Anti-TSLP antibodies: Targeting a master regulator of type 2 immune responses DOI Creative Commons
Saeko Nakajima, Hiroki Kabata, Kenji Kabashima

и другие.

Allergology International, Год журнала: 2020, Номер 69(2), С. 197 - 203

Опубликована: Янв. 21, 2020

TSLP is an epithelial cell-derived cytokine synthesized in response to various stimuli, including protease allergens and microorganisms like viruses bacteria. Biological functions of require heterodimer formation between the receptor (TSLPR) IL-7 receptor-α, which polarize dendritic cells induce type 2 inflammation directly expand and/or activate Th2 cells, group innate lymphoid basophils, other immune cells. thus considered a master regulator responses at barrier surfaces skin respiratory/gastrointestinal tract. Indeed, genetic, experimental, clinical evidence suggests that TSLP-TSLPR pathway associated with pathogenesis allergic diseases such as atopic dermatitis (AD) asthma. Tezepelumab (AMG-157/MEDI9929) human anti-TSLP antibody prevents interactions. A phase trial for moderate severe AD showed greater but not statistically significant percentage tezepelumab-treated patients improvements compared placebo group. uncontrolled, asthma decreases exacerbation rate improved pulmonary function control patients. Levels biomarkers inflammation, blood/sputum eosinophil counts fraction exhaled nitric oxide decreased, however, efficacy was observed irrespective baseline levels these biomarkers. blockade likely will exert effects on AD, asthma, diseases. The antibodies biologics needs be further examined.

Язык: Английский

Type 2 immunity in the skin and lungs DOI Open Access
Cezmi A. Akdiş, Peter D. Arkwright, Marie‐Charlotte Brüggen

и другие.

Allergy, Год журнала: 2020, Номер 75(7), С. 1582 - 1605

Опубликована: Апрель 22, 2020

Abstract There has been extensive progress in understanding the cellular and molecular mechanisms of inflammation immune regulation allergic diseases skin lungs during last few years. Asthma atopic dermatitis (AD) are typical type 2 responses. interleukin (IL)‐25, IL‐33, thymic stromal lymphopoietin essential cytokines epithelial cells that activated by allergens, pollutants, viruses, bacteria, toxins derive Th2 innate lymphoid (ILC) produce secrete such as IL‐4, IL‐5, IL‐9, IL‐13. IL‐4 IL‐13 activate B to class‐switch IgE also play a role T‐cell eosinophil migration inflammatory tissues. contributes maturation, activation, nitric oxide production differentiation epithelia, mucus well smooth muscle contraction, extracellular matrix generation. open tight junction barrier cause leakiness lungs. IL‐5 acts on recruitment, survival eosinophils. IL‐9 general phenotype enhancing all aspects, eosinophilia. Type ILC contribute AD asthma activity cells, eosinophils, their cytokines. Currently, five biologics licensed suppress via IgE, its receptor, receptor alpha. Some patients with severe disease have little evidence hyperactivity do not respond which target this pathway. Studies responder nonresponder demonstrate complexity these diseases. In addition, primary deficiency related regulatory development, signaling, Omenn syndrome, combined deficiencies, immunodysregulation, polyendocrinopathy, enteropathy, X‐linked DOCK8, STAT3, CARD11 help our importance redundancy various components. The present review aims highlight recent advances immunity discuss sources, targets, roles AD.

Язык: Английский

Процитировано

427

Skin Barrier Abnormalities and Immune Dysfunction in Atopic Dermatitis DOI Open Access
Gabsik Yang, Jin Kyung Seok, Han Chang Kang

и другие.

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(8), С. 2867 - 2867

Опубликована: Апрель 20, 2020

Atopic dermatitis (AD) is a common and relapsing skin disease that characterized by barrier dysfunction, inflammation, chronic pruritus. While AD was previously thought to occur primarily in children, increasing evidence suggests more adults than assumed. Accumulating from experimental, genetic, clinical studies indicates expression precondition for the later development of other atopic diseases, such as asthma, food allergies, allergic rhinitis. Although exact mechanisms pathogenesis remain unclear, it evident both cutaneous dysfunction immune dysregulation are critical etiologies pathology. This review explores recent findings on possible underlying involved its pathogenesis, which immunological integrity function, supporting idea systemic disease. These provide further insights therapeutic developments aiming repair decrease inflammation.

