Chronobiology and Chronomedicine

Royal Society of Chemistry eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 23, 2024

Circadian rhythms have been shown to be ubiquitous and critically important in the experimental laboratory, accounting for difference between life death response identical stimulus. The partly endogenous nature of circadian has well documented methods their characterisation developed enabling cellular molecular mechanisms understood. Chronobiology Chronomedicine aims provide a review these underlying illustrate role brain’s suprachiasmatic nuclei ‘pace-making’ process effects caused by ‘clock genes’ present almost all cells. Beyond involved, book discusses relationship body systems, disease, proper function; particular, how disruption rhythm is associated with ill health disease status from observations made at organismic level. organised an ideal introduction postgraduate various fields, reviewing developments outlining show depth breadth chronobiology chronomedicine, as invaluable companion researchers healthcare professionals working field interest developing novel therapeutic approaches.

Language: Английский

---

Acetate enables metabolic fitness and cognitive performance during sleep disruption

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(9), P. 1998 - 2014.e15

Published: Aug. 19, 2024

Language: Английский

---

Monitoring Sleep Quality Through Low α-Band Activity in the Prefrontal Cortex Using a Portable Electroencephalogram Device: Longitudinal Study

Journal of Medical Internet Research, Journal Year: 2025, Volume and Issue: 27, P. e67188 - e67188

Published: March 10, 2025

Background The pursuit of sleep quality has become an important aspect people’s global quest for overall health. However, the objective neurobiological features corresponding to subjective perceptions remain poorly understood. Although previous studies have investigated relationship between electroencephalogram (EEG) and sleep, lack longitudinal follow-up raises doubts about reproducibility their findings. Objective Currently, there is a gap in research regarding stable associations EEG data assessed through multiple collection sessions, which could help identify potential targets related quality. Methods In this study, we used portable device collect resting-state prefrontal cortex over 3-month period from 42 participants (27 first month, 25 second 40 third month). Each participants’ was using Pittsburgh Sleep Quality Index (PSQI) estimate recent Results We found that significant consistent positive correlation low α band activity PSQI scores (r=0.45, P<.001). More importantly, remained across all recordings (P<.05), regardless whether considered same cohort or expanded sample size. Furthermore, discovered periodic component primarily contributed association with PSQI. Conclusions These findings represent identification reliable target sessions. Our results provide solid foundation future applications devices monitoring screening disorders broad population.

Language: Английский

---

Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension - 2021 NHLBI Workshop Report

Hypertension, Journal Year: 2022, Volume and Issue: 80(3), P. 503 - 522

Published: Nov. 30, 2022

Healthy individuals exhibit blood pressure variation over a 24-hour period with higher during wakefulness and lower sleep. Loss or disruption of the circadian rhythm has been linked to adverse health outcomes, for example, cardiovascular disease, dementia, chronic kidney disease. However, current diagnostic therapeutic approaches lack sufficient attention rhythmicity pressure. Sleep patterns, hormone release, eating habits, digestion, body temperature, renal function, other important host functions as well gut microbiota rhythms, influence rhythms Potential benefits nonpharmacologic interventions such meal timing, pharmacologic chronotherapeutic interventions, bedtime administration antihypertensive medications, have recently suggested in some studies. mechanisms underlying rhythm-mediated regulation efficacy chronotherapy hypertension remain unclear. This review summarizes results National Heart, Lung, Blood Institute workshop convened on October 27 29, 2021 assess knowledge gaps research opportunities study hypertension.

Language: Английский

---

Effects of exercise on circadian rhythms in humans

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 11, 2023

The biological clock system is an intrinsic timekeeping device that integrates internal physiology and external cues. Maintaining a healthy crucial for life. Disruptions to the body’s can lead disturbances in sleep-wake cycle abnormalities hormone regulation, blood pressure, heart rate, other vital processes. Long-term have been linked development of various common major diseases, including cardiovascular metabolic disorders, tumors, neuropsychiatric conditions, so on. External factors, such as diurnal rhythm light, significant impact on clock. Additionally, important non-photic zeitgeber, exercise regulate rhythms certain extent, making it possible become non-drug intervention preventing treating circadian disorders. This comprehensive review encompasses behavioral, physiological, molecular perspectives provide deeper understanding how influences its association with related diseases.

