International Journal of Molecular Sciences,
Год журнала:
2019,
Номер
20(16), С. 3884 - 3884
Опубликована: Авг. 9, 2019
Breast
cancer,
ranking
first
among
women's
cancers
worldwide,
develops
from
the
breast
tissue.
Study
of
tissue
is,
therefore
great
significance
to
diagnosis
and
treatment
cancer.
Exosomes,
acting
as
an
effective
communicator
between
cells,
are
in
ascendant
recent
years.
One
most
important
cargoes
contained
exosomes
is
microRNAs,
belonging
non-coding
RNA
family.
When
exosomal
microRNAs
absorbed
into
intracellular
location,
will
act
tumor
promoters
or
suppressors
by
inhibiting
translation
process
target
mRNA,
thus
affecting
behavior
other
stromal
cells
microenvironment.
At
present,
growing
research
focuses
on
different
types
donor
cell
sources,
their
contribution
miRNA
profiling,
biomarker
potential,
etc.
This
review
aims
state
function
diverse
miRNAs
medicated
cell-cell
communication
potency
some
specific
enriched
molecular
markers
clinical
trials.
We
also
describe
mechanism
anti-cancer
compounds
through
exploration
artificially
engineered
techniques
that
lead
miRNA-inhibitors
for
therapeutic
use.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(1), С. 415 - 415
Опубликована: Янв. 6, 2025
Cancer
is
a
complex
genetic
disorder
characterized
by
abnormalities
in
both
coding
and
regulatory
non-coding
RNAs.
microRNAs
(miRNAs)
are
key
RNAs
that
modulate
cancer
development,
functioning
as
tumor
suppressors
oncogenes.
miRNAs
play
critical
roles
progression,
influencing
processes
such
initiation,
promotion,
metastasis.
They
exert
their
effects
targeting
suppressor
genes,
thereby
facilitating
while
also
inhibiting
oncogenes
to
prevent
further
disease
advancement.
The
miR-10
family,
particularly
miR-10a-5p
miR-10b-5p
(miR-10a/b-5p),
notably
involved
progression.
Intriguingly,
functions
can
differ
across
different
cancers,
sometimes
promoting
at
other
times
suppressing
growth
depending
on
the
type
target
genes.
This
review
explores
dual
of
miR-10a/b-5p
tumor-suppressive
(TSmiRs)
or
oncogenic
(oncomiRs)
various
cancers
examining
molecular
cellular
mechanisms
impact
microenvironment.
Furthermore,
we
discuss
potential
therapeutic
targets,
emphasizing
miRNA-based
strategies
for
treatment.
insights
discussed
this
aim
advance
our
understanding
miR-10a/b-5p’s
biology
application
developing
innovative
therapies.
Oncotarget,
Год журнала:
2015,
Номер
6(12), С. 10253 - 10266
Опубликована: Март 10, 2015
//
Nicolas
Bovy
1
,
Benoît
Blomme
Pierre
Frères
2
Stella
Dederen
Olivier
Nivelles
Michelle
Lion
Oriane
Carnet
3
Joseph
A.
Martial
Agnès
Noël
Marc
Thiry
4
Guy
Jérusalem
5
Claire
Josse
Vincent
Bours
Sébastien
P.
Tabruyn
and
Ingrid
Struman
Laboratory
of
Molecular
Angiogenesis,
GIGA-R,
University
Liège,
Belgium
Human
Genetics,
Tumor
&
Development
Biology,
Cell
Tissues
Department
Medical
Oncology,
CHU,
Correspondence
to:
Struman,
email:
Keywords
:
Exosomes,
microRNAs,
Cancer,
miR-503,
Angiogenesis
Received
January
30,
2015
Accepted
February
17,
Published
March
10,
Abstract
The
interaction
between
tumor
cells
their
microenvironment
is
an
essential
aspect
development.
Therefore,
understanding
how
this
communicates
with
crucial
for
the
development
new
anti-cancer
therapies.
MicroRNAs
(miRNAs)
are
small
non-coding
RNAs
that
inhibit
gene
expression.
They
secreted
into
extracellular
medium
in
vesicles
called
exosomes,
which
allow
communication
via
transfer
cargo.
Consequently,
we
hypothesized
circulating
endothelial
miRNAs
could
be
transferred
to
modify
phenotype.
Using
exogenous
miRNA,
demonstrated
can
miRNA
exosomes.
profiling,
identified
exhibited
downregulated
levels
exosomes
released
from
cultured
under
tumoral
conditions.
modulation
miR-503
breast
cancer
altered
proliferative
invasive
capacities.
We
then
two
targets
CCND2
CCND3.
