Consensus Parameter: Research Methodologies to Evaluate Neurodevelopmental Effects of Pubertal Suppression in Transgender Youth DOI Creative Commons
Diane Chen, John F. Strang, Victoria D. Kolbuck

и другие.

Transgender Health, Год журнала: 2020, Номер 5(4), С. 246 - 257

Опубликована: Июнь 9, 2020

Purpose: Pubertal suppression is standard of care for early pubertal transgender youth to prevent the development undesired and distressing secondary sex characteristics incongruent with gender identity. Preliminary evidence suggests improves mental health functioning. Given widespread changes in brain cognition that occur during puberty, a critical question whether this treatment impacts neurodevelopment. Methods: A Delphi consensus procedure engaged 24 international experts neurodevelopment, development, puberty/adolescence, neuroendocrinology, statistics/psychometrics identify priority research methodologies address empirical question: associated real-world neurocognitive sequelae? Recommended study approaches reaching 80% were included parameter. Results: The identified 160 initial expert recommendations, 44 which ultimately achieved consensus. Consensus design elements include following: minimum three measurement time points, staging at baseline, statistical modeling analyses, use analytic account heterogeneity, multiple comparison groups minimize limitations any one group. untreated matched on stage, cisgender (i.e., congruent) an independent sample from large-scale database. domains assessment includes: health, executive function/cognitive control, social awareness/functioning. Conclusion: An interdisciplinary team around primary methods assessing neurodevelopmental effects benefits and/or difficulties) youth.

Язык: Английский

Delphi methodology in healthcare research: How to decide its appropriateness DOI Open Access
Prashant Nasa, Ravi Jain, Deven Juneja

и другие.

World Journal of Methodology, Год журнала: 2021, Номер 11(4), С. 116 - 129

Опубликована: Июль 19, 2021

The Delphi technique is a systematic process of forecasting using the collective opinion panel members. structured method developing consensus among members methodology has gained acceptance in diverse fields medicine. methods assumed pivotal role last few decades to develop best practice guidance intelligence where research limited, ethically/logistically difficult or evidence conflicting. However, attempts assess quality standard studies have reported significant variance, and details followed are usually unclear. We recommend tools for evaluation methodology; identification problem area research, selection panel, anonymity panelists, controlled feedback, iterative rounds, criteria, analysis consensus, closing stability results. Based on these nine qualitative points, we assessed medical field related coronavirus disease 2019. There was inconsistency reporting vital elements such as members, defining criteria presenting propose our points researchers, journal editorial boards, reviewers evaluate healthcare research.

Язык: Английский

Процитировано

809

Consensus on revised definitions of Morphological Uterus Sonographic Assessment (MUSA) features of adenomyosis: results of modified Delphi procedure DOI Creative Commons
Marissa J. Harmsen, T. Van den Bosch, Robert A. de Leeuw

и другие.

Ultrasound in Obstetrics and Gynecology, Год журнала: 2021, Номер 60(1), С. 118 - 131

Опубликована: Сен. 29, 2021

To evaluate whether the Morphological Uterus Sonographic Assessment (MUSA) features of adenomyosis need to be better defined and, if deemed necessary, reach consensus on updated definitions.A modified Delphi procedure was performed among European gynecologists with expertise in ultrasound diagnosis adenomyosis. identify MUSA that might revision, 15 two-dimensional (2D) video recordings (four also included three-dimensional (3D) still images) transvaginal (TVS) examinations uterus were presented first round (online questionnaire). Experts asked confirm or refute presence each nine (described original statement) videoclips and provide comments. In second questionnaire), results suggestions for revision shared experts before they assess a new set 2D 3D images TVS feedback proposed revisions. A third (virtual group meeting) conducted discuss final revised definitions features. Consensus predefined as at least 66.7% agreement between experts.Of 18 invited experts, 16 agreed participate procedure. Eleven completed four partly finished round. The identified more detailed some They recommended use optimize visualization junctional zone. Fifteen participated reached absence most images. all except those subendometrial lines buds interrupted Thirteen joined online meeting, which discussed revisions definitions. There distinguish direct adenomyosis, i.e. indicating ectopic endometrial tissue myometrium, indirect features, reflecting changes myometrium secondary myometrium. Myometrial cysts, hyperechogenic islands echogenic classified unanimously Globular uterus, asymmetrical myometrial thickening, fan-shaped shadowing, translesional vascularity, irregular zone adenomyosis.Consensus achieved regarding classification signs © 2021 Authors. Ultrasound Obstetrics & Gynecology published by John Wiley Sons Ltd behalf International Society Gynecology.

