Allergology International,
Год журнала:
2020,
Номер
69(2), С. 197 - 203
Опубликована: Янв. 21, 2020
TSLP
is
an
epithelial
cell-derived
cytokine
synthesized
in
response
to
various
stimuli,
including
protease
allergens
and
microorganisms
like
viruses
bacteria.
Biological
functions
of
require
heterodimer
formation
between
the
receptor
(TSLPR)
IL-7
receptor-α,
which
polarize
dendritic
cells
induce
type
2
inflammation
directly
expand
and/or
activate
Th2
cells,
group
innate
lymphoid
basophils,
other
immune
cells.
thus
considered
a
master
regulator
responses
at
barrier
surfaces
skin
respiratory/gastrointestinal
tract.
Indeed,
genetic,
experimental,
clinical
evidence
suggests
that
TSLP-TSLPR
pathway
associated
with
pathogenesis
allergic
diseases
such
as
atopic
dermatitis
(AD)
asthma.
Tezepelumab
(AMG-157/MEDI9929)
human
anti-TSLP
antibody
prevents
interactions.
A
phase
trial
for
moderate
severe
AD
showed
greater
but
not
statistically
significant
percentage
tezepelumab-treated
patients
improvements
compared
placebo
group.
uncontrolled,
asthma
decreases
exacerbation
rate
improved
pulmonary
function
control
patients.
Levels
biomarkers
inflammation,
blood/sputum
eosinophil
counts
fraction
exhaled
nitric
oxide
decreased,
however,
efficacy
was
observed
irrespective
baseline
levels
these
biomarkers.
blockade
likely
will
exert
effects
on
AD,
asthma,
diseases.
The
antibodies
biologics
needs
be
further
examined.
Allergy,
Год журнала:
2020,
Номер
75(7), С. 1582 - 1605
Опубликована: Апрель 22, 2020
Abstract
There
has
been
extensive
progress
in
understanding
the
cellular
and
molecular
mechanisms
of
inflammation
immune
regulation
allergic
diseases
skin
lungs
during
last
few
years.
Asthma
atopic
dermatitis
(AD)
are
typical
type
2
responses.
interleukin
(IL)‐25,
IL‐33,
thymic
stromal
lymphopoietin
essential
cytokines
epithelial
cells
that
activated
by
allergens,
pollutants,
viruses,
bacteria,
toxins
derive
Th2
innate
lymphoid
(ILC)
produce
secrete
such
as
IL‐4,
IL‐5,
IL‐9,
IL‐13.
IL‐4
IL‐13
activate
B
to
class‐switch
IgE
also
play
a
role
T‐cell
eosinophil
migration
inflammatory
tissues.
contributes
maturation,
activation,
nitric
oxide
production
differentiation
epithelia,
mucus
well
smooth
muscle
contraction,
extracellular
matrix
generation.
open
tight
junction
barrier
cause
leakiness
lungs.
IL‐5
acts
on
recruitment,
survival
eosinophils.
IL‐9
general
phenotype
enhancing
all
aspects,
eosinophilia.
Type
ILC
contribute
AD
asthma
activity
cells,
eosinophils,
their
cytokines.
Currently,
five
biologics
licensed
suppress
via
IgE,
its
receptor,
receptor
alpha.
Some
patients
with
severe
disease
have
little
evidence
hyperactivity
do
not
respond
which
target
this
pathway.
Studies
responder
nonresponder
demonstrate
complexity
these
diseases.
In
addition,
primary
deficiency
related
regulatory
development,
signaling,
Omenn
syndrome,
combined
deficiencies,
immunodysregulation,
polyendocrinopathy,
enteropathy,
X‐linked
DOCK8,
STAT3,
CARD11
help
our
importance
redundancy
various
components.
The
present
review
aims
highlight
recent
advances
immunity
discuss
sources,
targets,
roles
AD.
International Journal of Molecular Sciences,
Год журнала:
2020,
Номер
21(8), С. 2867 - 2867
Опубликована: Апрель 20, 2020
Atopic
dermatitis
(AD)
is
a
common
and
relapsing
skin
disease
that
characterized
by
barrier
dysfunction,
inflammation,
chronic
pruritus.
