Bugs and Brains: The Microbiome & Dementia DOI Creative Commons

H. Robert Patterson,

Thomas Varkey, Jacob Lahti

и другие.

Galician Medical Journal, Год журнала: 2024, Номер 31(3)

Опубликована: Авг. 31, 2024

Interest in the microbiome and its correlation with different neurological diseases has grown significantly over past decade. The gut contains a vast array of diverse organisms living gastrointestinal (GI) tract. Predominantly composed bacteria, helps regulate homeostasis metabolism host, aiding immune system development as well vitamin nutrient absorption. Studies suggest that, addition to providing humans these physiological benefits, is also linked communicates brain via gut-brain axis (GBA). Long-standing research on GBA demonstrated that GI tract central nervous are interconnected through both immunological signaling pathways. Recent expanding our understanding GBA, revealing correlations between impact conditions such Alzheimer’s dementia Lewy body dementia, going far identify highlight specific microbial species may serve risk or protective factors for various forms dementia. This letter aims current findings recommend use tools cell-free DNA testing gain better role dysbiosis patients.

Язык: Английский

Gut microbiota, circulating cytokines and dementia: a Mendelian randomization study DOI Creative Commons

Dong Ji,

Wen-Zhu Chen,

Lei Zhang

и другие.

Journal of Neuroinflammation, Год журнала: 2024, Номер 21(1)

Опубликована: Янв. 4, 2024

Abstract Background Some studies have shown that gut microbiota may be associated with dementia. However, the causal effects between and different types of dementia whether cytokines act as a mediator remain unclear. Methods Gut microbiota, cytokines, five types, including Alzheimer’s disease (AD), frontotemporal (FTD), Lewy body (DLB), vascular (VD), Parkinson’s (PDD) were identified from large-scale genome-wide association (GWAS) summary data. We used Mendelian randomization (MR) to investigate relationships Inverse variance weighting (IVW) was main statistical method. In addition, we explored mediating factor in pathway Results There 20 positive 16 negative genetic liability Also, there four dementias. Cytokines did not factors. Conclusions causally dementia, seemed factors

Язык: Английский

Процитировано

57
Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence DOI Creative Commons
Xiaoyan Liu, Yi Liu, Junlin Liu

и другие.

Neural Regeneration Research, Год журнала: 2023, Номер 19(4), С. 833 - 845

Опубликована: Авг. 14, 2023

A growing body of evidence suggests that the gut microbiota contributes to development neurodegenerative diseases via microbiota-gut-brain axis. As a contributing factor, dysbiosis always occurs in pathological changes diseases, such as Alzheimer's disease, Parkinson's and amyotrophic lateral sclerosis. High-throughput sequencing technology has helped reveal bidirectional communication between central nervous system enteric is facilitated by microbiota's diverse microorganisms, for both neuroimmune neuroendocrine systems. Here, we summarize bioinformatics analysis wet-biology validation metagenomics with an emphasis on multi-omics studies virome. The pathogen-associated signaling biomarkers identifying brain disorders potential therapeutic targets are also elucidated. Finally, discuss role diet, prebiotics, probiotics, postbiotics exercise interventions remodeling microbiome reducing symptoms diseases.

Язык: Английский

Процитировано

31
Time‐restricted feeding mitigates Alzheimer's disease‐associated cognitive impairments via a B. pseudolongum‐propionic acid‐FFAR3 axis DOI Creative Commons
Yihang Zhao, Mengzhen Jia, Chen Ding

и другие.

iMeta, Год журнала: 2025, Номер 4(2)

Опубликована: Фев. 21, 2025

Abstract Time‐restricted feeding (TRF) holds promise for alleviating cognitive decline in aging, albeit the precise mechanism via gut‐brain axis remains elusive. In a clinical trial, we observed, first time, that 4‐month TRF ameliorated impairments among Alzheimer's disease (AD) patients. Experiments 5xFAD mice corroborated gut microbiota‐dependent effect of on mitigating dysfunction, amyloid‐beta deposition, and neuroinflammation. Multi‐omics integration linked Bifidobacterium pseudolongum ( B. ) propionic acid (PA) with key genes AD pathogenesis. Oral supplementation or PA mimicked TRF's protective effects. Positron emission tomography imaging confirmed PA's blood‐brain barrier penetration, while knockdown free fatty receptor 3 (FFAR3) diminished benefits. Notably, observed positive correlation between fecal improved function an cohort, further indicating enhanced production. These findings highlight microbiota‐metabolites‐brain as pivotal benefits, proposing potential therapies.

