Frontiers in Computational Neuroscience,
Год журнала:
2024,
Номер
17
Опубликована: Янв. 18, 2024
We
study
how
stimulus
information
can
be
represented
in
the
dynamical
signatures
of
an
oscillatory
model
neural
activity—a
whose
activity
modulated
by
input
akin
to
signals
involved
working
memory
(WM).
developed
a
field
model,
tuned
near
instability,
which
WM-like
modulate
frequency
and
amplitude
oscillation.
Our
has
spatial-like
domain
that
preferentially
targets
point—a
feature—on
will
induce
feature-specific
changes.
These
changes
affect
both
mean
rate
spikes
relative
timing
spiking
global
oscillation—the
phase
activity.
From
these
two
signatures,
we
define
spike
code
code.
assess
performance
codes
discriminate
features
using
information-theoretic
analysis.
show
WM
modulations
enhance
discrimination
while
simultaneously
reducing
discrimination.
Moreover,
find
is
roughly
orders
magnitude
larger
than
defined
for
same
solutions.
The
results
our
have
applications
sensory
areas
brain,
prefrontal
send
inputs
reflecting
content
WM.
been
established
similar
model.
suggest
mechanism
may
beyond
comparatively
weak
representations
based
on
In
most
animals,
a
relatively
small
number
of
descending
neurons
(DNs)
connect
higher
brain
centers
in
the
animal’s
head
to
circuits
and
motor
(MNs)
nerve
cord
body
that
effect
movement
limbs.
To
understand
how
signals
generate
behavior,
it
is
critical
these
pathways
are
organized
onto
MNs.
fly,
Drosophila
melanogaster
,
MNs
controlling
muscles
leg,
wing,
other
systems
reside
ventral
(VNC),
analogous
mammalian
spinal
cord.
companion
papers,
we
introduced
densely-reconstructed
connectome
Male
Adult
Nerve
Cord
(MANC,
Takemura
et
al.,
2023),
including
cell
type
developmental
lineage
annotation
(Marin
which
provides
complete
VNC
connectivity
at
synaptic
resolution.
Here,
present
first
look
organization
networks
connecting
DNs
based
on
this
new
information.
We
proofread
curated
all
ensure
accuracy
reliability,
then
systematically
matched
DN
axon
terminals
MN
dendrites
with
light
microscopy
data
link
their
morphology
inputs
or
muscle
targets.
report
both
broad
organizational
patterns
entire
network
fine-scale
analysis
selected
interest.
discover
direct
DN-MN
connections
infrequent
identify
communities
intrinsic
linked
control
different
systems,
putative
for
walking,
dorsal
flight
steering
power
generation,
intermediate
lower
tectulum
coordinated
action
wings
legs.
Our
generates
hypotheses
future
functional
experiments
and,
together
MANC
connectome,
empowers
others
investigate
richer
mechanistic
detail.
Annual Review of Neuroscience,
Год журнала:
2021,
Номер
44(1), С. 517 - 546
Опубликована: Апрель 29, 2021
The
mouse,
as
a
model
organism
to
study
the
brain,
gives
us
unprecedented
experimental
access
mammalian
cerebral
cortex.
By
determining
cortex's
cellular
composition,
revealing
interaction
between
its
different
components,
and
systematically
perturbing
these
we
are
obtaining
mechanistic
insight
into
some
of
most
basic
properties
cortical
function.
In
this
review,
describe
recent
advances
in
our
understanding
how
circuits
neurons
implement
computations,
revealed
by
mouse
primary
visual
Further,
discuss
studying
has
broadened
range
computations
performed
Finally,
address
future
approaches
will
fulfill
promise
elucidating
fundamental
operations
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Июнь 7, 2023
Abstract
In
most
animals,
a
relatively
small
number
of
descending
neurons
(DNs)
connect
higher
brain
centers
in
the
animal’s
head
to
circuits
and
motor
(MNs)
nerve
cord
body
that
effect
movement
limbs.
To
understand
how
signals
generate
behavior,
it
is
critical
these
pathways
are
organized
onto
MNs.
fly,
Drosophila
melanogaster
,
MNs
controlling
muscles
leg,
wing,
other
systems
reside
ventral
(VNC),
analogous
mammalian
spinal
cord.
companion
papers,
we
introduced
densely-reconstructed
connectome
Male
Adult
Nerve
Cord
(MANC,
Takemura
et
al.,
2023),
including
cell
type
developmental
lineage
annotation
(Marin
which
provides
complete
VNC
connectivity
at
synaptic
resolution.
