In
addition,
introduction
AgNPs
endows
nanosystems
chemotherapy
ability,
causes
destructive
effect
on
cell
membrane,
including
membrane
ATPase
protein
fatty
acids.
show
excellent
synergistic
drug‐resistant
killing
efficiency
through
multiple
mechanisms,
further
restrain
resistance.
biocompatible
pose
potential
ability
in
both
Methicillin–resistant
Staphylococcus
aureus
(MRSA)‐related
soft
hard
infection.
Overall,
this
study
provides
promising
perspective
exploration
as
nano
antibacterial
medicine
against
infected
future.
ACS Nano,
Год журнала:
2021,
Номер
15(12), С. 18895 - 18930
Опубликована: Дек. 6, 2021
Light
is
an
attractive
tool
that
has
a
profound
impact
on
modern
medicine.
Particularly,
light-based
photothermal
therapy
(PTT)
and
photodynamic
(PDT)
show
great
application
prospects
in
the
prevention
of
wound
infection
promoting
healing.
In
addition,
hydrogels
have
shown
advantages
field
dressings
due
to
their
excellent
biochemical
effects.
Therefore,
multifunctional
photoresponsive
(MPRHs)
integrate
light
are
increasingly
used
biomedicine,
especially
repair.
However,
comprehensive
review
MPRHs
for
regeneration
still
lacking.
This
first
focuses
various
types
prepared
by
diverse
photosensitizers,
agents
(PHTAs)
including
transition
metal
sulfide/oxides
nanomaterials,
nanostructure-based
PHTAs,
carbon-based
conjugated
polymer
or
complex-based
and/or
(PHDAs)
such
as
ZnO-based,
black-phosphorus-based,
TiO2-based,
small
organic
molecule-based
PHDAs.
We
also
then
discuss
how
PTT,
PDT,
photothermal/photodynamic
synergistic
can
modulate
microenvironments
bacteria
inhibit
infection.
Overall,
with
both
therapeutic
tissue
capabilities
been
discussed
existing
challenges,
well
future
research
directions
management
argued.
Biomacromolecules,
Год журнала:
2020,
Номер
21(8), С. 2983 - 3006
Опубликована: Июль 16, 2020
Wound
healing
is
usually
accompanied
by
bacterial
infection.
The
excessive
use
of
synthetic
antibiotics
leads
to
drug
resistance,
posing
a
significant
threat
human
health.
Hydrogel-based
wound
dressings
aimed
at
mitigating
infections
have
emerged
as
an
effective
treatment.
review
presented
herein
particularly
focuses
on
the
hydrogels
originating
from
natural
polymers.
To
further
enhance
performance
dressings,
various
strategies
and
approaches
been
developed
endow
with
excellent
broad-spectrum
antibacterial
activity.
Those
that
are
summarized
in
current
intrinsic
or
stimuli-triggered
bactericidal
properties
others
serve
vehicles
for
loading
agents
without
antibiotics.
Specific
attention
paid
antimicrobial
mechanisms
hydrogels.
Practical
applications
accelerate
employing
these
antibiotic-free
also
introduced
along
discussion
challenges
perspectives
leading
new
technologies.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(9), С. 3324 - 3340
Опубликована: Янв. 1, 2022
This
tutorial
review
highlights
the
concept
and
significance
of
antibacterial
phototherapy.
Recent
developments,
advantages,
challenges
organic
photosensitizers
in
this
area
are
also
discussed.
Theranostics,
Год журнала:
2019,
Номер
10(2), С. 757 - 781
Опубликована: Дек. 6, 2019
The
marked
augment
of
drug-resistance
to
traditional
antibiotics
underlines
the
crying
need
for
novel
replaceable
antibacterials.Research
advances
have
revealed
considerable
sterilization
potential
two-dimension
graphene-based
nanomaterials.Subsequently,
two-dimensional
nanomaterials
beyond
graphene
(2D
NBG)
as
antibacterials
also
demonstrated
their
power
disinfection
due
unique
physicochemical
properties
and
good
biocompatibility.Therefore,
exploration
antibacterial
mechanisms
2D
NBG
is
vital
manipulate
future
applications.Herein,
we
summarize
recent
research
progress
NBG-based
agents,
starting
with
a
detailed
introduction
relevant
mechanisms,
including
direct
contact
destruction,
oxidative
stress,
photo-induced
antibacterial,
control
drug/metallic
ions
releasing,
multi-mode
synergistic
antibacterial.Then,
effect
on
activities
discussed.Additionally,
summary
different
kinds
given,
such
transition-metal
dichalcogenides/oxides,
metal-based
compounds,
nitride-based
nanomaterials,
black
phosphorus,
transition
metal
carbides,
nitrides.Finally,
rationally
analyze
current
challenges
new
perspectives
study
more
effective
agents.This
review
not
only
can
help
researchers
grasp
status
antibacterials,
but
may
catalyze
breakthroughs
in
this
fast-growing
field.
ACS Applied Bio Materials,
Год журнала:
2021,
Номер
4(5), С. 3909 - 3936
Опубликована: Янв. 7, 2021
Pathogens
on
wounds
and
infected
tissues
or
pathogens
in
drinking
water
public
facilities
have
been
doing
great
harm
human
life.
Because
of
booming
drug
resistance
superbacteria,
the
abuse
excessive
use
antibiotics
during
systemic
treatment
has
caused
a
global
antibiotic
crisis.
