Implementing value-based healthcare: a scoping review of key elements, outcomes, and challenges for sustainable healthcare systems DOI Creative Commons
Hanan Khalil, Mary Ameen,

Charles Davies

и другие.

Frontiers in Public Health, Год журнала: 2025, Номер 13

Опубликована: Апрель 9, 2025

Value-Based Health Care (VBHC) is an increasingly important healthcare paradigm that focuses on maximizing health outcomes relative to the cost of care delivered. Various organizations have adopted VBHC principles, but significant barriers remain in adapting models, engaging stakeholders, and measuring outcomes. Moreover, lack standardized methods for financial sustainability further complicates transition VBHC. Understanding factors facilitate or hinder adoption crucial informing policy practice broader implementation. The objective map literature addressing concerning population, study characteristics, funding outcome measures, facilitators. Following JBI methodology PRISMA-ScR reporting guidance, a scoping review was undertaken include primary secondary research across various settings. Searches were nine relevant databases. Peer-reviewed quantitative qualitative studies published English included analyzed. A total 145 after screening 2,725 studies. findings show United States leads research, contributing 65% studies, followed by European countries. Cohort cross-sectional predominant, focusing populations, including hospitals, surgical patients, cancer patients. Key highlight Purchasing Time-Driven Activity-Based Costing models most frequently reported models. Traditional in-hospital remains dominant delivery model, with increasing interest telemedicine. Outcome measure diverse, ranging from patient-reported savings both patients providers. Barriers implementation insufficient funding, fee-for-service model persistence, resistance professionals. Facilitators strong leadership, multidisciplinary collaboration, use digital tools. highlights need consistent measurements, incentives, improved data transparency ensure successful scalable systems. While shows promise improving efficiency quality, challenges aligning operational structures fully support this shift.

Язык: Английский

Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine DOI Open Access
Deirdre K. Tobias, Jordi Merino, Abrar Ahmad

и другие.

Nature Medicine, Год журнала: 2023, Номер 29(10), С. 2438 - 2457

Опубликована: Окт. 1, 2023

Язык: Английский

Процитировано

108
An atlas of genetic scores to predict multi-omic traits DOI
Yu Xu, Scott C. Ritchie,

Yujian Liang

и другие.

Nature, Год журнала: 2023, Номер 616(7955), С. 123 - 131

Опубликована: Март 29, 2023

Язык: Английский

Процитировано

77
A deep catalogue of protein-coding variation in 983,578 individuals DOI Creative Commons
Kathie Sun, Xiaodong Bai, Siying Chen

и другие.

Nature, Год журнала: 2024, Номер 631(8021), С. 583 - 592

Опубликована: Май 20, 2024

Abstract Rare coding variants that substantially affect function provide insights into the biology of a gene 1–3 . However, ascertaining frequency such requires large sample sizes 4–8 Here we present catalogue human protein-coding variation, derived from exome sequencing 983,578 individuals across diverse populations. In total, 23% Regeneron Genetics Center Million Exome (RGC-ME) data come African, East Asian, Indigenous American, Middle Eastern and South Asian ancestry. The includes more than 10.4 million missense 1.1 predicted loss-of-function (pLOF) variants. We identify with rare biallelic pLOF in 4,848 genes, 1,751 which have not been previously reported. From precise quantitative estimates selection against heterozygous loss (LOF), 3,988 LOF-intolerant including 86 were assessed as tolerant 1,153 lack established disease annotation. also define regions depletion at high resolution. Notably, 1,482 genes are depleted despite being Finally, estimate 3% clinically actionable genetic variant, 11,773 reported ClinVar unknown significance likely to be deleterious cryptic splice sites. To facilitate variant interpretation genetics-informed precision medicine, make this resource variation RGC-ME dataset publicly accessible through allele browser.

Язык: Английский

Процитировано

22
Harnessing Big Data Analytics for Healthcare: A Comprehensive Review of Frameworks, Implications, Applications, and Impacts DOI Creative Commons
Awais Ahmed, Rui Xi, Mengshu Hou

и другие.

IEEE Access, Год журнала: 2023, Номер 11, С. 112891 - 112928

Опубликована: Янв. 1, 2023

Big Data Analytics (BDA) has garnered significant attention in both academia and industries, particularly sectors such as healthcare, owing to the exponential growth of data advancements technology. The integration from diverse sources utilization advanced analytical techniques potential revolutionize healthcare by improving diagnostic accuracy, enabling personalized medicine, enhancing patient outcomes. In this paper, we aim provide a comprehensive literature review on application big analytics focusing its ecosystem, applications, sources. To achieve this, an extensive analysis scientific studies published between 2013 2023 was conducted overall 180 were thoroughly evaluated, establishing strong foundation for future research identifying collaboration opportunities domain. study delves into various areas BDA highlights successful implementations, explores their enhance outcomes while reducing costs. Additionally, it outlines challenges limitations associated with discusses modelling tools techniques, showcases deployed solutions, presents advantages through real-world use cases. Furthermore, identifies key open field aiming push boundaries contribute enhanced decision-making processes.

Язык: Английский

Процитировано

40
Screening embryos for polygenic disease risk: a review of epidemiological, clinical, and ethical considerations DOI Creative Commons
Antonio Capalbo,

G. de Wert,

Heidi Mertes

и другие.