Moreover,
measured
increased
plasmatic
patients
after
neoadjuvant
chemotherapy,
partly
due
secretion
by
cells.
Taken
together,
our
data
first
reveal
involvement
endothelium
response
chemotherapy
treatment.
JNCI Journal of the National Cancer Institute,
Год журнала:
2017,
Номер
109(10)
Опубликована: Март 16, 2017
Current
therapies
against
cancer
utilize
the
patient's
immune
system
for
tumor
eradication.
However,
cells
can
evade
surveillance
of
CD8+
T
and/or
natural
killer
(NK)
by
various
strategies.
These
include
aberrant
expression
human
leukocyte
antigen
(HLA)
class
I
antigens,
co-inhibitory
or
costimulatory
molecules,
and
components
interferon
(IFN)
signal
transduction
pathway.
In
addition,
alterations
microenvironment
could
interfere
with
efficient
antitumor
responses
downregulating
inhibiting
frequency
functional
activity
effector
professional
antigen-presenting
cells.
Recently,
microRNAs
(miRNAs)
have
been
identified
as
major
players
in
post-transcriptional
regulation
gene
expression,
thereby
controlling
many
physiological
also
pathophysiological
processes
including
neoplastic
transformation.
Indeed,
cellular
miRNA
pattern
is
frequently
altered
tumors
distinct
origin,
demonstrating
suppressive
oncogenic
potential
miRNAs.
Furthermore,
there
increasing
evidence
that
miRNAs
influence
affecting
modulatory
molecules
Apart
from
their
important
role
escape
tumor-host
interaction,
often
exert
properties,
thus
representing
promising
targets
future
combined
immunotherapy
approaches.
This
review
focuses
on
characterization
involved
use
diagnostic
prognostic
biomarkers
therapeutic
targets.
International Journal of Molecular Sciences,
Год журнала:
2018,
Номер
19(7), С. 1901 - 1901
Опубликована: Июнь 28, 2018
Transcriptional
and
post-transcriptional
regulation
shapes
the
transcriptome
proteome
changes
induced
by
various
cellular
signaling
cascades.
MicroRNAs
(miRNAs)
are
small
regulatory
RNAs
that
approximately
22
nucleotides
long,
which
direct
of
diverse
target
genes
control
cell
states.
Transforming
growth
factor
(TGF)-β
family
is
a
multifunctional
cytokine
family,
plays
many
roles
in
development
pathogenesis
diseases,
including
fibrotic
disease,
cardiovascular
disease
cancer.
Previous
studies
have
shown
TGF-β
pathway
includes
miRNA
as
an
important
component
its
downstream
Multiple
epithelial–mesenchymal
transition
(EMT)-related
miRNAs
highlighted
constitute
intrinsic
bistable
molecular
switches
states
forming
double
negative
feedback
loops
with
EMT-inducing
transcription
factors.
This
may
be
for
understanding
reversibility
EMT
at
single-cell
level,
presence
distinct
intra-
inter-tumor
heterogeneity
cancer
phenotypes.
In
present
review,
I
summarize
connection
between
pathway,
placing
particular
emphasis
on
expression
signaling,
modulation
miRNAs,
miRNA-mediated
endothelial–mesenchymal
well
crosstalk
pathways
tumor
microenvironment.
Frontiers in Cell and Developmental Biology,
Год журнала:
2020,
Номер
8
Опубликована: Авг. 5, 2020
Hepatic
stellate
cells
(HSCs)
are
a
significant
component
of
the
hepatocellular
carcinoma
(HCC)
tumor
microenvironment
(TME).
Activated
HSCs
transform
into
myofibroblast-like
to
promote
fibrosis
in
response
liver
injury
or
chronic
inflammation,
leading
cirrhosis
and
HCC.
The
hepatic
TME
is
comprised
cellular
components,
including
activated
HSCs,
tumor-associated
macrophages,
endothelial
cells,
immune
non-cellular
components
such
as
growth
factors,
proteolytic
enzymes
their
inhibitors,
other
extracellular
matrix
(ECM)
proteins.
Interactions
between
HCC
have
become
topics
under
active
investigation.
These
interactions
within
potential
drive
carcinogenesis
create
challenges
generating
effective
therapies.
Current
studies
reveal
mechanisms
through
which
hepatocarcinogenesis
utilizing
matricellular
proteins
paracrine
crosstalk
TME.
Since
primary
secretors
ECM
during
they
help
fibrogenesis,
infiltrate
stroma,
contribute
development.