However,
it
usually
takes
long
time
to
develop
antibiotics.
In
recent
years,
photocatalytic
antibacterial
agents
no
side-effects
due
their
rapid
efficient
bactericidal
efficacy.
They
are
becoming
one
most
hopeful
substitutions
for
dealing
with
bacterial
diseases
pollution
by
certain
pathogens.
Photocatalysis
unique
advantages
field
antibacterials,
its
controllability
plays
an
irreplaceable
role.
This
review
focuses
mechanism
photocatalysis,
which
involves
representative
semiconductors
(metal
oxides,
metal
sulfides,
carbon
nitride,
heterojunction
composite
materials)
organics
(organic
polymers
organic
small
molecules-aggregation
induced
emission)
as
well
mechanism.
this
paper,
we
summarize
mechanisms
numbers
current
developing
antimicrobial
materials
applications.
Current
difficulties
expectations
future
these
fields
presented
stimulate
material
manufacturing
technologies
industrialization
combat
infections.
addition,
potential
application
limitations
research
highlighted.
Nano-Micro Letters,
Год журнала:
2022,
Номер
14(1)
Опубликована: Авг. 24, 2022
The
pernicious
bacterial
proliferation
and
emergence
of
super-resistant
bacteria
have
already
posed
a
great
threat
to
public
health,
which
drives
researchers
develop
antibiotic-free
strategies
eradicate
these
fierce
microbes.
Although
enormous
achievements
been
achieved,
it
remains
an
arduous
challenge
realize
efficient
sterilization
cut
off
the
drug
resistance
generation.
Recently,
photothermal
therapy
(PTT)
has
emerged
as
promising
solution
efficiently
damage
integrity
pathogenic
based
on
hyperthermia
beyond
their
tolerance.
Until
now,
numerous
agents
studied
for
antimicrobial
PTT.
Among
them,
MXenes
(a
type
two-dimensional
transition
metal
carbides
or
nitrides)
are
extensively
investigated
one
most
candidates
due
high
aspect
ratio,
atomic-thin
thickness,
excellent
performance,
low
cytotoxicity,
ultrahigh
dispersibility
in
aqueous
systems.
Besides,
application
scenarios
using
antibacterial
properties
can
be
tailored
via
elaborated
designs
MXenes-based
materials.
In
this
review,
synthetic
approaches
textural
systematically
presented
first,
then
mechanisms
materials
documented.
Subsequently,
recent
progress
diverse
fields
making
use
performances
well
summarized
reveal
potential
applications
various
purposes,
including
vitro
vivo
sterilization,
solar
water
evaporation
purification,
flexible
fabrics.
Last
but
not
least,
current
challenges
future
perspectives
discussed
provide
theoretical
guidance
fabrication
systems
MXenes.
ACS Applied Materials & Interfaces,
Год журнала:
2020,
Номер
12(20), С. 22479 - 22491
Опубликована: Апрель 24, 2020
In
recent
years,
with
the
emergence
of
various
kinds
drug-resistant
bacteria,
existing
antibiotics
have
become
inefficient
in
killing
these
and
formation
biofilms
has
further
weakened
therapeutic
effect.
More
problematically,
massive
use
abuse
caused
severe
side
effects.
Thus,
development
ultra-efficient
safe
antibacterial
systems
is
urgently
needed.
Herein,
a
photodynamic
therapy
(PDT)-driven
CO-controlled
delivery
system
(Ce6&CO@FADP)
developed
for
synergistic
ablation
biofilms.
Ce6&CO@FADP
constructed
using
fluorinated
amphiphilic
dendritic
peptide
(FADP)
physically
loaded
Ce6
CORM-401.
After
efficiently
entering
can
rapidly
release
CO
intracellularly
by
consumption
H2O2
generated
during
PDT
process,
without
affecting
generation
singlet
oxygen
(1O2).
As
such,
combination
1O2
exerts
notable
biofilm
effects
both
vitro
vivo
(including
subcutaneous
bacterial
infection
catheter
models)
experiments.
importantly,
all
biosafety
assessments
suggest
good
biocompatibility
Ce6&CO@FADP.
Together,
results
reveal
that
an
efficient
system,
which
essential
application
prospects
treatment
infections
vivo.
International Journal of Nanomedicine,
Год журнала:
2021,
Номер
Volume 16, С. 5831 - 5867
Опубликована: Авг. 1, 2021
Abstract:
Around
the
globe,
surges
of
bacterial
diseases
are
causing
serious
health
threats
and
related
concerns.
Recently,
metal
ion
release
photodynamic
photothermal
effects
nanomaterials
were
demonstrated
to
have
substantial
efficiency
in
eliminating
resistance
bacteria.
Nanomaterials
with
characteristics
such
as
surface
plasmonic
resonance,
photocatalysis,
structural
complexities,
optical
features
been
utilized
control
release,
generate
reactive
oxygen
species,
produce
heat
for
antibacterial
applications.
The
superior
present
an
opportunity
explore
enhance
their
activities
leading
clinical
In
this
review,
we
comprehensively
list
three
different
mechanisms
therapy,
therapy
based
on
nanomaterials.
These
divided
into
respective
subgroups
accordance
recent
achievements,
showcasing
prospective
challenges
opportunities
clinical,
environmental,
fields.
Keywords:
nanomaterials,
ions,
photodynamic,
photothermal,
mechanism,
species
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