Corticosterone effects induced by stress and immunity and inflammation: mechanisms of communication DOI Creative Commons

Jingyu Xu,

B Wang,

Haiqing Ao

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 20, 2025

The body instinctively responds to external stimuli by increasing energy metabolism and initiating immune responses upon receiving stress signals. Corticosterone (CORT), a glucocorticoid (GC) that regulates secretion along the hypothalamic-pituitary-adrenal (HPA) axis, mediates neurotransmission humoral regulation. Due widespread expression of receptors (GR), effects CORT are almost ubiquitous in various tissue cells. Therefore, on one hand, is molecular signal activates body’s system during other due chemical properties GCs, anti-inflammatory act as stabilizers control response stress. Inflammation manifestation activation. plays dual roles this process both promoting inflammation exerting As hormone, levels fluctuate with degree duration stress, determining its changes it induces. essential for resist diseases maintain homeostasis, imbalance being key factor development diseases. understanding role mechanisms action immunity crucial. This review addresses important issue summarizes interactions between system.

Language: Английский

Neurobiological basis of stress resilience DOI
Eric J. Nestler, Scott J. Russo

Neuron, Journal Year: 2024, Volume and Issue: 112(12), P. 1911 - 1929

Published: May 24, 2024

Language: Английский

Citations

27
Neurobiology and systems biology of stress resilience DOI
Raffaël Kalisch, Scott J. Russo,

Marianne B. Müller

et al.

Physiological Reviews, Journal Year: 2024, Volume and Issue: 104(3), P. 1205 - 1263

Published: March 14, 2024

Stress resilience is the phenomenon that some people maintain their mental health despite exposure to adversity or show only temporary impairments followed by quick recovery. Resilience research attempts unravel factors and mechanisms make possible harness its insights for development of preventative interventions in individuals at risk acquiring stress-related dysfunctions. Biological has been lagging behind psychological social sciences but seen a massive surge recent years. At same time, progress this field hampered methodological challenges related finding suitable operationalizations study designs, replicating findings, modeling animals. We embed review behavioral, neuroimaging, neurobiological, systems biological findings adults critical methods discussion. find preliminary evidence hippocampus-based pattern separation prefrontal-based cognitive control functions protect against pathological fears aftermath singular, event-type stressors [as found fear-related disorders, including simpler forms posttraumatic stress disorder (PTSD)] facilitating perception safety. Reward system-based pursuit savoring positive reinforcers appear more generalized dysfunctions anxious-depressive spectrum resulting from severe longer-lasting (as depression, comorbid anxiety, PTSD). Links between preserved functioning these neural under neuroplasticity, immunoregulation, gut microbiome composition, integrity barrier blood-brain are beginning emerge. On basis, avenues pointed out.

Language: Английский

Citations

25
The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms DOI Creative Commons
Jiao Wang, Jiayi Lin,

Yanfang Deng

et al.

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: Jan. 19, 2025

Major depressive disorder is a prevalent mental disorder, yet its pathogenesis remains poorly understood. Accumulating evidence implicates dysregulated immune mechanisms as key contributors to disorders. This review elucidates the complex interplay between peripheral and central components underlying pathology. Peripherally, systemic inflammation, gut dysregulation, dysfunction in organs including gut, liver, spleen adipose tissue influence brain function through neural molecular pathways. Within nervous system, aberrant microglial astrocytes activation, cytokine imbalances, compromised blood-brain barrier integrity propagate neuroinflammation, disrupting neurotransmission, impairing neuroplasticity, promoting neuronal injury. The crosstalk immunity creates vicious cycle exacerbating neuropathology. Unraveling these multifaceted immune-mediated provides insights into major disorder's pathogenic basis potential biomarkers targets. Modulating both responses represent promising multidimensional therapeutic strategy.

Language: Английский

Citations

4
The pathogenesis of depression: roles of connexin 43-based gap junctions and inflammation DOI
Hong Jiang, Meng Zhang,

Xin-Mu Li

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: 989, P. 177260 - 177260

Published: Jan. 9, 2025

Language: Английский

Citations

2
Integrating genetics and transcriptomics to characterize shared mechanisms in digestive diseases and psychiatric disorders DOI Creative Commons

Huanxin Ding,

Yue Jiang, Qiang Sun

et al.

