Microbial Pathogenesis, Год журнала: 2023, Номер 179, С. 106096 - 106096
Опубликована: Апрель 1, 2023
Язык: Английский
Foods, Год журнала: 2024, Номер 13(11), С. 1754 - 1754
Опубликована: Июнь 3, 2024
Dietary intake of natural substances to regulate physiological functions is currently regarded as a potential way promoting health. As one the recommended dietary ingredients, phytosterols that are bioactive compounds distributed in plants have received increasing attention for their health effects. Phytosterols attracted great from scientists because many functions, example, cholesterol-lowering, anticancer, anti-inflammatory, and immunomodulatory In addition, phytosterols, purification, structure analysis, synthesis, food application been widely studied. Nowadays, bioactivities assessed vivo vitro. However, mechanisms pharmacological activities not yet fully understood, in-depth investigation relationship between function crucial. Therefore, contemporaneous overview extraction, beneficial properties, mechanisms, well current states phytosterol application, field provided this review.
Язык: Английский
Процитировано
11
Phytochemistry Reviews, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 2, 2024
Язык: Английский
Процитировано
9
Food Hydrocolloids, Год журнала: 2025, Номер unknown, С. 111078 - 111078
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Environmental Research, Год журнала: 2025, Номер 271, С. 121115 - 121115
Опубликована: Фев. 13, 2025
Язык: Английский
Процитировано
1
Advances in Colloid and Interface Science, Год журнала: 2023, Номер 321, С. 103011 - 103011
Опубликована: Сен. 29, 2023
Язык: Английский
Процитировано
20
Frontiers in Pharmacology, Год журнала: 2023, Номер 14
Опубликована: Сен. 28, 2023
Cancer is the world’s leading cause of human death today, and treatment process cancer highly complex. Chemotherapy targeted therapy are commonly used in treatment, emergence drug resistance a significant problem treatment. Therefore, mechanism during has become hot issue current research. A series studies have found that lipid metabolism closely related to resistance. This paper details changes how affects More importantly, most reported combination may lead lipid-related metabolic pathways, which reverse development enhance or rescue sensitivity therapeutic drugs. summarizes progress design targeting improving resistance, providing new ideas strategies for future tumor this reviews issues combining medications with
Язык: Английский
Процитировано
20
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 248, С. 125725 - 125725
Опубликована: Июль 6, 2023
Язык: Английский
Процитировано
19
Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Май 10, 2023
Psoriasis is a chronic autoinflammatory skin disease associated with multiple comorbidities, prevalence ranging from 2 to 3% in the general population. Decades of preclinical and clinical studies have revealed that alterations cholesterol lipid metabolism are strongly psoriasis. Cytokines (tumor necrosis factor-α (TNF-α), interleukin (IL)-17), which important pathogenesis psoriasis, been shown affect metabolism. Cholesterol metabolites metabolic enzymes, on other hand, influence not only biofunction keratinocytes (a primary type cell epidermis) but also immune response inflammation. However, relationship between psoriasis has thoroughly reviewed. This review mainly focuses disturbances their crosstalk psoriatic
Язык: Английский
Процитировано
18
Cancers, Год журнала: 2023, Номер 15(15), С. 3948 - 3948
Опубликована: Авг. 3, 2023
Statins, a class of HMG-CoA reductase inhibitors best known for their cholesterol-reducing and cardiovascular protective activity, have also demonstrated promise in cancer prevention treatment. This review focuses on potential applications head neck (HNC), common malignancy which established treatment often fails despite incurring debilitating adverse effects. Preclinical clinical studies suggested that statins may enhance HNC sensitivity to radiation other conventional therapies while protecting normal tissue, but the underlying mechanisms remain poorly defined, likely involving both cholesterol-dependent -independent effects diverse cancer-related pathways. brings together recent discoveries concerning anticancer activity relevant HNC, highlighting anti-inflammatory impacts DNA-damage response. We explore molecular targets discuss integrate into regimens improve patient outcomes.
Язык: Английский
Процитировано
18
Cell Communication and Signaling, Год журнала: 2023, Номер 21(1)
Опубликована: Сен. 14, 2023
Abstract Cholesterol plays a significant role in stabilizing lipid or membrane rafts, which are specific cellular structures. is involved numerous processes, including regulating virus entry into the host cell. Multiple viruses have been shown to rely on cholesterol for and/or morphogenesis. Research indicates that reprogramming of host’s metabolism associated with hepatitis B (HBV) and C (HCV) infections progression severe liver disease cause chronic hepatitis. Moreover, knowing precise mode viral interaction target cells sheds light pathogenesis aids development vaccines therapeutic targets. As result, area cholesterol-lowering therapy quickly evolving has many novel antiviral targets medications. It microRNAs (miRNAs) either directly indirectly genome, preventing replication. miRNAs recently be strong post-transcriptional regulators genes metabolism, particularly those homeostasis. important homeostasis several infections, come light. In addition, multiple studies demonstrated during infection, modulate enzymes mevalonate/cholesterol pathway. essential life cycle other viruses, sophisticated understanding miRNA regulation may contribute anti-HCV treatment. The mechanisms underlying effectiveness as against explored this review. Graphical
Язык: Английский
Процитировано
18