Immunometabolism,
Год журнала:
2025,
Номер
7(2), С. e00059 - e00059
Опубликована: Март 19, 2025
In
the
last
couple
of
decades,
cancer
research
has
been
shifting
its
focus
to
immune
system.
Cancer
cells,
with
their
ability
adapt
and
evade
responses,
seem
accelerate
evolutionary
pressure
that
put
on
our
system
during
evolution.
We
thus
try
aid
these
natural
selection
processes
assist
combat
cancer.
Here,
we
are
discussing
a
study
by
Greg
Delgoffe
colleagues
was
published
in
Nature
Immunology
December
2024,
exploring
new
approach
bring
dysfunctional
cells
back
life
blocking
lactate
uptake.
Cells,
Год журнала:
2023,
Номер
12(12), С. 1584 - 1584
Опубликована: Июнь 8, 2023
Kidney
disease
is
a
significant
health
problem
worldwide,
affecting
an
estimated
10%
of
the
global
population.
encompasses
diverse
group
disorders
that
vary
in
their
underlying
pathophysiology,
clinical
presentation,
and
outcomes.
These
include
acute
kidney
injury
(AKI),
chronic
(CKD),
glomerulonephritis,
nephrotic
syndrome,
polycystic
disease,
diabetic
many
others.
Despite
distinct
etiologies,
these
share
common
feature
immune
system
dysregulation
metabolic
disturbances.
The
pathways
are
intimately
connected
interact
to
modulate
pathogenesis
diseases.
responses
diseases
includes
complex
interplay
between
various
cell
types,
including
resident
infiltrating
cells,
cytokines,
chemokines,
complement
factors.
factors
can
trigger
perpetuate
inflammation,
causing
renal
tissue
progressive
fibrosis.
In
addition,
play
critical
roles
diseases,
glucose
lipid
metabolism,
oxidative
stress,
mitochondrial
dysfunction,
altered
nutrient
sensing.
Dysregulation
contributes
progression
by
inducing
tubular
injury,
apoptosis,
Recent
studies
have
provided
insights
into
intricate
revealing
novel
therapeutic
targets
for
prevention
treatment
Potential
strategies
modulating
through
targeting
key
or
inhibiting
pro-inflammatory
signaling
pathways,
improving
function,
nutrient-sensing
such
as
mTOR,
AMPK,
SIRT1.
This
review
highlights
importance
potential
implications
pathways.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 27, 2024
Cellular
metabolism
is
a
crucial
determinant
of
immune
cell
fate
and
function.
Extensive
studies
have
demonstrated
that
metabolic
decisions
influence
activation,
differentiation,
cellular
capacity,
in
the
process
impacting
an
organism’s
ability
to
stave
off
infection
or
recover
from
injury.
Conversely,
dysregulation
can
contribute
severity
multiple
disease
conditions
including
autoimmunity,
alloimmunity,
cancer.
Emerging
data
also
demonstrate
cues
profiles
success
failure
adoptive
therapies.
Importantly,
immunometabolism
not
one
size
fits
all;
different
types,
even
subdivisions
within
distinct
populations
utilize
pathways
optimize
Metabolic
preference
change
depending
on
microenvironment
which
cells
are
activated.
For
this
reason,
understanding
requirements
subsets
critical
therapeutically
modulating
states
maximizing
function
for
downstream
applications.
Fatty
acid
oxidation
(FAO),
particular,
plays
roles
cells,
providing
both
pro-
anti-inflammatory
effects.
Herein,
we
review
major
available
then
focus
more
closely
role
FAO
subsets.
Understanding
how
why
utilized
by
will
allow
design
optimal
therapeutic
interventions
targeting
pathway.
Clinical and Translational Medicine,
Год журнала:
2024,
Номер
14(3)
Опубликована: Март 1, 2024
The
interplay
between
the
immune
system
and
metabolic
state
of
a
cell
is
intricate.
In
all
phases
an
response,
corresponding
changes
shall
occur
to
support
its
modulation,
in
addition
signalling
through
cytokine
environment
receptor
stimulation.
While
autoimmune
disorders
may
develop
because
imbalance
that
modulates
switching
T-cell
phenotypes,
effects
interaction
T
B
cells
have
on
one
another's
cellular
metabolism
are
yet
be
understood
disease
context.
Here,
we
propose
perspective
which
highlights
potential
targeting
modulate
T-
B-cell
subtypes
populations
as
well
T-B
B-T
interactions
successfully
treat
disorders.
Specifically,
envision
how
can
tip
balance
interactions,
definite
mechanisms
both
health
disease,
explain
phenotype
switches
cells.
Within
this
scenario,
highlight
link
inflammation,
immunometabolism,
epigenetics
ageing,
critical
understand
inflammatory
combination
treatments
cause
(T/B)
imbalances,
pathways
involved,
increase
effectiveness
treatment
disorders,
and/or
ameliorate
their
symptoms
improve
patients'
quality
life.
Frontiers in Physiology,
Год журнала:
2024,
Номер
15
Опубликована: Март 21, 2024
Cardiac
fibrosis
is
a
major
and
complex
pathophysiological
process
that
ultimately
culminates
in
cardiac
dysfunction
heart
failure.
