Mechanisms of alkaliptosis DOI Creative Commons
Fangquan Chen, Rui Kang, Jiao Liu

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2023, Номер 11

Опубликована: Авг. 4, 2023

Malignant tumors represent a major threat to global health and the search for effective treatments is imperative. While various exist, including surgery, radiotherapy, chemotherapy, immunotherapy combination therapies, there remains need develop therapies that target regulated cell death pathways eliminate cancer cells while preserving normal cells. Alkaliptosis, pH-dependent process triggered by small molecular compound JTC801, has been identified as novel approach malignant tumor treatment, particularly in pancreatic cancer. Two signaling pathways, NF-κB-CA9 pathway ATP6V0D1-STAT3 pathway, contribute induction of alkaliptosis. This review summarizes recent developments our understanding alkaliptosis signals, mechanisms, modulation, explores its context-dependent effects on drug resistance, inflammation, immunity. By providing deeper heterogeneity plasticity this information holds promise informing design more anti-tumor therapies.

Язык: Английский

Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency DOI
Zhilin Li,

Xiaoqin Lai,

Shiqin Fu

и другие.

Advanced Science, Год журнала: 2022, Номер 9(22)

Опубликована: Июнь 2, 2022

Abstract Tumor immunotherapy is only effective in a fraction of patients due to low response rate and severe side effects, these challenges clinics can be addressed through induction immunogenic cell death (ICD). ICD elicited from many antitumor therapies release danger associated molecular patterns (DAMPs) tumor‐associated antigens facilitate maturation dendritic cells (DCs) infiltration cytotoxic T lymphocytes (CTLs). The process reverse the tumor immunosuppressive microenvironment improve sensitivity immunotherapy. Nanostructure‐based drug delivery systems (NDDSs) are explored induce by incorporating therapeutic molecules for chemotherapy, photosensitizers (PSs) photodynamic therapy (PDT), photothermal conversion agents (PTT), radiosensitizers radiotherapy (RT). These NDDSs loaded at right dose place time, resulting greater effectiveness lower toxicity. Immunotherapeutic also combined with achieve synergic effect multi‐modality approach. In this review, harnessed load multiple PDT, PTT, RT combination promote reduce effects cancer treatment.

Язык: Английский

Процитировано

387
The multifunctional protein HMGB1: 50 years of discovery DOI
Daolin Tang, Rui Kang, Herbert J. Zeh

и другие.

Nature reviews. Immunology, Год журнала: 2023, Номер 23(12), С. 824 - 841

Опубликована: Июнь 15, 2023

Язык: Английский

Процитировано

158
Molecular mechanisms of ferroptosis and relevance to inflammation DOI Open Access

Liyan Deng,

Shasha He,

Nuoqing Guo

и другие.

Inflammation Research, Год журнала: 2022, Номер 72(2), С. 281 - 299

Опубликована: Дек. 19, 2022

Язык: Английский

Процитировано

131
Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy DOI Creative Commons

Saixian Shi,

Ye Chen,

Zhijian Luo

и другие.

Cell Communication and Signaling, Год журнала: 2023, Номер 21(1)

Опубликована: Март 14, 2023

Doxorubicin (DOX) is a powerful and commonly used chemotherapeutic drug, alone or in combination variety of cancers, while it has been found to cause serious cardiac side effects clinical application. More more researchers are trying explore the molecular mechanisms DOX-induced cardiomyopathy (DIC), which oxidative stress inflammation considered play significant role. This review summarizes signaling pathways related DIC compounds that exert cardioprotective by acting on relevant pathways, including role Nrf2/Keap1/ARE, Sirt1/p66Shc, Sirt1/PPAR/PGC-1α NOS, NOX, Fe2+ stress, as well NLRP3/caspase-1/GSDMD, HMGB1/TLR4/MAPKs/NF-κB, mTOR/TFEB/NF-κB inflammation. Hence, we attempt explain terms inflammation, provide theoretical basis new idea for further drug research reducing DIC. Video Abstract.

Язык: Английский

Процитировано

110
Neutrophil intrinsic and extrinsic regulation of NETosis in health and disease DOI
Valentina Poli, Ivan Zanoni

Trends in Microbiology, Год журнала: 2022, Номер 31(3), С. 280 - 293

Опубликована: Ноя. 5, 2022

Язык: Английский

Процитировано

89
Chronic E-Cigarette Use Impairs Endothelial Function on the Physiological and Cellular Levels DOI Open Access
Leila Mohammadi, Daniel D Han,

Fengyun Xu

и другие.

Arteriosclerosis Thrombosis and Vascular Biology, Год журнала: 2022, Номер 42(11), С. 1333 - 1350

Опубликована: Окт. 26, 2022

The harmful vascular effects of smoking are well established, but the chronic use electronic cigarettes (e-cigarettes) on endothelial function less understood. We hypothesized that e-cigarette causes changes in blood milieu impair function.

Язык: Английский

Процитировано

74
Multifaceted role of redox pattern in the tumor immune microenvironment regarding autophagy and apoptosis DOI Creative Commons
Yuqing Ren, Ruizhi Wang, Siyuan Weng

и другие.

