Chem, Год журнала: 2021, Номер 7(5), С. 1308 - 1320
Опубликована: Март 11, 2021
Язык: Английский
Nature Reviews Materials, Год журнала: 2020, Номер 5(9), С. 686 - 705
Опубликована: Июль 6, 2020
Язык: Английский
Процитировано
655
Bioactive Materials, Год журнала: 2021, Номер 8, С. 267 - 295
Опубликована: Июль 6, 2021
Polymeric hydrogels are fascinating platforms as 3D scaffolds for tissue repair and delivery systems of therapeutic molecules cells. Among others, methacrylated gelatin (GelMA) has become a representative hydrogel formulation, finding various biomedical applications. Recent efforts on GelMA-based have been devoted to combining them with bioactive functional nanomaterials, aiming provide enhanced physicochemical biological properties GelMA. The benefits this approach multiple: i) reinforcing mechanical properties, ii) modulating viscoelastic property allow printability bio-inks, iii) rendering electrical/magnetic produce electro-/magneto-active the specific tissues (e.g., muscle, nerve), iv) providing stimuli-responsiveness actively deliver molecules, v) endowing capacity in process antioxidant effects). nanomaterial-combined GelMA shown significantly extraordinary behaviors (bone, skin, cardiac, nerve) that rarely observable Here we systematically review these recent nanomaterials-combined considered next-generation multifunctional therapeutics. approaches used can also apply other existing polymeric systems.
Язык: Английский
Процитировано
328
Exploration, Год журнала: 2021, Номер 1(3)
Опубликована: Дек. 1, 2021
Bioactive materials are a kind of with unique bioactivities, which can change the cellular behaviors and elicit biological responses from living tissues. came into spotlight in late 1960s when researchers found that such as bioglass could react surrounding bone tissue for regeneration. In following decades, advances nanotechnology brought new development opportunities to bioactive nanomaterials. nanomaterials not simple miniaturization macroscopic materials. They exhibit bioactivities due their nanoscale size effect, high specific surface area, precise nanostructure, significantly influence interactions systems. Nowadays, have represented an important exciting area research. Current future applications ensure academic clinical importance. This review summaries recent field nanomaterials, evaluate factors bioactivities. Then, range potential biomedical discussed. Furthermore, limitations, challenges, also
Язык: Английский
Процитировано
262
Advanced Science, Год журнала: 2020, Номер 7(17)
Опубликована: Июль 17, 2020
Abstract Light‐responsive inorganic biomaterials are an emerging class of materials used for developing noninvasive, noncontact, precise, and controllable medical devices in a wide range biomedical applications, including photothermal therapy, photodynamic drug delivery, regenerative medicine. Herein, is discussed, carbon‐based nanomaterials, gold nanoparticles, graphite carbon nitride, transition metal dichalcogenides, up‐conversion nanoparticles that the design light‐responsive devices. The importance these explored to light‐guided nanovehicle, modulate cellular behavior, as well regulate extracellular microenvironments. Additionally, future perspectives on clinical use highlighted.
Язык: Английский
Процитировано
248
ACS Applied Materials & Interfaces, Год журнала: 2020, Номер 12(41), С. 45673 - 45701
Опубликована: Сен. 16, 2020
Functional polymeric micro-/nanofibers have emerged as promising materials for the construction of structures potentially useful in biomedical fields. Among all kinds technologies to produce polymer fibers, spinning methods gained considerable attention. Herein, we provide a recent review on advances design micro- and nanofibrous platforms via techniques applications. Specifically, emphasize electrospinning, solution blow spinning, centrifugal microfluidic approaches. We first introduce fundamentals these then highlight potential applications such nanostructured fibers drug delivery, tissue engineering, regenerative medicine, disease modeling, sensing/biosensing. Finally, outline current challenges future perspectives practical field.
Язык: Английский
Процитировано
206
ACS Applied Materials & Interfaces, Год журнала: 2020, Номер 12(14), С. 16058 - 16075
Опубликована: Март 17, 2020
Recent studies show that biomaterials are capable of regulating immune responses to induce a favorable osteogenic microenvironment and promote osteogenesis angiogenesis. In this study, we investigated the effects zinc silicate/nanohydroxyapatite/collagen (ZS/HA/Col) scaffolds on bone regeneration angiogenesis explored related mechanism. We demonstrate 10ZS/HA/Col significantly enhanced in vivo compared with HA/Col scaffolds. ZS/HA/Col increased tartrate-resistant acid phosphatase (TRAP)-positive cells, nestin-positive marrow stromal cells (BMSCs) CD31-positive neovessels, expression (Bmp-2 Osterix) angiogenesis-related (Vegf-α Cd31) genes nascent bone. 10 wt % ZS activated p38 signaling pathway monocytes. The monocytes subsequently differentiated into TRAP+ expressed higher levels cytokines SDF-1, TGF-β1, VEGF-α, PDGF-BB, which recruited BMSCs endothelial (ECs) defect areas. Blocking reduced differentiation cytokine secretion resulted decrease BMSC EC homing Overall, these findings modulate and, thereby, create promotes migration vessel formation by activating pathway.