Human Reproduction Update, Год журнала: 2024, Номер 30(5), С. 529 - 557

Опубликована: Май 28, 2024

The genetic composition of embryos generated by in vitro fertilization (IVF) can be examined with preimplantation testing (PGT). Until recently, PGT was limited to detecting single-gene, high-risk pathogenic variants, large structural and aneuploidy. Recent advances have made genome-wide genotyping IVF feasible affordable, raising the possibility screening for their risk polygenic diseases such as breast cancer, hypertension, diabetes, or schizophrenia. Despite a heated debate around this new technology, called embryo (PES; also PGT-P), it is already available patients some countries. Several articles studied epidemiological, clinical, ethical perspectives on PES; however, comprehensive, principled review emerging field missing.

Язык: Английский

Процитировано

11
Challenges and opportunities for digital twins in precision medicine from a complex systems perspective DOI Creative Commons
Manlio De Domenico,

Luca Allegri,

Guido Caldarelli

и другие.

npj Digital Medicine, Год журнала: 2025, Номер 8(1)

Опубликована: Янв. 17, 2025

Digital twins (DTs) in precision medicine are increasingly viable, propelled by extensive data collection and advancements artificial intelligence (AI), alongside traditional biomedical methodologies. We argue that including mechanistic simulations produce behavior based on explicitly defined biological hypotheses multiscale mechanisms is beneficial. It enables the exploration of diverse therapeutic strategies supports dynamic clinical decision-making through insights from network science, quantitative biology, digital medicine.

Язык: Английский

Процитировано

1
Current perspectives in tackling glaucoma blindness DOI Creative Commons

Shibal Bhartiya,

Parul Ichhpujani, Meenakshi Wadhwani

и другие.

Indian Journal of Ophthalmology, Год журнала: 2025, Номер 73(Suppl 2), С. S189 - S196

Опубликована: Фев. 21, 2025

As a major reason for irreversible vision loss, glaucoma is significant public health concern. Its multifactorial nature demands nuanced understanding of its pathophysiology, risk factors, and management. An understanding, continuous refinement, diagnostic therapeutic modalities, including pharmacological interventions, novel methods drug delivery, surgical techniques (including minimally invasive surgeries) are critical. The advent personalized medicine, genetic profiling, innovative biomarkers identifying susceptible individuals tailoring treatment strategies may help prevent blindness improve patient outcomes. Evaluation the impact lifestyle modifications holistic approaches integration telemedicine artificial intelligence in management revolutionize current practice. In addressing global challenge blindness, this narrative review highlights ongoing initiatives, policies, community-based interventions. This includes raising awareness, enhancing early detection programs, access to care, particularly underserved populations.

Язык: Английский

Процитировано

1
A call to action to scale up research and clinical genomic data sharing DOI
Zornitza Stark, David Glazer, Oliver Hofmann

и другие.

Nature Reviews Genetics, Год журнала: 2024, Номер unknown

Опубликована: Окт. 7, 2024

Язык: Английский

Процитировано

6
The Health for Life in Singapore (HELIOS) Study: delivering Precision Medicine research for Asian populations DOI Creative Commons
Xiaoyan Wang, Theresia Mina, Nilanjana Sadhu

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 15, 2024

Abstract Asian people are under-represented in population-based, clinical, and genomic research. 1,2 To address this gap, we have initiated the HELIOS longitudinal cohort study, comprising comprehensive behavioural, phenotypic, measurements from 10,004 men women of Chinese, Indian or Malay background. Phenotyping has been carried out using validated approaches, that internationally interoperable. Health record linkage enriches both baseline phenotyping evaluation prospective outcomes. The integrated multi-omics data include whole-genome RNA sequencing, quantification DNA methylation, metabolomic profiling. Our reveal extensive lifestyle, physiological, genomic, molecular diversity between distinct ethnic groups, biological interconnectivity functional layers. This includes characterisation divergent patterns genome regulation individuals, correlate with differences educational attainment, dietary quality, adiposity, which overlap transcription factors methylation sites linked to development diabetes other chronic diseases. unique Precision Medicine study represents a state-of-the art platform enable biomedical researchers understand aetiology pathogenesis diverse disease outcomes Asia, generate insights potential improve health for populations globally.

Язык: Английский

Процитировано

5
Integrated clinical risk prediction of type 2 diabetes with a multifactorial polygenic risk score DOI Creative Commons
Scott C. Ritchie, Henry J. Taylor,

Yujian Liang

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 22, 2024

Combining information from multiple GWASs for a disease and its risk factors has proven powerful approach development of polygenic scores (PRSs). This may be particularly useful type 2 diabetes (T2D), highly heterogeneous where the additional predictive value PRS is unclear. Here, we use meta-scoring to develop metaPRS T2D that incorporated genome-wide associations both European non-European genetic ancestries factors. We evaluated performance this benchmarked it against existing in 620,059 participants 50,572 cases amongst six diverse UK Biobank, INTERVAL, All Us Research Program, Singapore Multi-Ethnic Cohort. show our was most predicting population-based cohorts had comparable top ancestry-specific PRS, highlighting transferability. In stronger power 10-year than all individual apart BMI biomarkers dysglycemia. The modestly improved stratification QDiabetes prediction, when prioritising individuals blood tests Overall, present transferrable demonstrate potential incrementally improve prediction into guideline-recommended screening with clinical score.

Язык: Английский

Процитировано

5