Candida–bacterial cross-kingdom interactions

Trends in Microbiology, Год журнала: 2023, Номер 31(12), С. 1287 - 1299

Опубликована: Авг. 26, 2023

Язык: Английский

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Manipulating the diseased oral microbiome: the power of probiotics and prebiotics

Journal of Oral Microbiology, Год журнала: 2024, Номер 16(1)

Опубликована: Янв. 31, 2024

Dental caries and periodontal disease are amongst the most prevalent global disorders. Their aetiology is rooted in microbial activity within oral cavity, through generation of detrimental metabolites instigation potentially adverse host immune responses. Due to increasing threat antimicrobial resistance, alternative approaches readdress balance necessary. Advances sequencing technologies have established relationships between dysbiosis, commercial enterprises seek identify probiotic prebiotic formulations tackle preventable disorders colonisation with, or promotion of, beneficial microbes. It metabolic characteristics immunomodulatory capabilities resident species which underlie health status. Research emphasis on environment cavity has elucidated commensal pathogenic organisms, for example, sequential metabolism fermentable carbohydrates deemed central acid production cariogenicity. Therefore, a focus preservation an ecological homeostasis may be appropriate approach conservation. In this review we discuss maintenance healthy debate potential use supplementation, specifically targeted at sustaining niches preserve delicately balanced microbiome.

Язык: Английский

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Effect of an Exclusive Human Milk Diet on the Gut Microbiome in Preterm Infants

JAMA Network Open, Год журнала: 2023, Номер 6(3), С. e231165 - e231165

Опубликована: Март 1, 2023

The effect of using an exclusive human milk diet compared with one that uses bovine products in preterm infants is uncertain, but some studies demonstrate lower rates key neonatal morbidities. A potential mediating pathway the gut microbiome.To determine on bacterial richness, diversity, and proportions specific taxa from enrollment to 34 weeks' postmenstrual age.In this randomized clinical trial conducted at 4 intensive care units United Kingdom 2017 2020, microbiome analyses were blind group. Infants less than 30 gestation who had only received own mother's recruited before 72 hours age. Statistical analysis was performed July 2019 September 2021.Exclusive pasteurized for any shortfall supply milk-derived fortifiers (intervention) formula bovine-derived fortifier (control) until Fortifier commenced 48 tolerating 150 mL/kg per day.Gut profile including alpha beta presence taxa.Of 126 enrolled study, 63 control (median [IQR] gestation: 27.0 weeks [26.0-28.1 weeks]; median birthweight: 910 g [704-1054 g]; 32 [51%] male) intervention 27.1 [25.7-28.1 930 [733-1095 38 [60%] male); 472 stool samples 116 analyzed. There no differences richness or Shannon diversity over time, between groups. group reduced relative abundance Lactobacillus after adjustment confounders (coefficient estimate, 0.056; P = .03), not false discovery rate adjustment. time full feeds, necrotizing enterocolitis, other morbidities.In and/or enable diet, there effects overall measures previously associated receipt. These findings suggest impact modulated via microbiomic mechanisms.ISRCTN registry identifier: ISRCTN16799022.

Язык: Английский

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Translating neonatal microbiome science into commercial innovation: metabolism of human milk oligosaccharides as a basis for probiotic efficacy in breast-fed infants

Gut Microbes, Год журнала: 2023, Номер 15(1)

Опубликована: Апрель 3, 2023

For over a century, physicians have witnessed common enrichment of bifidobacteria in the feces breast-fed infants that was readily associated with infant health status. Recent advances bacterial genomics, metagenomics, and glycomics helped explain nature this unique enabled tailored use probiotic supplementation to restore missing bifidobacterial functions at-risk infants. This review documents 20-year span discoveries set stage for current human milk oligosaccharide-consuming beneficially colonize, modulate, protect intestines at-risk, milk-fed, neonates. also presents model applications wherein functions, form colonization HMO-related catabolic activity situ, represent measurable metabolic outcomes by which efficacy can be scored toward improving health.

Язык: Английский

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Bifidobacterium and Lactobacillus Probiotics and Gut Dysbiosis in Preterm Infants

