Parkinsonism & Related Disorders, Journal Year: 2024, Volume and Issue: 129, P. 107176 - 107176
Published: Oct. 16, 2024
Language: Английский
Journal of Neuroinflammation, Journal Year: 2024, Volume and Issue: 21(1)
Published: Jan. 4, 2024
Abstract Background Some studies have shown that gut microbiota may be associated with dementia. However, the causal effects between and different types of dementia whether cytokines act as a mediator remain unclear. Methods Gut microbiota, cytokines, five types, including Alzheimer’s disease (AD), frontotemporal (FTD), Lewy body (DLB), vascular (VD), Parkinson’s (PDD) were identified from large-scale genome-wide association (GWAS) summary data. We used Mendelian randomization (MR) to investigate relationships Inverse variance weighting (IVW) was main statistical method. In addition, we explored mediating factor in pathway Results There 20 positive 16 negative genetic liability Also, there four dementias. Cytokines did not factors. Conclusions causally dementia, seemed factors
Language: Английский
Citations
51
Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(4), P. 833 - 845
Published: Aug. 14, 2023
A growing body of evidence suggests that the gut microbiota contributes to development neurodegenerative diseases via microbiota-gut-brain axis. As a contributing factor, dysbiosis always occurs in pathological changes diseases, such as Alzheimer's disease, Parkinson's and amyotrophic lateral sclerosis. High-throughput sequencing technology has helped reveal bidirectional communication between central nervous system enteric is facilitated by microbiota's diverse microorganisms, for both neuroimmune neuroendocrine systems. Here, we summarize bioinformatics analysis wet-biology validation metagenomics with an emphasis on multi-omics studies virome. The pathogen-associated signaling biomarkers identifying brain disorders potential therapeutic targets are also elucidated. Finally, discuss role diet, prebiotics, probiotics, postbiotics exercise interventions remodeling microbiome reducing symptoms diseases.
Language: Английский
Citations
29
npj Parkinson s Disease, Journal Year: 2023, Volume and Issue: 9(1)
Published: May 5, 2023
Abstract Parkinson’s disease (PD) is pathologically characterized by the abnormal accumulation of α-synuclein fibrils (Lewy bodies) in substantia nigra and other brain regions, although role Lewy bodies remains elusive. Constipation usually precedes motor symptoms PD, which accordance with notion that start from intestinal neural plexus ascend to at least half PD patients. The gut microbiota likely be involved pathologies. Analyses rapid-eye-movement sleep behavior disorder, dementia suggest three pathological pathways. First, Akkermansia , increased degrades mucus layer increases permeability, triggers inflammation oxidative stress plexus. Second, decreased short-chain fatty acids (SCFAs)-producing bacteria reduce number regulatory T cells. Third, SCFAs also aggravate microglial activation an unelucidated pathway. In addition, (DLB), another form α-synucleinopathies, genera, Ruminococcus torques Collinsella may mitigate neuroinflammation increasing secondary bile acids. Interventions for their metabolites potentially delay or development progression body diseases.
Language: Английский
Citations
23
Molecular Neurodegeneration, Journal Year: 2025, Volume and Issue: 20(1)
Published: Jan. 30, 2025
Abstract Gastrointestinal (GI) involvement in Lewy body diseases (LBDs) has been observed since the initial descriptions of patients by James Parkinson. Recent experimental and human observational studies raise possibility that pathogenic alpha-synuclein (⍺-syn) might develop GI tract subsequently spread to susceptible brain regions. The cellular mechanistic origins ⍺-syn propagation disease are under intense investigation. Experimental LBD models have implicated important contributions from intrinsic gut microbiome, intestinal immune system, environmental toxicants, acting as triggers modifiers pathologies. Here, we review primary clinical observations link dysfunctions LBDs. We first provide an overview anatomy repertoire relevant for disease, with a focus on luminal-sensing cells epithelium including enteroendocrine express make direct contact nerves. describe interactions within resident microbes exogenous how these may directly contribute pathology along related metabolic immunological responses. Finally, critical knowledge gaps field highlighted, focusing pivotal questions remain some 200 years after dysfunction predict better understanding pathophysiologies influence risk progression will accelerate discoveries lead deeper overall potential therapeutic strategies targeting gut-brain axis delay, arrest, or prevent progression.
Language: Английский
Citations
1
iMeta, Journal Year: 2025, Volume and Issue: 4(2)
Published: Feb. 21, 2025
Abstract Time‐restricted feeding (TRF) holds promise for alleviating cognitive decline in aging, albeit the precise mechanism via gut‐brain axis remains elusive. In a clinical trial, we observed, first time, that 4‐month TRF ameliorated impairments among Alzheimer's disease (AD) patients. Experiments 5xFAD mice corroborated gut microbiota‐dependent effect of on mitigating dysfunction, amyloid‐beta deposition, and neuroinflammation. Multi‐omics integration linked Bifidobacterium pseudolongum ( B. ) propionic acid (PA) with key genes AD pathogenesis. Oral supplementation or PA mimicked TRF's protective effects. Positron emission tomography imaging confirmed PA's blood‐brain barrier penetration, while knockdown free fatty receptor 3 (FFAR3) diminished benefits. Notably, observed positive correlation between fecal improved function an cohort, further indicating enhanced production. These findings highlight microbiota‐metabolites‐brain as pivotal benefits, proposing potential therapies.
