Medical Device-Associated Biofilm Infections and Multidrug-Resistant Pathogens DOI Creative Commons

Nesrine Bouhrour,

Peter H. Nibbering, Farida Bendali

и другие.

Pathogens, Год журнала: 2024, Номер 13(5), С. 393 - 393

Опубликована: Май 8, 2024

Medical devices such as venous catheters (VCs) and urinary (UCs) are widely used in the hospital setting. However, implantation of these is often accompanied by complications. About 60 to 70% nosocomial infections (NIs) linked biofilms. The main complication ability microorganisms adhere surfaces form biofilms which protect them help persist host. Indeed, crossing skin barrier, insertion VC inevitably allows flora or accidental environmental contaminants access underlying tissues cause fatal complications like bloodstream (BSIs). In fact, 80,000 central catheters-BSIs (CVC-BSIs)-mainly occur intensive care units (ICUs) with a death rate 12 25%. Similarly, catheter-associated tract (CA-UTIs) most commonlyhospital-acquired (HAIs) worldwide.These represent up 40% NIs.In this review, we present summary biofilm formation steps. We provide an overview two important clinical settings medical devices, namely catheter-asociated (CA-BSIs) (CA-UTIs), highlight also multidrug resistant bacteria implicated infections. Furthermore, draw attention toseveral useful prevention strategies, advanced antimicrobial antifouling approaches developed reduce bacterial colonization on catheter incidence catheter-related

Язык: Английский

Beneficial applications of biofilms DOI
Laura-Alina Philipp, Katja Bühler, Roland Ulber

и другие.

Nature Reviews Microbiology, Год журнала: 2023, Номер 22(5), С. 276 - 290

Опубликована: Ноя. 13, 2023

Язык: Английский

Процитировано

42
Active biointegrated living electronics for managing inflammation DOI
Jiuyun Shi,

Saehyun Kim,

Pengju Li

и другие.

Science, Год журнала: 2024, Номер 384(6699), С. 1023 - 1030

Опубликована: Май 30, 2024

Seamless interfaces between electronic devices and biological tissues stand to revolutionize disease diagnosis treatment. However, biomechanical disparities synthetic materials living present challenges at bioelectrical signal transduction interfaces. We introduce the active biointegrated electronics (ABLE) platform, encompassing capabilities across biogenic, biomechanical, properties simultaneously. The biointerface, comprising a bioelectronics layout

Язык: Английский

Процитировано

37
De Novo Designed Ru(II) Metallacycle as a Microenvironment‐Adaptive Sonosensitizer and Sonocatalyst for Multidrug‐Resistant Biofilms Eradication DOI
Yuling Xu,

Yida Pang,

Lishi Luo

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(15)

Опубликована: Фев. 8, 2024

Abstract Albeit sonodynamic therapy (SDT) has achieved encouraging progress in microbial sterilization, the scarcity of guidelines for designing highly effective sonosensitizers and intricate biofilm microenvironment (BME), substantially hamper therapeutic efficacy against infections. To address bottlenecks, we innovatively design a Ru(II) metallacycle‐based sonosensitizer/sonocatalyst (named Ru‐A3‐TTD ) to enhance potency sonotherapy by employing molecular engineering strategies tailored BME. Our approach involves augmenting ’s production ultrasonic‐triggered reactive oxygen species (ROS), surpassing performance commercial sonosensitizers, through straightforward but potent π‐expansion approach. Within BME, synergistically amplifies sonotherapeutic via triple‐modulated approaches: (i) alleviation hypoxia, leading increased ROS generation, (ii) disruption antioxidant defense system, which shields from glutathione consumption, (iii) enhanced penetration, enabling deep sites. Notably, sono‐catalytically oxidizes NADPH, critical coenzyme involved defenses. Consequently, demonstrates superior eradication multidrug‐resistant Escherichia coli compared conventional clinical antibiotics, both vitro vivo. our knowledge, this study represents pioneering instance supramolecular sonosensitizer/sonocatalyst. It provides valuable insights into structure‐activity relationship paves promising pathway treatment

Язык: Английский

Процитировано

30
Mechanisms of antimicrobial resistance in biofilms DOI Creative Commons
H. Liu,

Emma L. Prentice,

Mark Webber

и другие.

npj Antimicrobials and Resistance, Год журнала: 2024, Номер 2(1)

Опубликована: Окт. 1, 2024

Most bacteria in nature exist aggregated communities known as biofilms, and cells within a biofilm demonstrate major physiological changes compared to their planktonic counterparts. Biofilms are associated with many different types of infections which can have severe impacts on patients. Infections involving component often chronic highly recalcitrant antibiotic therapy result intrinsic physical factors including extracellular matrix production, low growth rates, altered target production efficient exchange resistance genes. This review describes the lifecycle, phenotypic characteristics biofilm, contribution persister biofilms tolerance antimicrobials. We also describe how evolve transfer genes biofilms. Multispecies various interactions, cooperation competition, between species antimicrobials polymicrobial discussed.

Язык: Английский

Процитировано

29
Medical Device-Associated Biofilm Infections and Multidrug-Resistant Pathogens DOI Creative Commons

Nesrine Bouhrour,

Peter H. Nibbering, Farida Bendali

и другие.

Pathogens, Год журнала: 2024, Номер 13(5), С. 393 - 393

Опубликована: Май 8, 2024

Medical devices such as venous catheters (VCs) and urinary (UCs) are widely used in the hospital setting. However, implantation of these is often accompanied by complications. About 60 to 70% nosocomial infections (NIs) linked biofilms. The main complication ability microorganisms adhere surfaces form biofilms which protect them help persist host. Indeed, crossing skin barrier, insertion VC inevitably allows flora or accidental environmental contaminants access underlying tissues cause fatal complications like bloodstream (BSIs). In fact, 80,000 central catheters-BSIs (CVC-BSIs)-mainly occur intensive care units (ICUs) with a death rate 12 25%. Similarly, catheter-associated tract (CA-UTIs) most commonlyhospital-acquired (HAIs) worldwide.These represent up 40% NIs.In this review, we present summary biofilm formation steps. We provide an overview two important clinical settings medical devices, namely catheter-asociated (CA-BSIs) (CA-UTIs), highlight also multidrug resistant bacteria implicated infections. Furthermore, draw attention toseveral useful prevention strategies, advanced antimicrobial antifouling approaches developed reduce bacterial colonization on catheter incidence catheter-related

Язык: Английский

Процитировано

24