Extra-hippocampal contributions to pattern separation

eLife, Год журнала: 2023, Номер 12

Опубликована: Март 27, 2023

Pattern separation, or the process by which highly similar stimuli experiences in memory are represented non-overlapping neural ensembles, has typically been ascribed to processes supported hippocampus. Converging evidence from a wide range of studies, however, suggests that pattern separation is multistage network brain regions. Based on this evidence, considered together with related findings interference resolution literature, we propose 'cortico-hippocampal separation' (CHiPS) framework, asserts regions involved cognitive control play significant role separation. Particularly, these may contribute (1) resolving sensory project hippocampus, thus regulating its cortical input, (2) directly modulating hippocampal accordance task demands. Considering recent interest how operations modulated goal states likely and regulated extra-hippocampal regions, argue similarly neocortical-hippocampal interactions.

Язык: Английский

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Predictions transform memories: How expected versus unexpected events are integrated or separated in memory

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 153, С. 105368 - 105368

Опубликована: Авг. 22, 2023

Язык: Английский

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Multiple Memory Subsystems: Reconsidering Memory in the Mind and Brain

Perspectives on Psychological Science, Год журнала: 2023, Номер 19(1), С. 103 - 125

Опубликована: Июнь 30, 2023

The multiple-memory-systems framework-that distinct types of memory are supported by brain systems-has guided learning and research for decades. However, recent work challenges the one-to-one mapping between structures central to this taxonomy, with key memory-related supporting multiple functions across substructures. Here we integrate cross-species findings in hippocampus, striatum, amygdala propose an updated framework subsystems (MMSS). We provide evidence two organizational principles MMSS theory: First, opposing representations colocated same structures; second, parallel structures. discuss why burgeoning has potential a useful revision classic theories long-term memory, what is needed further validate framework, how novel perspective on organization may guide future research.

Язык: Английский

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Abrupt hippocampal remapping signals resolution of memory interference

Nature Communications, Год журнала: 2021, Номер 12(1)

Опубликована: Авг. 10, 2021

Abstract Remapping refers to a decorrelation of hippocampal representations similar spatial environments. While it has been speculated that remapping may contribute the resolution episodic memory interference in humans, direct evidence is surprisingly limited. We tested this idea using high-resolution, pattern-based fMRI analyses. Here we show activity patterns human CA3/dentate gyrus exhibit an abrupt, temporally-specific highly precisely coupled with behavioral expressions successful learning. The magnitude learning-related was predicted by amount pattern overlap during initial stages learning, greater leading stronger decorrelation. Finally, remapped carry relatively more information about learned associations compared competing associations, further validating significance remapping. Collectively, these findings establish critical link between and provide insight into why occurs.

Язык: Английский

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From remembering to reconstruction: The transformative neural representation of episodic memory

Progress in Neurobiology, Год журнала: 2022, Номер 219, С. 102351 - 102351

Опубликована: Сен. 8, 2022

Язык: Английский

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Partially overlapping spatial environments trigger reinstatement in hippocampus and schema representations in prefrontal cortex

Nature Communications, Год журнала: 2021, Номер 12(1)

Опубликована: Окт. 28, 2021

When we remember a city that have visited, retrieve places related to finding our goal but also non-target locations within this environment. Yet, understanding how the human brain implements neural computations underlying holistic retrieval remains unsolved, particularly for shared aspects of environments. Here, participants learned and retrieved details from three partially overlapping environments while undergoing high-resolution functional magnetic resonance imaging (fMRI). Our findings show reinstatement stores even when they are not specific trial probe, providing evidence environmental retrieval. For between cities, find pattern separation (representational orthogonalization) in hippocampal subfield CA2/3/DG repulsion CA1 (differentiation beyond orthogonalization). Additionally, demonstrate medial prefrontal cortex (mPFC) representations common spatial structure, termed schema, across Together, suggest unique elements multiple accessed computationally neurally.

Язык: Английский

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Forming cognitive maps for abstract spaces: the roles of the human hippocampus and orbitofrontal cortex

Communications Biology, Год журнала: 2024, Номер 7(1)

Опубликована: Май 1, 2024

How does the human brain construct cognitive maps for decision-making and inference? Here, we conduct an fMRI study on a navigation task in multidimensional abstract spaces. Using deep neural network model, assess learning levels categorized paths into exploration exploitation stages. Univariate analyses show higher activation bilateral hippocampus lateral prefrontal cortex during exploration, positively associated with level response accuracy. Conversely, orbitofrontal (OFC) retrosplenial exploitation, negatively Representational similarity analysis that hippocampus, entorhinal cortex, OFC more accurately represent destinations than These findings highlight collaboration between medial temporal lobe space structures. The may be involved spatial memory formation representation, while integrates sensory information

Язык: Английский

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Reaching the Goal: Superior Navigators in Late Adulthood Provide a Novel Perspective into Successful Cognitive Aging

Topics in Cognitive Science, Год журнала: 2022, Номер 15(1), С. 15 - 45

Опубликована: Май 18, 2022

Abstract Normal aging is typically associated with declines in navigation and spatial memory abilities. However, increased interindividual variability performance across various navigation/spatial tasks also evident advancing age. In this review paper, we shed the spotlight on those older individuals who exhibit exceptional, sometimes even youth‐like navigational/spatial Importantly, (1) showcase observations from existing studies that demonstrate superior late adulthood, (2) explore possible cognitive correlates neurophysiological mechanisms underlying these preserved abilities, (3) discuss potential link between navigators adulthood SuperAgers (older adults episodic memory). closing section, given lack of directly focus subpopulation, highlight several important directions future could look into to better understand characteristics factors enabling such successful aging.

Язык: Английский

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Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements

Journal of Neuroscience, Год журнала: 2023, Номер 43(43), С. 7198 - 7212

Опубликована: Окт. 9, 2023

Stress can powerfully influence episodic memory, often enhancing memory encoding for emotionally salient information. These stress-induced enhancements stand at odds with demonstrations that stress and the stress-related hormone cortisol negatively affect hippocampus, a brain region important encoding. To resolve this apparent conflict determine whether how hippocampus supports under cortisol, we combined behavioral assays of associative high-resolution fMRI, pharmacological manipulation in within-participant, double-blinded procedure (in both sexes). Behaviorally, hydrocortisone promoted subjectively arousing, positive memories. Neurally, led to enhanced functional connectivity between hippocampal subregions, which predicted subsequent emotional associations. Cortisol also modified relationship representations memory: whereas signatures distinctiveness placebo, relative integration cortisol. Together, these data provide novel evidence human contains necessary machinery support

Язык: Английский

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The effects of mnemonic variability and spacing on memory over multiple timescales

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(12)

Опубликована: Март 12, 2024

The memory benefit that arises from distributing learning over time rather than in consecutive sessions is one of the most robust effects cognitive psychology. While prior work has mainly focused on repeated exposures to same information, real world, mnemonic content dynamic, with some pieces information staying stable while others vary. Thus, open questions remain about efficacy spacing effect face variability content. Here, two experiments, we investigated contributions and timescale intervals, ranging seconds days, long-term memory. For item memory, both intervals were beneficial for memory; however, was greater at shorter intervals. In contrast, associative repetition benefits only emerged absence variability. These results highlight a critical role effect, bringing this classic paradigm into more ecologically valid contexts.

Язык: Английский

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