Language: Английский
Citations
1
Journal of Fungi, Journal Year: 2024, Volume and Issue: 10(6), P. 394 - 394
Published: May 31, 2024
This review evaluates the therapeutic effects of polysaccharides derived from mushroom species that have medicinal and edible properties. The fungal were recently studied, focusing on their modulation gut microbiota impact various diseases. study covers both clinical preclinical studies, detailing results highlighting significant influence these modulation. It discusses potential health benefits incorporating into diet for managing chronic diseases such as diabetes, neurodegenerative disorders, cancer. Furthermore, emphasizes interaction between microbiota, underscoring role in modulating microbial community. presents a systematic analysis findings, demonstrating substantial composition function, which may contribute to conditions. We conclude by play crucial mediating effects, offering promising avenue further research applications disease prevention treatment.
Language: Английский
Citations
6
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14686 - 14686
Published: Sept. 28, 2023
Alzheimer’s disease (AD) is a common cause of dementia characterized by neurodegenerative dysregulations, cognitive impairments, and neuropsychiatric symptoms. Physical exercise (PE) has emerged as powerful tool for reducing chronic inflammation, improving overall health, preventing decline. The connection between the immune system, gut microbiota (GM), neuroinflammation highlights role gut–brain axis in maintaining brain health diseases. Neglected so far, PE beneficial effects on microbial composition diversity, thus providing potential to alleviate neurological There bidirectional communication muscle, with GM diversity modulation short-chain fatty acid (SCFA) production affecting muscle metabolism preservation, activity/exercise turn inducing significant changes composition, functionality, SCFA production. This gut–muscle muscle–gut interplay can then modulate cognition. For instance, irisin, an exercise-induced myokine, promotes neuroplasticity function through BDNF signaling. Irisin muscle-generated may mediate positive physical activity against some aspects AD pathophysiology interaction ecosystem, neural plasticity, anti-inflammatory signaling pathways, neurogenesis. Understanding gut–muscle–brain interconnections hold promise developing strategies promote fight age-associated decline, improve longevity.
Language: Английский
Citations
12
Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(2)
Published: Feb. 1, 2025
Abstract Wheat bran is the processing byproduct of wheat, which thought to have great potential applications. To make a full utilization resource, this study investigated effects steam explosion (SE) modification, with intensity at 1.0 MPa 20, 60, 100, 140, 180, and 220 s, respectively, on wheat soluble dietary fiber (SDF) content, physical‐chemical quality, antioxidant capacity, intestinal microbial spectrum. The impact long‐term intake WB100 (wheat modified under SE conditions 100 s) weight control in obese mice was also studied. results showed that 3.36‐fold increase SDF 61.78% 109.77% DPPH ABTS free radical scavenging rate, maintained good hydration properties compared untreated group. Besides, 5‐HMF content 16.93 mg/kg, within allowable range ensured safety bran. In addition, significantly increased specifically enriched abundance Agathobacter , Fusicatenibacter Faecalibacterium after fermentation. Long‐term could play role by reducing blood lipid levels fasting glucose values, stimulating appetite suppression‐related hormones, fat accumulation, protecting liver health. This highlighted importance technology for enhancement added value industrial upgrading. Practical Application And it can be applied agricultural field or development new food .
Language: Английский
Citations
0
Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19
Published: March 12, 2025
Introduction A growing body of evidence recognises the role signaling molecule microbiota-gut-brain axis (MGBA) in cognitive impairment (CI), but data on link with alterations specific domains are limited. We compared functioning several (i.e., memory, visuo-constructional, executive, and language) among cognitively unimpaired (CU) subjects, patients CI due to Alzheimer’s disease (CI-AD) not AD (CI-NAD). Then, we investigated association these gut microbiota (GM), MGBA mediators, neurodegeneration-related markers. Materials methods The study included 34 CI-AD, 38 CI-NAD, 13 CU. Memory, language were assessed using composite measures. Faecal GM composition was inferred 16S rRNA gene sequencing. mediators blood quantification bacterial products (lipolysaccharide, LPS), cell adhesion molecules indicative endothelial damage, vascular changes or overexpressed response infections, pro- anti-inflammatory cytokines. Neurodegeneration-related markers plasma phosphorylated tau (p-tau181), neurofilament light chain (NfL), glial fibrillary protein (GFAP). Results CI-NAD CI-AD groups had significantly lower scores than CU group for all ( p < 0.043). Associations modulators pro-inflammatory cytokines, dysfunction infection both (| ρ | > 0.33, s 0.042). In pooled group, specifically associated higher abundance Dialister Clostridia_UCG-014 , levels LPS neurodegeneration (|ρ| 0.32, 0.048 all). performance Acetonema Bifidobacterium [Eubacterium]_coprostanoligenes_group Collinsella 0.30, 0.049). Discussion These results support hypothesis that dysbiosis may have distinct effects different mechanisms action depending disease.
Language: Английский
Citations
0
Plant Molecular Biology, Journal Year: 2025, Volume and Issue: 115(2)
Published: March 24, 2025
Language: Английский
Citations
0