Язык: Английский

Процитировано

316

Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease DOI Creative Commons
Zeynep Çelebi Sözener, Betül Özdel Öztürk, Pamir Çerçi

и другие.

Allergy, Год журнала: 2022, Номер 77(5), С. 1418 - 1449

Опубликована: Фев. 2, 2022

Environmental exposure plays a major role in the development of allergic diseases. The exposome can be classified into internal (e.g., aging, hormones, and metabolic processes), specific external chemical pollutants or lifestyle factors), general broader socioeconomic psychological contexts) domains, all which are interrelated. All factors we exposed to, from moment conception to death, part exposome. Several hundreds thousands new chemicals have been introduced modern life without our having full understanding their toxic health effects ways mitigate these effects. Climate change, air pollution, microplastics, tobacco smoke, changes loss biodiversity, alterations dietary habits, microbiome due modernization, urbanization, globalization constitute surrounding environment Some disrupt epithelial barriers skin mucosal surfaces, disruptions linked last few decades increasing prevalence severity inflammatory diseases such as atopic dermatitis, food allergy, rhinitis, chronic rhinosinusitis, eosinophilic esophagitis, asthma. barrier hypothesis provides mechanistic explanation how explain rapid increase autoimmune In this review, discuss affecting planet's context 'epithelial hypothesis,' including climate emphasize on addition, roles increased fatty acid consumption environmental substances (detergents, airborne pollen, ozone, nanoparticles, tobacco) discussed. Considering emerging data recent studies, suggest stringent governmental regulations, global policy adjustments, patient education, establishment individualized control measures threats decrease disease.

Язык: Английский

Процитировано

268

Trial of Nemolizumab and Topical Agents for Atopic Dermatitis with Pruritus DOI Open Access
Kenji Kabashima, Takayo Matsumura, Hiroshi Komazaki

и другие.

New England Journal of Medicine, Год журнала: 2020, Номер 383(2), С. 141 - 150

Опубликована: Июль 8, 2020

Nemolizumab is a subcutaneously administered humanized monoclonal antibody against interleukin-31 receptor A, which involved in pruritus and inflammation atopic dermatitis. In phase 2 studies, nemolizumab lessened the severity of

Язык: Английский

Процитировано

264

Delgocitinib ointment, a topical Janus kinase inhibitor, in adult patients with moderate to severe atopic dermatitis: A phase 3, randomized, double-blind, vehicle-controlled study and an open-label, long-term extension study DOI Creative Commons
Hidemi Nakagawa,

Osamu Nemoto,

Atsuyuki Igarashi

и другие.

Journal of the American Academy of Dermatology, Год журнала: 2020, Номер 82(4), С. 823 - 831

Опубликована: Фев. 3, 2020

BackgroundPrevious studies showed the potential effectiveness of delgocitinib ointment, a novel topical Janus kinase inhibitor, in atopic dermatitis (AD).ObjectiveThis study aimed to evaluate efficacy and safety 0.5% ointment.MethodsIn part 1, 4-week double-blind period, Japanese patients aged 16 years or older with moderate severe AD were randomly assigned 2:1 ratio ointment vehicle ointment. Eligible entered 2, 24-week extension receive ointment.ResultsAt end treatment least-squares mean percent changes from baseline modified Eczema Area Severity Index score, primary endpoint, significantly greater group than (-44.3% vs 1.7%, P < .001). The improvement score was maintained 2. Most adverse events mild unrelated across periods.LimitationsOnly included. vehicle-controlled period lasted only 4 weeks. In corticosteroids allowed for worsening AD.ConclusionDelgocitinib effective well tolerated adult up 28 Previous (AD). This At periods. Only AD. Delgocitinib

Язык: Английский

Процитировано

198

Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System DOI Creative Commons
Kinga Tóth, Dorottya Ádám, Tamás Bı́ró

и другие.

