The Role of Exosomal MicroRNAs in the Tumor Microenvironment of Breast Cancer DOI Open Access
Qingqing Liu, Fu Peng, Jianping Chen

и другие.

International Journal of Molecular Sciences, Год журнала: 2019, Номер 20(16), С. 3884 - 3884

Опубликована: Авг. 9, 2019

Breast cancer, ranking first among women's cancers worldwide, develops from the breast tissue. Study of tissue is, therefore great significance to diagnosis and treatment cancer. Exosomes, acting as an effective communicator between cells, are in ascendant recent years. One most important cargoes contained exosomes is microRNAs, belonging non-coding RNA family. When exosomal microRNAs absorbed into intracellular location, will act tumor promoters or suppressors by inhibiting translation process target mRNA, thus affecting behavior other stromal cells microenvironment. At present, growing research focuses on different types donor cell sources, their contribution miRNA profiling, biomarker potential, etc. This review aims state function diverse miRNAs medicated cell-cell communication potency some specific enriched molecular markers clinical trials. We also describe mechanism anti-cancer compounds through exploration artificially engineered techniques that lead miRNA-inhibitors for therapeutic use.

Язык: Английский

Dual Roles of miR-10a-5p and miR-10b-5p as Tumor Suppressors and Oncogenes in Diverse Cancers DOI Open Access
Rajan Singh, Se Eun Ha, Tae Yang Yu

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(1), С. 415 - 415

Опубликована: Янв. 6, 2025

Cancer is a complex genetic disorder characterized by abnormalities in both coding and regulatory non-coding RNAs. microRNAs (miRNAs) are key RNAs that modulate cancer development, functioning as tumor suppressors oncogenes. miRNAs play critical roles progression, influencing processes such initiation, promotion, metastasis. They exert their effects targeting suppressor genes, thereby facilitating while also inhibiting oncogenes to prevent further disease advancement. The miR-10 family, particularly miR-10a-5p miR-10b-5p (miR-10a/b-5p), notably involved progression. Intriguingly, functions can differ across different cancers, sometimes promoting at other times suppressing growth depending on the type target genes. This review explores dual of miR-10a/b-5p tumor-suppressive (TSmiRs) or oncogenic (oncomiRs) various cancers examining molecular cellular mechanisms impact microenvironment. Furthermore, we discuss potential therapeutic targets, emphasizing miRNA-based strategies for treatment. insights discussed this aim advance our understanding miR-10a/b-5p’s biology application developing innovative therapies.

Язык: Английский

Процитировано

4

Endothelial exosomes contribute to the antitumor response during breast cancer neoadjuvant chemotherapy via microRNA transfer DOI Open Access

Nicolas Bovy,

Benoît Blomme,

Pierre Frères

и другие.

Oncotarget, Год журнала: 2015, Номер 6(12), С. 10253 - 10266

Опубликована: Март 10, 2015

// Nicolas Bovy 1 , Benoît Blomme Pierre Frères 2 Stella Dederen Olivier Nivelles Michelle Lion Oriane Carnet 3 Joseph A. Martial Agnès Noël Marc Thiry 4 Guy Jérusalem 5 Claire Josse Vincent Bours Sébastien P. Tabruyn and Ingrid Struman Laboratory of Molecular Angiogenesis, GIGA-R, University Liège, Belgium Human Genetics, Tumor & Development Biology, Cell Tissues Department Medical Oncology, CHU, Correspondence to: Struman, email: Keywords : Exosomes, microRNAs, Cancer, miR-503, Angiogenesis Received January 30, 2015 Accepted February 17, Published March 10, Abstract The interaction between tumor cells their microenvironment is an essential aspect development. Therefore, understanding how this communicates with crucial for the development new anti-cancer therapies. MicroRNAs (miRNAs) are small non-coding RNAs that inhibit gene expression. They secreted into extracellular medium in vesicles called exosomes, which allow communication via transfer cargo. Consequently, we hypothesized circulating endothelial miRNAs could be transferred to modify phenotype. Using exogenous miRNA, demonstrated can miRNA exosomes. profiling, identified exhibited downregulated levels exosomes released from cultured under tumoral conditions. modulation miR-503 breast cancer altered proliferative invasive capacities. We then two targets CCND2 CCND3. Moreover, measured increased plasmatic patients after neoadjuvant chemotherapy, partly due secretion by cells. Taken together, our data first reveal involvement endothelium response chemotherapy treatment.