Язык: Английский

Процитировано

154

A review of big data and medical research DOI Creative Commons
Mary C. Mallappallil,

Jacob Sabu,

Angelika C. Gruessner

и другие.

SAGE Open Medicine, Год журнала: 2020, Номер 8

Опубликована: Янв. 1, 2020

Universally, the volume of data has increased, with collection rate doubling every 40 months, since 1980s. “Big data” is a term that was introduced in 1990s to include sets too large be used common software. Medicine major field predicted increase use big 2025. Big medicine may by commercial, academic, government, and public sectors. It includes biologic, biometric, electronic health data. Examples biologic biobanks; biometric have individual wellness from devices; medical record; other demographics images. also contributed changes research methodology. Changes clinical paradigm been fueled large-scale biological harvesting (biobanks), which developed, analyzed, managed cheaper computing technology (big data), supported greater flexibility study design (real-world data) relationships between industry, government regulators, academics. Cultural along easy access information via Internet facilitate ease participation more people. Current needs demand quick answers supplied data, biobanks, design. can reveal patterns, promises provide solutions previously out society’s grasp; however, murkiness international laws, questions ownership, ignorance, privacy security concerns are slowing down progress could otherwise achieved The goal this descriptive review create awareness ramifications for encourage readers trend positive will likely lead better solutions, but, caution must exercised reduce harm.

Язык: Английский

Процитировано

78

Essential Emergency and Critical Care: a consensus among global clinical experts DOI Creative Commons
Carl Otto Schell, Karima Khalid, Alexandra Wharton–Smith

и другие.

BMJ Global Health, Год журнала: 2021, Номер 6(9), С. e006585 - e006585

Опубликована: Сен. 1, 2021

Background Globally, critical illness results in millions of deaths every year. Although many these are potentially preventable, the basic, life-saving care critically ill patients often overlooked health systems. Essential Emergency and Critical Care (EECC) has been devised as that should be provided to all hospitals world. EECC includes effective low cost complexity for identification treatment across medical specialties. This study aimed specify content additionally, given surge ongoing pandemic, essential diagnosis-specific with COVID-19. Methods In a Delphi process, consensus (>90% agreement) was sought from diverse panel global clinical experts. The iteratively rated proposed treatments actions based on previous guidelines WHO/ICRC’s Basic Care. output adapted specialist reviewers into coherent feasible package processes plus list hospital readiness requirements. Results 269 experts had experience different acute specialties 59 countries resource settings. agreed contains 40 67 requirements, additions specific Conclusion specified patients. Implementing could an strategy policy makers reduce preventable worldwide.

Язык: Английский

Процитировано

76

A systematic review of the influences of food store product placement on dietary-related outcomes DOI Creative Commons
Sarah Shaw, Georgia Ntani, Janis Baird

и другие.

Nutrition Reviews, Год журнала: 2020, Номер unknown

Опубликована: Март 31, 2020

Product placement strategies have been used to influence customers' food purchases in stores for some time; however, assessment of the evidence that these techniques can limit unhealthy, and promote healthy, choices has not completed.

Язык: Английский

Процитировано

71

Expert Panel Survey to Update the American Congress of Rehabilitation Medicine Definition of Mild Traumatic Brain Injury DOI Creative Commons
Noah D. Silverberg, Grant L. Iverson, David B. Arciniegas

и другие.

Archives of Physical Medicine and Rehabilitation, Год журнала: 2020, Номер 102(1), С. 76 - 86

Опубликована: Окт. 7, 2020

As part of an initiative led by the Brain Injury Special Interest Group Mild Traumatic (TBI) Task Force American Congress Rehabilitation Medicine (ACRM) to update 1993 ACRM definition mild TBI, present study aimed characterize current expert opinion on diagnostic considerations.Cross-sectional web-based survey.Not applicable.An international, interdisciplinary group clinician-scientists (N=31) with expertise in TBI completed survey invitation between May and July 2019 (100% completion rate).Not applicable.Ratings agreement statements related diagnosis ratings importance various clinical signs, symptoms, test findings, contextual factors for increasing likelihood that individual sustained a scale ranging from 1 ("not at all important") 10 ("extremely important").Men (n=25; 81%) Americans (n=21; 68%) were over-represented sample. The revealed areas (eg, acute symptoms are diagnostically useful) disagreement whether abnormal structural neuroimaging should be considered same entity as "concussion"). Observable signs generally rated more important than subjective (Wilcoxon signed ranks test, Z=3.77; P<.001; r=0.68). Diagnostic varied widely, some common postconcussion fatigue) unhelpful (<75% respondents indicated least 5 out importance). Certain findings cognitive balance impairments) absence confounds) consistently highly (≥75% 7 10).The identified several potential revisions consider when updating definition, including preferentially weighing observable probabilistic framework, incorporating adding differential considerations.

