BMC Infectious Diseases, Год журнала: 2022, Номер 22(1)
Опубликована: Июль 15, 2022
Coronavirus disease 2019 (COVID-19) is accompanied by activated immune-inflammatory pathways and oxidative stress, which both induce indoleamine-2,3-dioxygenase (IDO), a key enzyme of the tryptophan (TRP) catabolite (TRYCAT) pathway. The aim this study was to systematically review meta-analyze status TRYCAT pathway, including levels TRP kynurenine (KYN) activity IDO, as measured ratio KYN/TRP.
Язык: Английский
European Heart Journal, Год журнала: 2022, Номер 43(11), С. 1157 - 1172
Опубликована: Фев. 7, 2022
Abstract Emerging as a new epidemic, long COVID or post-acute sequelae of coronavirus disease 2019 (COVID-19), condition characterized by the persistence COVID-19 symptoms beyond 3 months, is anticipated to substantially alter lives millions people globally. Cardiopulmonary including chest pain, shortness breath, fatigue, and autonomic manifestations such postural orthostatic tachycardia are common associated with significant disability, heightened anxiety, public awareness. A range cardiovascular (CV) abnormalities has been reported among patients acute phase include myocardial inflammation, infarction, right ventricular dysfunction, arrhythmias. Pathophysiological mechanisms for delayed complications still poorly understood, dissociation seen between ongoing objective measures cardiopulmonary health. long-term trajectory many chronic cardiac diseases which abundant in those at risk severe disease. In this review, we discuss definition its epidemiology, an emphasis on symptoms. We further review pathophysiological underlying CV injury, sequelae, impact multiorgan propose possible model referral post-COVID-19 services future directions research priorities clinical trials that currently underway evaluate efficacy treatment strategies sequelae.
Язык: Английский
Процитировано
536
EBioMedicine, Год журнала: 2021, Номер 72, С. 103629 - 103629
Опубликована: Окт. 1, 2021
The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) poses an unprecedented challenge to humanity. SARS-CoV-2 infections range from asymptomatic severe courses of with acute respiratory distress syndrome (ARDS), multiorgan involvement and death. Risk factors for disease severity include older age, male sex, increased BMI pre-existing comorbidities. Ethnicity is also relevant susceptibility severity. Host genetic predisposition now increasingly recognized whole genome candidate gene association studies regarding have been performed. Several common rare variants in genes related inflammation or immune responses identified. We summarize research on host genetics compile associated discuss that should be investigated further understand such associations provide insights pathogenesis, risk classification, therapy response, precision medicine, drug repurposing.
Язык: Английский
Процитировано
184
Molecules, Год журнала: 2023, Номер 28(13), С. 4982 - 4982
Опубликована: Июнь 25, 2023
Flavonoids represent the main class of plant secondary metabolites and occur in tissues organs various species. In plants, flavonoids are involved many biological processes response to environmental stresses. The consumption has been known reduce risk chronic diseases due their antioxidant free radical scavenging properties. present review, we summarize classification, distribution, biosynthesis pathways, regulatory mechanisms flavonoids. Moreover, investigated activities discuss applications food processing cosmetics, as well pharmaceutical medical uses. Current trends flavonoid research also briefly described, including mining new functional genes through omics engineering using nanotechnology. This review provides a reference for basic applied on compounds.
Язык: Английский
Процитировано
148
European journal of medical research, Год журнала: 2022, Номер 27(1)
Опубликована: Янв. 13, 2022
SARS-CoV-2, a novel coronavirus, is the agent responsible for COVID-19 pandemic and major public health concern nowadays. The rapid global spread of this coronavirus leads to an increase in hospitalizations thousands deaths many countries. To date, great efforts have been made worldwide efficient management crisis, but there still no effective specific treatment COVID-19. primary therapies treat disease are antivirals, anti-inflammatories respiratory therapy. In addition, antibody currently active essential part SARS-CoV-2 infection treatment. Ongoing trials proposed different therapeutic options including various drugs, convalescent plasma therapy, monoclonal antibodies, immunoglobulin cell present study summarized current evidence these approaches assess their efficacy safety We tried provide comprehensive information about available potential against support researchers physicians any future progress treating patients.