Язык: Английский
Процитировано
184
Bone Research, Год журнала: 2021, Номер 9(1)
Опубликована: Март 16, 2021
Abstract Bone tumors, especially those in osteosarcoma, usually occur adolescents. The standard clinical treatment includes chemotherapy, surgical therapy, and radiation therapy. Unfortunately, resection often fails to completely remove the tumor, which is main cause of postoperative recurrence metastasis, resulting a high mortality rate. Moreover, bone tumors invade large areas bone, cannot repair itself, causes serious effect on quality life patients. Thus, tumor therapy regeneration are challenging clinic. Herein, this review presents recent developments bifunctional biomaterials achieve new strategy for selected materials include 3D-printed scaffolds, nano/microparticle-containing hydrogels, bone-targeting nanomaterials. Numerous related studies combining photothermal with enhanced were reviewed. Finally, perspective future development tissue engineering discussed. This will provide useful reference tumor-related disease field complex diseases combine engineering.
Язык: Английский
Процитировано
182
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(3), С. 1923 - 1923
Опубликована: Фев. 8, 2022
In recent decades, as a subclass of biomaterials, biologically sensitive nanoparticles have attracted increased scientific interest. Many the demands for physiologically responsive nanomaterials in applications involving human body cannot be met by conventional technologies. Due to field’s importance, considerable effort has been expended, and achieved remarkable success thus far. This review summarizes advancements their biosensing molecular imaging. The change structure or increase chemical reaction ratio response specific bio-relevant stimuli (such pH, redox potentials, enzyme kinds, concentrations) order improve signal diagnosis. We use various case studies illustrate existing issues provide clear sense direction this area. Furthermore, limitations prospects these diagnosis are also discussed.
Язык: Английский
Процитировано
171
ACS Applied Materials & Interfaces, Год журнала: 2020, Номер 12(14), С. 15976 - 15988
Опубликована: Фев. 24, 2020
Bioprinting is an emerging additive manufacturing approach to the fabrication of patient-specific, implantable three-dimensional (3D) constructs for regenerative medicine. However, developing cell-compatible bioinks with high printability, structural stability, biodegradability, and bioactive characteristics still a primary challenge translating 3D bioprinting technology preclinical clinal models. To overcome this challenge, we developed nanoengineered ionic covalent entanglement (NICE) bioink formulation bone bioprinting. The NICE allow precise control over mechanical properties, degradation characteristics, enabling custom mechanically resilient, cellularized structures. We demonstrate cell-induced remodeling bioprinted scaffolds 60 days, demonstrating deposition nascent extracellular matrix proteins. Interestingly, induce endochondral differentiation encapsulated human mesenchymal stem cells (hMSCs) in absence osteoinducing agent. Using next-generation transcriptome sequencing (RNA-seq) technology, establish role nanosilicates, component bioink, stimulate at level. Overall, osteoinductive has ability formation osteo-related mineralized by hMSCs growth factor-free conditions. Furthermore, fabricate repair craniomaxillofacial defects. envision development toward realistic clinical process patient-specific tissue
Язык: Английский
Процитировано
147
Regenerative Biomaterials, Год журнала: 2022, Номер 9
Опубликована: Янв. 1, 2022
Nowadays, biomaterials have evolved from the inert supports or functional substitutes to bioactive materials able trigger promote regenerative potential of tissues. The interdisciplinary progress has broadened definition 'biomaterials', and a typical new insight is concept tissue induction biomaterials. term 'regenerative biomaterials' thus contents this article are relevant yet beyond This review summarizes recent medical including metals, ceramics, hydrogels, other polymers bio-derived materials. As application aspects concerned, introduces for bone cartilage regeneration, cardiovascular repair, 3D bioprinting, wound healing cosmetology. Cell-biomaterial interactions highlighted. Since global pandemic coronavirus disease 2019, particularly mentions public health emergency. In last section, perspectives suggested: (i) creation source innovation; (ii) modification existing an effective strategy performance improvement; (iii) biomaterial degradation regeneration required be harmonious with each other; (iv) host responses can significantly influence clinical outcomes; (v) long-term outcomes should paid more attention to; (vi) noninvasive approaches monitoring
Язык: Английский
Процитировано
146