ACS Nano,
Год журнала:
2023,
Номер
17(12), С. 11466 - 11480
Опубликована: Май 18, 2023
Intratumoral
pathogens
can
contribute
to
cancer
progression
and
affect
therapeutic
response.
Fusobacterium
nucleatum,
a
core
pathogen
of
colorectal
(CRC),
is
an
important
cause
low
efficacy
metastasis.
Thus,
the
modulation
intratumoral
may
provide
target
for
therapy
metastasis
inhibition.
Herein,
we
propose
F.
nucleatum-modulating
strategy
enhancing
CRC
inhibiting
lung
by
designing
antibacterial
nanoplatform
(Au@BSA-CuPpIX),
which
produced
reactive
oxygen
species
(ROS)
under
ultrasound
exhibited
strong
activity.
Importantly,
Au@BSA-CuPpIX
reduced
levels
apoptosis-inhibiting
proteins
thereby
ROS-induced
apoptosis.
In
vivo
results
demonstrated
that
effectively
eliminated
nucleatum
enhance
sonodynamic
(SDT)
orthotopic
inhibit
Notably,
entrapped
gold
nanoparticles
phototoxicity
metalloporphyrin
accumulated
in
skin
during
tumor
treatment,
preventing
severe
inflammation
damage
skin.
Therefore,
this
study
proposes
elimination
effect
SDT,
thus
providing
promising
paradigm
improving
treatment
with
fewer
toxic
side
effects
promoting
clinical
translational
potential
SDT.
Cell,
Год журнала:
2022,
Номер
185(20), С. 3789 - 3806.e17
Опубликована: Сен. 1, 2022
Cancer-microbe
associations
have
been
explored
for
centuries,
but
cancer-associated
fungi
rarely
examined.
Here,
we
comprehensively
characterize
the
cancer
mycobiome
within
17,401
patient
tissue,
blood,
and
plasma
samples
across
35
types
in
four
independent
cohorts.
We
report
fungal
DNA
cells
at
low
abundances
many
major
human
cancers,
with
differences
community
compositions
that
differ
among
types,
even
when
accounting
technical
background.
Fungal
histological
staining
of
tissue
microarrays
supported
intratumoral
presence
frequent
spatial
association
macrophages.
Comparing
communities
matched
bacteriomes
immunomes
revealed
co-occurring
bi-domain
ecologies,
often
permissive,
rather
than
competitive,
microenvironments
distinct
immune
responses.
Clinically
focused
assessments
suggested
prognostic
diagnostic
capacities
mycobiomes,
stage
I
synergistic
predictive
performance
bacteriomes.
Cancers,
Год журнала:
2023,
Номер
15(3), С. 866 - 866
Опубликована: Янв. 30, 2023
Colorectal
cancer
(CRC)
is
the
second-leading
cause
of
cancer-related
deaths
worldwide.
While
CRC
thought
to
be
an
interplay
between
genetic
and
environmental
factors,
several
lines
evidence
suggest
involvement
gut
microbiota
in
promoting
inflammation
tumor
progression.
Gut
refer
~40
trillion
microorganisms
that
inhabit
human
gut.
Advances
next-generation
sequencing
technologies
metagenomics
have
provided
new
insights
into
microbial
ecology
helped
linking
CRC.
Many
studies
carried
out
humans
animal
models
emphasized
role
certain
bacteria,
such
as
Fusobacterium
nucleatum,
enterotoxigenic
Bacteroides
fragilis,
colibactin-producing
Escherichia
coli,
onset
progression
Metagenomic
opened
up
avenues
for
application
diagnosis,
prevention,
treatment
This
review
article
summarizes
development
its
use
a
biomarker
predict
disease
potential
therapeutic
applications.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Ноя. 6, 2023
Abstract
The
perturbations
of
the
gut
microbiota
and
metabolites
are
closely
associated
with
progression
inflammatory
bowel
disease
(IBD).
However,
inconsistent
findings
across
studies
impede
a
comprehensive
understanding
their
roles
in
IBD
potential
as
reliable
diagnostic
biomarkers.
To
address
this
challenge,
here
we
comprehensively
analyze
9
metagenomic
4
metabolomics
cohorts
from
different
populations.
Through
cross-cohort
integrative
analysis
(CCIA),
identify
consistent
characteristic
commensal
microbiota.
Especially,
three
bacteria,
namely
Asaccharobacter
celatus
,
Gemmiger
formicilis
Erysipelatoclostridium
ramosum
which
rarely
reported
IBD.
Metagenomic
functional
reveals
that
essential
gene
Two-component
system
pathway,
linked
to
fecal
calprotectin,
implicated
Metabolomics
shows
36
identified
significant
differences,
while
these
still
unknown.
further
elucidate
relationship
between
metabolites,
construct
multi-omics
biological
correlation
(MOBC)
maps,
highlights
microbial
biotransformation
deficiencies
alterations
aminoacyl-tRNA
synthetases.
Finally,
biomarkers
for
diagnosis,
validated
multiple
global
(AUROC
values
ranging
0.92
0.98).
Our
results
offer
valuable
insights
resource
developing
mechanistic
hypotheses
on
host-microbiome
interactions
Colorectal
cancer
(CRC)
is
the
third
most
common
malignant
tumor
worldwide.
The
incidence
and
mortality
rates
of
CRC
have
been
increasing
in
China,
possibly
due
to
economic
development,
lifestyle,
dietary
changes.
Evidence
suggests
that
gut
microbiota
plays
an
essential
role
tumorigenesis
CRC.
Gut
dysbiosis,
specific
pathogenic
microbes,
metabolites,
virulence
factors,
microbial
carcinogenic
mechanisms
contribute
initiation
progression
biomarkers
potential
translational
applications
screening
early
diagnosis.
microbiota-related
interventions
could
improve
anti-tumor
therapy's
efficacy
severe
intestinal
toxic
effects.
Chinese
researchers
made
many
achievements
relationship
between
CRC,
although
some
challenges
remain.
This
review
summarizes
current
evidence
from
China
on
mainly
including
characteristics,
especially
Fusobacterium
nucleatum
Parvimonas
micra,
which
identified
be
enriched
patients;
pathogens
such
as
F.
enterotoxigenic
Bacteroides
fragilis,
P.
scientists
extensively
studied;
diagnostic
nucleatum;
therapeutic
effects,
microecological
agents
represented
by
certain
Lactobacillus
strains,
fecal
transplantation,
traditional
medicines
Berberine
Curcumin.
More
efforts
should
focused
exploring
underlying
pathogenesis
providing
novel
preventive
strategies.
Microorganisms,
Год журнала:
2023,
Номер
11(2), С. 318 - 318
Опубликована: Янв. 26, 2023
The
oral
microbiome
is
an
emerging
field
that
has
been
a
topic
of
discussion
since
the
development
next
generation
sequencing
and
implementation
human
project.
This
article
reviews
current
literature
surrounding
microbiome,
briefly
highlighting
most
recent
methods
characterization
including
cutting
edge
omics,
databases
for
areas
with
gaps
in
knowledge.
also
describes
reports
on
microorganisms
contained
which
include
viruses,
archaea,
fungi,
bacteria,
provides
in-depth
analysis
their
significant
roles
tissue
homeostasis.
Finally,
we
detail
key
bacteria
involved
disease,
cancer,
research
role
stimulation
inflammatory
cytokines,
gingival
crevicular
fluid
periodontal
creation
network
interactions
between
microorganisms,
influence
planktonic
cospecies
biofilms,
implications
antibiotic
resistance.
paper
comprehensive
while
identifying
knowledge
to
enable
future
studies
be
conducted.