While
AD
was
previously
thought
to
occur
primarily
in
children,
increasing
evidence
suggests
more
adults
than
assumed.
Accumulating
from
experimental,
genetic,
clinical
studies
indicates
expression
precondition
for
the
later
development
of
other
atopic
diseases,
such
as
asthma,
food
allergies,
allergic
rhinitis.
Although
exact
mechanisms
pathogenesis
remain
unclear,
it
evident
both
cutaneous
dysfunction
immune
dysregulation
are
critical
etiologies
pathology.
This
review
explores
recent
findings
on
possible
underlying
involved
its
pathogenesis,
which
immunological
integrity
function,
supporting
idea
systemic
disease.
These
provide
further
insights
therapeutic
developments
aiming
repair
decrease
inflammation.
Allergy,
Год журнала:
2022,
Номер
77(5), С. 1418 - 1449
Опубликована: Фев. 2, 2022
Environmental
exposure
plays
a
major
role
in
the
development
of
allergic
diseases.
The
exposome
can
be
classified
into
internal
(e.g.,
aging,
hormones,
and
metabolic
processes),
specific
external
chemical
pollutants
or
lifestyle
factors),
general
broader
socioeconomic
psychological
contexts)
domains,
all
which
are
interrelated.
All
factors
we
exposed
to,
from
moment
conception
to
death,
part
exposome.
Several
hundreds
thousands
new
chemicals
have
been
introduced
modern
life
without
our
having
full
understanding
their
toxic
health
effects
ways
mitigate
these
effects.
Climate
change,
air
pollution,
microplastics,
tobacco
smoke,
changes
loss
biodiversity,
alterations
dietary
habits,
microbiome
due
modernization,
urbanization,
globalization
constitute
surrounding
environment
Some
disrupt
epithelial
barriers
skin
mucosal
surfaces,
disruptions
linked
last
few
decades
increasing
prevalence
severity
inflammatory
diseases
such
as
atopic
dermatitis,
food
allergy,
rhinitis,
chronic
rhinosinusitis,
eosinophilic
esophagitis,
asthma.
barrier
hypothesis
provides
mechanistic
explanation
how
explain
rapid
increase
autoimmune
In
this
review,
discuss
affecting
planet's
context
'epithelial
hypothesis,'
including
climate
emphasize
on
addition,
roles
increased
fatty
acid
consumption
environmental
substances
(detergents,
airborne
pollen,
ozone,
nanoparticles,
tobacco)
discussed.
Considering
emerging
data
recent
studies,
suggest
stringent
governmental
regulations,
global
policy
adjustments,
patient
education,
establishment
individualized
control
measures
threats
decrease
disease.
New England Journal of Medicine,
Год журнала:
2020,
Номер
383(2), С. 141 - 150
Опубликована: Июль 8, 2020
Nemolizumab
is
a
subcutaneously
administered
humanized
monoclonal
antibody
against
interleukin-31
receptor
A,
which
involved
in
pruritus
and
inflammation
atopic
dermatitis.
In
phase
2
studies,
nemolizumab
lessened
the
severity
of
Journal of the American Academy of Dermatology,
Год журнала:
2020,
Номер
82(4), С. 823 - 831
Опубликована: Фев. 3, 2020
BackgroundPrevious
studies
showed
the
potential
effectiveness
of
delgocitinib
ointment,
a
novel
topical
Janus
kinase
inhibitor,
in
atopic
dermatitis
(AD).ObjectiveThis
study
aimed
to
evaluate
efficacy
and
safety
0.5%
ointment.MethodsIn
part
1,
4-week
double-blind
period,
Japanese
patients
aged
16
years
or
older
with
moderate
severe
AD
were
randomly
assigned
2:1
ratio
ointment
vehicle
ointment.
Eligible
entered
2,
24-week
extension
receive
ointment.ResultsAt
end
treatment
least-squares
mean
percent
changes
from
baseline
modified
Eczema
Area
Severity
Index
score,
primary
endpoint,
significantly
greater
group
than
(-44.3%
vs
1.7%,
P
<
.001).
The
improvement
score
was
maintained
2.