Язык: Английский

Процитировано

70

WAO consensus on DEfinition of Food Allergy SEverity (DEFASE) DOI Creative Commons
Stefania Arasi, Ulugbek Nurmatov, Audrey DunnGalvin

и другие.

World Allergy Organization Journal, Год журнала: 2023, Номер 16(3), С. 100753 - 100753

Опубликована: Март 1, 2023

Язык: Английский

Процитировано

27

Examine an Intelligence Education Framework of Landscape Architecture (EFLA) Based on Network Model of Technology in Landscape Architecture (NMTLA) DOI Open Access
Mengting Ge, Jie Kong,

Qiuyi Yang

и другие.

Sustainability, Год журнала: 2023, Номер 15(14), С. 11277 - 11277

Опубликована: Июль 19, 2023

The discipline of Landscape Architecture (LA) is currently expanding its disciplinary boundary. supporting Technology in LA (TLA) always evolving and optimized to solve environmental problems. Considering the uncertain classification current knowledge for education importance technology education, a refined framework needed. This research first established Network Model (NMTLA) using Analysis (NA) expert interviews. Then, this proposed an Education Framework (EFLA) based on NMTLA. To build NMTLA, identified 23 key categories TLA through content analysis secondary research. interview network theory were used analyze visualize relationships among categories. By examining degree centrality, closeness betweenness centrality different TLA, study developed EFLA which summarizes twenty-three into four domains: core techniques, applied technologies, integrated specific technologies. also proposes series suggestions how apply today’s future education. NMTLA can contribute development higher They potentially address Sustainable Development Goals (SDGs) industry. However, scope limited USA, could be expanded include worldwide perspective enhance validity conclusions, larger sample size interviews should employed further studies.

Язык: Английский

Процитировано

22

Too good to waste: Examining circular economy opportunities, barriers, and indicators for sustainable construction and demolition waste management DOI Creative Commons
Héctor Martín,

Deeksha Chebrolu,

Aaron Anil Chadee

и другие.

Sustainable Production and Consumption, Год журнала: 2024, Номер 48, С. 460 - 480

Опубликована: Июнь 7, 2024

There is a significant deficiency in addressing the unique characteristics of construction and demolition waste (C&DW) United Kingdom (UK) as it remains primary contributor to landfills. Circular economy (CE) practices are explored address this risk shortfall management comprehend reduction strategies for C&DW. Using Fuzzy Delphi approach, study maps assesses uncertainties associated with identifying indicators ranked CE adoption barriers achieve agreement twelve respondents. Consensus was also achieved C&DW measurement indicators. Concurrently, eleven separate interviews were conducted understand CE's effectiveness improving management. The results indicated that most barrier inefficient recycling policies ensure high-quality recycled materials. findings underscore influence design, managerial, legal surpasses social, knowledge, culture. Despite highlighting focus on recycling, reusing, reducing raw materials, deeply established tendencies prioritise linear economic models exist widely, resource conservation less considered. This provides concrete implementation responsible consumption production, challenges adoption, offers 25 industry-specific measuring implementation.

Язык: Английский

Процитировано

13

The definition of treatment resistance in anxiety disorders: a Delphi method‐based consensus guideline DOI Open Access
Katharina Domschke,

Patrik D. Seuling,

Miriam A. Schiele

и другие.

World Psychiatry, Год журнала: 2024, Номер 23(1), С. 113 - 123

Опубликована: Янв. 12, 2024

Anxiety disorders are very prevalent and often persistent mental disorders, with a considerable rate of treatment resistance which requires regulatory clinical trials innovative therapeutic interventions. However, an explicit definition treatment-resistant anxiety (TR-AD) informing such is currently lacking. We used Delphi method-based consensus approach to provide internationally agreed, consistent clinically useful operational criteria for TR-AD in adults. Following summary the current state knowledge based on international guidelines available systematic review, survey free-text responses 29-item questionnaire relevant aspects TR-AD, online meeting, panel 36 multidisciplinary experts stakeholders voted anonymously written statements three rounds. Consensus was defined as ≥75% agreeing statement. The agreed set 14 recommendations providing detailed pharmacological and/or psychotherapeutic treatment, well potential staging model. also evaluated further regarding epidemiological subgroups, comorbidities biographical factors, terminology vs. "difficult-to-treat" preferences attitudes persons these future research directions. This expected serve systematic, practical guideline aid designing mechanistic studies facilitate purposes. effort could ultimately lead development more effective evidence-based stepped-care algorithms patients disorders.

Язык: Английский

Процитировано

12