Light Science & Applications,
Год журнала:
2021,
Номер
10(1)
Опубликована: Май 28, 2021
Abstract
Circulating
tumor
cells
(CTCs)
is
an
established
biomarker
of
cancer
metastasis.
The
circulation
dynamics
CTCs
are
important
for
understanding
the
mechanisms
underlying
cell
dissemination.
Although
studies
have
revealed
that
circadian
rhythm
may
disrupt
growth
tumors,
it
generally
unclear
whether
controls
release
CTCs.
In
clinical
examinations,
current
in
vitro
methods
detecting
blood
samples
based
on
a
fundamental
assumption
CTC
counts
peripheral
do
not
change
significantly
over
time,
which
being
challenged
by
recent
studies.
Since
practical
to
draw
from
patients
repeatedly,
feasible
strategy
investigate
monitor
them
vivo
detection
methods.
Fluorescence
flow
cytometry
(IVFC)
powerful
optical
technique
able
detect
fluorescent
circulating
directly
living
animals
noninvasive
manner
long
period
time.
this
study,
we
applied
fluorescence
IVFC
noninvasively
orthotopic
mouse
model
human
prostate
cancer.
We
observed
exhibited
stochastic
bursts
progression.
probability
bursting
activity
was
higher
at
early
stages
than
late
stages.
longitudinally
monitored
24-h
period,
and
our
results
striking
daily
oscillations
peaked
onset
night
(active
phase
rodents),
suggesting
might
be
regulated
rhythm.
Signal Transduction and Targeted Therapy,
Год журнала:
2020,
Номер
5(1)
Опубликована: Март 12, 2020
Abstract
Metastasis
is
the
hallmark
of
cancer
that
responsible
for
greatest
number
cancer-related
deaths.
Yet,
it
remains
poorly
understood.
The
continuous
evolution
biology
research
and
emergence
new
paradigms
in
study
metastasis
have
revealed
some
molecular
underpinnings
this
dissemination
process.
invading
tumor
cell,
on
its
way
to
target
site,
interacts
with
other
proteins
cells.
Recognition
these
interactions
improved
understanding
biological
principles
metastatic
cell
govern
mobility
plasticity.
Communication
microenvironment
allows
cells
overcome
stromal
challenges,
settle,
colonize.
These
characteristics
are
driven
by
genetic
epigenetic
modifications
within
itself
microenvironment.
Establishing
mechanisms
process
crucial
finding
open
therapeutic
windows
successful
interventions.
In
review,
authors
explore
recent
advancements
field
highlight
latest
insights
contribute
shaping
cancer.
Cancer Discovery,
Год журнала:
2020,
Номер
10(3), С. 371 - 381
Опубликована: Янв. 9, 2020
Glioblastoma
(GBM)
is
a
lethal
brain
tumor
containing
subpopulation
of
glioma
stem
cells
(GSC).
Pan-cancer
analyses
have
revealed
that
stemness
cancer
correlates
positively
with
immunosuppressive
pathways
in
many
solid
tumors,
including
GBM,
prompting
us
to
conduct
gain-of-function
screen
epigenetic
regulators
may
influence
GSC
self-renewal
and
immunity.
The
circadian
regulator
CLOCK
emerged
as
top
hit
enhancing
stem-cell
self-renewal,
which
was
amplified
about
5%
human
GBM
cases.
its
heterodimeric
partner
BMAL1
enhanced
triggered
protumor
immunity
via
transcriptional
upregulation
OLFML3,
novel
chemokine
recruiting
immune-suppressive
microglia
into
the
microenvironment.
In
models,
or
OLFML3
depletion
reduced
intratumoral
density
extended
overall
survival.
We
conclude
CLOCK-BMAL1
complex
contributes
key
hallmarks
maintenance
immunosuppression
and,
together
downstream
target
represents
new
therapeutic
targets
for
this
disease.
SIGNIFICANCE:
Circadian
drives
metabolism
promotes
infiltration
through
direct
regulation
microglia-attracting
chemokine,
OLFML3.
and/or
represent
GBM.This
article
highlighted
This
Issue
feature,
p.
327.
