Supramolecular Adhesive Hydrogels for Tissue Engineering Applications

Chemical Reviews, Год журнала: 2022, Номер 122(6), С. 5604 - 5640

Опубликована: Янв. 13, 2022

Tissue engineering is a promising and revolutionary strategy to treat patients who suffer the loss or failure of an organ tissue, with aim restore dysfunctional tissues enhance life expectancy. Supramolecular adhesive hydrogels are emerging as appealing materials for tissue applications owing their favorable attributes such tailorable structure, inherent flexibility, excellent biocompatibility, near-physiological environment, dynamic mechanical strength, particularly attractive self-adhesiveness. In this review, key design principles various supramolecular strategies construct comprehensively summarized. Thereafter, recent research progress regarding applications, including primarily dermal repair, muscle bone neural vascular oral corneal cardiac fetal membrane hepatic gastric systematically highlighted. Finally, scientific challenges remaining opportunities underlined show full picture hydrogels. This review expected offer comparative views critical insights inspire more advanced studies on pave way different fields even beyond applications.

Язык: Английский

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Recent applications of immunomodulatory biomaterials for disease immunotherapy

Exploration, Год журнала: 2022, Номер 2(6)

Опубликована: Май 23, 2022

Immunotherapy is used to regulate systemic hyperactivation or hypoactivation treat various diseases. Biomaterial-based immunotherapy systems can improve therapeutic effects through targeted drug delivery, immunoengineering, etc. However, the immunomodulatory of biomaterials themselves cannot be neglected. In this review, we outline with functions discovered in recent years and their applications disease treatment. These inflammation, tumors, autoimmune diseases by regulating immune cell function, exerting enzyme-like activity, neutralizing cytokines, The prospects challenges biomaterial-based modulation are also discussed.

Язык: Английский

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Inorganic Biomaterials for Regenerative Medicine

ACS Applied Materials & Interfaces, Год журнала: 2020, Номер 12(5), С. 5319 - 5344

Опубликована: Янв. 28, 2020

Regenerative medicine leverages the innate potential of human body to efficiently repair and regenerate damaged tissues using engineered biomaterials. By designing responsive biomaterials with appropriate biophysical biochemical characteristics, cellular response can be modulated direct tissue healing. Recently, inorganic have been shown regulate responses including cell–cell cell–matrix interactions. Moreover, ions released from these mineral-based play a vital role in defining cell identity, as well driving tissue-specific functions. The intrinsic properties biomaterials, such release bioactive (e.g., Ca, Mg, Sr, Si, B, Fe, Cu, Zn, Cr, Co, Mo, Mn, Au, Ag, V, Eu, La), leveraged induce phenotypic changes cells or modulate immune microenvironment healing regeneration. Biophysical characteristics topography, charge, size, electrostatic interactions, stiffness by addition micro- nanoparticles polymeric networks also an important their biological response. In this Review, we discuss recent emergence harness regenerative body. Specifically, will various effects inorganic-based materials directing for applications.

Язык: Английский

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Injectable, self-healing hydrogel adhesives with firm tissue adhesion and on-demand biodegradation for sutureless wound closure

Science Advances, Год журнала: 2023, Номер 9(33)

Опубликована: Авг. 16, 2023

Tissue adhesives have garnered extensive interest as alternatives and supplements to sutures, whereas major challenges still remain, including weak tissue adhesion, inadequate biocompatibility, uncontrolled biodegradation. Here, injectable biocompatible hydrogel are developed via catalyst-free o-phthalaldehyde/amine (hydrazide) cross-linking reaction. The hydrogels demonstrate rapid firm adhesion various tissues, an o-phthalaldehyde-mediated mechanism is established. show controlled degradation profiles of 6 22 weeks in vivo through the incorporation disulfide bonds into network. In liver blood vessel injury, effectively seal incisions rapidly stop bleeding. rat rabbit models full-thickness skin incision, quickly close accelerate wound healing, which exhibit efficacies superior those commercially available fibrin glue cyanoacrylate glue. Thus, great potential for sutureless closure, hemostasis sealing, prevention leakage surgical applications.

Язык: Английский

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Polysaccharide hydrogels: Functionalization, construction and served as scaffold for tissue engineering

Carbohydrate Polymers, Год журнала: 2021, Номер 278, С. 118952 - 118952

Опубликована: Ноя. 30, 2021

Язык: Английский

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Additively manufactured biodegradable porous metals

Acta Biomaterialia, Год журнала: 2020, Номер 115, С. 29 - 50

Опубликована: Авг. 24, 2020

Partially due to the unavailability of ideal bone substitutes, treatment large bony defects remains one most important challenges orthopedic surgery. Additively manufactured (AM) biodegradable porous metals that have emerged since 2018 provide unprecedented opportunities for fulfilling requirements an implant. First, multi-scale geometry these implants can be customized mimic human in terms both micro-architecture and mechanical properties. Second, a structure with interconnected pores possesses surface area, which is favorable adhesion proliferation cells and, thus, ingrowth. Finally, freeform geometrical design such biomaterials could exploited adjust their biodegradation behavior so as maintain structural integrity implant during healing process while ensuring disappears afterwards, paving way full regeneration. While AM been studied far shown many unique properties compared solid counterparts, degree flexibility has not yet fully optimize performance. In order develop implants, it take advantage potential through detailed systematic study on behavior, properties, biocompatibility, regeneration This review paper presents state art focused effects material type, processing, design, post-AM treatments vitro vivo performance Mg, Fe, Zn well alloys. We also identify number knowledge gaps encountered adopting applications suggest some promising areas future research.

Язык: Английский

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Personalized 3D printed bone scaffolds: A review

Acta Biomaterialia, Год журнала: 2022, Номер 156, С. 110 - 124

Опубликована: Апрель 13, 2022

Язык: Английский

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Recent advances in regenerative biomaterials

Regenerative Biomaterials, Год журнала: 2022, Номер 9

Опубликована: Янв. 1, 2022

Nowadays, biomaterials have evolved from the inert supports or functional substitutes to bioactive materials able trigger promote regenerative potential of tissues. The interdisciplinary progress has broadened definition 'biomaterials', and a typical new insight is concept tissue induction biomaterials. term 'regenerative biomaterials' thus contents this article are relevant yet beyond This review summarizes recent medical including metals, ceramics, hydrogels, other polymers bio-derived materials. As application aspects concerned, introduces for bone cartilage regeneration, cardiovascular repair, 3D bioprinting, wound healing cosmetology. Cell-biomaterial interactions highlighted. Since global pandemic coronavirus disease 2019, particularly mentions public health emergency. In last section, perspectives suggested: (i) creation source innovation; (ii) modification existing an effective strategy performance improvement; (iii) biomaterial degradation regeneration required be harmonious with each other; (iv) host responses can significantly influence clinical outcomes; (v) long-term outcomes should paid more attention to; (vi) noninvasive approaches monitoring

Язык: Английский

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Injectable immunomodulation-based porous chitosan microspheres/HPCH hydrogel composites as a controlled drug delivery system for osteochondral regeneration

Biomaterials, Год журнала: 2022, Номер 285, С. 121530 - 121530

Опубликована: Апрель 25, 2022

Язык: Английский

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Biomedical polymers: synthesis, properties, and applications

Science China Chemistry, Год журнала: 2022, Номер 65(6), С. 1010 - 1075

Опубликована: Апрель 24, 2022

Язык: Английский

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