Язык: Английский

Процитировано

2
Gastrointestinal disorders in Parkinson’s disease and other Lewy body diseases DOI Creative Commons
Masaaki Hirayama, Hiroshi Nishiwaki, Tomonari Hamaguchi

и другие.

npj Parkinson s Disease, Год журнала: 2023, Номер 9(1)

Опубликована: Май 5, 2023

Abstract Parkinson’s disease (PD) is pathologically characterized by the abnormal accumulation of α-synuclein fibrils (Lewy bodies) in substantia nigra and other brain regions, although role Lewy bodies remains elusive. Constipation usually precedes motor symptoms PD, which accordance with notion that start from intestinal neural plexus ascend to at least half PD patients. The gut microbiota likely be involved pathologies. Analyses rapid-eye-movement sleep behavior disorder, dementia suggest three pathological pathways. First, Akkermansia , increased degrades mucus layer increases permeability, triggers inflammation oxidative stress plexus. Second, decreased short-chain fatty acids (SCFAs)-producing bacteria reduce number regulatory T cells. Third, SCFAs also aggravate microglial activation an unelucidated pathway. In addition, (DLB), another form α-synucleinopathies, genera, Ruminococcus torques Collinsella may mitigate neuroinflammation increasing secondary bile acids. Interventions for their metabolites potentially delay or development progression body diseases.

Язык: Английский

Процитировано

23
Therapeutic Potential of Fungal Polysaccharides in Gut Microbiota Regulation: Implications for Diabetes, Neurodegeneration, and Oncology DOI Creative Commons
Alexandru Stefan Barcan,

Rares Andrei Barcan,

Emanuel Vamanu

и другие.

Journal of Fungi, Год журнала: 2024, Номер 10(6), С. 394 - 394

Опубликована: Май 31, 2024

This review evaluates the therapeutic effects of polysaccharides derived from mushroom species that have medicinal and edible properties. The fungal were recently studied, focusing on their modulation gut microbiota impact various diseases. study covers both clinical preclinical studies, detailing results highlighting significant influence these modulation. It discusses potential health benefits incorporating into diet for managing chronic diseases such as diabetes, neurodegenerative disorders, cancer. Furthermore, emphasizes interaction between microbiota, underscoring role in modulating microbial community. presents a systematic analysis findings, demonstrating substantial composition function, which may contribute to conditions. We conclude by play crucial mediating effects, offering promising avenue further research applications disease prevention treatment.

Язык: Английский

Процитировано

7
Lewy body diseases and the gut DOI Creative Commons
Timothy R. Sampson, Malú G. Tansey, Andrew B. West

и другие.

Molecular Neurodegeneration, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 30, 2025

Abstract Gastrointestinal (GI) involvement in Lewy body diseases (LBDs) has been observed since the initial descriptions of patients by James Parkinson. Recent experimental and human observational studies raise possibility that pathogenic alpha-synuclein (⍺-syn) might develop GI tract subsequently spread to susceptible brain regions. The cellular mechanistic origins ⍺-syn propagation disease are under intense investigation. Experimental LBD models have implicated important contributions from intrinsic gut microbiome, intestinal immune system, environmental toxicants, acting as triggers modifiers pathologies. Here, we review primary clinical observations link dysfunctions LBDs. We first provide an overview anatomy repertoire relevant for disease, with a focus on luminal-sensing cells epithelium including enteroendocrine express make direct contact nerves. describe interactions within resident microbes exogenous how these may directly contribute pathology along related metabolic immunological responses. Finally, critical knowledge gaps field highlighted, focusing pivotal questions remain some 200 years after dysfunction predict better understanding pathophysiologies influence risk progression will accelerate discoveries lead deeper overall potential therapeutic strategies targeting gut-brain axis delay, arrest, or prevent progression.

Язык: Английский

Процитировано

1
Leaky gut in systemic inflammation: exploring the link between gastrointestinal disorders and age-related diseases DOI Creative Commons

Jonathan Escalante,

Olivia Artaiz,

Shanti Diwakarla

и другие.

