Microbiome-based therapeutics

Nature Reviews Microbiology, Год журнала: 2022, Номер 20(6), С. 365 - 380

Опубликована: Янв. 6, 2022

Язык: Английский

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Microbiota-mediated colonization resistance: mechanisms and regulation

Nature Reviews Microbiology, Год журнала: 2022, Номер 21(6), С. 347 - 360

Опубликована: Дек. 20, 2022

Язык: Английский

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Staphylococcus epidermidis and its dual lifestyle in skin health and infection

Nature Reviews Microbiology, Год журнала: 2022, Номер 21(2), С. 97 - 111

Опубликована: Авг. 30, 2022

Язык: Английский

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Commensal Staphylococcus epidermidis contributes to skin barrier homeostasis by generating protective ceramides

Cell Host & Microbe, Год журнала: 2022, Номер 30(3), С. 301 - 313.e9

Опубликована: Фев. 4, 2022

Язык: Английский

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Targeting gut microbiota and metabolism as the major probiotic mechanism - An evidence-based review

Trends in Food Science & Technology, Год журнала: 2023, Номер 138, С. 178 - 198

Опубликована: Июнь 11, 2023

The human gut hosts complex microbial communities, which are linked to health and disease. microbiota is continuously reshaped by multiple environmental factors, especially diet. Gut dysbiosis may promote various metabolic, neurological, intestinal, cardiovascular diseases, even tumor development. Probiotics have shown promising prophylactic, mitigating, or curative effects when use as nutrient supplements adjunctive therapy. These beneficial and/or symptom alleviation often accompanied microbiome metabolome changes. Differing from other published review articles, here we summarized the latest knowledge of evidence-based health-promoting probiotics scouring literature recent animal probiotic intervention studies. To elucidate mechanisms in enhancing intestinal homeostasis, barrier function, host immunity, through modulating its metabolites. Meanwhile, also discussed challenges data analysis clinical research comparison between laboratories, provides an outlook for future perspectives applications probiotics. achieved modulation. Current discussed. Finally, provided.

Язык: Английский

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Bacteriocin-Producing Probiotic Lactic Acid Bacteria in Controlling Dysbiosis of the Gut Microbiota

Frontiers in Cellular and Infection Microbiology, Год журнала: 2022, Номер 12

Опубликована: Май 16, 2022

Several strains of lactic acid bacteria are potent probiotics and can cure a variety diseases using different modes actions. These produce antimicrobial peptides, bacteriocins, which inhibit or kill generally closely related bacterial other pathogenic such as Listeria, Clostridium, Salmonella. Bacteriocins cationic peptides that the target cells by pore formation dissipation cytosolic contents, leading to cell death. also known modulate native microbiota host immunity, affecting several health-promoting functions host. In this review, we have discussed ability bacteriocin-producing probiotic in modulation gut correcting dysbiosis treatment/maintenance few important human disorders chronic infections, inflammatory bowel diseases, obesity, cancer.

Язык: Английский

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Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer

Advanced Science, Год журнала: 2023, Номер 10(23)

Опубликована: Июнь 1, 2023

Colorectal cancer (CRC) is the most common of digestive system with high mortality and morbidity rates. Gut microbiota found in intestines, especially colorectum, has structured crosstalk interactions host that affect several physiological processes. The gut include CRC-promoting bacterial species, such as Fusobacterium nucleatum, Escherichia coli, Bacteroides fragilis, CRC-protecting Clostridium butyricum, Streptococcus thermophilus, Lacticaseibacillus paracasei, which along other microorganisms, viruses fungi, play critical roles development CRC. Different features are identified patients early-onset CRC, combined different patterns between fecal intratumoral microbiota. may be beneficial diagnosis treatment CRC; some bacteria serve biomarkers while others regulators chemotherapy immunotherapy. Furthermore, metabolites produced by essential CRC cells. Harmful primary bile acids short-chain fatty acids, whereas others, including ursodeoxycholic acid butyrate, impede tumor progression. This review focuses on its metabolites, their potential development, diagnosis,

Язык: Английский

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Emerging strategies for engineering Escherichia coli Nissle 1917-based therapeutics

Trends in Pharmacological Sciences, Год журнала: 2022, Номер 43(9), С. 772 - 786

Опубликована: Фев. 26, 2022

Язык: Английский

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Mechanisms and implications of bacterial–fungal competition for soil resources

The ISME Journal, Год журнала: 2024, Номер 18(1)

Опубликована: Янв. 1, 2024

Abstract Elucidating complex interactions between bacteria and fungi that determine microbial community structure, composition, functions in soil, as well regulate carbon (C) nutrient fluxes, is crucial to understand biogeochemical cycles. Among the various interactions, competition for resources main factor determining adaptation niche differentiation these two big groups soil. This because C energy limitations growth are a rule rather than an exception. Here, we review demands of fungi—the major kingdoms soil—the mechanisms their other resources, leading differentiation, global change impacts on this competition. The normalized utilization preference showed 1.4–5 times more efficient uptake simple organic compounds substrates, whereas 1.1–4.1 effective utilizing compounds. Accordingly, strongly outcompete while take advantage Bacteria also compete with products released during degradation substrates. Based specifics, differentiated spatial, temporal, chemical niches will increase under five changes including elevated CO2, N deposition, soil acidification, warming, drought. Elevated warming bacterial dominance, acidification drought fungal competitiveness.

Язык: Английский

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The honeybee microbiota and its impact on health and disease

Nature Reviews Microbiology, Год журнала: 2023, Номер 22(3), С. 122 - 137

Опубликована: Дек. 4, 2023

Язык: Английский

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