Frontiers in Endocrinology,
Год журнала:
2025,
Номер
16
Опубликована: Март 20, 2025
The
body
instinctively
responds
to
external
stimuli
by
increasing
energy
metabolism
and
initiating
immune
responses
upon
receiving
stress
signals.
Corticosterone
(CORT),
a
glucocorticoid
(GC)
that
regulates
secretion
along
the
hypothalamic-pituitary-adrenal
(HPA)
axis,
mediates
neurotransmission
humoral
regulation.
Due
widespread
expression
of
receptors
(GR),
effects
CORT
are
almost
ubiquitous
in
various
tissue
cells.
Therefore,
on
one
hand,
is
molecular
signal
activates
body’s
system
during
other
due
chemical
properties
GCs,
anti-inflammatory
act
as
stabilizers
control
response
stress.
Inflammation
manifestation
activation.
plays
dual
roles
this
process
both
promoting
inflammation
exerting
As
hormone,
levels
fluctuate
with
degree
duration
stress,
determining
its
changes
it
induces.
essential
for
resist
diseases
maintain
homeostasis,
imbalance
being
key
factor
development
diseases.
understanding
role
mechanisms
action
immunity
crucial.
This
review
addresses
important
issue
summarizes
interactions
between
system.
Physiological Reviews,
Год журнала:
2024,
Номер
104(3), С. 1205 - 1263
Опубликована: Март 14, 2024
Stress
resilience
is
the
phenomenon
that
some
people
maintain
their
mental
health
despite
exposure
to
adversity
or
show
only
temporary
impairments
followed
by
quick
recovery.
Resilience
research
attempts
unravel
factors
and
mechanisms
make
possible
harness
its
insights
for
development
of
preventative
interventions
in
individuals
at
risk
acquiring
stress-related
dysfunctions.
Biological
has
been
lagging
behind
psychological
social
sciences
but
seen
a
massive
surge
recent
years.
At
same
time,
progress
this
field
hampered
methodological
challenges
related
finding
suitable
operationalizations
study
designs,
replicating
findings,
modeling
animals.
We
embed
review
behavioral,
neuroimaging,
neurobiological,
systems
biological
findings
adults
critical
methods
discussion.
find
preliminary
evidence
hippocampus-based
pattern
separation
prefrontal-based
cognitive
control
functions
protect
against
pathological
fears
aftermath
singular,
event-type
stressors
[as
found
fear-related
disorders,
including
simpler
forms
posttraumatic
stress
disorder
(PTSD)]
facilitating
perception
safety.
Reward
system-based
pursuit
savoring
positive
reinforcers
appear
more
generalized
dysfunctions
anxious-depressive
spectrum
resulting
from
severe
longer-lasting
(as
depression,
comorbid
anxiety,
PTSD).
Links
between
preserved
functioning
these
neural
under
neuroplasticity,
immunoregulation,
gut
microbiome
composition,
integrity
barrier
blood-brain
are
beginning
emerge.
On
basis,
avenues
pointed
out.
Communications Biology,
Год журнала:
2025,
Номер
8(1)
Опубликована: Янв. 14, 2025
Digestive
and
psychiatric
disorders
tend
to
co-occur,
yet
mechanisms
remain
unclear.
Leveraging
genetic
transcriptomic
data
integration,
we
conduct
multi-trait
analysis
of
GWAS
(MTAG)
weighted
gene
co-expression
network
(WGCNA)
explore
shared
mechanism
between
gastrointestinal
disorders.
Significant
correlations
were
found
these
disorders,
especially
in
irritable
bowel
syndrome
(IBS),
gastroesophageal
reflux
disease
(GERD),
depression
(DEP),
neuroticism
(NE).
MTAG
identify
60
novel
pleiotropic
loci
for
IBS
14
GERD,
predominantly
located
near
genes
associated
with
neurological
pathways.
Further
WGCNA
identifies
multiple
modules
enriched
involved
pathways
digestive
tissues,
some
strongly
preserved
across
brain
tissues.
