The
gut
microbiota
and
its
homeostasis
play
a
crucial
role
in
human
health.
However,
for
some
diseases
related
to
the
microbiota,
current
traditional
medicines
can
only
relieve
symptoms,
it
is
difficult
solve
root
causes
or
even
cause
side
effects
like
disturbances
microbiota.
Increasing
clinical
studies
evidences
have
demonstrated
that
probiotics,
prebiotics,
postbiotics
prevent
treat
various
diseases,
but
currently
they
be
used
as
dietary
supplements
rather
than
medicines,
which
restricts
application
of
probiotics
field
medicine.
Here,
this
review
analyzes
importance
health
problems
systematically
summarizes
effectiveness
mechanisms
maintaining
treating
based
on
animal
models
trials.
And
research
outcomes
development
trends
field,
challenges
prospects
their
health,
alleviating
are
analyzed.
It
hoped
promote
disease
treatment
open
up
new
frontiers
probiotic
research.
Antioxidants,
Год журнала:
2024,
Номер
13(1), С. 76 - 76
Опубликована: Янв. 5, 2024
Heavy
metals
are
often
found
in
soil
and
can
contaminate
drinking
water,
posing
a
serious
threat
to
human
health.
Molecular
pathways
curation
therapies
for
mitigating
heavy
metal
toxicity
have
been
studied
long
time.
Recent
studies
on
oxidative
stress
aging
shown
that
the
molecular
foundation
of
cellular
damage
caused
by
metals,
namely,
apoptosis,
endoplasmic
reticulum
stress,
mitochondrial
share
same
as
those
involved
senescence
aging.
In
recent
studies,
many
types
exposures
used
both
animal
models.
Chelation
therapy
is
traditional
treatment
toxicity.
However,
recently,
various
antioxidants
be
effective
treating
metal-induced
damage,
shifting
research
focus
investigating
interplay
between
metals.
this
review,
we
introduce
basis
its
relationship
with
aging,
summarize
clinical
implications,
discuss
other
agents
protective
effects
against
damage.
Foods,
Год журнала:
2024,
Номер
13(7), С. 978 - 978
Опубликована: Март 22, 2024
Heavy
metals
(HMs)
are
natural
elements
present
in
the
Earth’s
crust,
characterised
by
a
high
atomic
mass
and
density
more
than
five
times
higher
water.
Despite
their
origin
from
sources,
extensive
usage
processing
of
raw
materials
presence
as
silent
poisons
our
daily
products
diets
have
drastically
altered
biochemical
balance,
making
them
threat
to
environment
human
health.
Particularly,
food
chain
polluted
with
toxic
represents
crucial
route
exposure.
Therefore,
impact
HMs
on
health
has
become
matter
concern
because
severe
chronic
effects
induced
excessive
levels
body.
Chelation
therapy
is
an
approved
valid
treatment
for
HM
poisoning;
however,
despite
efficacy
demonstrated
chelating
agents,
various
dramatic
side
may
occur.
Numerous
data
demonstrate
that
dietary
components
phytoantioxidants
play
significant
role
preventing
or
reducing
damage
HMs.
This
review
summarises
phytochemicals,
plant
herbal
extracts
probiotics
promoting
mitigating
different
Gut
microbiota
is
an
important
modulator
of
human
health
and
contributes
to
high
inter-individual
variation
in
response
food
pharmaceutical
ingredients.
The
clinical
outcomes
interventions
with
prebiotics,
probiotics,
synbiotics
have
been
mixed
often
unpredictable,
arguing
for
novel
approaches
developing
microbiome-targeted
therapeutics.
Here,
we
review
how
the
gut
determines
fate
individual
responses
dietary
xenobiotic
compounds
via
its
immense
metabolic
potential.
We
highlight
that
microbial
metabolites
play
a
crucial
role
as
targetable
mediators
microbiota-host
relationship.
With
this
mind,
expand
concept
beyond
prebiotics'
facilitating
growth
engraftment
by
focusing
on
metabolism
vital
mode
action
thereof.
Consequently,
discuss
synbiotic
compositions
enable
guided
or
co-formulated
ingredients
specific
microbes
leading
target
molecules
beneficial
functions.
A
workflow
develop
presented,
including
selection
promising
(e.g.
equol,
urolithin
A,
spermidine,
indole-3
derivatives),
identification
suitable
substrates
producer
strains
applying
bioinformatic
tools,
models,
eventually
trials.
Molecular Nutrition & Food Research,
Год журнала:
2024,
Номер
68(7)
Опубликована: Март 13, 2024
Gut
microbiota
(GM)
dysbiosis
and
dysregulated
bile
acids
(BAs)
metabolism
have
been
linked
to
ulcerative
colitis
(UC)
pathogenesis.
The
possibility
of
utilizing
live
probiotics
with
a
defined
BAs-metabolizing
capability
modify
the
composition
BAs
for
UC
treatment
remains
unexplored.
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 19, 2024
Microorganisms,
especially
rare
microbial
species,
are
crucial
in
estuarine
ecosystems
for
driving
biogeochemical
processes
and
preserving
biodiversity.
However,
the
understanding
of
links
between
ecosystem
multifunctionality
(EMF)
diversity
bacterial
taxa
estuary
remains
limited.
Employing
high-throughput
sequencing
a
variety
statistical
methods,
we
assessed
diversities
assembly
process
abundant
bacterioplankton
their
contributions
to
EMF
subtropical
estuary.
Taxonomic
analysis
revealed
Proteobacteria
as
predominant
phylum
among
both
taxa.
Notably,
demonstrated
significantly
higher
taxonomic
larger
species
pool
than
Additionally,
our
findings
highlighted
that
deterministic
predominantly
shape
communities,
with
heterogeneous
selection
exerting
stronger
influence
on
Further
reveals
beta-diversity
impacts
EMF,
whereas
alpha
did
not.
The
partial
least
squares
path
modeling
(PLS-PM)
beta
taxa,
main
biotic
factor,
directly
affected
while
temperature
total
organic
carbon
(TOC)
were
additional
key
factors
determine
relationship
EMF.
These
advance
distribution
features
ecological
knowledge
estuaries,
provide
reference
exploring
different
biospheres
aquatic
environments.