Язык: Английский

Процитировано

156

A step-by-step microRNA guide to cancer development and metastasis DOI
Γεώργιος Μαρκόπουλος, Eugenia Roupakia,

Maria Tokamani

и другие.

Cellular Oncology, Год журнала: 2017, Номер 40(4), С. 303 - 339

Опубликована: Июль 26, 2017

Язык: Английский

Процитировано

146

Immune Modulatory microRNAs Involved in Tumor Attack and Tumor Immune Escape DOI Open Access
Stefan B. Eichmüller, Wolfram Osen, Ofer Mandelboim

и другие.

JNCI Journal of the National Cancer Institute, Год журнала: 2017, Номер 109(10)

Опубликована: Март 16, 2017

Current therapies against cancer utilize the patient's immune system for tumor eradication. However, cells can evade surveillance of CD8+ T and/or natural killer (NK) by various strategies. These include aberrant expression human leukocyte antigen (HLA) class I antigens, co-inhibitory or costimulatory molecules, and components interferon (IFN) signal transduction pathway. In addition, alterations microenvironment could interfere with efficient antitumor responses downregulating inhibiting frequency functional activity effector professional antigen-presenting cells. Recently, microRNAs (miRNAs) have been identified as major players in post-transcriptional regulation gene expression, thereby controlling many physiological also pathophysiological processes including neoplastic transformation. Indeed, cellular miRNA pattern is frequently altered tumors distinct origin, demonstrating suppressive oncogenic potential miRNAs. Furthermore, there increasing evidence that miRNAs influence affecting modulatory molecules Apart from their important role escape tumor-host interaction, often exert properties, thus representing promising targets future combined immunotherapy approaches. This review focuses on characterization involved use diagnostic prognostic biomarkers therapeutic targets.

Язык: Английский

Процитировано

140

Design of nanocarriers based on complex biological barriers in vivo for tumor therapy DOI

Junjie Liu,

Menghuan Li,

Zhong Luo

и другие.

Nano Today, Год журнала: 2017, Номер 15, С. 56 - 90

Опубликована: Авг. 1, 2017

Язык: Английский

Процитировано

130

MicroRNA Control of TGF-β Signaling DOI Open Access
Hiroshi Suzuki

International Journal of Molecular Sciences, Год журнала: 2018, Номер 19(7), С. 1901 - 1901

Опубликована: Июнь 28, 2018

Transcriptional and post-transcriptional regulation shapes the transcriptome proteome changes induced by various cellular signaling cascades. MicroRNAs (miRNAs) are small regulatory RNAs that approximately 22 nucleotides long, which direct of diverse target genes control cell states. Transforming growth factor (TGF)-β family is a multifunctional cytokine family, plays many roles in development pathogenesis diseases, including fibrotic disease, cardiovascular disease cancer. Previous studies have shown TGF-β pathway includes miRNA as an important component its downstream Multiple epithelial–mesenchymal transition (EMT)-related miRNAs highlighted constitute intrinsic bistable molecular switches states forming double negative feedback loops with EMT-inducing transcription factors. This may be for understanding reversibility EMT at single-cell level, presence distinct intra- inter-tumor heterogeneity cancer phenotypes. In present review, I summarize connection between pathway, placing particular emphasis on expression signaling, modulation miRNAs, miRNA-mediated endothelial–mesenchymal well crosstalk pathways tumor microenvironment.

Язык: Английский

Процитировано

125

Hepatic Stellate Cells and Hepatocarcinogenesis DOI Creative Commons
Anna E. Barry, Rajkumar Baldeosingh, Ryan Lamm

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2020, Номер 8

Опубликована: Авг. 5, 2020

Hepatic stellate cells (HSCs) are a significant component of the hepatocellular carcinoma (HCC) tumor microenvironment (TME). Activated HSCs transform into myofibroblast-like to promote fibrosis in response liver injury or chronic inflammation, leading cirrhosis and HCC. The hepatic TME is comprised cellular components, including activated HSCs, tumor-associated macrophages, endothelial cells, immune non-cellular components such as growth factors, proteolytic enzymes their inhibitors, other extracellular matrix (ECM) proteins. Interactions between HCC have become topics under active investigation. These interactions within potential drive carcinogenesis create challenges generating effective therapies. Current studies reveal mechanisms through which hepatocarcinogenesis utilizing matricellular proteins paracrine crosstalk TME. Since primary secretors ECM during they help fibrogenesis, infiltrate stroma, contribute development. In this review, we examine several recent revealing roles clinical implications development

Язык: Английский

Процитировано

122

Conjugated Photosensitizers for Imaging and PDT in Cancer Research DOI
João C. S. Simões, Sophia Sarpaki, Panagiotis Papadimitroulas

и другие.

