Biomedicines,
Год журнала:
2023,
Номер
11(6), С. 1742 - 1742
Опубликована: Июнь 17, 2023
Three-dimensional
bioprinting
is
the
process
of
manipulating
cell-laden
bioinks
to
fabricate
living
structures.
techniques
have
brought
considerable
innovation
in
biomedicine,
especially
field
tissue
engineering,
allowing
production
3D
organ
and
models
for
vivo
transplantation
purposes
or
in-depth
precise
vitro
analyses.
Naturally
derived
hydrogels,
those
obtained
from
decellularization
biological
tissues,
are
promising
printing
purposes,
as
they
present
best
biocompatibility
characteristics.
Despite
this,
many
natural
hydrogels
do
not
possess
necessary
mechanical
properties
allow
a
simple
immediate
application
process.
In
this
review,
we
focus
on
bioactive
characteristics
that
may
efficient
organs
tissues
biomedical
applications,
emphasizing
reinforcement
improve
their
biomechanical
properties.
Materials Today Bio,
Год журнала:
2024,
Номер
24, С. 100948 - 100948
Опубликована: Янв. 5, 2024
Articular
cartilage
injury
is
a
frequent
worldwide
disease,
while
effective
treatment
urgently
needed.
Due
to
lack
of
blood
vessels
and
nerves,
the
ability
self-repair
limited.
Despite
availability
various
clinical
treatments,
unfavorable
prognoses
complications
remain
prevalent.
However,
advent
tissue
engineering
regenerative
medicine
has
generated
considerable
interests
in
using
biomaterials
for
articular
repair.
Nevertheless,
there
remains
notable
scarcity
comprehensive
reviews
that
provide
an
in-depth
exploration
strategies
applications.
Herein,
we
present
overview
primary
bioactive
substances
from
perspective
repair
cartilage.
The
include
regeneration,
substitution,
immunization.
We
comprehensively
delineate
influence
mechanically
supportive
scaffolds
on
cellular
behavior,
shedding
light
emerging
scaffold
technologies,
including
stimuli-responsive
smart
scaffolds,
3D-printed
bionic
scaffolds.
Biologically
active
substances,
factors,
stem
cells,
extracellular
vesicles
(EVs),
organoids,
are
elucidated
their
roles
regulating
activity
chondrocytes.
Furthermore,
composite
produced
industrially
put
into
use,
also
explicitly
presented.
This
review
offers
innovative
solutions
treating
ailments
emphasizes
potential
translation.
Bioactive Materials,
Год журнала:
2024,
Номер
34, С. 494 - 519
Опубликована: Янв. 21, 2024
Biomaterial
choice
is
an
essential
step
during
the
development
tissue
engineering
and
regenerative
medicine
(TERM)
applications.
The
selected
biomaterial
must
present
properties
allowing
physiological-like
recapitulation
of
several
processes
that
lead
to
reestablishment
homeostatic
or
organ
function.
Biomaterials
derived
from
extracellular
matrix
(ECM)
many
such
their
use
in
field
has
been
steadily
increasing.
Considering
this
growing
importance,
it
becomes
imperative
provide
a
comprehensive
overview
ECM
biomaterials,
encompassing
sourcing,
processing,
integration
into
TERM
This
review
compiles
main
strategies
used
isolate
process
ECM-derived
biomaterials
as
well
different
techniques
for
its
characterization,
namely
biochemical
chemical,
physical,
morphological,
biological.
Lastly,
some
applications
are
explored
discussed.
Biomacromolecules,
Год журнала:
2024,
Номер
25(4), С. 2243 - 2260
Опубликована: Март 25, 2024
Cartilage
repair
has
been
a
significant
challenge
in
orthopedics
that
not
yet
fully
resolved.
Due
to
the
absence
of
blood
vessels
and
almost
cell-free
nature
mature
cartilage
tissue,
limited
ability
resulted
socioeconomic
pressures.
Polysaccharide
materials
have
recently
widely
used
for
tissue
due
their
excellent
cell
loading,
biocompatibility,
chemical
modifiability.
They
also
provide
suitable
microenvironment
regeneration.
In
this
Review,
we
summarize
techniques
clinically
repair,
focusing
on
polysaccharides,
polysaccharides
differences
between
these
other
materials.
addition,
engineering
strategies
an
outlook
developing
next-generation
regeneration
from
polysaccharides.
