A complex molecular landscape to drug delivery concept for achieving precise therapy in psoriasis

Medicine in Drug Discovery, Год журнала: 2024, Номер 22, С. 100183 - 100183

Опубликована: Март 8, 2024

Psoriasis is a chronic autoimmune disorder that has major effect on the quality of life for millions people throughout world. The pathogenesis psoriasis revealed intricate molecular networks and signaling pathways, opening new avenues precision medicine. treatments include topical therapy, phototherapy, systemic therapies, biologics, but achieving optimal outcomes difficult. Despite advancements in understanding causes development various treatments, optimizing therapeutic remains challenging. Managing poses challenges terms drug delivery evaluation models. Novel systems capable navigating complex skin barriers delivering therapeutics precisely to target cells are crucial advancing treatment options. This article provides an inclusive overview psoriasis, highlighting recent discoveries potential targets. emphasizes importance combining different modalities, such as synthetic herbal agents, with biologics improve efficacy. Nanocarriers show promise targeted they can encapsulate antipsoriatic drugs, gene providing enhanced stability, improved tissue penetration, precise cellular targeting. These have revolutionize by maximizing efficacy while minimizing side effects. also discusses commercial formulations, including patents related ongoing clinical trials, which provide valuable insights into evolving landscape therapeutics. provided contribute field offer hope patients suffering from psoriasis.

Язык: Английский

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Network pharmacology and gut microbiota insights: unraveling Shenling Baizhu powder’s role in psoriasis treatment

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Фев. 14, 2024

Background: Psoriasis, a chronic skin condition characterized by systemic inflammation and altered gut microbiota, has been target of Traditional Chinese Medicine (TCM) for centuries. Shenling Baizhu Powder (SLBZP), TCM formulation, holds promise treating inflammatory diseases, but its specific role in psoriasis impact on microbiota is not fully understood. Objective: This study aims to elucidate the mechanism SLBZP psoriasis, integrating component analysis, network pharmacology, experimental validation mice models. Methods: We commenced with detailed analysis using liquid chromatograph mass spectrometer (LC-MS). Network pharmacology was used predict potential action targets pathways psoriasis. An vivo experiment conducted models, treated SLBZP. Therapeutic effects were assessed via symptomatology, histopathology, immunohistochemical analysis. Gut composition analyzed 16S rRNA gene sequencing. Results: A total 42 main components quality markers identified, primarily from licorice ginseng, including flavonoids, saponins other markers. PPI topology showed that TNF, IL-6, IL-1β, TP53 JUN core DEPs. 168 signaling lipid atherosclerosis, AGE-RAGE pathway, IL-17 pathway Th17 cell differentiation enriched KEGG. demonstrated significant therapeutic mice, alterations pathology biomarkers. Additionally, notable changes observed post-treatment, indicating possible gut-skin axis involvement. Conclusion: research pinpointed metabolism as key treatment It explores how SLBZP’s modulation can alleviate suggesting balancing may reduce mediators offer benefits. underscores new strategy treatment.

Язык: Английский

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Effects of tumor necrosis factor-alpha inhibitors on lipid profiles in patients with psoriasis: a systematic review and meta-analysis

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Март 4, 2024

Background There is no consensus on the effect of tumor necrosis factor-alpha (TNF-alpha) inhibitors lipid profiles in patients with psoriasis. This study aimed to investigate effects TNF-alpha (triglycerides, total cholesterol, low-density lipoprotein, or high-density lipoprotein) Methods We searched PubMed, Embase, and Cochrane Library databases for articles published before October 17, 2023. Four (infliximab, etanercept, adalimumab, certolizumab) were included our study. (PROSPERO ID: CRD42023469703). Results A twenty trials included. Overall results revealed that elevated lipoprotein levels psoriasis (WMD = 2.31; 95% CI: 0.96, 3.67; P 0.001), which was supported by sensitivity analyses excluding lipid-lowering drugs. Subgroup indicated significantly increased less than equal 3 months group 2.88; 1.37, 4.4; < etanercept 3.4; CI 1.71, 5.09, 2.52; 0.57, 4.48, 0.011). Triglyceride 6-month 4.98; 1.97, 7.99, 0.001) decreased older -19.84; -23.97, -15.7, 0.001). Additionally, 5.22; 2.23, 8.21, Conclusion Our might temporarily increase However, changes triglycerides not consistent among different durations treatment, significant increases after 6 treatment. Future prospective long-term follow-up contribute confirming extending findings. Systematic Review Registration https://www.crd.york.ac.uk/PROSPERO/ , identifier CRD42023469703.

Язык: Английский

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Comparative Analysis of Redox Homeostasis Biomarkers in Patients with Psoriasis and Atopic Dermatitis

Antioxidants, Год журнала: 2023, Номер 12(10), С. 1875 - 1875

Опубликована: Окт. 18, 2023

Aim: There are no studies regarding comparative analysis of serum biomarkers oxidative stress in patients with psoriasis (PsO) and atopic dermatitis (AD). We aimed to compare the redox homeostasis parameters PsO vs. AD an attempt find sensitive specific biomarker that could best reflect existence one these disease entities. Methods: Forty forty were consecutively included this cross-sectional study. Parameters homeostasis, i.e., pro-oxidants [malondialdehyde (MDA) advanced oxidation protein products (AOPP)] antioxidants [catalase (CAT) superoxide dismutase (SOD)] determined. Results: was difference between group, except for higher CAT activity group (p < 0.001). Among all examined biomarkers, ROC showed only exhibited good diagnostic accuracy (AUC = 0.719) discrimination AD, 0.436 U/L as cut-off value activity. Conclusions: The from those PsO. obtained results suggest importance use a potential therapeutic strategy treatment two skin inflammatory diseases.

