Cell Reports, Journal Year: 2025, Volume and Issue: 44(2), P. 115287 - 115287
Published: Feb. 1, 2025
Language: Английский
Cellular and Molecular Immunology, Journal Year: 2023, Volume and Issue: 20(2), P. 131 - 142
Published: Jan. 4, 2023
Language: Английский
Citations
33
Cells, Journal Year: 2023, Volume and Issue: 12(12), P. 1584 - 1584
Published: June 8, 2023
Kidney disease is a significant health problem worldwide, affecting an estimated 10% of the global population. encompasses diverse group disorders that vary in their underlying pathophysiology, clinical presentation, and outcomes. These include acute kidney injury (AKI), chronic (CKD), glomerulonephritis, nephrotic syndrome, polycystic disease, diabetic many others. Despite distinct etiologies, these share common feature immune system dysregulation metabolic disturbances. The pathways are intimately connected interact to modulate pathogenesis diseases. responses diseases includes complex interplay between various cell types, including resident infiltrating cells, cytokines, chemokines, complement factors. factors can trigger perpetuate inflammation, causing renal tissue progressive fibrosis. In addition, play critical roles diseases, glucose lipid metabolism, oxidative stress, mitochondrial dysfunction, altered nutrient sensing. Dysregulation contributes progression by inducing tubular injury, apoptosis, Recent studies have provided insights into intricate revealing novel therapeutic targets for prevention treatment Potential strategies modulating through targeting key or inhibiting pro-inflammatory signaling pathways, improving function, nutrient-sensing such as mTOR, AMPK, SIRT1. This review highlights importance potential implications pathways.
Language: Английский
Citations
31
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: June 27, 2024
Cellular metabolism is a crucial determinant of immune cell fate and function. Extensive studies have demonstrated that metabolic decisions influence activation, differentiation, cellular capacity, in the process impacting an organism’s ability to stave off infection or recover from injury. Conversely, dysregulation can contribute severity multiple disease conditions including autoimmunity, alloimmunity, cancer. Emerging data also demonstrate cues profiles success failure adoptive therapies. Importantly, immunometabolism not one size fits all; different types, even subdivisions within distinct populations utilize pathways optimize Metabolic preference change depending on microenvironment which cells are activated. For this reason, understanding requirements subsets critical therapeutically modulating states maximizing function for downstream applications. Fatty acid oxidation (FAO), particular, plays roles cells, providing both pro- anti-inflammatory effects. Herein, we review major available then focus more closely role FAO subsets. Understanding how why utilized by will allow design optimal therapeutic interventions targeting pathway.
Language: Английский
Citations
10
Journal of Biological Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108252 - 108252
Published: Feb. 1, 2025
Every cell in the body is exposed to a certain level of CO2 and O2. Hypercapnia hypoxia elicit stress signals influence cellular metabolism function. Both conditions exert profound yet distinct effects on metabolic pathways mitochondrial dynamics, highlighting need for cells adapt changes gaseous microenvironment. The interplay between hypercapnia signalling key dictating homeostasis as microenvironmental O2 levels are inextricably linked. Hypercapnia, characterized by elevated pCO₂, introduces adaptations within aerobic pathways, affecting TCA cycle flux, lipid, amino acid metabolism, OXPHOS ETC. Hypoxia, defined reduced oxygen availability, necessitates shift from anaerobic glycolysis sustain ATP production, process orchestrated stabilisation HIF-1α. Given that present both physiological cancerous microenvironments, how might coexistence function niches tumor microenvironment?
Language: Английский
Citations
1
Human Immunology, Journal Year: 2025, Volume and Issue: 86(3), P. 111269 - 111269
Published: Feb. 24, 2025
Language: Английский
Citations
1
Molecular Therapy — Methods & Clinical Development, Journal Year: 2025, Volume and Issue: 33(2), P. 101451 - 101451
Published: March 14, 2025
Language: Английский
Citations
1
Nature Reviews Rheumatology, Journal Year: 2023, Volume and Issue: 19(10), P. 650 - 665
Published: Sept. 8, 2023
Language: Английский
Citations
17
Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15
Published: March 21, 2024
Cardiac fibrosis is a major and complex pathophysiological process that ultimately culminates in cardiac dysfunction heart failure. This phenomenon includes not only the replacement of damaged tissue by fibrotic scar produced activated fibroblasts/myofibroblasts but also spatiotemporal alteration structural, biochemical, biomechanical parameters ventricular wall, eliciting reactive remodeling process. Though mechanical stress, post-infarct homeostatic imbalances, neurohormonal activation are classically attributed to fibrosis, emerging evidence supports roles immune system modulation, inflammation, metabolic dysregulation initiation progression fibrogenesis has been reported. Adaptive changes, cell phenoconversions, shifts nonmyocyte population provide initial protection, persistent altered demand eventually contributes adverse heart. Altered energy metabolism, mitochondrial dysfunction, various cells, mediators, cross-talks between cells cardiomyocytes play crucial orchestrating transdifferentiation fibroblasts ensuing Manipulation plasticity, fibroblast–myofibroblast transition, modulation response may hold promise for favorably modulating following different cardiovascular pathological processes. Although immunologic perspectives being reported literature, they lack comprehensive sketch bridging these two arenas illustrating synchrony them. review aims overview intricate relationship pathways as well summarizes current understanding involvement immune–metabolic attempts identify some previously unaddressed questions require further investigation. Moreover, potential therapeutic strategies pharmacological interventions, including modulators, show preventing or attenuating restoring function will be discussed.
Language: Английский
Citations
8
Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(3)
Published: March 1, 2024
The interplay between the immune system and metabolic state of a cell is intricate. In all phases an response, corresponding changes shall occur to support its modulation, in addition signalling through cytokine environment receptor stimulation. While autoimmune disorders may develop because imbalance that modulates switching T-cell phenotypes, effects interaction T B cells have on one another's cellular metabolism are yet be understood disease context. Here, we propose perspective which highlights potential targeting modulate T- B-cell subtypes populations as well T-B B-T interactions successfully treat disorders. Specifically, envision how can tip balance interactions, definite mechanisms both health disease, explain phenotype switches cells. Within this scenario, highlight link inflammation, immunometabolism, epigenetics ageing, critical understand inflammatory combination treatments cause (T/B) imbalances, pathways involved, increase effectiveness treatment disorders, and/or ameliorate their symptoms improve patients' quality life.
Language: Английский
Citations
7
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 1, 2024
New and emerging pathogens, such as SARS-CoV2 have highlighted the requirement for threat agnostic therapies. Some antibiotics or antivirals can demonstrate broad-spectrum activity against pathogens in same family genus but efficacy quickly reduce due to their specific mechanism of action ability disease causing agent evolve. This has led generation antimicrobial resistant strains, making infectious diseases more difficult treat. Alternative approaches therefore need be considered, which include exploring utility Host-Directed Therapies (HDTs). is a growing area with huge potential difficulties arise complexity profiles. For example, HDT given early during infection may not appropriate effective when become chronic patient intensive care. With understanding immune function, new treatment could allow targeting pathways augment diminish host response, dependent upon profile, bespoke therapeutic management plans. review highlights promising approved HDTs that manipulate system throughout spectrum disease, particular viral bacterial demonstrates how advantages will soon outweigh side effects.
Language: Английский
Citations
7