Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
171, P. 116192 - 116192
Published: Jan. 22, 2024
Statins,
inhibitors
of
3-hydroxy-3-methylglutaryl-coenzyme
A,
are
widely
used
to
treat
hypercholesterolemia.
In
addition,
statins
have
been
suggested
reduce
the
risk
cardiovascular
events
owing
their
pleiotropic
effects
on
vascular
system,
including
vasodilation,
anti-inflammation,
anti-coagulation,
anti-oxidation,
and
inhibition
smooth
muscle
cell
proliferation.
The
major
beneficial
effect
in
maintaining
homeostasis
is
induction
nitric
oxide
(NO)
bioavailability
by
activating
endothelial
NO
synthase
(eNOS)
cells.
mechanisms
underlying
increased
eNOS
activation
well-established
various
fields,
transcriptional
post-transcriptional
regulation,
kinase-dependent
phosphorylation
protein-protein
interactions.
However,
mechanism
which
affect
metabolism
L-arginine,
a
precursor
biosynthesis,
has
rarely
discussed.
Autophagy,
crucial
for
energy
homeostasis,
regulates
functions,
production
angiogenesis,
potential
therapeutic
target
diseases.
this
review,
addition
summarizing
molecular
statins,
we
also
discuss
L-arginine.
Molecular Metabolism,
Journal Year:
2023,
Volume and Issue:
74, P. 101755 - 101755
Published: June 16, 2023
Recently,
the
hallmarks
of
aging
were
updated
to
include
dysbiosis,
disabled
macroautophagy,
and
chronic
inflammation.
In
particular,
low-grade
inflammation
during
aging,
without
overt
infection,
is
defined
as
"inflammaging,"
which
associated
with
increased
morbidity
mortality
in
population.
Emerging
evidence
suggests
a
bidirectional
cyclical
relationship
between
development
age-related
conditions,
such
cardiovascular
diseases,
neurodegeneration,
cancer,
frailty.
How
crosstalk
other
underlies
biological
mechanisms
disease
thus
particular
interest
current
geroscience
research.
ACS Chemical Neuroscience,
Journal Year:
2023,
Volume and Issue:
15(1), P. 1 - 30
Published: Dec. 14, 2023
Aging
is
a
dynamic,
time-dependent
process
that
characterized
by
gradual
accumulation
of
cell
damage.
Continual
functional
decline
in
the
intrinsic
ability
living
organisms
to
accurately
regulate
homeostasis
leads
increased
susceptibility
and
vulnerability
diseases.
Many
efforts
have
been
put
forth
understand
prevent
effects
aging.
Thus,
major
cellular
molecular
hallmarks
aging
identified,
their
relationships
age-related
diseases
malfunctions
explored.
Here,
we
use
data
from
CAS
Content
Collection
analyze
publication
landscape
recent
aging-related
research.
We
review
advances
knowledge
delineate
trends
research
advancements
on
factors
attributes
across
time
geography.
also
current
concepts
related
molecular,
cellular,
organismic
level,
age-associated
diseases,
with
attention
brain
health,
as
well
biochemical
processes
associated
Major
outlined,
correlations
features
are
hope
this
will
be
helpful
for
apprehending
field
mechanisms
progression,
an
effort
further
solve
remaining
challenges
fulfill
its
potential.
Frontiers in Public Health,
Journal Year:
2023,
Volume and Issue:
11
Published: Oct. 13, 2023
Aging
is
a
progressive
and
irreversible
pathophysiological
process
that
manifests
as
the
decline
in
tissue
cellular
functions,
along
with
significant
increase
risk
of
various
aging-related
diseases,
including
metabolic
diseases.
While
advances
modern
medicine
have
significantly
promoted
human
health
extended
lifespan,
diseases
such
obesity
type
2
diabetes
among
older
adults
pose
major
challenge
to
global
public
societies
age.
Therefore,
understanding
complex
interaction
between
factors
crucial
for
promoting
well-being
healthy
aging.
This
review
article
explores
environmental
behavioral
associated
their
impact
on
The
environment,
an
obesogenic
environment
exposure
toxins,
strongly
correlated
rising
prevalence
its
comorbidities.