This
Review
will
theoretical
guidance
polysaccharide-based
with
clinical
applications
Frontiers in Sustainable Food Systems,
Год журнала:
2025,
Номер
9
Опубликована: Март 26, 2025
With
a
growing
global
population,
ways
to
counterbalance
the
demand
for
meat
products
with
effective
food
security
and
waste
management
innovative
scalable
solutions.
Concurrently,
alarming
incidence
of
end-stage
organ
failure,
limited
availability
transplantable
organs,
directives
reduce
reliance
on
animal
testing
underscore
need
clinically
viable
sustainable
alternatives.
Our
approach
introduces
hypothesis-driven,
renewable
tissue
engineering
strategy
that
creates
low-cost
keratoplasty
models
derived
entirely
from
agri-food
waste.
Specifically,
we
hypothesize
abundant
by-products,
such
as
eyes
bladders,
provide
practically
unlimited
readily
available
supplies
corneal
tissues
urine-derived
stem
cells
(USCs)
can
be
repurposed
into
cost-effective,
relevant
Traditional
approaches
often
rely
cadaveric
tissues,
invasive
cell
sourcing,
or
expensive
commercial
lines,
which
require
complex
resource-intensive
processes,
including
high-end
bioreactor
systems
manufacturing
environments.
These
requirements
limit
widespread
adoption
technological
progress
needed
increase
supply
keratografts.
proposed
leverages
combination
post-mortem
bladder
harvesting,
in
turn
facilitates
decellularization,
non-invasive
USC
differentiation,
compartment-specific
recellularization
help
overcome
barriers
associated
traditional
seeding
generate
this
type
Overall,
our
perspective
suggests
way
devise
transformative
resource-efficient
engineering,
specifically
geared
toward
improving
outcomes
while
offering
broader
applications
regeneration
other
bodily
tissues/organs
biotechnological
innovation.
Heliyon,
Год журнала:
2024,
Номер
10(6), С. e27306 - e27306
Опубликована: Март 1, 2024
Currently,
stem
cells
are
a
prominent
focus
of
regenerative
engineering
research.
However,
due
to
the
limitations
commonly
used
cell
sources,
their
application
in
therapy
is
often
restricted
experimental
stage
and
constrained
by
ethical
considerations.
In
contrast,
urine-derived
(USCs)
offer
promising
advantages
for
clinical
trials
applications.
The
noninvasive
nature
collection
process
allows
repeated
retrieval
within
short
period,
making
it
more
feasible
option.
Moreover,
studies
have
shown
that
USCs
protective
effect
on
organs,
promoting
vascular
regeneration,
inhibiting
oxidative
stress,
reducing
inflammation
various
acute
chronic
organ
dysfunctions.
has
also
been
enhanced
advancements
biomaterials
technology,
enabling
better
targeting
controlled
release
capabilities.
This
review
aims
summarize
current
state
research
USCs,
providing
insights
future
applications
basic
settings.
Bioactive Materials,
Год журнала:
2024,
Номер
42, С. 85 - 111
Опубликована: Авг. 29, 2024
Hemophilic
articular
cartilage
damage
presents
a
significant
challenge
for
surgeons,
characterized
by
recurrent
intraarticular
bleeding,
severe
inflammatory
microenvironment,
and
limited
self-repair
capability
of
tissue.
Currently,
there
is
lack
tissue
engineering-based
integrated
therapies
that
address
both
early
hemostasis,
anti-inflammation,
long-lasting
chondrogenesis
hemophilic
defects.
Herein,
we
developed
an
adhesive
hydrogel
using
oxidized
chondroitin
sulfate
gelatin,
loaded
with
exosomes
derived
from
bone
marrow
stem
cells
(BMSCs)
(Hydrogel-Exos).
This
demonstrated
favorable
injectability,
self-healing,
biocompatibility,
biodegradability,
swelling,
frictional
mechanical
properties,
providing
comprehensive
approach
to
treating
The
hydrogel,
featuring
dynamic
Schiff
base
bonds
hydrogen
bonds,
exhibited
excellent
wet
adhesiveness
hemostatic
properties.
In
pig
model,
the
could
be
smoothly
injected
into
knee
joint
defect
site
gelled
Materials Horizons,
Год журнала:
2023,
Номер
10(11), С. 4724 - 4745
Опубликована: Янв. 1, 2023
The
advances
in
biomaterials
for
the
construction
of
organs-on-chips
are
reviewed,
including
design,
fabrication,
functions,
applications,
and
future
directions
these
biomaterial-based
platforms.