In
this
review,
we
examine
several
recent
revealing
roles
clinical
implications
development
Journal of Medicinal Chemistry,
Год журнала:
2020,
Номер
63(23), С. 14119 - 14150
Опубликована: Сен. 29, 2020
Early
cancer
detection
and
perfect
understanding
of
the
disease
are
imperative
toward
efficient
treatments.
It
is
straightforward
that,
for
choosing
a
specific
treatment
methodology,
diagnostic
agents
undertake
critical
role.
Imaging
an
extremely
intriguing
tool
since
it
assumes
follow
up
to
treatments
survey
accomplishment
recognize
any
conceivable
repeating
injuries.
also
permits
analysis
disease,
as
well
pursue
monitor
possible
changes
that
happen
on
tumor.
Likewise,
allows
screening
adequacy
visualizing
state
Additionally,
when
finished,
observing
patient
evaluate
methodology
adjust
if
necessary.
The
goal
this
review
present
overview
conjugated
photosensitizers
imaging
therapy.
Oncotarget,
Год журнала:
2015,
Номер
6(30), С. 29161 - 29177
Опубликована: Июль 22, 2015
//
Sanchaika
Gaur
1,2,9
,
Yunfei
Wen
3
Jian
H.
Song
1
Nila
U.
Parikh
Lingegowda
S.
Mangala
3,4
Alicia
M.
Blessing
5
Cristina
Ivan
Sherry
Y.
Wu
Andreas
Varkaris
Yan
Shi
Gabriel
Lopez-Berestein
4,6
Daniel
E.
Frigo
5,7
Anil
K.
Sood
2,3,4,8
and
Gary
Gallick
1,2
Department
of
Genitourinary
Medical
Oncology,
David
Koch
Center
for
Applied
Research
Cancers,
The
University
Texas,
MD
Anderson
Cancer
Center,
Houston,
TX,
USA
2
Program
in
Biology
Metastasis,
Texas
Graduate
School
Biomedical
Sciences
at
Gynecologic
Oncology
Reproductive
Medicine,
4
RNA
Interference
Non-Coding
RNA,
Nuclear
Receptors
Cell
Signaling,
Departments
Biochemistry,
6
Experimental
Therapeutics,
7
Genomic
Medicine
Program,
Houston
Methodist
Institute,
8
Biology,
9
Sciences,
Cedars
Sinai
Los
Angeles,
CA,
Correspondence:
Gallick,
email:
Keywords
:
prostate
cancer,
miR-34a,
bone
metastasis,
apoptosis,
autophagy
Received
April
07,
2015
Accepted
July
11,
Published
22,
Abstract
While
several
new
therapies
are
FDA-approved
bone-metastatic
cancer
(PCa),
patient
survival
has
only
improved
marginally.
Here,
we
report
that
chitosan
nanoparticle-mediated
delivery
a
tumor
suppressive
microRNA
downregulates
multiple
gene
products
involved
PCa
progression
inhibited
growth
preserved
integrity
xenograft
model
representative
established
metastasis.
Expression
miR-34a
induced
apoptosis
cells,
and,
accord
with
downregulation
targets
associated
growth,
including
MET
Axl
c-Myc,
also
form
non-canonical
is
independent
Beclin-1,
ATG4,
ATG5
ATG7.
MiR-34a-induced
anti-proliferative
as
blocking
still
resulted
inhibition
cells.
Thus,
combined
effects
responsible
miR-34a-mediated
inhibition,
have
translational
impact,
this
inhibitory.
Together,
these
results
provide
understanding
the
biological
highlight
clinical
potential
treatment
metastatic
cancer.
Oncotarget,
Год журнала:
2017,
Номер
8(40), С. 68769 - 68779
Опубликована: Июнь 1, 2017
To
develop
a
cerebrospinal
fluid
(CSF)
miRNA
diagnostic
biomarker
for
glioblastoma.Glioblastoma
tissue
and
matched
CSF
from
the
same
patient
(obtained
prior
to
tumor
manipulation)
were
profiled
by
TaqMan
OpenArray®
Human
MicroRNA
Panel.
profiles
glioblastoma
patients
controls
created
three
discovery
cohorts
confirmed
in
two
validation
cohorts.miRNA
clinical
correlated
with
those
found
tissues.
Comparison
of
between
non-brain
yielded
"signature"
consisting
nine
miRNAs.
The
volume
(p=0.008).
When
prospectively
applied
cisternal
CSF,
sensitivity
specificity
'signature'
detection
67%
80%,
respectively.
For
lumbar
signature
28%
95%,
Comparable
results
obtained
analyses
extracellular
vesicles
(EVs)
crude
CSF.We
report
as
"liquid
biopsy"
platform
glioblastoma.