Lipid metabolism around the body clocks

Progress in Lipid Research, Год журнала: 2023, Номер 91, С. 101235 - 101235

Опубликована: Май 15, 2023

Lipids play important roles in energy metabolism along with diverse aspects of biological membrane structure, signaling and other functions. Perturbations lipid are responsible for the development various pathologies comprising metabolic syndrome, obesity, type 2 diabetes. Accumulating evidence suggests that circadian oscillators, operative most cells our body, coordinate temporal homeostasis. In this review we summarize current knowledge on regulation digestion, absorption, transportation, biosynthesis, catabolism, storage. Specifically, focus molecular interactions between functional clockwork biosynthetic pathways major classes cholesterol, fatty acids, triacylglycerols, glycerophospholipids, glycosphingolipids, sphingomyelins. A growing body epidemiological studies associate a socially imposed misalignment common modern society incidence disorders, however disruption rhythms connection has only been recently revealed. Here, highlight recent unravel mechanistic link intracellular clocks, homeostasis diseases based animal models clock innovative translational humans. We also discuss perspectives manipulating oscillators as potentially powerful approach preventing managing disorders human patients.

Язык: Английский

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Exposome in ischaemic heart disease: beyond traditional risk factors

European Heart Journal, Год журнала: 2024, Номер 45(6), С. 419 - 438

Опубликована: Янв. 18, 2024

Abstract Ischaemic heart disease represents the leading cause of morbidity and mortality, typically induced by detrimental effects risk factors on cardiovascular system. Although preventive interventions tackling conventional have helped to reduce incidence ischaemic disease, it remains a major death worldwide. Thus, attention is now shifting non-traditional in built, natural, social environments that collectively contribute substantially burden perpetuate residual risk. Of importance, these complex interact non-linearly unpredictable ways often enhance attributable single or collection factors. For this reason, new paradigm called ‘exposome’ has recently been introduced epidemiologists order define totality exposure The purpose review outline how emerging may occurrence with particular impact long-term different environmental pollutants, socioeconomic psychological factors, along infectious diseases such as influenza COVID-19. Moreover, potential mitigation strategies for both individuals communities will be discussed.

Язык: Английский

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Breast cancer: pathogenesis and treatments

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Фев. 18, 2025

Abstract Breast cancer, characterized by unique epidemiological patterns and significant heterogeneity, remains one of the leading causes malignancy-related deaths in women. The increasingly nuanced molecular subtypes breast cancer have enhanced comprehension precision treatment this disease. mechanisms tumorigenesis progression been central to scientific research, with investigations spanning various perspectives such as tumor stemness, intra-tumoral microbiota, circadian rhythms. Technological advancements, particularly those integrated artificial intelligence, significantly improved accuracy detection diagnosis. emergence novel therapeutic concepts drugs represents a paradigm shift towards personalized medicine. Evidence suggests that optimal diagnosis models tailored individual patient risk expected are crucial, supporting era oncology for cancer. Despite rapid advancements increasing emphasis on clinical comprehensive update summary panoramic knowledge related disease needed. In review, we provide thorough overview global status including its epidemiology, factors, pathophysiology, subtyping. Additionally, elaborate latest research into contributing progression, emerging strategies, long-term management. This review offers valuable insights Cancer Research, thereby facilitating future progress both basic application.

Язык: Английский

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Heart healthy cities: genetics loads the gun but the environment pulls the trigger

European Heart Journal, Год журнала: 2021, Номер 42(25), С. 2422 - 2438

Опубликована: Апрель 7, 2021

The world's population is estimated to reach 10 billion by 2050 and 75% of this will live in cities. Two-third the European already urban areas proportion continues grow. Between 60% 80% global energy use consumed areas, with 70% greenhouse gas emissions produced within areas. World Health Organization states that city planning now recognized as a critical part comprehensive solution tackle adverse health outcomes. In present review, we address non-communicable diseases focus on cardiovascular disease urbanization process relation environmental risk exposures including noise, air pollution, temperature, outdoor light. review reports why heat islands develop how greening cities can improve public health, climate concerns, sustainability, liveability. addition, discuss planning, transport interventions, novel technologies assess external exposures, e.g. using digital technologies, promote heart healthy future. Lastly, highlight new paradigms integrative thinking such exposome planetary challenging one-exposure-one-health-outcome association expand our understanding totality human exposures.

