Journal of Ovarian Research,
Год журнала:
2024,
Номер
17(1)
Опубликована: Март 27, 2024
Abstract
Polycystic
ovary
syndrome
(PCOS)
is
a
common
reproductive
and
metabolic
condition
in
women
of
childbearing
age
major
cause
anovulatory
infertility.
The
pathophysiology
PCOS
complex.
Recent
studies
have
reported
that
apart
from
hyperandrogenism,
insulin
resistance,
systemic
chronic
inflammation,
ovarian
dysfunction,
gut
microbiota
dysbiosis
also
involved
development
may
aggravate
inflammation
forming
vicious
cycle.
As
naturally
occurring
plant
secondary
metabolites,
polyphenols
been
demonstrated
to
anticancer,
antibacterial,
vasodilator,
analgesic
properties,
mechanistically
creating
putative
bioactive,
low-molecular-weight
metabolites
the
human
gut.
Here,
we
summarize
role
demonstrate
ability
different
-
including
anthocyanin,
catechins,
resveratrol
regulate
microbes
alleviate
thus
providing
new
insights
assist
novel
therapeutic
strategies
treat
with
PCOS.
A
significant
obstacle
to
avoiding
chronic
illnesses
in
people
worldwide
is
the
increasing
development
of
obesity.
They
are
supported
by
economic
expansion,
mechanized
transportation,
a
rise
sedentary
behavior,
and
switch
from
wholesome,
healthy
diet
processed
foods
high-calorie
meals,
including
fast
food
sugary
drinks.
Many
developed
or
emerging
countries
have
seen
prevalence
obesity
their
populations
increase
twice
over.
Therefore,
it
must
now
be
treated
as
disease
concern.
Since
intimately
linked
diabetes
hypertension
hemodynamic,
structural,
histological
renal
alterations,
has
been
identified
one
major
causes
kidney
(CKD).
Type
2
mellitus
(Type-2
DM)
directly
related
lack
insulin
sensitivity
intensifies
effects
angiotensin-II,
aggravates
proteinuria,
triggers
production
inflammatory
cytokines,
which
contribute
pathophysiological
mechanism
underlying
damage.
These
conditions
include
glomerular
hyperfiltration,
hypertrophy,
hypercellularity,
widening
mesangial
regions.
days,
serious
issue
that
needs
addressed.
If
child
obese
birth,
then
negative
consequences
on
kidneys
also
occur
childhood.
Although
simple
prevent,
recommended
children
encouraged
play
outside,
eat
decent,
nutritious,
balanced
diet,
consume
little
possible.
Obesity
problem
affects
earliest
years
life.
We
need
public
awareness
so
middle
consider
health
well-being
priority.
aware
subsequent
issues
even
mild
might
cause,
such
CKD,
cardiac
illnesses,
hypertension,
diabetes,
etc.
looked
up
following
terms
PubMed,
Medline,
Google:
"obesity,"
"CKD,"
"Diabetes,"
"Hypertension,"
"Developmental
Programming/developmental
origins
(DOHaD),"
"Renal
programming"
describe
relationship
between
CKD
risk
factor
this
review.
Food Chemistry X,
Год журнала:
2022,
Номер
13, С. 100245 - 100245
Опубликована: Фев. 4, 2022
Sustainable
extraction
processes
based
on
alternative
solvents
to
recover
bioactive
compounds
of
different
raw
materials
have
been
highlighted
as
excellent
alternatives
supply
the
needs
society
towards
a
bioeconomy
strategy.
Little
is
known
about
safety
and
biological
effect
extracted
by
these
processes.
In
this
work,
carotenoids
from
Bactris
gasipaes
wastes
obtained
an
IL-based
process
were
investigated
in
terms
safety,
anti-inflammatory
and,
antioxidant
activity
high-fat-diet
animal
model
kidney.
Wistar
rats
supplemented
or
not
with
IL
VOS.
The
animals
had
lower
weight
than
control
high-fat
diets.
carotenoids,
group
improved
compared
Also,
HFD-VOS
showed
moderate-severe
injuries
Then,
ILs
could
represent
novel
tool
for
natural
pigments
safely
applied
food
industry.
Kidney
disease
(KD)
is
a
life-threatening
characterized
by
high
morbidity
and
mortality
in
clinical
settings,
which
can
be
caused
many
reasons,
the
incidence
increases
with
age.
However,
supportive
therapy
kidney
transplantation
still
have
limitations
alleviating
KD
progression.
Recently,
mesenchymal
stem
cells
(MSCs)
shown
great
potential
repairing
injury
through
their
multidirectional
differentiation
self-renewal
ability.
Of
note,
MSCs
serve
as
safe
effective
therapeutic
strategy
for
treating
preclinical
trials.
Functionally,
ameliorate
progression
regulating
immune
response,
renal
tubular
cell
apoptosis,
epithelial–mesenchymal
transition,
oxidative
stress,
angiogenesis,
so
on.
In
addition,
exhibit
remarkable
efficacy
both
acute
(AKI)
chronic
(CKD)
paracrine
mechanisms.
this
review,
we
outline
biological
characteristics
of
MSCs,
discuss
mechanisms
MSCs-based
KD,
summarize
completed
ongoing
trials,
well
analyze
new
strategies,
aiming
to
provide
ideas
approaches
experiments
trials
KD.
Journal of Ovarian Research,
Год журнала:
2024,
Номер
17(1)
Опубликована: Март 27, 2024
Abstract
Polycystic
ovary
syndrome
(PCOS)
is
a
common
reproductive
and
metabolic
condition
in
women
of
childbearing
age
major
cause
anovulatory
infertility.
The
pathophysiology
PCOS
complex.
Recent
studies
have
reported
that
apart
from
hyperandrogenism,
insulin
resistance,
systemic
chronic
inflammation,
ovarian
dysfunction,
gut
microbiota
dysbiosis
also
involved
development
may
aggravate
inflammation
forming
vicious
cycle.
As
naturally
occurring
plant
secondary
metabolites,
polyphenols
been
demonstrated
to
anticancer,
antibacterial,
vasodilator,
analgesic
properties,
mechanistically
creating
putative
bioactive,
low-molecular-weight
metabolites
the
human
gut.
Here,
we
summarize
role
demonstrate
ability
different
-
including
anthocyanin,
catechins,
resveratrol
regulate
microbes
alleviate
thus
providing
new
insights
assist
novel
therapeutic
strategies
treat
with
PCOS.