Язык: Английский
Процитировано
139
Frontiers in Immunology, Год журнала: 2021, Номер 12
Опубликована: Сен. 30, 2021
The coronavirus disease-19 (COVID-19) elicited by the severe acute respiratory syndrome 2 (SARS-CoV-2) has caused devastating health, economic and social impact worldwide. Its clinical spectrum ranges from asymptomatic to failure multi-organ or death. pathogenesis of SARS-CoV-2 infection is attributed a complex interplay between virus host immune response. It involves activation multiple inflammatory pathways leading hyperinflammation cytokine storm, resulting in tissue damage, distress (ARDS) failure. Accumulating evidence raised concern over long-term health effects COVID-19. Importantly, neuroinvasive potential may have consequences brain. This review provides conceptual framework on how tricks system induce cause disease. We also explore key differences mild COVID-19 its short- effects, particularly human
Язык: Английский
Процитировано
135
International Journal of Biological Macromolecules, Год журнала: 2021, Номер 193, С. 948 - 955
Опубликована: Окт. 18, 2021
Язык: Английский
Процитировано
115
EBioMedicine, Год журнала: 2021, Номер 75, С. 103803 - 103803
Опубликована: Дек. 31, 2021
The Coronavirus Disease 2019 (COVID-19) pandemic has been a great threat to global public health since 2020. Although the advance on vaccine development largely achieved, strategy alleviate immune overactivation in severe COVID-19 patients is still needed. NLRP3 inflammasome activated upon SARS-CoV-2 infection and associated with severity. However, processes by which involved disease remain unclear.We infected THP-1 derived macrophages, knockout mice, human ACE2 transgenic mice live Biosafety Level 3 (BSL-3) laboratory. We performed quantitative real-time PCR for targeted viral or host genes from mouse tissues, conducted histological immunofluorescence analysis tissues. also injected intranasally AAV-hACE2 intraperitoneally inhibitor MCC950 before as indicated.We have provided multiple lines of evidence that plays an important role response invasion lungs. Inhibition attenuated release related pro-inflammatory cytokines cell cultures mice. pathology induced lung tissues was reduced Nlrp3-/- compared wild-type C57BL/6 Finally, specific inhibition alleviated excessive inflammation thus like mice.Inflammatory activation stimulator immunopathology. Targeting promising intervention against disease.This work supported grants Bureau Frontier Sciences Education, CAS (grant no. QYZDJ-SSW-SMC005 Y.G.Y.), key project "Light West China" Program (to D.Y.) Yunnan Province (202001AS070023 D.Y.).
Язык: Английский
Процитировано
111
Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)
Опубликована: Ноя. 22, 2023
The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and hyperactivation, highlights the potential renormalization as a promising strategy in disease treatment. In recent years, our primary focus has centered on γδ T cell-based immunotherapy, particularly pioneering use allogeneic Vδ2
Язык: Английский
Процитировано
111
Gastroenterology, Год журнала: 2022, Номер 164(2), С. 272 - 288
Опубликована: Сен. 23, 2022
Background & AimsWe investigate interrelationships between gut microbes, metabolites, and cytokines that characterize COVID-19 its complications, we validate the results with follow-up, Japanese 4D (Disease, Drug, Diet, Daily Life) microbiome cohort, non-Japanese data sets.MethodsWe performed shotgun metagenomic sequencing metabolomics on stools cytokine measurements plasma from 112 hospitalized patients SARS-CoV-2 infection non–COVID-19 control individuals matched by important confounders.ResultsMultiple correlations were found COVID-19–related microbes (eg, oral short-chain fatty acid producers) metabolites branched-chain aromatic amino acids, carbohydrates, neurotransmitters, vitamin B6). Both also linked to inflammatory dynamics interferon γ, λ3, interleukin 6, CXCL-9, CXCL-10). Such detected highly in severe disease pneumonia; moderately high D-dimer level, kidney dysfunction, liver dysfunction groups; but rarely diarrhea group. We confirmed concordances of altered spermidine, putrescine, B6) their corresponding microbial functional genes. Results metabolomic alterations cross-sectional set partly concordant those follow-up set. Microbial signatures for distinct diabetes, bowel disease, proton-pump inhibitors overlapping rheumatoid arthritis. Random forest classifier models using microbiomes can predict disease. The showed moderate concordance Hong Kong Japan.ConclusionsMultiomics analysis revealed multiple microbe-metabolite-cytokine COVID-19related complications few gastrointestinal suggesting microbiota-mediated immune responses organ sites. Our underscore existence a gut-lung axis COVID-19. sets. confounders. Multiple Japan. Multiomics
Язык: Английский
Процитировано
100
Tropical Medicine and Infectious Disease, Год журнала: 2024, Номер 9(1), С. 13 - 13
Опубликована: Янв. 4, 2024
Interleukins (ILs) are signaling molecules that crucial in regulating immune responses during infectious diseases. Pro-inflammatory ILs contribute to the activation and recruitment of cells, whereas anti-inflammatory help suppress excessive inflammation promote tissue repair. Here, we provide a comprehensive overview role pro-inflammatory diseases, with focus on mechanisms underlying their effects, diagnostic therapeutic potential, emerging trends IL-based therapies.
Язык: Английский
Процитировано
89