Язык: Английский

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Circadian Rhythms, Disease and Chronotherapy

Journal of Biological Rhythms, Год журнала: 2021, Номер 36(6), С. 503 - 531

Опубликована: Сен. 22, 2021

Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology and behavior, exemplified by cycles sleep/wake, hormone release, metabolism. The adaptive value is evident when internal body daily environmental mismatched, such as in the case shift work jet lag or even mistimed eating, all which associated with physiological disruption disease. Studies animal human models have also unraveled an important role functional circadian modulating cellular organismal responses to cues (ex., food intake, exercise), pathological insults (e.g. virus parasite infections), medical interventions medication). With growing knowledge molecular underlying pathophysiology, it becoming possible target for disease prevention treatment. In this review, we discuss recent advances research potential therapeutic applications take patient into account treating

Язык: Английский

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Outdoor light at night and risk of coronary heart disease among older adults: a prospective cohort study

European Heart Journal, Год журнала: 2020, Номер 42(8), С. 822 - 830

Опубликована: Сен. 27, 2020

Abstract Aims We estimated the association between outdoor light at night residence and risk of coronary heart disease (CHD) within a prospective cohort older adults in Hong Kong. Methods results Over median 11 years follow-up, we identified 3772 incident CHD hospitalizations 1695 deaths. Annual levels participants’ residential addresses were using time-varying satellite data for composite persistent night-time illumination ∼1 km2 scale. used Cox proportional hazards models to estimate hazard ratios (HRs) 95% confidence intervals (CIs) CHD. The hospitalization mortality exhibited monotonic exposure-response function. An interquartile range (IQR) (60.0 nW/cm2/sr) increase was associated with an HR 1.11 (95% CI: 1.03, 1.18) 1.10 1.00, 1.22) deaths after adjusting both individual area-level factors. did not vary across strata hypothesized Conclusion Among adults, higher caution against causal interpretation these novel findings. Future studies more detailed information on exposure, adaptive behaviours, potential mediators are warranted further examine relationship risk.

Язык: Английский

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Redox-related biomarkers in human cardiovascular disease - classical footprints and beyond

Redox Biology, Год журнала: 2021, Номер 42, С. 101875 - 101875

Опубликована: Янв. 23, 2021

Global epidemiological studies show that chronic non-communicable diseases such as atherosclerosis and metabolic disorders represent the leading cause of premature mortality morbidity. Cardiovascular disease ischemic heart is a major contributor to global burden socioeconomic health costs. Clinical data an association typical oxidative stress markers lipid peroxidation products, 3-nitrotyrosine or oxidized DNA/RNA bases with all cardiovascular diseases. This supports concept formation reactive oxygen nitrogen species by various sources (NADPH oxidases, xanthine oxidase mitochondrial respiratory chain) represents hallmark comorbidities hyperlipidemia, hypertension diabetes. These can lead damage but also adverse redox signaling at level kinases, calcium handling, inflammation, epigenetic control, circadian clock proteasomal system. The in vivo footprints these processes (redox biomarkers) are discussed present review focus on their clinical relevance, whereas details mechanisms technical aspects detection only briefly mentioned. categories biomarkers summarized explained basis suitable examples. Also potential prognostic value critically understand what kind information they provide cannot achieve.

Язык: Английский

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Circadian Rhythm: Potential Therapeutic Target for Atherosclerosis and Thrombosis

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(2), С. 676 - 676

Опубликована: Янв. 12, 2021

Every organism has an intrinsic biological rhythm that orchestrates processes in adjusting to daily environmental changes. Circadian rhythms are maintained by networks of molecular clocks throughout the core and peripheral tissues, including immune cells, blood vessels, perivascular adipose tissues. Recent findings have suggested strong correlations between circadian clock cardiovascular diseases. Desynchronization body metabolism contributes development diseases arteriosclerosis thrombosis. involved controlling inflammatory metabolisms, which can influence pathology genes critical maintaining robust relationship diurnal variation system. The machinery vascular system may be a novel therapeutic target for prevention treatment research on is still progressing. In this review, we briefly summarize recent studies homeostasis, focusing control metabolisms. Based findings, discuss potential molecules future strategies against targeting clock.

Язык: Английский

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Myocardial Rev-erb–Mediated Diurnal Metabolic Rhythm and Obesity Paradox

Circulation, Год журнала: 2022, Номер 145(6), С. 448 - 464

Опубликована: Янв. 17, 2022

The nuclear receptor Rev-erbα/β, a key component of the circadian clock, emerges as drug target for heart diseases, but function cardiac Rev-erb has not been studied in vivo. Circadian disruption is implicated it unknown whether molecular clock dysfunction associated with progression any naturally occurring human diseases. Obesity paradox refers to seemingly protective role obesity failure, mechanism unclear.

Язык: Английский

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Meal Timing, Meal Frequency and Metabolic Syndrome

Nutrients, Год журнала: 2022, Номер 14(9), С. 1719 - 1719

Опубликована: Апрель 21, 2022

Individuals with metabolic syndrome have increased risk for developing health conditions, including cardiovascular diseases and stroke. Modifiable factors, such as exercise diet, are key components in the prevention control of syndrome. Specifically, dietary patterns habits extremely successful controlling more than one factors. Meal timing frequency been associated type 2 diabetes, diseases, other chronic conditions. However, there is limited evidence linking to meal frequency. This review summarizes discusses how impact outcomes adults.

Язык: Английский

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