Clinical Nutrition, Год журнала: 2022, Номер 41(8), С. 1660 - 1666
Опубликована: Июнь 18, 2022
Язык: Английский
Nature Aging, Год журнала: 2022, Номер 2(11), С. 1024 - 1039
Опубликована: Ноя. 17, 2022
Язык: Английский
Процитировано
46
Advanced Science, Год журнала: 2023, Номер 10(9)
Опубликована: Фев. 3, 2023
Overnutrition is a risk factor for various human diseases, including neurodegenerative metabolic disorders, and cancers. Therefore, targeting overnutrition represents simple but attractive strategy the treatment of these increasing public health threats. Fasting as dietary intervention combating has been extensively studied. practiced millennia, only recently have its roles in molecular clock, gut microbiome, tissue homeostasis function emerged. can slow aging most species protect against These centuried unfading adventures explorations suggest that fasting potential to delay help prevent treat diseases while minimizing side effects caused by chronic interventions. In this review, recent animal studies concerning role underlying mechanism physiology pathology are summarized, therapeutic highlighted, combination pharmacological discussed new regimen diseases.
Язык: Английский
Процитировано
38
Trends in Endocrinology and Metabolism, Год журнала: 2023, Номер 34(8), С. 489 - 501
Опубликована: Июнь 17, 2023
Cancer remains the second leading cause of mortality, with nearly 10 million deaths worldwide in 2020. In many cases, radiotherapy is used for its anticancer effects. However, radiation causes healthy tissue toxicity as a side effect. intra-abdominal and pelvic malignancies, bowel inevitably included field, causing radiation-induced enteritis dramatically affecting gut microbiome. This condition associated significant morbidity mortality that impairs cancer patients' survivors' quality life. Review provides critical overview main drivers modulating microenvironment homeostasis, disease, injury, focusing on microbial metabolites microorganisms influence epithelial regeneration upon injury.
Язык: Английский
Процитировано
37
Frontiers in Nutrition, Год журнала: 2023, Номер 10
Опубликована: Июнь 29, 2023
Dementia is a growing public health concern, with an estimated prevalence of 57 million adults worldwide. Alzheimer’s disease (AD) accounts for 60–80% the cases. Clinical trials testing potential drugs and neuroprotective agents have proven futile, currently approved only provide symptomatic benefits. Emerging epidemiological clinical studies suggest that lifestyle changes, including diet physical activity, offer alternative therapeutic route slowing preventing cognitive decline dementia. Age single most common risk factor dementia, it associated cellular bioenergetics metabolic processes. Therefore, nutrient-rich critical optimal brain health. Furthermore, type 2 diabetes (T2D) AD, diets reduce T2D may confer neuroprotection. Foods predominant in Mediterranean, MIND, DASH diets, fruits, leafy green vegetables, fish, nuts, olive oil, prevent or slow decline. The mechanisms by which these nutrients promote health, however, are not yet completely understood. Other dietary approaches eating regimes, ketogenic intermittent fasting, also emerging as beneficial This review summarizes pathophysiology, factors, pathways activated several regimes shown promising results promoting
Язык: Английский
Процитировано
35
Advances in Nutrition, Год журнала: 2023, Номер 14(5), С. 1211 - 1225
Опубликована: Июль 30, 2023
Each cell is equipped with a conserved housekeeping mechanism, known as autophagy, to recycle exhausted materials and dispose of injured organelles via lysosomal degradation. Autophagy an early-stage cellular response stress stimuli in both physiological pathological situations. It thought that the promotion autophagy flux prevents host cells from subsequent injuries by removing damaged misfolded proteins. As correlate, modulation suggested therapeutic approach diverse conditions. Accumulated evidence suggests intermittent fasting or calorie restriction can lead induction adaptive increase longevity eukaryotic cells. However, prolonged excessive harmful stimulate type II autophagic death. Despite existence close relationship between deprivation different types, precise molecular mechanisms associated this phenomenon remain unclear. Here, we aimed highlight possible effects short-term on homeostasis.
Язык: Английский
Процитировано
32
MedComm, Год журнала: 2023, Номер 4(1)
Опубликована: Фев. 1, 2023
Abstract For centuries, the search for nutritional interventions to underpin cardiovascular treatment and prevention guidelines has contributed rapid development of field dietary patterns cardiometabolic disease (CMD). Numerous studies have demonstrated that healthy with emphasis on food‐based recommendations are gold standard extending lifespan reducing risks CMD mortality. Healthy include various permutations energy restriction, macronutrients, food intake such as calorie intermittent fasting, Mediterranean diet, plant‐based diets, etc. Early implementation in patients is encouraged, but an understanding mechanisms by which these trigger benefits remains incomplete. Hence, this review examined several may improve health, including restrictive patterns, regional diets based controlled macronutrients groups, summarizing cutting‐edge evidence potential treatment. Particularly, considering individual differences responses composition changes organ tissue diversity, we highlighted critical role gut microbiota crosstalk between diet recommend a more precise dynamic strategy developing profiles.
