Marine Drugs,
Journal Year:
2023,
Volume and Issue:
21(5), P. 299 - 299
Published: May 14, 2023
Numerous
compounds
present
in
the
ocean
are
contributing
to
development
of
biomedical
field.
Agarose,
a
polysaccharide
derived
from
marine
red
algae,
plays
vital
role
applications
because
its
reversible
temperature-sensitive
gelling
behavior,
excellent
mechanical
properties,
and
high
biological
activity.
Natural
agarose
hydrogel
has
single
structural
composition
that
prevents
it
adapting
complex
environments.
Therefore,
can
be
developed
into
different
forms
through
physical,
biological,
chemical
modifications,
enabling
perform
optimally
Agarose
biomaterials
being
increasingly
used
for
isolation,
purification,
drug
delivery,
tissue
engineering,
but
most
still
far
clinical
approval.
This
review
classifies
discusses
preparation,
modification,
agarose,
focusing
on
isolation
wound
dressings,
3D
printing.
In
addition,
attempts
address
opportunities
challenges
associated
with
future
agarose-based
It
should
help
rationalize
selection
suitable
functionalized
hydrogels
specific
industry.
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
122(6), P. 5604 - 5640
Published: Jan. 13, 2022
Tissue
engineering
is
a
promising
and
revolutionary
strategy
to
treat
patients
who
suffer
the
loss
or
failure
of
an
organ
tissue,
with
aim
restore
dysfunctional
tissues
enhance
life
expectancy.
Supramolecular
adhesive
hydrogels
are
emerging
as
appealing
materials
for
tissue
applications
owing
their
favorable
attributes
such
tailorable
structure,
inherent
flexibility,
excellent
biocompatibility,
near-physiological
environment,
dynamic
mechanical
strength,
particularly
attractive
self-adhesiveness.
In
this
review,
key
design
principles
various
supramolecular
strategies
construct
comprehensively
summarized.
Thereafter,
recent
research
progress
regarding
applications,
including
primarily
dermal
repair,
muscle
bone
neural
vascular
oral
corneal
cardiac
fetal
membrane
hepatic
gastric
systematically
highlighted.
Finally,
scientific
challenges
remaining
opportunities
underlined
show
full
picture
hydrogels.
This
review
expected
offer
comparative
views
critical
insights
inspire
more
advanced
studies
on
pave
way
different
fields
even
beyond
applications.
Exploration,
Journal Year:
2022,
Volume and Issue:
2(6)
Published: May 23, 2022
Immunotherapy
is
used
to
regulate
systemic
hyperactivation
or
hypoactivation
treat
various
diseases.
Biomaterial-based
immunotherapy
systems
can
improve
therapeutic
effects
through
targeted
drug
delivery,
immunoengineering,
etc.
However,
the
immunomodulatory
of
biomaterials
themselves
cannot
be
neglected.
In
this
review,
we
outline
with
functions
discovered
in
recent
years
and
their
applications
disease
treatment.
These
inflammation,
tumors,
autoimmune
diseases
by
regulating
immune
cell
function,
exerting
enzyme-like
activity,
neutralizing
cytokines,
The
prospects
challenges
biomaterial-based
modulation
are
also
discussed.
ACS Applied Materials & Interfaces,
Journal Year:
2020,
Volume and Issue:
12(5), P. 5319 - 5344
Published: Jan. 28, 2020
Regenerative
medicine
leverages
the
innate
potential
of
human
body
to
efficiently
repair
and
regenerate
damaged
tissues
using
engineered
biomaterials.
By
designing
responsive
biomaterials
with
appropriate
biophysical
biochemical
characteristics,
cellular
response
can
be
modulated
direct
tissue
healing.
Recently,
inorganic
have
been
shown
regulate
responses
including
cell–cell
cell–matrix
interactions.
Moreover,
ions
released
from
these
mineral-based
play
a
vital
role
in
defining
cell
identity,
as
well
driving
tissue-specific
functions.
The
intrinsic
properties
biomaterials,
such
release
bioactive
(e.g.,
Ca,
Mg,
Sr,
Si,
B,
Fe,
Cu,
Zn,
Cr,
Co,
Mo,
Mn,
Au,
Ag,
V,
Eu,
La),
leveraged
induce
phenotypic
changes
cells
or
modulate
immune
microenvironment
healing
regeneration.
Biophysical
characteristics
topography,
charge,
size,
electrostatic
interactions,
stiffness
by
addition
micro-
nanoparticles
polymeric
networks
also
an
important
their
biological
response.