Here,
present
first
look
organization
networks
connecting
DNs
based
on
this
new
information.
We
proofread
curated
all
ensure
accuracy
reliability,
then
systematically
matched
DN
axon
terminals
MN
dendrites
with
light
microscopy
data
link
their
morphology
inputs
or
muscle
targets.
report
both
broad
organizational
patterns
entire
network
fine-scale
analysis
selected
interest.
discover
direct
DN-MN
connections
infrequent
identify
communities
intrinsic
linked
control
different
systems,
putative
for
walking,
dorsal
flight
steering
power
generation,
intermediate
lower
tectulum
coordinated
action
wings
legs.
Our
generates
hypotheses
future
functional
experiments
and,
together
MANC
connectome,
empowers
others
investigate
richer
mechanistic
detail.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Сен. 30, 2023
Recent
work
has
demonstrated
that
the
relationship
between
structural
and
functional
connectivity
varies
regionally
across
human
brain,
with
reduced
coupling
emerging
along
sensory-association
cortical
hierarchy.
The
biological
underpinnings
driving
this
expression,
however,
remain
largely
unknown.
Here,
we
postulate
intracortical
myelination
excitation-inhibition
(EI)
balance
mediate
heterogeneous
expression
of
structure-function
(SFC)
its
temporal
variance
We
employ
atlas-
voxel-based
approaches
to
analyze
neuroimaging
data
acquired
from
two
groups
healthy
participants.
Our
findings
are
consistent
six
complementary
processing
pipelines:
1)
SFC
respectively
decrease
increase
unimodal-transmodal
granular-agranular
gradients;
2)
increased
lower
EI-ratio
associated
more
rigid
restricted
moment-to-moment
fluctuations;
3)
a
gradual
shift
as
principal
predictor
occurs
when
traversing
granular
agranular
regions.
Collectively,
our
delivers
framework
conceptualize
relationships
in
paving
way
for
an
improved
understanding
how
demyelination
and/or
EI-imbalances
induce
reorganization
brain
disorders.
How
is
the
massive
dimensionality
and
complexity
of
microscopic
constituents
nervous
system
brought
under
sufficiently
tight
control
so
as
to
coordinate
adaptive
behaviour?
A
powerful
means
for
striking
this
balance
poise
neurons
close
critical
point
a
phase
transition,
at
which
small
change
in
neuronal
excitability
can
manifest
nonlinear
augmentation
activity.
brain
could
mediate
transition
key
open
question
neuroscience.
Here,
I
propose
that
different
arms
ascending
arousal
provide
with
diverse
set
heterogeneous
parameters
be
used
modulate
receptivity
target
neurons-in
other
words,
act
mediating
order.
Through
series
worked
examples,
demonstrate
how
neuromodulatory
interact
inherent
topological
subsystems
complex
behaviour.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 20, 2024
Summary
A
fundamental
question
in
neuroscience
is
how
memory
formation
shapes
brain
activity
at
the
level
of
populations
neurons.
Recent
studies
hippocampal
‘engram’
cells,
identified
by
immediate-early
genes
(IEGs)
induced
learning,
propose
that
these
act
as
a
neuronal
substrate
for
storage.
The
current
framework
engram
proposes
cells
join
ensembles
based
on
increased
intrinsic
excitability,
and
after
initial
they
co-activate
to
support
retrieval.
However,
direct
evidence
population
dynamics
evolve
across
learning
limited.
Here
we
combined
activity-dependent
genetic
tagging
two-photon
calcium
imaging
characterize
CA1
before
learning.
We
observed
spontaneous
two
days
predicted
tagging,
consistent
with
model
which
fluctuations
bias
into
forming
assemblies.
Surprisingly,
were
unable
detect
rates
or
pairwise
correlations
amongst
tagged
neurons
These
results
computational
network
models
incorporate
strong
specific
inhibitory
connections,
supporting
idea
excitatory/inhibitory
balance
may
play
key
role
dynamics.
Together
highlight
potential
slow
time
scale
excitability
driving
suggest
excitatory-inhibitory
regulate
cell
co-activation.
Highlights
Tracked
Fos
Spontaneous
predicts
TetTagging.
No
changes
TetTagged
Modeling
suggests
E/I
regulates