Journal of Medicinal Chemistry, Год журнала: 2020, Номер 63(23), С. 14119 - 14150

Опубликована: Сен. 29, 2020

Early cancer detection and perfect understanding of the disease are imperative toward efficient treatments. It is straightforward that, for choosing a specific treatment methodology, diagnostic agents undertake critical role. Imaging an extremely intriguing tool since it assumes follow up to treatments survey accomplishment recognize any conceivable repeating injuries. also permits analysis disease, as well pursue monitor possible changes that happen on tumor. Likewise, allows screening adequacy visualizing state Additionally, when finished, observing patient evaluate methodology adjust if necessary. The goal this review present overview conjugated photosensitizers imaging therapy.

Язык: Английский

Процитировано

122

Chitosan nanoparticle-mediated delivery of miRNA-34a decreases prostate tumor growth in the bone and its expression induces non-canonical autophagy DOI Open Access

Sanchaika Gaur,

Yunfei Wen, Jian H. Song

и другие.

Oncotarget, Год журнала: 2015, Номер 6(30), С. 29161 - 29177

Опубликована: Июль 22, 2015

// Sanchaika Gaur 1,2,9 , Yunfei Wen 3 Jian H. Song 1 Nila U. Parikh Lingegowda S. Mangala 3,4 Alicia M. Blessing 5 Cristina Ivan Sherry Y. Wu Andreas Varkaris Yan Shi Gabriel Lopez-Berestein 4,6 Daniel E. Frigo 5,7 Anil K. Sood 2,3,4,8 and Gary Gallick 1,2 Department of Genitourinary Medical Oncology, David Koch Center for Applied Research Cancers, The University Texas, MD Anderson Cancer Center, Houston, TX, USA 2 Program in Biology Metastasis, Texas Graduate School Biomedical Sciences at Gynecologic Oncology Reproductive Medicine, 4 RNA Interference Non-Coding RNA, Nuclear Receptors Cell Signaling, Departments Biochemistry, 6 Experimental Therapeutics, 7 Genomic Medicine Program, Houston Methodist Institute, 8 Biology, 9 Sciences, Cedars Sinai Los Angeles, CA, Correspondence: Gallick, email: Keywords : prostate cancer, miR-34a, bone metastasis, apoptosis, autophagy Received April 07, 2015 Accepted July 11, Published 22, Abstract While several new therapies are FDA-approved bone-metastatic cancer (PCa), patient survival has only improved marginally. Here, we report that chitosan nanoparticle-mediated delivery a tumor suppressive microRNA downregulates multiple gene products involved PCa progression inhibited growth preserved integrity xenograft model representative established metastasis. Expression miR-34a induced apoptosis cells, and, accord with downregulation targets associated growth, including MET Axl c-Myc, also form non-canonical is independent Beclin-1, ATG4, ATG5 ATG7. MiR-34a-induced anti-proliferative as blocking still resulted inhibition cells. Thus, combined effects responsible miR-34a-mediated inhibition, have translational impact, this inhibitory. Together, these results provide understanding the biological highlight clinical potential treatment metastatic cancer.

Язык: Английский

Процитировано

121

A cerebrospinal fluid microRNA signature as biomarker for glioblastoma DOI Open Access

Johnny Akers,

Wei Hua, Hongying Li

и другие.

Oncotarget, Год журнала: 2017, Номер 8(40), С. 68769 - 68779

Опубликована: Июнь 1, 2017

To develop a cerebrospinal fluid (CSF) miRNA diagnostic biomarker for glioblastoma.Glioblastoma tissue and matched CSF from the same patient (obtained prior to tumor manipulation) were profiled by TaqMan OpenArray® Human MicroRNA Panel. profiles glioblastoma patients controls created three discovery cohorts confirmed in two validation cohorts.miRNA clinical correlated with those found tissues. Comparison of between non-brain yielded "signature" consisting nine miRNAs. The volume (p=0.008). When prospectively applied cisternal CSF, sensitivity specificity 'signature' detection 67% 80%, respectively. For lumbar signature 28% 95%, Comparable results obtained analyses extracellular vesicles (EVs) crude CSF.We report as "liquid biopsy" platform glioblastoma.

Язык: Английский

Процитировано

120