The Role of Serotonin Neurotransmission in Gastrointestinal Tract and Pharmacotherapy DOI Creative Commons
Tomasz Guzel, Dagmara Mirowska‐Guzel

Molecules, Год журнала: 2022, Номер 27(5), С. 1680 - 1680

Опубликована: Март 3, 2022

5-Hydroxytryptamine (5-HT, serotonin) is a neurotransmitter in both the central nervous system and peripheral structures, acting also as hormone platelets. Although its concentration gut covers >90% of all organism resources, serotonin mainly known that takes part pathology mental diseases. Serotonin modulates not only CNS neurons, but pain transmission platelet aggregation. In periphery, 5-HT influences muscle motility gut, bronchi, uterus, vessels directly through neurons. synthesis starts from hydroxylation orally delivered tryptophan, followed by decarboxylation. acts via numerous types receptors clinically plays role several neural, mental, other chronic disorders, such migraine, carcinoid syndrome, some dysfunctions alimentary system. paracrine growth factor. brain are targets for drugs modifying neurotransmission. The aim present article to review gastrointestinal (GI) tract determine GI physiology pathology, including diseases pharmacotherapy.

Язык: Английский

A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease DOI Creative Commons
Qingdong Guan

Journal of Immunology Research, Год журнала: 2019, Номер 2019, С. 1 - 16

Опубликована: Дек. 1, 2019

Inflammatory bowel disease (IBD) is a chronic and life-threating inflammatory of gastroenteric tissue characterized by episodes intestinal inflammation. The pathogenesis IBD complex. Recent studies have greatly improved our knowledge the pathophysiology IBD, leading to great advances in treatment as well diagnosis IBD. In this review, we systemically reviewed highlighted recent host genetic factors, gut microbiota, environmental factors and, especially, abnormal innate adaptive immune responses their interactions, which may hold keys identify novel predictive or prognostic biomarkers develop new therapies.

Язык: Английский

Процитировано

792
The Gut Microbiota in the First Decade of Life DOI Creative Commons
Muriel Derrien,

Anne-Sophie Alvarez,

Willem M. de Vos

и другие.

Trends in Microbiology, Год журнала: 2019, Номер 27(12), С. 997 - 1010

Опубликована: Авг. 29, 2019

Appreciation of the importance gut microbiome is growing, and it becoming increasingly relevant to identify preventive or therapeutic solutions targeting it. The composition function microbiota are relatively well described for infants (less than 3 years) adults, but have been largely overlooked in pre-school (3-6 primary school-age (6-12 children, as teenagers (12-18 years). Early reports suggested that infant would attain an adult-like structure at age years, recent studies development may take longer. This time key because there evidence suggest deviations this consequences later life. In review, we provide overview current knowledge concerning microbiota, its evolution, variation, response dietary challenges during first decade life with a focus on healthy children (up 12 from various populations around globe. should facilitate identification diet-based approaches individuals group, promote

Язык: Английский

Процитировано

459
Understanding oxidants and antioxidants: Classical team with new players DOI Open Access

Syed Saqib Ali,

Haseeb Ahsan, Mohammad Khalid Zia

и другие.

Journal of Food Biochemistry, Год журнала: 2020, Номер 44(3)

Опубликована: Янв. 20, 2020

The free radical oxidants such as reactive oxygen species, nitrogen and sulfur species are produced inside cells through various metabolic processes. body is equipped with an antioxidant defense system that guards against oxidative damage caused by these plays a major role in protecting from stress damage. Antioxidants glutathione (GSH), thioredoxin, ascorbic acid enzymes, for example, superoxide dismutase (SOD), peroxidase (GPx), catalase (CAT) counter the protect lipids, proteins, DNA. tocopherols, acid, carotenoids, flavonoids, amino acids also natural antioxidants present foods. There increasing demand availability of designer foods fortified probiotics may be important human health. review article presents brief overview systems including inflammation. Practical applications GSH, etc. protective SOD, GPx, CAT, cellular biomolecules. acids, phospholipids, sterols found consumed They play scavenging non-radical oxidants, importance can understood fact now associated variety diseases cancer, neurodegeneration, diabetes, Several approaches to improve health achieve longevity use dietary formulation diet maintain freshness prolonging shelf life food products. or added nutrients microorganisms increasingly available market supplements.

Язык: Английский

Процитировано

379
Alterations in Fecal Fungal Microbiome of Patients With COVID-19 During Time of Hospitalization until Discharge DOI Creative Commons
Tao Zuo,

Hui Zhan,

Fen Zhang

и другие.

Gastroenterology, Год журнала: 2020, Номер 159(4), С. 1302 - 1310.e5

Опубликована: Июнь 26, 2020

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects intestinal cells, and might affect the microbiota. We investigated changes in fecal fungal microbiomes (mycobiome) of patients with SARS-CoV-2 infection during hospitalization on recovery.