Behavioral
factors,
diet,
physical
activity,
smoking,
alcohol
consumption,
sleep
patterns,
influence
throughout
Public
interventions
targeting
modifiable
can
effectively
promote
healthier
lifestyles
prevent
Collaboration
government
agencies,
healthcare
providers
community
organizations
essential
implementing
these
creating
supportive
environments
foster
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(5), P. 4491 - 4491
Published: Feb. 24, 2023
The
life
expectancy
of
the
global
population
has
increased.
Aging
is
a
natural
physiological
process
that
poses
major
challenges
in
an
increasingly
long-lived
and
frail
population.
Several
molecular
mechanisms
are
involved
aging.
Likewise,
gut
microbiota,
which
influenced
by
environmental
factors
such
as
diet,
plays
crucial
role
modulation
these
mechanisms.
Mediterranean
well
components
present
it,
offer
some
proof
this.
Achieving
healthy
aging
should
be
focused
on
promotion
lifestyle
habits
reduce
development
pathologies
associated
with
aging,
order
to
increase
quality
In
this
review
we
analyze
influence
diet
pathways
microbiota
more
favorable
patterns,
its
possible
anti-aging
treatment.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(8), P. 985 - 985
Published: Aug. 14, 2024
Gut
dysbiosis,
resulting
from
an
imbalance
in
the
gut
microbiome,
can
induce
excessive
production
of
reactive
oxygen
species
(ROS),
leading
to
inflammation,
DNA
damage,
activation
immune
system,
and
epigenetic
alterations
critical
genes
involved
metabolic
pathways.
dysbiosis-induced
inflammation
also
disrupt
barrier
integrity
increase
intestinal
permeability,
which
allows
gut-derived
toxic
products
enter
liver
systemic
circulation,
further
triggering
oxidative
stress,
associated
with
diseases.
However,
specific
metabolites,
such
as
short-chain
fatty
acids
(SCFAs),
lactate,
vitamins,
modulate
stress
system
through
mechanisms,
thereby
improving
function.
microbiota
diet-induced
diseases,
obesity,
insulin
resistance,
dyslipidemia,
hypertension,
transfer
next
generation,
involving
mechanisms.
In
this
review,
we
will
introduce
key
that,
along
dysbiosis
ROS,
are
engaged
developing
Finally,
discuss
potential
therapeutic
interventions
dietary
modifications,
prebiotics,
probiotics,
postbiotics,
fecal
transplantation,
may
reduce
syndrome
by
altering
alterations.
summary,
review
highlights
crucial
role
pathogenesis
a
particular
focus
on
(including
histone
methylomics,
RNA
interference)
that
prevent
or
improve
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(4), P. 3658 - 3658
Published: Feb. 11, 2023
Senescence
is
a
cellular
aging
process
in
all
multicellular
organisms.
It
characterized
by
decay
functions
and
proliferation,
resulting
increased
damage
death.
This
condition
plays
an
essential
role
the
significantly
contributes
to
development
of
age-related
complications.
On
other
hand,
ferroptosis
systemic
cell
death
pathway
excessive
iron
accumulation
followed
generation
reactive
oxygen
species
(ROS).
Oxidative
stress
common
trigger
this
may
be
induced
various
factors
such
as
toxins,
drugs,
inflammation.
Ferroptosis
linked
numerous
disorders,
including
cardiovascular
disease,
neurodegeneration,
cancer.
believed
contribute
tissue
organ
occurring
with
aging.
has
also
been
pathologies,
diseases,
diabetes,
In
particular,
senescent
cells
have
shown
produce
inflammatory
cytokines
pro-inflammatory
molecules
that
can
these
conditions.
turn,
health
known
play
pathologies
promoting
damaged
or
diseased
contributing
inflammation
often
associated.
Both
senescence
are
complex
pathways
still
not
fully
understood.
Further
research
needed
thoroughly
investigate
processes
identify
potential
interventions
target
order
prevent
treat
systematic
review
aims
assess
mechanisms
underlying
link
connecting
senescence,
ferroptosis,
aging,
whether
they
exploited
block
limit
physiological
elderly
people
for
healthy
longevity.