Язык: Английский
Процитировано
29
Nutrients, Год журнала: 2023, Номер 15(16), С. 3525 - 3525
Опубликована: Авг. 10, 2023
Over the last decade, studies suggested that dietary behavior modification, including fasting, can improve metabolic and cardiovascular markers as well body composition. Given increasing prevalence of people with type 1 (T1DM) 2 diabetes mellitus (T2DM) obesity (also in combination diabetes), nutritional therapies are gaining importance, besides pharmaceutical interventions. Fasting has demonstrated beneficial effects for both healthy individuals those diseases, leading to increased research interest its impact on glycemia associated short- long-term complications. Therefore, this review aimed investigate whether fasting be used safely effectively addition medications support therapy T1DM T2DM. A literature search interaction was conducted via PubMed September 2022. potential minimize risk hypoglycemia T1DM, lower glycaemic variability, fat metabolism It also increases insulin sensitivity, reduces endogenous glucose production diabetes, lowers weight, improves To conclude, is efficient management T2DM performed, when necessary, health care professionals.
Язык: Английский
Процитировано
24
Nutrients, Год журнала: 2024, Номер 16(2), С. 316 - 316
Опубликована: Янв. 20, 2024
Intermittent fasting (IF) and caloric restriction (CR) are dietary strategies to prevent attenuate obesity associated with conditions aging-related outcomes. This scoping review examined the cardiometabolic, cancer, neurocognitive outcome differences between IF CR interventions among adults. We applied a systematic approach scope published randomized controlled trials (databases: PubMed, CINAHL Plus, PsychInfo, Scopus, Google Scholar) from inception through August 2023. The initial search provided 389 unique articles which were critically appraised. Thirty met eligibility criteria for inclusion: 12 IF, 10 CR, 8 combined interventions. weight loss; however, studies tended report greater adherence compared CR. Overall, equivalently effective across Our findings suggest that has health benefits in variety of may be better accepted tolerated than but more comparative research is required.
Язык: Английский
Процитировано
13
Canadian Journal of Cardiology, Год журнала: 2024, Номер 40(8), С. 1445 - 1457
Опубликована: Фев. 12, 2024
Population aging and the associated increase in cardiovascular disease rates pose serious threats to global public health. Different forms of fasting have become an increasingly attractive strategy directly address potentially limit or delay onset diseases. A growing number experimental studies clinical trials indicate that amount timing food intake as well daily time window during which is consumed, are crucial determinants Indeed, intermittent counteracts molecular hallmarks promotes different aspects cardiometabolic health, including blood pressure glycemic control, body weight reduction. Here, we summarize current evidence from randomized on composition metabolic risk factors. Moreover, critically discuss preventive therapeutic potential fasting, but also possible detrimental effects context related disease. We delve into physiological mechanisms through might improve raise important factors consider design examining efficacy reduce major adverse events among aged individuals at high conclude despite interest both lay scientific communities health-improving further research efforts appropriate caution warranted before broadly implementing regimens, especially elderly.
Язык: Английский
Процитировано
13
Diabetes Obesity and Metabolism, Год журнала: 2024, Номер 26(9), С. 3830 - 3841
Опубликована: Июль 2, 2024
Abstract Aim To perform a meta‐analysis to investigate the effects of intermittent fasting (IF), as compared with either control diet (CON) and/or calorie restriction (CR), on body composition and cardiometabolic health in individuals prediabetes type 2 diabetes (T2D). Methods PubMed, Web Science, Scopus were searched from their inception March 2024 identify original randomized trials parallel or crossover designs that studied IF health. Weighted mean differences (WMDs) standardized 95% confidence intervals (CIs) calculated using random‐effects models. Results Overall, 14 studies involving 1101 adults T2D included meta‐analysis. decreased weight (WMD −4.56 kg [95% CI −6.23 −2.83]; p = 0.001), mass index (BMI; WMD −1.99 kg.m −2.74 −1.23]; glycated haemoglobin (HbA1c; −0.81% −1.24 −0.38]; glucose −0.36 mmol/L −0.63 −0.09]; 0.008), total cholesterol −0.31 −0.60 −0.02]; 0.03) triglycerides −0.14 −0.27 −0.01]; 0.02), but did not significantly decrease fat mass, insulin, low‐densitiy lipoprotein, high‐density blood pressure CON. Furthermore, −1.14 −1.69 −0.60]; 0.001) BMI −0.43 −0.58 −0.27]; affect lean visceral fat, HbA1c, lipid profiles pressure. Conclusion Intermittent is effective for loss specific markers T2D. Additionally, associated reduction CR, without glycaemic markers,
Язык: Английский
Процитировано
11