Language: Английский

---

Chronotherapy in Glioblastoma: state of the art and future perspectives

EBioMedicine, Journal Year: 2023, Volume and Issue: 89, P. 104470 - 104470

Published: Feb. 15, 2023

Language: Английский

---

Circadian Disruption and Mental Health: The Chronotherapeutic Potential of Microbiome-Based and Dietary Strategies

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 7579 - 7579

Published: April 20, 2023

Mental illness is alarmingly on the rise, and circadian disruptions linked to a modern lifestyle may largely explain this trend. Impaired rhythms are associated with mental disorders. The evening chronotype, which misalignment, risk factor for severe psychiatric symptoms metabolic comorbidities. Resynchronization of commonly improves symptoms. Furthermore, evidence indicates that preventing misalignment help reduce disorders impact neuro–immuno–metabolic disturbances in psychiatry. gut microbiota exhibits diurnal rhythmicity, as governed by meal timing, regulates host’s rhythms. Temporal regulation feeding has emerged promising chronotherapeutic strategy prevent and/or treatment illnesses, through modulation microbiota. Here, we provide an overview link between disruption illness. We summarize connection rhythms, supporting idea aid resynchronization disrupted describe microbiome rhythmicity its related factors, highlighting role timing. Lastly, emphasize necessity rationale further research develop effective safe dietary strategies based chrononutrition combat

Language: Английский

---

Sleep and Oxidative Stress: Current Perspectives on the Role of NRF2

Cellular and Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 44(1)

Published: June 25, 2024

Abstract Sleep is a fundamental conserved physiological state across evolution, suggesting vital biological functions that are yet to be fully clarified. However, our understanding of the neural and molecular basis sleep regulation has increased rapidly in recent years. Among various processes implicated controlling homeostasis, bidirectional relationship between oxidative stress recently emerged. One proposed function may mitigation both brain peripheral tissues, contributing clearance reactive species accumulate during wakefulness. Conversely, species, such as oxygen (ROS) nitrogen (RNS), at levels, act signaling agents regulate redox-sensitive transcriptional factors, enzymes, other effectors involved sleep. As primary sensor intracellular oxidation, transcription factor NRF2 emerging an indispensable component maintain cellular redox homeostasis Indeed, number studies have revealed association dysfunction most common conditions, including loss, obstructive apnea, circadian disturbances. This review examines evidence intricate link context sleep, highlights potential modulators alleviate Graphical A been shown, indicating play protective role against accumulation wakefulness deprivation. might also serve molecules influence mechanisms. Notably, changes, key regulator homeostasis.

Language: Английский

---

Effects of sex, mating status, and genetic background on circadian behavior in Drosophila

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 8, 2025

Circadian rhythms play a crucial role in regulating behavior, physiology, and health. Sexual dimorphism, widespread phenomenon across species, influences circadian behaviors. Additionally, post-mating physiological changes females are known to modulate various behaviors, yet their effects on remain underexplored. Here, using Drosophila melanogaster, powerful model for studying mechanisms, we systematically assessed the impact of sex mating status behavior. We measured period length rhythm strength virgin mated males females, including lacking Sex Peptide (SP), key mediator changes. Across four wild-type control strains, found that consistently exhibited shorter periods than regardless status, suggesting is robust sexually dimorphic trait. In contrast, was influenced by interaction between with female generally reducing presence SP signaling. Notably, genetic background significantly modulated these strength. Our findings demonstrate while stable sex-specific trait, shaped complex interplay sex, background. This study advances our understanding how influence provides foundation future research into mechanisms underlying human diseases associated disruptions.

Language: Английский

---

Calcineurin governs baseline and homeostatic regulations of non–rapid eye movement sleep in mice

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(4)

Published: Jan. 23, 2025

Sleep need accumulates during waking and dissipates sleep to maintain homeostasis (process S). Besides the regulation of daily (baseline) amount, homeostatic commonly refers universal phenomenon that deprivation (SD) causes an increase need, hence, amount intensity subsequent recovery sleep. The central regulators signaling pathways govern baseline regulations in mammals remain unclear. Here, we report enhanced activity calcineurin Aα (CNAα)—a catalytic subunit calcineurin—in mouse brain neurons sharply increases (to ~17-h/d) delta power—a measure intensity—of non–rapid eye movement (NREMS). Knockout regulatory ( CnB1 ) or CnAα CnAβ subunits diminishes ~4-h/d) power NREMS, but also nearly abrogates NREMS following SD. Accordingly, mathematical modeling process S reveals inability accumulate spontaneous forced wakefulness deficient mice. Moreover, promotes by antagonizing wake-promoting protein kinase A and, part, activating sleep-promoting SIK3. Together, these results indicate is important regulator governs both

Language: Английский

---