GeroScience, Год журнала: 2024, Номер unknown

Опубликована: Дек. 6, 2024

Abstract Global average life expectancy has steadily increased over the last several decades and is projected to reach ~ 77 years by 2050. As it stands, number of people > 60 currently outnumbers children younger than 5 years, 2050, anticipated that global population aged will double, surpassing 2.1 billion. This demographic shift in our expected have substantial consequences on health services globally due disease burden associated with aging. Osteoarthritis, chronic obstructive pulmonary disease, diabetes, cardiovascular cognitive decline dementia are among most common age-related diseases contribute significantly morbidity mortality population. Many these been linked low-grade systemic inflammation which often accompanies Gastrointestinal barrier dysfunction, also known as “leaky gut,” shown including inflammatory bowel irritable syndrome, but its role development and/or progression during aging unclear. review outlines current literature leaky gut aging, how might inflammation, links between gastrointestinal provide insight into a potential relationship intestinal inflammation.

Язык: Английский

Процитировано

5
Physical Exercise as Disease-Modifying Alternative against Alzheimer’s Disease: A Gut–Muscle–Brain Partnership DOI Open Access
Debora Cutuli, Davide Decandia, Giacomo Giacovazzo

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(19), С. 14686 - 14686

Опубликована: Сен. 28, 2023

Alzheimer’s disease (AD) is a common cause of dementia characterized by neurodegenerative dysregulations, cognitive impairments, and neuropsychiatric symptoms. Physical exercise (PE) has emerged as powerful tool for reducing chronic inflammation, improving overall health, preventing decline. The connection between the immune system, gut microbiota (GM), neuroinflammation highlights role gut–brain axis in maintaining brain health diseases. Neglected so far, PE beneficial effects on microbial composition diversity, thus providing potential to alleviate neurological There bidirectional communication muscle, with GM diversity modulation short-chain fatty acid (SCFA) production affecting muscle metabolism preservation, activity/exercise turn inducing significant changes composition, functionality, SCFA production. This gut–muscle muscle–gut interplay can then modulate cognition. For instance, irisin, an exercise-induced myokine, promotes neuroplasticity function through BDNF signaling. Irisin muscle-generated may mediate positive physical activity against some aspects AD pathophysiology interaction ecosystem, neural plasticity, anti-inflammatory signaling pathways, neurogenesis. Understanding gut–muscle–brain interconnections hold promise developing strategies promote fight age-associated decline, improve longevity.

Язык: Английский

Процитировано

13
Association between environmental phthalates exposure and gut microbiota and metabolome in dementia with Lewy bodies DOI Creative Commons
Zhe Deng, Ling Li, Zhen Jing

и другие.

Environment International, Год журнала: 2024, Номер 190, С. 108806 - 108806

Опубликована: Июнь 12, 2024

Emerging evidence has shown the potential involvement of phthalates (PAEs) exposure in development dementia with Lewy bodies (DLB). Metabolomics can reflect endogenous metabolites variation progress disease after chemicals exposure. However, little is known about association between PAEs, gut microbiota and metabolome DLB.

Язык: Английский

Процитировано

3
The physicochemical characteristics and functional properties of steam explosion modified wheat bran in vitro and in vivo DOI

Wanqing Deng,

Yun Deng, Zhenyu Zhang

и другие.

Journal of Food Science, Год журнала: 2025, Номер 90(2)

Опубликована: Фев. 1, 2025

Abstract Wheat bran is the processing byproduct of wheat, which thought to have great potential applications. To make a full utilization resource, this study investigated effects steam explosion (SE) modification, with intensity at 1.0 MPa 20, 60, 100, 140, 180, and 220 s, respectively, on wheat soluble dietary fiber (SDF) content, physical‐chemical quality, antioxidant capacity, intestinal microbial spectrum. The impact long‐term intake WB100 (wheat modified under SE conditions 100 s) weight control in obese mice was also studied. results showed that 3.36‐fold increase SDF 61.78% 109.77% DPPH ABTS free radical scavenging rate, maintained good hydration properties compared untreated group. Besides, 5‐HMF content 16.93 mg/kg, within allowable range ensured safety bran. In addition, significantly increased specifically enriched abundance Agathobacter , Fusicatenibacter Faecalibacterium after fermentation. Long‐term could play role by reducing blood lipid levels fasting glucose values, stimulating appetite suppression‐related hormones, fat accumulation, protecting liver health. This highlighted importance technology for enhancement added value industrial upgrading. Practical Application And it can be applied agricultural field or development new food .

Язык: Английский

Процитировано

0