Язык: Английский

Процитировано

317
Gut microbiome, liver immunology, and liver diseases DOI Open Access
Rui Wang, Ruqi Tang, Bo Li

и другие.

Cellular and Molecular Immunology, Год журнала: 2020, Номер 18(1), С. 4 - 17

Опубликована: Дек. 14, 2020

Язык: Английский

Процитировано

303
High-resolution mycobiota analysis reveals dynamic intestinal translocation preceding invasive candidiasis DOI
Bing Zhai, Mihaela Ola, Thierry Rolling

и другие.

Nature Medicine, Год журнала: 2020, Номер 26(1), С. 59 - 64

Опубликована: Янв. 1, 2020

Язык: Английский

Процитировано

255
Parthenolide ameliorates colon inflammation through regulating Treg/Th17 balance in a gut microbiota-dependent manner DOI Creative Commons

Yaojiang Liu,

Bo Tang, Fengchao Wang

и другие.

Theranostics, Год журнала: 2020, Номер 10(12), С. 5225 - 5241

Опубликована: Янв. 1, 2020

Inflammatory bowel disease (IBD) is a global health problem in which gut microbiota dysbiosis plays an important pathogenic role.However, the current drugs for IBD treatment are far from optimal.Previous researches indicated that parthenolide (PTL) had not only anti-cancer properties but also strong anti-inflammatory activities.Rationale: To investigate protective effect of PTL on colon inflammation and demonstrate underlying microbiota-dependent mechanism.Methods: Colon severity mouse model was measured by body weight change, mortality, length, activity index (DAI) score, H&E staining colonoscopy evaluation.Gut alteration short-chain fatty acids (SCFAs) production were analyzed through 16S rRNA sequencing targeted metabolomics.Luminex cytokine microarray Enzyme-linked immunosorbent assay (ELISA) conducted to measure cytokines profile.The frequency immune cells lamina propria (LP) spleen phenotyped flow cytometry.Results: The PTL-treated mice showed significantly relieved inflammation, as evidenced reduction loss, survival rate, shortening DAI histology score score.Notably, when depleted using antibiotic cocktails, disappeared.PTL downregulated level proinflammatory cytokines, including IL-1β, TNF-α, IL-6, IL-17A upregulated immunosuppressive IL-10 tissue.16S exhibited much more abundant microbial diversity flora composition.Targeted metabolomics analysis manifested increased SCFAs mice.Additionally, administration selectively colonic regulatory T (Treg) well ratio helper type 17 (Th17) cells, improving Treg/Th17 balance maintain intestinal homeostasis.Gut depletion fecal transplantation (FMT) performed confirm this mechanism.Conclusions: ameliorated manner.The mechanism associated with improved mucosa mediated microbiota-derived production.Collectively, our results demonstrated role potential modulator prevent treat IBD.

Язык: Английский

Процитировано

237
The gut mycobiome in health, disease, and clinical applications in association with the gut bacterial microbiome assembly DOI Creative Commons
Fen Zhang, Dominik Aschenbrenner, Ji Youn Yoo

и другие.

The Lancet Microbe, Год журнала: 2022, Номер 3(12), С. e969 - e983

Опубликована: Сен. 29, 2022

Язык: Английский

Процитировано

219
The Gut Microbiota at the Service of Immunometabolism DOI Creative Commons
Chloé Michaudel, Harry Sokol

Cell Metabolism, Год журнала: 2020, Номер 32(4), С. 514 - 523

Опубликована: Сен. 17, 2020

Язык: Английский

Процитировано

218
ILC3 function as a double-edged sword in inflammatory bowel diseases DOI Creative Commons
Boning Zeng, Shengnan Shi,

Gareth Ashworth

и другие.

Cell Death and Disease, Год журнала: 2019, Номер 10(4)

Опубликована: Апрель 8, 2019

Abstract Inflammatory bowel diseases (IBD), composed mainly of Crohn’s disease (CD) and ulcerative colitis (UC), are strongly implicated in the development intestinal inflammation lesions. Its exact etiology pathogenesis still undetermined. Recently accumulating evidence supports that group 3 innate lymphoid cells (ILC3) responsible for gastrointestinal mucosal homeostasis through moderate generation IL-22, IL-17, GM-CSF physiological state. ILC3 contribute to progression aggravation IBD while both IL-22 along with IFN-γ, overexpressed by dysregulation NCR − or + function bias towards ILC1 as well regulatory ILC dysfunction pathological Herein, we feature cells’ development, biological function, maintenance gut homeostasis, mediation occurrence, potential application therapy.

Язык: Английский

Процитировано

214