JAMA Pediatrics, Год журнала: 2024, Номер 178(10), С. 985 - 985

Опубликована: Авг. 5, 2024

Importance The effects of probiotic interventions on colonization with resistant bacteria and early microbiome development in preterm infants remain to be clarified. Objective To examine the efficacy Bifidobacterium longum subsp infantis , animalis lactis (BB-12), Lactobacillus acidophilus (La-5) probiotics prevent multidrug-resistant organisms or highly epidemic (MDRO+) shape toward eubiotic state healthy full-term infants. Design, Setting, Participants multicenter, double-blinded, placebo-controlled, group sequential, phase 3 Priming Immunity at Beginning Life (PRIMAL) randomized clinical trial, conducted from April 2018 June 2020, included gestational age 28 32 weeks 18 German neonatal units. Data analyses were March 2020 August 2023. Intervention A total days multistrain diluted human milk/formula starting within first 72 hours life. Main Outcomes Measures Colonization MDRO+ day 30 life (primary end point), late-onset sepsis severe gastrointestinal complication (safety points), gut dysbiosis, ie, deviations healthy, term (eubiosis score) based 16-subunit ribosomal RNA metagenomic sequencing. Results Among 643 until stop recruitment interim results, 618 (median [IQR] age, 31.0 [29.7-32.1] weeks; 333 male [53.9%]; mean [SD] birth weight, 1502 [369] g) had follow-up 30. analysis all available data 219 revealed 43 115 (37.4%) 39 104 (37.5%) control (adjusted risk ratio, 0.99; 95% CI, 0.54-1.81; P = .97). Safety outcomes similar both groups, (probiotics group: 8 316 [2.5%]; 12 322 [3.7%]) complications 6 [1.9%]; 7 [2.2%]). higher eubiosis scores than genus level (254 vs 258 infants; median scores, 0.47 0.41; odds ratio [OR], 1.07; 1.02-1.13) species (96 83 0.87 0.59; OR, 1.28; 1.19-1.38). Environmental uptake B strain was common (41 84 [49%]), which variable across sites particularly occurred a sibling who treated probiotics. Conclusions Relevance Multistrain did not reduce incidence but modulated their eubiosis. Trial Registration Clinical Trials Register: DRKS00013197

Язык: Английский

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An Updated Review on Probiotic Production and Applications

Gastroenterology Insights, Год журнала: 2024, Номер 15(1), С. 221 - 236

Опубликована: Март 11, 2024

Microorganisms are ubiquitous and have been exploited for centuries to generate primary secondary metabolites essential human welfare environmental sustainability. occupy a prominent position in the industrial sector due their unique properties, such as limited time space required growth proliferation, well easy manipulation of genetic material. Among all microorganisms, probiotics grabbed attention researchers because nonpathogenic nature immersive application treating digestive ailments vitamin deficiency, boosting immunity, detoxifying harmful chemicals. Furthermore, widely used treat various diseases constipation, colon cancer, type 2 diabetes mellitus, obesity, range intestinal disorders, including inflammatory bowel disease, among others. The updated information on these role has not past few years. present review covers topics. populations around globe attracted scientists, primarily investigating diverse technologies meet gap between probiotic production demand. With support standardized tools techniques, explored potent strains feasible health ailments. In current review, we curated potential screening, strain selection, production, necessary researchers.

Язык: Английский

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The alleviative effects of viable and inactive Lactobacillus paracasei CCFM1120 against alcoholic liver disease via modulation of gut microbiota and the Nrf2/HO-1 and TLR4/MyD88/NF-κB pathways

Food & Function, Год журнала: 2024, Номер 15(17), С. 8797 - 8809

Опубликована: Янв. 1, 2024

Probiotics can alleviate alcoholic liver disease.

Язык: Английский

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Mother’s milk microbiota is associated with the developing gut microbial consortia in very-low-birth-weight infants

Cell Reports Medicine, Год журнала: 2024, Номер 5(9), С. 101729 - 101729

Опубликована: Сен. 1, 2024

Язык: Английский

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Milk microbiome transplantation: recolonizing donor milk with mother's own milk microbiota

Applied Microbiology and Biotechnology, Год журнала: 2024, Номер 108(1)

Опубликована: Янв. 9, 2024

Donor human milk (DHM) provides myriad nutritional and immunological benefits for preterm low birthweight infants. However, pasteurization leaves DHM devoid of potentially beneficial microbiota. In the present study, we performed microbiome transplantation from freshly collected mother's own (MOM) into pasteurized DHM. Small volumes MOM (5%, 10%, or 30% v/v) were inoculated incubated at 37 °C up to 8 h. Further, compared recolonization in UV-C-treated Holder-pasteurized DHM, as UV-C treatment has been shown conserve important biochemical components that are lost during Holder pasteurization. Bacterial culture viability-coupled metataxonomic sequencing employed assess effectiveness transplantation. Growth transplanted bacteria occurred rapidly recolonized samples; however, a greater level growth was observed due conserved antimicrobial properties Viability-coupled analysis demonstrated similarity between samples fresh samples, suggesting can be successfully These results highlight potential microbiota restore microbial composition enhance vulnerable KEY POINTS: • Mother's donor milk. Recolonization is equally successful time should restricted rapid bacterial growth.

Язык: Английский

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The impact of gut microbiota on morbidities in preterm infants

The Kaohsiung Journal of Medical Sciences, Год журнала: 2024, Номер 40(9), С. 780 - 788

Опубликована: Июль 29, 2024

Abstract The gut microbiota undergoes substantial development from birth, and its in the initial years of life has a potentially lifelong effect on health individual. However, various factors can disrupt microbiota, leading to condition known as dysbiosis, particularly preterm infants. Current studies involving adults have suggested that not only influences but also multidimensional effects remote organs; these pathways are often referred gut–organ axis. Imbalance may lead multiple diseases. Recent revealed dysbiosis infants cause several acute morbidities—such necrotizing enterocolitis, late‐onset sepsis, bronchopulmonary dysplasia, retinopathy prematurity—and it influence long‐term outcomes including neurodevelopment somatic growth. This review mainly presents existing evidence regarding relationships between morbidities explores role axis morbidities. paper thus offers insights into future perspectives interventions for promoting

Язык: Английский

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