Gut Microbiota Dysbiosis, Oxidative Stress, Inflammation, and Epigenetic Alterations in Metabolic Diseases

Antioxidants, Год журнала: 2024, Номер 13(8), С. 985 - 985

Опубликована: Авг. 14, 2024

Gut dysbiosis, resulting from an imbalance in the gut microbiome, can induce excessive production of reactive oxygen species (ROS), leading to inflammation, DNA damage, activation immune system, and epigenetic alterations critical genes involved metabolic pathways. dysbiosis-induced inflammation also disrupt barrier integrity increase intestinal permeability, which allows gut-derived toxic products enter liver systemic circulation, further triggering oxidative stress, associated with diseases. However, specific metabolites, such as short-chain fatty acids (SCFAs), lactate, vitamins, modulate stress system through mechanisms, thereby improving function. microbiota diet-induced diseases, obesity, insulin resistance, dyslipidemia, hypertension, transfer next generation, involving mechanisms. In this review, we will introduce key that, along dysbiosis ROS, are engaged developing Finally, discuss potential therapeutic interventions dietary modifications, prebiotics, probiotics, postbiotics, fecal transplantation, may reduce syndrome by altering alterations. summary, review highlights crucial role pathogenesis a particular focus on (including histone methylomics, RNA interference) that prevent or improve

Язык: Английский

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Feeding gut microbes to nourish the brain: unravelling the diet–microbiota–gut–brain axis

Nature Metabolism, Год журнала: 2024, Номер 6(8), С. 1454 - 1478

Опубликована: Авг. 22, 2024

Язык: Английский

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Differences in cancer rates among adults born between 1920 and 1990 in the USA: an analysis of population-based cancer registry data

The Lancet Public Health, Год журнала: 2024, Номер 9(8), С. e583 - e593

Опубликована: Июль 31, 2024

BackgroundTrends in cancer incidence recent birth cohorts largely reflect changes exposures during early life and foreshadow the future disease burden. Herein, we examined mortality trends, by cohort, for 34 types of USA.MethodsIn this analysis, obtained data 25 individuals aged 25–84 years period Jan 1, 2000, to Dec 31, 2019 from North American Association Central Cancer Registries US National Center Health Statistics, respectively. We calculated cohort-specific rate ratios (IRRs) (MRRs), adjusted age effects, nominal separated 5 year intervals, 1920 1990.FindingsWe extracted 23 654 000 patients diagnosed with 7 348 137 deaths cancers 2019. found that IRRs increased each successive cohort born since approximately eight (pcohort<0·050). Notably, was two-to-three times higher 1990 than 1955 small intestine (IRR 3·56 [95% CI 2·96–4·27]), kidney renal pelvis (2·92 [2·50–3·42]), pancreatic (2·61 [2·22–3·07]) both male female individuals; liver intrahepatic bile duct (2·05 [1·23–3·44]). Additionally, younger cohorts, after a decline older nine remaining (pcohort<0·050): oestrogen-receptor-positive breast cancer, uterine corpus colorectal non-cardia gastric gallbladder other biliary ovarian testicular anal individuals, Kaposi sarcoma individuals. Across types, ranged 12% (IRR1990 vs 1975 1·12 1·03–1·21] cancer) 169% 1930 2·69 [2·34–3·08] lowest rate. The MRRs successively alongside corpus, biliary, testicular, cancers, while declined or stabilised most types.Interpretation17 had an increasing including previously declining cohorts. These findings add growing evidence risk generations, highlighting need identify tackle underlying factors.FundingAmerican Society.

Язык: Английский

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Understanding the therapeutic toolkit for inflammatory bowel disease

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 31, 2025

Язык: Английский

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Microbes Saving Lives and Reducing Suffering

Microbial Biotechnology, Год журнала: 2025, Номер 18(1)

Опубликована: Янв. 1, 2025

Язык: Английский

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Emerging technologies in reducing dietary advanced glycation end products in ultra‐processed foods: Formation, health risks, and innovative mitigation strategies

Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2025, Номер 24(2)

Опубликована: Фев. 19, 2025

Abstract The widespread consumption of ultra‐processed foods (UPFs) results from industrialization and globalization, with their elevated content sugar, fat, salt, additives, alongside the formation dietary advanced glycation end products (AGEs), generating considerable health risks. These risks include an increased incidence diabetes, cardiovascular diseases, neurodegenerative disorders. This review explores mechanisms AGE in UPFs evaluates emerging technologies additives aimed at mitigating these Both thermal methods (air frying, low‐temperature vacuum heating, microwave infrared heating) non‐thermal techniques (high‐pressure processing, pulsed electric fields, ultrasound, cold plasma) are discussed for potential reduction. Additionally, efficacy exogenous including amino acids, polysaccharides, phenolic compounds, nanomaterials, inhibiting formation, though may vary depending on specific additive food matrix. findings demonstrate promise reducing AGEs, potentially contributing to healthier processing practices promotion improved public outcomes.

Язык: Английский

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The Detrimental Impact of Ultra-Processed Foods on the Human Gut Microbiome and Gut Barrier

Nutrients, Год журнала: 2025, Номер 17(5), С. 859 - 859

Опубликована: Фев. 28, 2025

Ultra-processed foods (UPFs) have become a widely consumed food category in modern diets. However, their impact on gut health is raising increasing concerns. This review investigates how UPFs the microbiome and barrier, emphasizing dysbiosis increased permeability. UPFs, characterized by high content of synthetic additives emulsifiers, low fiber content, are associated with decrease microbial diversity, lower levels beneficial bacteria like Akkermansia muciniphila Faecalibacterium prausnitzii, an increase pro-inflammatory microorganisms. These alterations community contribute to persistent inflammation, which various chronic disorders including metabolic syndrome, irritable bowel type 2 diabetes, colorectal cancer. In addition, may alter gut-brain axis, potentially affecting cognitive function mental health. Dietary modifications incorporating fiber, fermented foods, probiotics can help mitigate effects UPFs. Furthermore, public needs stricter regulations for banning along well-defined labels. Further studies necessary elucidate mechanisms connecting systemic illnesses, thereby informing evidence-based dietary guidelines.

Язык: Английский

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Ultra-Processed Foods: A Narrative Review of the Impact on the Human Gut Microbiome and Variations in Classification Methods

Nutrients, Год журнала: 2024, Номер 16(11), С. 1738 - 1738

Опубликована: Июнь 1, 2024

Ultra-processed foods (UPFs) are that industrially processed and often pre-packaged, convenient, energy-dense, nutrient-poor. UPFs widespread in the current Western diet their proposed contribution to non-communicable diseases such as obesity cardiovascular disease is supported by numerous studies. hypothesized affect body multiple ways, including inducing changes gut microbiome. This review summarizes available research on effect of We also usage NOVA food classification system randomized controlled trials observational studies how its implementation effects UPF research. Despite some differences methodology between studies, results associate consumption with a number negative health consequences. There attempts standardize system; however, reaching implementing consensus difficult. Future focusing mechanisms which body, through microbiome metabolome, will be essential refine our understanding human health.

Язык: Английский

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Diet and Microbiome-Directed Therapy 2.0 for IBD

Clinical Gastroenterology and Hepatology, Год журнала: 2024, Номер 23(3), С. 406 - 418

Опубликована: Июль 9, 2024

Язык: Английский

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Meat products in human nutrition and health – About hazards and risks

Meat Science, Год журнала: 2024, Номер 218, С. 109628 - 109628

Опубликована: Авг. 24, 2024

Язык: Английский

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