Cell Metabolism,
Год журнала:
2022,
Номер
34(2), С. 329 - 345.e8
Опубликована: Янв. 13, 2022
Tissue
sensitivity
and
response
to
exercise
vary
according
the
time
of
day
alignment
circadian
clocks,
but
optimal
elicit
a
desired
metabolic
outcome
is
not
fully
defined.
To
understand
how
tissues
independently
collectively
respond
timed
exercise,
we
applied
systems
biology
approach.
We
mapped
compared
global
metabolite
responses
seven
different
mouse
serum
after
an
acute
bout
performed
at
times
day.
Comparative
analyses
intra-
inter-tissue
dynamics,
including
temporal
profiling
blood
sampling
across
liver
hindlimb
muscles,
uncovered
unbiased
view
local
systemic
unique
This
comprehensive
atlas
metabolism
provides
clarity
physiological
context
regarding
production
distribution
canonical
novel
time-dependent
exerkine
metabolites,
such
as
2-hydroxybutyrate
(2-HB),
reveals
insight
into
health-promoting
benefits
on
metabolism.
Cell Death Discovery,
Год журнала:
2024,
Номер
10(1)
Опубликована: Апрель 27, 2024
Abstract
Circadian
rhythms
are
present
in
almost
all
cells
and
play
a
crucial
role
regulating
various
biological
processes.
Maintaining
stable
circadian
rhythm
is
essential
for
overall
health.
Disruption
of
this
can
alter
the
expression
clock
genes
cancer-related
genes,
affect
many
metabolic
pathways
factors,
thereby
affecting
function
immune
system
contributing
to
occurrence
progression
tumors.
This
paper
aims
elucidate
regulatory
effects
BMAL1,
other
on
cells,
reveal
molecular
mechanism
rhythm’s
involvement
tumor
its
microenvironment
regulation.
A
deeper
understanding
has
potential
provide
new
strategies
treatment
cancer
immune-related
diseases.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Янв. 15, 2024
Abstract
Ageing
is
often
characterised
by
progressive
accumulation
of
damage,
and
it
one
the
most
important
risk
factors
for
chronic
disease
development.
Epigenetic
mechanisms
including
DNA
methylation
could
functionally
contribute
to
organismal
aging,
however
key
functions
biological
processes
may
govern
ageing
are
still
not
understood.
Although
age
predictors
called
epigenetic
clocks
can
accurately
estimate
an
individual
based
on
cellular
methylation,
their
models
have
limited
ability
explain
prediction
algorithm
behind
underlying
controlling
ageing.
Here
we
present
XAI-AGE,
a
biologically
informed,
explainable
deep
neural
network
model
accurate
across
multiple
tissue
types.
We
show
that
XAI-AGE
outperforms
first-generation
achieves
similar
results
learning-based
models,
while
opening
up
possibility
infer
meaningful
insights
activity
pathways
other
abstract
directly
from
model.
The
intricate
relationship
between
cancer,
circadian
rhythms,
and
aging
is
increasingly
recognized
as
a
critical
factor
in
understanding
the
mechanisms
underlying
tumorigenesis
cancer
progression.
Aging
well-established
primary
risk
for
while
disruptions
rhythms
are
intricately
associated
with
progression
of
various
tumors.
Moreover,
itself
disrupts
leading
to
physiological
changes
that
may
accelerate
development.
Despite
these
connections,
specific
interplay
processes
their
collective
impact
on
remains
inadequately
explored
literature.
In
this
review,
we
systematically
explore
influence
We
discuss
how
core
genes
tumor
prognosis,
highlighting
shared
hallmarks
such
genomic
instability,
cellular
senescence,
chronic
inflammation.
Furthermore,
examine
aging,
focusing
crosstalk
contributes
tumorigenesis,
proliferation,
apoptosis,
well
metabolism
stability.
By
elucidating
common
pathways
linking
review
provides
new
insights
into
pathophysiology
identifies
potential
therapeutic
strategies.
propose
targeting
regulation
could
pave
way
novel
treatments,
including
chronotherapy
antiaging
interventions,
which
offer
important
benefits
clinical
management
cancer.