In
this
Review,
we
discuss
recent
emergence
harness
regenerative
body.
Specifically,
will
various
effects
inorganic-based
materials
directing
for
applications.
Acta Biomaterialia,
Journal Year:
2020,
Volume and Issue:
115, P. 29 - 50
Published: Aug. 24, 2020
Partially
due
to
the
unavailability
of
ideal
bone
substitutes,
treatment
large
bony
defects
remains
one
most
important
challenges
orthopedic
surgery.
Additively
manufactured
(AM)
biodegradable
porous
metals
that
have
emerged
since
2018
provide
unprecedented
opportunities
for
fulfilling
requirements
an
implant.
First,
multi-scale
geometry
these
implants
can
be
customized
mimic
human
in
terms
both
micro-architecture
and
mechanical
properties.
Second,
a
structure
with
interconnected
pores
possesses
surface
area,
which
is
favorable
adhesion
proliferation
cells
and,
thus,
ingrowth.
Finally,
freeform
geometrical
design
such
biomaterials
could
exploited
adjust
their
biodegradation
behavior
so
as
maintain
structural
integrity
implant
during
healing
process
while
ensuring
disappears
afterwards,
paving
way
full
regeneration.
While
AM
been
studied
far
shown
many
unique
properties
compared
solid
counterparts,
degree
flexibility
has
not
yet
fully
optimize
performance.
In
order
develop
implants,
it
take
advantage
potential
through
detailed
systematic
study
on
behavior,
properties,
biocompatibility,
regeneration
This
review
paper
presents
state
art
focused
effects
material
type,
processing,
design,
post-AM
treatments
vitro
vivo
performance
Mg,
Fe,
Zn
well
alloys.
We
also
identify
number
knowledge
gaps
encountered
adopting
applications
suggest
some
promising
areas
future
research.
Science Advances,
Journal Year:
2023,
Volume and Issue:
9(33)
Published: Aug. 16, 2023
Tissue
adhesives
have
garnered
extensive
interest
as
alternatives
and
supplements
to
sutures,
whereas
major
challenges
still
remain,
including
weak
tissue
adhesion,
inadequate
biocompatibility,
uncontrolled
biodegradation.
Here,
injectable
biocompatible
hydrogel
are
developed
via
catalyst-free
o-phthalaldehyde/amine
(hydrazide)
cross-linking
reaction.
The
hydrogels
demonstrate
rapid
firm
adhesion
various
tissues,
an
o-phthalaldehyde-mediated
mechanism
is
established.
show
controlled
degradation
profiles
of
6
22
weeks
in
vivo
through
the
incorporation
disulfide
bonds
into
network.
In
liver
blood
vessel
injury,
effectively
seal
incisions
rapidly
stop
bleeding.
rat
rabbit
models
full-thickness
skin
incision,
quickly
close
accelerate
wound
healing,
which
exhibit
efficacies
superior
those
commercially
available
fibrin
glue
cyanoacrylate
glue.
Thus,
great
potential
for
sutureless
closure,
hemostasis
sealing,
prevention
leakage
surgical
applications.
Regenerative Biomaterials,
Journal Year:
2022,
Volume and Issue:
9
Published: Jan. 1, 2022
Nowadays,
biomaterials
have
evolved
from
the
inert
supports
or
functional
substitutes
to
bioactive
materials
able
trigger
promote
regenerative
potential
of
tissues.
The
interdisciplinary
progress
has
broadened
definition
'biomaterials',
and
a
typical
new
insight
is
concept
tissue
induction
biomaterials.
term
'regenerative
biomaterials'
thus
contents
this
article
are
relevant
yet
beyond
This
review
summarizes
recent
medical
including
metals,
ceramics,
hydrogels,
other
polymers
bio-derived
materials.
As
application
aspects
concerned,
introduces
for
bone
cartilage
regeneration,
cardiovascular
repair,
3D
bioprinting,
wound
healing
cosmetology.
Cell-biomaterial
interactions
highlighted.
Since
global
pandemic
coronavirus
disease
2019,
particularly
mentions
public
health
emergency.
In
last
section,
perspectives
suggested:
(i)
creation
source
innovation;
(ii)
modification
existing
an
effective
strategy
performance
improvement;
(iii)
biomaterial
degradation
regeneration
required
be
harmonious
with
each
other;
(iv)
host
responses
can
significantly
influence
clinical
outcomes;
(v)
long-term
outcomes
should
paid
more
attention
to;
(vi)
noninvasive
approaches
monitoring