This
phenomenon
includes
not
only
the
replacement
of
damaged
tissue
by
fibrotic
scar
produced
activated
fibroblasts/myofibroblasts
but
also
spatiotemporal
alteration
structural,
biochemical,
biomechanical
parameters
ventricular
wall,
eliciting
reactive
remodeling
process.
Though
mechanical
stress,
post-infarct
homeostatic
imbalances,
neurohormonal
activation
are
classically
attributed
to
fibrosis,
emerging
evidence
supports
roles
immune
system
modulation,
inflammation,
metabolic
dysregulation
initiation
progression
fibrogenesis
has
been
reported.
Adaptive
changes,
cell
phenoconversions,
shifts
nonmyocyte
population
provide
initial
protection,
persistent
altered
demand
eventually
contributes
adverse
heart.
Altered
energy
metabolism,
mitochondrial
dysfunction,
various
cells,
mediators,
cross-talks
between
cells
cardiomyocytes
play
crucial
orchestrating
transdifferentiation
fibroblasts
ensuing
Manipulation
plasticity,
fibroblast–myofibroblast
transition,
modulation
response
may
hold
promise
for
favorably
modulating
following
different
cardiovascular
pathological
processes.
Although
immunologic
perspectives
being
reported
literature,
they
lack
comprehensive
sketch
bridging
these
two
arenas
illustrating
synchrony
them.
review
aims
overview
intricate
relationship
pathways
as
well
summarizes
current
understanding
involvement
immune–metabolic
attempts
identify
some
previously
unaddressed
questions
require
further
investigation.
Moreover,
potential
therapeutic
strategies
pharmacological
interventions,
including
modulators,
show
preventing
or
attenuating
restoring
function
will
be
discussed.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 1, 2024
New
and
emerging
pathogens,
such
as
SARS-CoV2
have
highlighted
the
requirement
for
threat
agnostic
therapies.
Some
antibiotics
or
antivirals
can
demonstrate
broad-spectrum
activity
against
pathogens
in
same
family
genus
but
efficacy
quickly
reduce
due
to
their
specific
mechanism
of
action
ability
disease
causing
agent
evolve.
This
has
led
generation
antimicrobial
resistant
strains,
making
infectious
diseases
more
difficult
treat.
Alternative
approaches
therefore
need
be
considered,
which
include
exploring
utility
Host-Directed
Therapies
(HDTs).
is
a
growing
area
with
huge
potential
difficulties
arise
complexity
profiles.
For
example,
HDT
given
early
during
infection
may
not
appropriate
effective
when
become
chronic
patient
intensive
care.
With
understanding
immune
function,
new
treatment
could
allow
targeting
pathways
augment
diminish
host
response,
dependent
upon
profile,
bespoke
therapeutic
management
plans.
review
highlights
promising
approved
HDTs
that
manipulate
system
throughout
spectrum
disease,
particular
viral
bacterial
demonstrates
how
advantages
will
soon
outweigh
side
effects.
The
immune
response
is
an
energy-demanding
process
that
must
be
coordinated
with
systemic
metabolic
changes
redirecting
nutrients
from
stores
to
the
system.
Although
this
interplay
fundamental
for
function
of
system,
underlying
mechanisms
remain
elusive.
Our
data
show
pro-inflammatory
polarization
Drosophila
macrophages
coupled
production
insulin
antagonist
ImpL2
through
activity
transcription
factor
HIF1α.
production,
reflecting
nutritional
demands
activated
macrophages,
subsequently
impairs
signaling
in
fat
body,
thereby
triggering
FOXO-driven
mobilization
lipoproteins.
This
adaptation
system
and
individual's
resistance
infection.
We
demonstrated
analogically
Drosophila,
mammalian
immune-activated
produce
homolog
IGFBP7
a
HIF1α-dependent
manner
enhanced
by
these
cells
induces
lipoproteins
hepatocytes.
Hence,
ImpL2/IGFBP7
represents
evolutionarily
conserved
mechanism
which
alleviate
central
organ
secure
necessary
their
upon
bacterial
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 23, 2024
Metabolism
and
immunity
are
crucial
monitors
of
the
whole-body
homeodynamics.
All
cells
require
energy
to
perform
their
basic
functions.
One
most
important
metabolic
skills
cell
is
ability
optimally
adapt
metabolism
according
demand
or
availability,
known
as
flexibility.
The
immune
cells,
first
line
host
defense
that
circulate
in
body
migrate
between
tissues,
need
function
also
environments
which
nutrients
not
always
available.
resilience
consists
precisely
high
adaptive
capacity,
a
challenge
arises
especially
framework
sustained
responses.
Pubmed
Scopus
databases
were
consulted
construct
extensive
background
explored
this
review,
from
Kennedy
Lehninger
studies
on
mitochondrial
biochemistry
1950s
recent
findings
immunometabolism.
In
detail,
we
focus
how
reconfiguration
influences
action
steps
system
modulates
fate
function.
Then,
highlighted
evidence
for
considering
mitochondria,
besides
conventional
cellular
suppliers,
powerhouses
Finally,
main
immunometabolic
hubs
organism
emphasizing
them
reciprocal
impact
components
both
physiological
pathological
conditions.