Molecular Cancer, Год журнала: 2023, Номер 22(1)

Опубликована: Авг. 10, 2023

Abstract The reversible oxidation-reduction homeostasis mechanism functions as a specific signal transduction system, eliciting related physiological responses. Disruptions to redox can have negative consequences, including the potential for cancer development and progression, which are closely linked series of processes, such adjustment reactive oxygen species (ROS) levels species, changes in antioxidant capacity, differential effects ROS on downstream cell fate immune capacity. tumor microenvironment (TME) exhibits complex interplay between immunity regulatory death, especially autophagy apoptosis, is crucially regulated by ROS. present study aims investigate multi-source affects autophagy, anti-tumor response TME mutual crosstalk these three processes. Given intricate role controlling immunity, we will further examine relationship traditional therapy It worth noting that discuss some ROS-related treatment options future studies.

Язык: Английский

Процитировано

53
Novel targets for immune-checkpoint inhibition in cancer DOI Creative Commons
Maxime Borgeaud, José Luís Sandoval, Michel Obéid

и другие.

Cancer Treatment Reviews, Год журнала: 2023, Номер 120, С. 102614 - 102614

Опубликована: Авг. 12, 2023

Immune-checkpoint inhibitors have revolutionized cancer therapy, yet many patients either do not derive any benefit from treatment or develop a resistance to checkpoint inhibitors. Intrinsic can result neoantigen depletion, defective antigen presentation, PD-L1 downregulation, immune-checkpoint ligand upregulation, immunosuppression, and tumor cell phenotypic changes. On the other hand, extrinsic involves acquired upregulation of inhibitory immune-checkpoints, leading T-cell exhaustion. Current data suggest that PD-1, CTLA-4, LAG-3 limits efficacy single-agent Ongoing clinical trials are investigating novel targets avoid overcome resistance. This review provides an in-depth analysis evolving landscape potentially targetable immune-checkpoints in cancer. We highlight their biology, emphasizing current understanding mechanisms focusing on promising strategies under investigation. also summarize results ongoing this crucial field could once again revolutionize outcomes for patients.

Язык: Английский

Процитировано

53
Hepatocyte HSPA12A inhibits macrophage chemotaxis and activation to attenuate liver ischemia/reperfusion injury via suppressing glycolysis-mediated HMGB1 lactylation and secretion of hepatocytes DOI Creative Commons

Shuya Du,

Xiaojin Zhang,

Yunxiao Jia

и другие.

Theranostics, Год журнала: 2023, Номер 13(11), С. 3856 - 3871

Опубликована: Янв. 1, 2023

Rationale: Liver ischemia-reperfusion (LI/R) injury is characterized by two interconnected phases: local ischemia that causes hepatic cell damage to release damage-associated molecular pattern (DAMPs), and DAMPs recruit immune cells elicit inflammatory cascade for further of hepatocytes.High-mobility group box 1 (HMGB1) a representative DAMP.Studies in macrophages demonstrated HMGB1 secreted after lactylation during sepsis.However, whether mediates secretion from hepatocytes LI/R known.Heat shock protein A12A (HSPA12A) an atypical member HSP70 family.Methods: Gene expression was examined microarray analysis immunoblotting.The analyzed using released ALT AST activities assays.Hepatic macrophage chemotaxis evaluated Transwell assays.Inflammatory mediators were immunoblotting.HMGB1 exosomes or serum.HMGB1 determined immunoprecipitation immunoblotting.Results: Here, we report decreased HSPA12A hepatocytes, while hepatocyte-specific overexpression attenuated LI/R-induced dysfunction mortality mice.We also noticed hepatocyte suppressed LI/R-exposed livers vivo hypoxia/reoxygenation (H/R)-exposed vitro.The LI/R-increased serum levels mice the H/R-increased inhibited overexpression.By contrast, knockout promoted not only H/R-induced but effects H/R-hepatocytes on activation, all these deleterious reversed following knockdown.Further analyses showed reduced glycolysis-generated lactate, thus decreasing thereby inhibiting subsequent cascade, which ultimately protecting against injury. Ivyspring

Язык: Английский

Процитировано

51
HMGB1 and Toll-like receptors: potential therapeutic targets in autoimmune diseases DOI Creative Commons

Wenxuan Ren,

Lei Zhao, Ying Sun

и другие.

Molecular Medicine, Год журнала: 2023, Номер 29(1)

Опубликована: Сен. 4, 2023

Abstract HMGB1, a nucleoprotein, is expressed in almost all eukaryotic cells. During cell activation and death, HMGB1 can function as an alarm protein (alarmin) or damage-associated molecular pattern (DAMP) mediate early inflammatory immune response when it translocated to the extracellular space. The binding of Toll-like receptors (TLRs), such TLR2 TLR4 transforms into pro-inflammatory cytokine, contributing occurrence development autoimmune diseases. TLRs, which are members family recognition receptors, bind endogenous DAMPs activate innate response. Additionally, TLRs key signaling molecules mediating play critical role host defense against pathogens maintenance balance. reported be upregulated several diseases, rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes mellitus, thyroid disease. expression levels some tissues patients with diseases animal models suppression inhibits progression inflammation models. Thus, indispensable biomarkers important therapeutic targets for This review provides comprehensive strategies treating preventing discovered recent years.

Язык: Английский

Процитировано

43