Systematic mining of the human microbiome identifies antimicrobial peptides with diverse activity spectra DOI
Andrew King, Zhengan Zhang,

Emerson Glassey

et al.

Nature Microbiology, Journal Year: 2023, Volume and Issue: 8(12), P. 2420 - 2434

Published: Nov. 16, 2023

Language: Английский

Microbiome-based therapeutics DOI

Matthew T. Sorbara,

Eric G. Pamer

Nature Reviews Microbiology, Journal Year: 2022, Volume and Issue: 20(6), P. 365 - 380

Published: Jan. 6, 2022

Language: Английский

Citations

299

Microbiota-mediated colonization resistance: mechanisms and regulation DOI
Gustavo Caballero-Flores, Joseph M. Pickard, Gabriel Núñez

et al.

Nature Reviews Microbiology, Journal Year: 2022, Volume and Issue: 21(6), P. 347 - 360

Published: Dec. 20, 2022

Language: Английский

Citations

180

Staphylococcus epidermidis and its dual lifestyle in skin health and infection DOI

Morgan M. Severn,

Alexander R. Horswill

Nature Reviews Microbiology, Journal Year: 2022, Volume and Issue: 21(2), P. 97 - 111

Published: Aug. 30, 2022

Language: Английский

Citations

174

Commensal Staphylococcus epidermidis contributes to skin barrier homeostasis by generating protective ceramides DOI Creative Commons
Yue Zheng, Rachelle L. Hunt,

Amer E. Villaruz

et al.

Cell Host & Microbe, Journal Year: 2022, Volume and Issue: 30(3), P. 301 - 313.e9

Published: Feb. 4, 2022

Language: Английский

Citations

166

Targeting gut microbiota and metabolism as the major probiotic mechanism - An evidence-based review DOI Creative Commons
Teng Ma, Xin Shen, Xuan Shi

et al.

Trends in Food Science & Technology, Journal Year: 2023, Volume and Issue: 138, P. 178 - 198

Published: June 11, 2023

The human gut hosts complex microbial communities, which are linked to health and disease. microbiota is continuously reshaped by multiple environmental factors, especially diet. Gut dysbiosis may promote various metabolic, neurological, intestinal, cardiovascular diseases, even tumor development. Probiotics have shown promising prophylactic, mitigating, or curative effects when use as nutrient supplements adjunctive therapy. These beneficial and/or symptom alleviation often accompanied microbiome metabolome changes. Differing from other published review articles, here we summarized the latest knowledge of evidence-based health-promoting probiotics scouring literature recent animal probiotic intervention studies. To elucidate mechanisms in enhancing intestinal homeostasis, barrier function, host immunity, through modulating its metabolites. Meanwhile, also discussed challenges data analysis clinical research comparison between laboratories, provides an outlook for future perspectives applications probiotics. achieved modulation. Current discussed. Finally, provided.

Language: Английский

Citations

157

Bacteriocin-Producing Probiotic Lactic Acid Bacteria in Controlling Dysbiosis of the Gut Microbiota DOI Creative Commons

Anjana Anjana,

Santosh Kumar Tiwari

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: May 16, 2022

Several strains of lactic acid bacteria are potent probiotics and can cure a variety diseases using different modes actions. These produce antimicrobial peptides, bacteriocins, which inhibit or kill generally closely related bacterial other pathogenic such as Listeria, Clostridium, Salmonella. Bacteriocins cationic peptides that the target cells by pore formation dissipation cytosolic contents, leading to cell death. also known modulate native microbiota host immunity, affecting several health-promoting functions host. In this review, we have discussed ability bacteriocin-producing probiotic in modulation gut correcting dysbiosis treatment/maintenance few important human disorders chronic infections, inflammatory bowel diseases, obesity, cancer.

Language: Английский

Citations

153

Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer DOI Creative Commons
Ruize Qu, Yi Zhang,

Yanpeng Ma

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(23)

Published: June 1, 2023

Colorectal cancer (CRC) is the most common of digestive system with high mortality and morbidity rates. Gut microbiota found in intestines, especially colorectum, has structured crosstalk interactions host that affect several physiological processes. The gut include CRC-promoting bacterial species, such as Fusobacterium nucleatum, Escherichia coli, Bacteroides fragilis, CRC-protecting Clostridium butyricum, Streptococcus thermophilus, Lacticaseibacillus paracasei, which along other microorganisms, viruses fungi, play critical roles development CRC. Different features are identified patients early-onset CRC, combined different patterns between fecal intratumoral microbiota. may be beneficial diagnosis treatment CRC; some bacteria serve biomarkers while others regulators chemotherapy immunotherapy. Furthermore, metabolites produced by essential CRC cells. Harmful primary bile acids short-chain fatty acids, whereas others, including ursodeoxycholic acid butyrate, impede tumor progression. This review focuses on its metabolites, their potential development, diagnosis,

Language: Английский

Citations

121

Emerging strategies for engineering Escherichia coli Nissle 1917-based therapeutics DOI Creative Commons
Jason P. Lynch, Lisa Goers, Cammie F. Lesser

et al.

Trends in Pharmacological Sciences, Journal Year: 2022, Volume and Issue: 43(9), P. 772 - 786

Published: Feb. 26, 2022

Language: Английский

Citations

113

Mechanisms and implications of bacterial–fungal competition for soil resources DOI Creative Commons
Chaoqun Wang, Yakov Kuzyakov

The ISME Journal, Journal Year: 2024, Volume and Issue: 18(1)

Published: Jan. 1, 2024

Abstract Elucidating complex interactions between bacteria and fungi that determine microbial community structure, composition, functions in soil, as well regulate carbon (C) nutrient fluxes, is crucial to understand biogeochemical cycles. Among the various interactions, competition for resources main factor determining adaptation niche differentiation these two big groups soil. This because C energy limitations growth are a rule rather than an exception. Here, we review demands of fungi—the major kingdoms soil—the mechanisms their other resources, leading differentiation, global change impacts on this competition. The normalized utilization preference showed 1.4–5 times more efficient uptake simple organic compounds substrates, whereas 1.1–4.1 effective utilizing compounds. Accordingly, strongly outcompete while take advantage Bacteria also compete with products released during degradation substrates. Based specifics, differentiated spatial, temporal, chemical niches will increase under five changes including elevated CO2, N deposition, soil acidification, warming, drought. Elevated warming bacterial dominance, acidification drought fungal competitiveness.

Language: Английский

Citations

109

The honeybee microbiota and its impact on health and disease DOI
Erick V. S. Motta, Nancy A. Moran

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 22(3), P. 122 - 137

Published: Dec. 4, 2023

Language: Английский

Citations

77