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 14, 2025

Digestive and psychiatric disorders tend to co-occur, yet mechanisms remain unclear. Leveraging genetic transcriptomic data integration, we conduct multi-trait analysis of GWAS (MTAG) weighted gene co-expression network (WGCNA) explore shared mechanism between gastrointestinal disorders. Significant correlations were found these disorders, especially in irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), depression (DEP), neuroticism (NE). MTAG identify 60 novel pleiotropic loci for IBS 14 GERD, predominantly located near genes associated with neurological pathways. Further WGCNA identifies multiple modules enriched involved pathways digestive tissues, some strongly preserved across brain tissues. Moreover, our suggests BSN, CELF4, NRXN1 as central players the regulation gut-brain axis (GBA). This study enhances understanding GBA underscores crucial targets future research. Genetics transcriptomics reveal highlighting loci. Genes regulate axis, revealing potential therapeutic targets.

Language: Английский

Citations

1
Neural circuits mediating chronic stress: Implications for major depressive disorder DOI
Hongling Guo, Tahir Ali, Shupeng Li

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: 137, P. 111280 - 111280

Published: Feb. 3, 2025

Language: Английский

Citations

1
The interaction between central and peripheral immune systems in methamphetamine use disorder: current status and future directions DOI Creative Commons
Sai Shi,

Yiwen Sun,

Gui‐Ying Zan

et al.

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: Feb. 15, 2025

Methamphetamine (METH) use disorder (MUD) is characterized by compulsive drug-seeking behavior and substantial neurotoxicity, posing a considerable burden on individuals society. Traditionally perceived as localized central nervous system disorder, recent preclinical clinical studies have elucidated that MUD multifaceted influenced various biological systems, particularly the immune system. Emerging evidence suggests both peripheral responses play crucial role in initiation persistence of MUD. Conceptualizing it systemic process prompts significant inquiries regarding mechanisms communication between compartments. Also, whether this intercommunication could serve diagnostic biomarkers or therapeutic targets. This review begins offering an overview mechanistic pertaining to neuroimmune systems. Finally, future directions are suggested through integration innovative technologies multidimensional data promote translation basic research into interventions.

Language: Английский

Citations

1
The dual roles of serotonin in antitumor immunity DOI Creative Commons
Yingru Zhang, Yan Wang

Pharmacological Research, Journal Year: 2024, Volume and Issue: 205, P. 107255 - 107255

Published: June 12, 2024

Research has shown that a significant portion of cancer patients experience depressive symptoms, often accompanied by neuroendocrine hormone imbalances. Depression is frequently associated with decreased levels serotonin the alternate name 5-hydroxytryptamine (5-HT), leading to common use selective reuptake inhibitors (SSRIs) as antidepressants. However, role in tumor regulation remains unclear, its expression displaying varied effects across different types tumors. Tumor initiation and progression are closely intertwined immune function human body. Neuroimmunity, an interdisciplinary subject, played unique study relationship between psychosocial factors tumors their mechanisms recent years. This article offers comprehensive review serotonin's regulatory roles onset progression, well impacts on cells microenvironment. The aim stimulate further research discover novel targets for treatment.

Language: Английский

Citations

6
Electroacupuncture Promotes Liver Regeneration by Activating DMV Acetylcholinergic Neurons‐Vagus‐Macrophage Axis in 70% Partial Hepatectomy of Mice DOI Creative Commons
Liu Yang, Yanyu Zhou,

Zhaoshuai Huang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(32)

Published: June 25, 2024

Abstract Lack of liver regenerative capacity is the primary cause hepatic failure and even mortality in patients undergoing hepatectomy, with no effective intervention strategies currently available. Therefore, identifying efficacious interventions to enhance regeneration pivotal for optimizing clinical outcomes. Recent studies have demonstrated that vagotomy exerts an inhibitory effect on following partial thereby substantiating role played by vagus nerve process regeneration. In recent years, electroacupuncture (EA) has emerged as a non‐invasive technique stimulating nerve. However, EA remains uncertain. this study, 70% hepatectomy (PH) mouse model utilized investigate effects acute elucidate its underlying molecular mechanisms. It observed at ST36 acutely activated cholinergic neurons dorsal motor nucleus (DMV), resulting increased release acetylcholine from vagal endings subsequent activation IL‐6 signaling macrophages. Ultimately, these events promoted hepatocyte proliferation facilitated These findings provide insights into fundamental brain‐liver axis mechanism through which promotes regeneration, offering novel therapeutic approach post‐hepatectomy disorders.

Language: Английский

Citations

5
Organ-specific sympathetic innervation defines visceral functions DOI
Tongtong Wang, Bochuan Teng,

Dickson R. Yao

et al.

Nature, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Language: Английский

Citations

5