In vivo NIR-II fluorescence imaging for biology and medicine

Nature Photonics, Год журнала: 2024, Номер 18(6), С. 535 - 547

Опубликована: Март 4, 2024

Язык: Английский

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Near-infrared II fluorescence imaging

Nature Reviews Methods Primers, Год журнала: 2024, Номер 4(1)

Опубликована: Апрель 4, 2024

Язык: Английский

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Neutral Cyanine: Ultra‐Stable NIR‐II Merocyanines for Highly Efficient Bioimaging and Tumor‐Targeted Phototheranostics

Advanced Materials, Год журнала: 2024, Номер 36(31)

Опубликована: Май 21, 2024

Fluorescence imaging (FLI)-guided phototheranostics using emission from the second near-infrared (NIR-II) window show significant potential for cancer diagnosis and treatment. Clinical imaging-used polymethine ionic indocyanine green (ICG) dye is widely adopted NIR fluorescence imaging-guided photothermal therapy (PTT) research due to its exceptional photophysical properties. However, ICG has limitations such as poor photostability, low conversion efficiency (PCE), short-wavelength peak, liver-targeting issues, which restrict wider use. In this study, two derivatives are transformed into neutral merocyanines (mCy) achieve much-enhanced performance NIR-II phototheranostics. Initial designs of dyes similar drawbacks in terms photostability performance. One modified molecules, mCy890, shows significantly improved stability, an peak over 1000 nm, a high PCE 51%, all considerably outperform ICG. vivo studies demonstrate that nanoparticles mCy890 can effectively accumulate at tumor sites guided by imaging. This provides valuable insights development enhanced

Язык: Английский

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An Emerging Toolkit of Ho³⁺ Sensitized Lanthanide Nanocrystals with NIR-II Excitation and Emission for in Vivo Bioimaging

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

Optical imaging in the second near-infrared window (NIR-II, 1000-1700 nm) holds great promise for biomedical detection due to reduced tissue scattering and autofluorescence. However, rational design of NIR-II probes with superior excitation wavelengths balance effects water absorption remains a challenge. To address this issue, here we developed series Ho

Язык: Английский

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Flexible near-infrared organic photodetectors for emergent wearable applications

Wearable electronics., Год журнала: 2024, Номер 1, С. 53 - 77

Опубликована: Май 13, 2024

With the evolution of Industry 4.0, next-generation wearable devices have come under spotlight, where organic electronics are playing an important role due to their flexible form factor, high performance, and integration capability. Designed conform soft dynamic surfaces, photodetectors (OPDs) integrated arrays stand out for application potential in non-invasive biosensing bio-imaging, with inherent advantages mitigating motion artifacts – a notable limitation traditional, rigid photodetector systems. Leveraging near-infrared (NIR) spectrum's capability deep skin penetration minimal scattering human tissues, NIR OPDs especially capable precise diagnostics enhanced signal quality. The adaptable factor further broadens applications human-environment interaction, marking shift towards more responsive intelligent technologies. This review summarizes latest challenges breakthroughs OPDs, emphasizing effective strategies toward high-performance device units We discuss remaining outlook on vast reshaping our interaction surroundings.

Язык: Английский

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White-light activatable organic NIR-II luminescence nanomaterials for imaging-guided surgery

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июль 11, 2024

Abstract While second near-infrared (NIR-II) fluorescence imaging is a promising tool for real-time surveillance of surgical operations, the previously reported organic NIR-II luminescent materials in vivo are predominantly activated by expensive lasers or X-ray with high power and poor illumination homogeneity, which significantly limits their clinical applications. Here we report white-light activatable agent taking advantages strong intramolecular/intermolecular D-A interactions conjugated Y6CT molecules nanoparticles (Y6CT-NPs), brightness as 13315.1, over two times that brightest laser-activated contrast agents thus far. Upon activation, Y6CT-NPs can achieve not only hepatic ischemia reperfusion, but also monitoring kidney transplantation surgery. During surgery, identification renal vasculature, post-reconstruction assessment allograft vascular integrity, blood supply analysis ureter be vividly depicted using signal-to-noise ratios upon laparoscopic LED activation. Our work provides efficient molecular design guidelines towards highlights an opportunity precision theranostics.