Most
adverse
events
mild
unrelated
across
periods.LimitationsOnly
included.
vehicle-controlled
period
lasted
only
4
weeks.
In
corticosteroids
allowed
for
worsening
AD.ConclusionDelgocitinib
effective
well
tolerated
adult
up
28
Previous
(AD).
This
At
periods.
Only
AD.
Delgocitinib
Molecules,
Год журнала:
2019,
Номер
24(5), С. 918 - 918
Опубликована: Март 6, 2019
The
endocannabinoid
system
(ECS)
has
lately
been
proven
to
be
an
important,
multifaceted
homeostatic
regulator,
which
influences
a
wide-variety
of
physiological
processes
all
over
the
body.
Its
members,
endocannabinoids
(eCBs;
e.g.,
anandamide),
eCB-responsive
receptors
(e.g.,
CB₁,
CB₂),
as
well
complex
enzyme
and
transporter
apparatus
involved
in
metabolism
ligands
were
shown
expressed
several
tissues,
including
skin.
Although
best
studied
functions
ECS
are
related
central
nervous
immune
processes,
experimental
efforts
last
two
decades
have
unambiguously
confirmed
that
cutaneous
cannabinoid
("c[ut]annabinoid")
signaling
is
deeply
maintenance
skin
homeostasis,
barrier
formation
regeneration,
its
dysregulation
was
implicated
contribute
highly
prevalent
diseases
disorders,
atopic
dermatitis,
psoriasis,
scleroderma,
acne,
hair
growth
pigmentation
keratin
diseases,
various
tumors,
itch.
current
review
aims
give
overview
available
skin-relevant
endo-
phytocannabinoid
literature
with
special
emphasis
on
putative
translational
potential,
highlight
promising
future
research
directions
existing
challenges.
Advanced Functional Materials,
Год журнала:
2021,
Номер
32(12)
Опубликована: Дек. 1, 2021
Abstract
Due
to
the
moist
environment
and
inevitable
movement,
efficient
wound
closure
healing
of
vulnerable
joint
skin
remains
a
great
challenge.
Herein,
poly(γ‐glutamic
acid)‐crosslinked
amino‐functionalized
PEGylated
poly(glycerol
sebacate)
(γ‐PGA/PEGS‐NH
2
)
adhesive
hydrogel
is
reported.
PEGS‐NH
γ‐PGA
not
only
forms
covalent
amide
bonds
with
biological
tissue
surfaces
achieve
strong
adhesion
but
also
establishes
stable
chemically
crosslinked
network
in
bulk
hydrogels
resist
deformation.
Furthermore,
bioinspired
gallic
acid‐modified
chitosan
(CS‐GA)
introduced
enhance
via
multiple
hydrogen
establish
dynamic
physically
dissipate
energy.
Consequently,
this
strongly
adheres
tissue,
showing
an
six
times
higher
than
that
fibrin
glue
comparable
cyanoacrylate
glue.
Moreover,
benefiting
from
high
mechanical
resilience
effective
energy
dissipation,
200
cycles
loading–unloading
tests
conducted
under
state
full‐thickness
rat
incision
model
applied
on
nape
further
confirmed
desirable
performance.
Combining
above
ideal
features
their
good
injectability
shape‐adaptability
complex
contours,
such
are
demonstrated
be
promising
candidates
for
physiological
environment.
Biomedicines,
Год журнала:
2022,
Номер
10(5), С. 1037 - 1037
Опубликована: Апрель 30, 2022
Evidence
has
shown
that
gut
microbiome
plays
a
role
in
modulating
the
development
of
diseases
beyond
gastrointestinal
tract,
including
skin
disorders
such
as
psoriasis.
The
gut-skin
axis
refers
to
bidirectional
relationship
between
and
health.
This
is
regulated
through
several
mechanisms
inflammatory
mediators
immune
system.
Dysregulation
microbiota
been
seen
numerous
conditions
atopic
dermatitis,
rosacea,
Understanding
how
are
involved
regulating
health
may
lead
novel
therapies
for
these
modulation,
particularly
In
this
review,
we
will
compare
psoriasis
patients
healthy
control,
explain
concept
effects
dysbiosis
on
physiology.
We
also
review
current
evidence
using
probiotics