Molecules, Год журнала: 2019, Номер 24(5), С. 918 - 918

Опубликована: Март 6, 2019

The endocannabinoid system (ECS) has lately been proven to be an important, multifaceted homeostatic regulator, which influences a wide-variety of physiological processes all over the body. Its members, endocannabinoids (eCBs; e.g., anandamide), eCB-responsive receptors (e.g., CB₁, CB₂), as well complex enzyme and transporter apparatus involved in metabolism ligands were shown expressed several tissues, including skin. Although best studied functions ECS are related central nervous immune processes, experimental efforts last two decades have unambiguously confirmed that cutaneous cannabinoid ("c[ut]annabinoid") signaling is deeply maintenance skin homeostasis, barrier formation regeneration, its dysregulation was implicated contribute highly prevalent diseases disorders, atopic dermatitis, psoriasis, scleroderma, acne, hair growth pigmentation keratin diseases, various tumors, itch. current review aims give overview available skin-relevant endo- phytocannabinoid literature with special emphasis on putative translational potential, highlight promising future research directions existing challenges.

Язык: Английский

Процитировано

178

Ångstrom-scale silver particle–embedded carbomer gel promotes wound healing by inhibiting bacterial colonization and inflammation DOI Creative Commons
Chun‐Yuan Chen, Hao Yin, Xia Chen

и другие.

Science Advances, Год журнала: 2020, Номер 6(43)

Опубликована: Окт. 23, 2020

L-AgÅPs-gel represents a highly effective and safe antibacterial anti-inflammatory material for promoting wound healing.

Язык: Английский

Процитировано

166

Injectable Double‐Crosslinked Adhesive Hydrogels with High Mechanical Resilience and Effective Energy Dissipation for Joint Wound Treatment DOI
Kai Chen, Zihan Wu, Yutong Liu

и другие.

Advanced Functional Materials, Год журнала: 2021, Номер 32(12)

Опубликована: Дек. 1, 2021

Abstract Due to the moist environment and inevitable movement, efficient wound closure healing of vulnerable joint skin remains a great challenge. Herein, poly(γ‐glutamic acid)‐crosslinked amino‐functionalized PEGylated poly(glycerol sebacate) (γ‐PGA/PEGS‐NH 2 ) adhesive hydrogel is reported. PEGS‐NH γ‐PGA not only forms covalent amide bonds with biological tissue surfaces achieve strong adhesion but also establishes stable chemically crosslinked network in bulk hydrogels resist deformation. Furthermore, bioinspired gallic acid‐modified chitosan (CS‐GA) introduced enhance via multiple hydrogen establish dynamic physically dissipate energy. Consequently, this strongly adheres tissue, showing an six times higher than that fibrin glue comparable cyanoacrylate glue. Moreover, benefiting from high mechanical resilience effective energy dissipation, 200 cycles loading–unloading tests conducted under state full‐thickness rat incision model applied on nape further confirmed desirable performance. Combining above ideal features their good injectability shape‐adaptability complex contours, such are demonstrated be promising candidates for physiological environment.

Язык: Английский

Процитировано

146

Cyclodextrin-based host–guest supramolecular hydrogels for local drug delivery DOI

Guihua Fang,

Xuewen Yang,

Sumeng Chen

и другие.

Coordination Chemistry Reviews, Год журнала: 2021, Номер 454, С. 214352 - 214352

Опубликована: Дек. 13, 2021

Язык: Английский

Процитировано

107

Gut–Skin Axis: Unravelling the Connection between the Gut Microbiome and Psoriasis DOI Creative Commons

Angel Yun-Kuan Thye,

Yi-Rou Bah, Jodi Woan‐Fei Law

и другие.

Biomedicines, Год журнала: 2022, Номер 10(5), С. 1037 - 1037

Опубликована: Апрель 30, 2022

Evidence has shown that gut microbiome plays a role in modulating the development of diseases beyond gastrointestinal tract, including skin disorders such as psoriasis. The gut-skin axis refers to bidirectional relationship between and health. This is regulated through several mechanisms inflammatory mediators immune system. Dysregulation microbiota been seen numerous conditions atopic dermatitis, rosacea, Understanding how are involved regulating health may lead novel therapies for these modulation, particularly In this review, we will compare psoriasis patients healthy control, explain concept effects dysbiosis on physiology. We also review current evidence using probiotics

Язык: Английский

Процитировано

93