Язык: Английский

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NIR‐II Protein‐Escaping Dyes Enable High‐Contrast and Long‐Term Prognosis Evaluation of Flap Transplantation

Advanced Materials, Год журнала: 2023, Номер 36(14)

Опубликована: Дек. 28, 2023

Abstract Real‐time vascular positioning, postoperative flap monitoring, and reconstruction assessment are of great importance in transplantation. Cyanine dyes offer the advantage high resolution Near‐infrared‐II (NIR‐II) imaging window. However, nonspecific binding many cyanine to endogenous albumin leads organ accumulation skin absorption, resulting low‐quality poor reproducibility contrast during long‐term (e.g., 7 days) monitoring. Here, a novel strategy is proposed that can be widely applied prevent protein for NIR‐I/II Cl‐containing dyes. This produces protein‐escaping dyes, ensuring fluorescence enhancement blood with rapid clearance no residual fluorescence, allowing short‐term repeatable injections imaging. perioperative monitoring pedicle perforator models mice rats successfully applied. Furthermore, leveraging universality this strategy, multiple nonoverlapping probes achieve dual‐excitation (808 1064 nm) interference‐free nerve‐vessel tumor‐vessel simultaneously designed synthesized. These enable dual‐color tumor localization, resection, at wound site.

Язык: Английский

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Targeting macrophages with multifunctional nanoparticles to detect and prevent atherosclerotic cardiovascular disease

Cardiovascular Research, Год журнала: 2024, Номер 120(8), С. 819 - 838

Опубликована: Май 1, 2024

Abstract Despite the emergence of novel diagnostic, pharmacological, interventional, and prevention strategies, atherosclerotic cardiovascular disease remains a significant cause morbidity mortality. Nanoparticle (NP)-based platforms encompass diverse imaging, delivery, pharmacological properties that provide opportunities for refining diagnostic therapeutic interventions atherosclerosis at cellular molecular levels. Macrophages play critical role in therefore represent an important disease-related target, especially given their inherent ability passive active NP uptake. In this review, we discuss array inorganic, carbon-based, lipid-based NPs magnetic, radiographic, fluorescent imaging capabilities range highly promising research clinical applications atherosclerosis. We design target macrophage-related functions such as lipoprotein oxidation, cholesterol efflux, vascular inflammation, defective efferocytosis. also examples systems were developed other pathologies cancer highlight potential repurposing disease. Finally, current state future theranostic NPs. Whilst is not without its challenges, multifunctional are possible ensures they will be part next frontier exciting new therapies simultaneously improve accuracy plaque diagnosis more effectively reduce with limited side effects.

Язык: Английский

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Biomimetic Tertiary Lymphoid Structures with Microporous Annealed Particle Scaffolds for Cancer Postoperative Therapy

ACS Nano, Год журнала: 2024, Номер 18(12), С. 9176 - 9186

Опубликована: Март 18, 2024

Immunotherapy plays a vital role in cancer postoperative treatment. Strategies to increase the variety of immune cells and their sustainable supply are essential improve therapeutic effect cell-based immunotherapy. Here, inspired by tertiary lymphoid structures (TLSs), we present microfluidic-assisted microporous annealed particle (MAP) scaffold for persistent recruitment diverse therapy. Based on thermochemical responsivity gelatin methacryloyl (GelMA), MAP was fabricated physical cross-linking sequential photo-cross-linking GelMA droplets, which were prepared microfluidic electrospraying. Due encapsulation liquid nitrogen-inactivated tumor immunostimulant, generated could recruit large number cells, involving T macrophages, dendritic B natural killer thereby forming biomimetic TLSs vivo. In addition, combination checkpoint inhibitors, synergistic anticancer response provoked inhibit recurrence metastasis. These properties make proposed scaffold-based artificial great value efficient

Язык: Английский

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Aqueous Grown Quantum Dots with Robust Near-Infrared Fluorescence for Integrated Traumatic Brain Injury Diagnosis and Surgical Monitoring

ACS Nano, Год журнала: 2024, Номер 18(29), С. 19038 - 19053

Опубликована: Июль 9, 2024

Surgical intervention is the most common first-line treatment for severe traumatic brain injuries (TBIs) associated with high intracranial pressure, while complexity of these surgical procedures often results in complications. Surgeons struggle to comprehensively evaluate TBI status, making it difficult select optimal strategy. Here, we introduce a fluorescence imaging-based technology that uses high-quality silver indium selenide-based quantum dots (QDs) integrated diagnosis and guidance. These engineered, poly(ethylene glycol)-capped QDs emit near-infrared region, are resistant phagocytosis, importantly, ultrastable after epitaxial growth an aluminum-doped zinc sulfide shell aqueous phase renders long-term light irradiation complex physiological environments. We found intravenous injection enabled both precise mouse model and, more comprehensive evaluation status before, during, operation distinguish from superficial hemorrhages, provide real-time monitoring secondary hemorrhage, guide decision on evacuation hematomas. This QD-based diagnostic system could ultimately complement existing clinical tools treating TBI, which may help surgeons improve patient outcomes avoid unnecessary procedures.

Язык: Английский

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