Язык: Английский

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Innovative Approaches to Psoriasis: Small Molecules Targeting Key Signaling Pathways

Immunological Investigations, Год журнала: 2025, Номер unknown, С. 1 - 37

Опубликована: Янв. 17, 2025

Psoriasis (Pso) is a chronic, immune-mediated dermatological condition characterized by dysregulated inflammatory responses and the hyperproliferation of keratinocytes. Biologics, which target specific cytokines such as IL-17 IL-23, have revolutionized management addressing key drivers its pathophysiology. Despite their efficacy, biologics are not without limitations, including need for intermittent administration ongoing monitoring. In contrast, small molecules offer promising alternative selectively inhibiting signaling pathways that modulate pro-inflammatory involved in cascade. This review suggests new therapeutic strategy Pso treatment, emphasizing intricate relationships between important pathophysiology skin conditions. Improving treatment outcomes reducing side effects associated with conventional medicines, this aims to better understand how tailored small-molecule inhibitors might efficiently control these pathways. creative approach promotes creation individualized plans can greatly enhance quality life patients Psoby utilizing knowledge gathered from recent developments pathway research. delves into molecular mechanisms underlying explores be harnessed outcomes, presenting paradigm managing chronic disorder.

Язык: Английский

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Effects of Th1/Th17 and Th2 cytokines on lipid metabolism in differentiated keratinocytes

Frontiers in Physiology, Год журнала: 2025, Номер 16

Опубликована: Фев. 19, 2025

Abnormalities of keratinocyte differentiation and impairment permeability barrier are features inflammatory skin diseases driven by Th1/Th17 Th2 immune response, such as psoriasis atopic dermatitis. We aimed at identifying the signature environments on keratinocytes, focusing expression genes involved in lipid metabolism profiles abundance metabolites. Human immortalized keratinocytes prodifferentiative conditions induced increasing calcium concentration, 3D epidermal equivalents were treated with mixtures either TNF-α IL-17A plus Th1-related cytokines (IL-1α, IL-6) or (IL-4, IL-13). The was evaluated RT-PCR 2, 4 7 days treatment. protein levels early late markers assessed. composition investigated GCMS LCMS. Both cytokine changed fatty acids (FAs), i.e., FAS, FADS2, SCD1, ALOX12B. Th1/ Th17 downregulated ELOVL3 gene, which is implicated FAs elongation, while mRNA ABCA12 HMGCR, lipids transport cholesterol synthesis, respectively, decreased both mixtures. DEGS1 DEGS2, key enzymes ceramide upregulated environments, respectively. CERS3, synthesizes ceramides containing long chain FAs, increased cytokines. lowered CERS6 differentiated keratinocytes. Effects specific to observed freely extractable cell lipids. significantly inhibited high calcium-induced synthesis phospholipids (PCs, PEs, SMs), short-chain ceramides, medium carbon chains upregulated. caused a generalized decrement free including long-chain ones. In contrast 2D cultures, allowed identification altered acyland hexosyl-ceramides. different effects exerted support, least part, alterations

Язык: Английский

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Association Between Short-term Ambient Air Pollution and Psoriasis: A Time-Stratified Case-Crossover Study

Asia Pacific Journal of Public Health, Год журнала: 2025, Номер unknown

Опубликована: Март 29, 2025

This time-stratified case-crossover study evaluated the association between short-term exposure to ambient air pollution and psoriasis. A total of 107 462 psoriasis cases 2002 2016 were retrieved from Taiwan's National Health Insurance Research Database. Conditional logistic regression was used estimate pollutants (O3, CO, NO2, SO2, PM2.5, PM10) with each interquartile range (IQR) increase. Consistent associations for IQR increase in NO2 CO noted at lag 0 both single-pollutant multiple-pollutant model. Exposure on had highest odds ratio (OR), decreasing consecutively 1 3. Both a stronger influence among men, older patients (>60 years old), chronic disease. Short-term associated link might provide insights into how pollution, least part, affects epidemiology pathogenesis

Язык: Английский

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The impact of metabolic reprogramming on tertiary lymphoid structure formation: enhancing cancer immunotherapy

BMC Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 13, 2025

Cancer immunotherapy has achieved unprecedented success in the field of cancer therapy. However, its potential is constrained by a low therapeutic response rate. Tertiary lymphoid structure (TLS) plays crucial role antitumor immunity and associated with good prognosis. Metabolic reprogramming, as hallmark tumor microenvironment, can influence promote formation follicular helper T cells germinal centers. many current studies focus on correlation between metabolism TLS factors, there insufficient direct evidence to suggest that drives formation. This review provided comprehensive summary relationship formation, highlighting glucose metabolism, lipid amino acid vitamin metabolism. In future, an in-depth exploration how affects cell interactions microorganisms will significantly advance our understanding metabolism-enhanced immunity.

Язык: Английский

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Bioinformatics analysis to reveal the potential comorbidity mechanism in psoriasis and nonalcoholic steatohepatitis

Skin Research and Technology, Год журнала: 2023, Номер 29(9)

Опубликована: Сен. 1, 2023

An increasing amount of evidence suggests that psoriasis and nonalcoholic steatohepatitis (NASH) may occur simultaneously, whereas the underlying mechanisms remain unclear. Our research aims to explore potential comorbidity mechanism in steatohepatitis.

Язык: Английский

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Decreased HMGCS1 inhibits proliferation and inflammatory response of keratinocytes and ameliorates imiquimod-induced psoriasis via the STAT3/IL-23 axis

International Immunopharmacology, Год журнала: 2024, Номер 133, С. 112033 - 112033

Опубликована: Апрель 11, 2024

Язык: Английский

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