Moreover,
our
suggests
BSN,
CELF4,
NRXN1
as
central
players
the
regulation
gut-brain
axis
(GBA).
This
study
enhances
understanding
GBA
underscores
crucial
targets
future
research.
Genetics
transcriptomics
reveal
highlighting
loci.
Genes
regulate
axis,
revealing
potential
therapeutic
targets.
Journal of Neuroinflammation,
Год журнала:
2025,
Номер
22(1)
Опубликована: Фев. 15, 2025
Methamphetamine
(METH)
use
disorder
(MUD)
is
characterized
by
compulsive
drug-seeking
behavior
and
substantial
neurotoxicity,
posing
a
considerable
burden
on
individuals
society.
Traditionally
perceived
as
localized
central
nervous
system
disorder,
recent
preclinical
clinical
studies
have
elucidated
that
MUD
multifaceted
influenced
various
biological
systems,
particularly
the
immune
system.
Emerging
evidence
suggests
both
peripheral
responses
play
crucial
role
in
initiation
persistence
of
MUD.
Conceptualizing
it
systemic
process
prompts
significant
inquiries
regarding
mechanisms
communication
between
compartments.
Also,
whether
this
intercommunication
could
serve
diagnostic
biomarkers
or
therapeutic
targets.
This
review
begins
offering
an
overview
mechanistic
pertaining
to
neuroimmune
systems.
Finally,
future
directions
are
suggested
through
integration
innovative
technologies
multidimensional
data
promote
translation
basic
research
into
interventions.
Pharmacological Research,
Год журнала:
2024,
Номер
205, С. 107255 - 107255
Опубликована: Июнь 12, 2024
Research
has
shown
that
a
significant
portion
of
cancer
patients
experience
depressive
symptoms,
often
accompanied
by
neuroendocrine
hormone
imbalances.
Depression
is
frequently
associated
with
decreased
levels
serotonin
the
alternate
name
5-hydroxytryptamine
(5-HT),
leading
to
common
use
selective
reuptake
inhibitors
(SSRIs)
as
antidepressants.
However,
role
in
tumor
regulation
remains
unclear,
its
expression
displaying
varied
effects
across
different
types
tumors.
Tumor
initiation
and
progression
are
closely
intertwined
immune
function
human
body.
Neuroimmunity,
an
interdisciplinary
subject,
played
unique
study
relationship
between
psychosocial
factors
tumors
their
mechanisms
recent
years.
This
article
offers
comprehensive
review
serotonin's
regulatory
roles
onset
progression,
well
impacts
on
cells
microenvironment.
The
aim
stimulate
further
research
discover
novel
targets
for
treatment.
Abstract
Lack
of
liver
regenerative
capacity
is
the
primary
cause
hepatic
failure
and
even
mortality
in
patients
undergoing
hepatectomy,
with
no
effective
intervention
strategies
currently
available.
Therefore,
identifying
efficacious
interventions
to
enhance
regeneration
pivotal
for
optimizing
clinical
outcomes.
Recent
studies
have
demonstrated
that
vagotomy
exerts
an
inhibitory
effect
on
following
partial
thereby
substantiating
role
played
by
vagus
nerve
process
regeneration.
In
recent
years,
electroacupuncture
(EA)
has
emerged
as
a
non‐invasive
technique
stimulating
nerve.
However,
EA
remains
uncertain.
this
study,
70%
hepatectomy
(PH)
mouse
model
utilized
investigate
effects
acute
elucidate
its
underlying
molecular
mechanisms.
It
observed
at
ST36
acutely
activated
cholinergic
neurons
dorsal
motor
nucleus
(DMV),
resulting
increased
release
acetylcholine
from
vagal
endings
subsequent
activation
IL‐6
signaling
macrophages.
Ultimately,
these
events
promoted
hepatocyte
proliferation
facilitated
These
findings
provide
insights
into
fundamental
brain‐liver
axis
mechanism
through
which
promotes
regeneration,
offering
novel
therapeutic
approach
post‐hepatectomy
disorders.
