Neural Regeneration Research,
Год журнала:
2023,
Номер
19(6), С. 1189 - 1190
Опубликована: Сен. 22, 2023
Division
of
Physiology,
School
Medicine,
Universidad
de
Cadiz,
Spain
(Hierro-Bujalance
C,
Garcia-Alloza
M)
Instituto
Investigacion
e
Innovacion
en
Ciencias
Biomedicas
la
Provincia
Cadiz
(INIBICA),
Salus
Infirmorum-Universidad
C)
*Correspondence
to:
Monica
Garcia-Alloza,
PhD,
[email
protected].
This
is
an
open-access
article
distributed
under
the
terms
Creative
Commons
Attribution-Noncommercial-Share
Alike
4.0
Unported,
which
permits
unrestricted
use,
distribution,
and
reproduction
in
any
medium,
provided
original
work
properly
cited.
The
advent
of
highthroughput
‘omics’
technologies
has
improved
our
knowledge
gut
microbiome
in
human
health
and
disease,
including
Alzheimer’s
disease
(AD),
a
neurodegenerative
disorder.
Frequent
bidirectional
communications
mutual
regulation
exist
between
the
gastrointestinal
tract
central
nervous
system
through
gut-brain
axis.
A
large
body
research
reported
close
association
microbiota
AD
development,
restoring
healthy
may
curb
or
even
improve
symptoms
progression.
Thus,
modulation
become
novel
paradigm
for
clinical
management
AD,
emerging
effort
focused
on
developing
potential
strategies
preventing
and/or
treating
disease.
In
this
review,
we
provide
an
overview
connection
causal
relationship
dysbiosis
mechanisms
driving
progression,
successes
challenges
implementing
available
microbiome-targeted
therapies
(including
probiotics,
prebiotics,
synbiotics,
postbiotics,
fecal
transplantation)
preventive
therapeutic
preclinical
intervention
studies
AD.
Finally,
discuss
future
directions
field.
Nutrition & Metabolism,
Год журнала:
2024,
Номер
21(1)
Опубликована: Март 19, 2024
Abstract
Context
Resveratrol
(RV),
a
natural
compound
found
in
grapes,
berries,
and
peanuts,
has
been
extensively
studied
for
its
potential
treating
Alzheimer’s
disease
(AD).
RV
shown
promise
inhibiting
the
formation
of
beta-amyloid
plaques
(Aβ)
neurofibrillary
tangles
(NFTs),
protecting
against
neuronal
damage
oxidative
stress,
reducing
inflammation,
promoting
neuroprotection,
improving
function
blood–brain
barrier
(BBB).
However,
conflicting
results
have
reported,
necessitating
comprehensive
umbrella
review
systematic
reviews
to
provide
an
unbiased
conclusion
on
therapeutic
effectiveness
AD.
Objective
The
objective
this
study
was
systematically
synthesize
evaluate
meta-analysis
investigating
role
AD
using
data
from
both
human
animal
studies.
Data
sources
extraction
Of
34
examining
association
between
that
were
collected,
six
included
based
specific
selection
criteria.
To
identify
pertinent
studies,
search
conducted
English-language
peer-reviewed
journals
without
any
restrictions
publication
date
until
October
15,
2023.
carried
out
across
multiple
databases,
including
Embase,
MEDLINE
(PubMed),
Cochrane
Library,
Web
Science,
Google
Scholar,
utilizing
appropriate
terms
relevant
research
field.
AMSTAR-2
ROBIS
tools
also
used
quality
risk
bias
reviews,
respectively.
Two
researchers
independently
extracted
analyzed
data,
resolving
discrepancies
through
consensus.
note,
adhered
PRIOR
checklist.
analysis
This
presented
robust
evidence
supporting
positive
impacts
AD,
irrespective
mechanisms
involved.
It
indeed
indicated
all
unanimously
concluded
consumption
can
be
effective
treatment
Conclusion
exhibits
promising
benefiting
individuals
with
various
mechanisms.
observed
enhance
cognitive
function,
reduce
Aβ
accumulation,
protect
BBB,
support
mitochondrial
facilitate
synaptic
plasticity,
stabilize
tau
proteins,
mitigate
neuroinflammation
commonly
associated
Graphical
abstract
Ageing Research Reviews,
Год журнала:
2024,
Номер
95, С. 102210 - 102210
Опубликована: Фев. 1, 2024
Alzheimer's
disease
(AD)
is
a
major
global
health
problem
today
and
the
most
common
form
of
dementia.
AD
characterized
by
formation
β-amyloid
(Aβ)
plaques
neurofibrillary
clusters,
leading
to
decreased
brain
acetylcholine
levels
in
brain.
Another
mechanism
underlying
pathogenesis
abnormal
phosphorylation
tau
protein
that
accumulates
at
level
aggregates,
areas
affected
this
pathological
process
are
usually
cholinergic
neurons
cortical,
subcortical,
hippocampal
areas.
These
effects
result
cognitive
function,
atrophy,
neuronal
death.
Malnutrition
weight
loss
frequent
manifestations
AD,
these
also
associated
with
greater
decline.
Several
studies
have
confirmed
balanced
low-calorie
diet
proper
nutritional
intake
may
be
considered
important
factors
counteracting
or
slowing
progression
whereas
high-fat
hypercholesterolemic
predisposes
an
increased
risk
developing
AD.
Especially,
fruits,
vegetables,
antioxidants,
vitamins,
polyunsaturated
fatty
acids,
micronutrients
supplementation
exert
positive
on
aging-related
changes
due
their
antioxidant,
anti-inflammatory,
radical
scavenging
properties.
The
purpose
review
summarize
some
possible
contribute
prevention
understand
role
nutrition
plays
Aβ
typical
neurodegenerative
disease,
identify
potential
therapeutic
strategies
involve
natural
compounds,
delaying
disease.
Antioxidants,
Год журнала:
2024,
Номер
13(5), С. 606 - 606
Опубликована: Май 15, 2024
Epigenetics
defines
changes
in
cell
function
without
involving
alterations
DNA
sequence.
Neuroepigenetics
bridges
neuroscience
and
epigenetics
by
regulating
gene
expression
the
nervous
system
its
impact
on
brain
function.
With
increase
research
recent
years,
it
was
observed
that
did
not
always
originate
from
genetic
sequence,
which
has
led
to
understanding
role
of
neurodegenerative
diseases
(NDDs)
including
Alzheimer's
disease
(AD)
Parkinson's
(PD).
Epigenetic
contribute
aberrant
genes
involved
neuroinflammation,
protein
aggregation,
neuronal
death.
Natural
phytochemicals
have
shown
promise
as
potential
therapeutic
agents
against
NDDs
because
their
antioxidant,
anti-inflammatory,
neuroprotective
effects
cellular
animal
models.
For
instance,
resveratrol
(grapes),
curcumin
(turmeric),
epigallocatechin
gallate
(EGCG;
green
tea)
exhibit
through
influence
methylation
patterns,
histone
acetylation,
non-coding
RNA
profiles.
Phytochemicals
also
aid
slowing
progression,
preserving
function,
enhancing
cognitive
motor
abilities.
The
present
review
focuses
various
epigenetic
modifications
pathology
NDDs,
AD
PD,
regulation
related
alterations,
specific
polyphenols
influencing
PD.
Aging Clinical and Experimental Research,
Год журнала:
2024,
Номер
36(1)
Опубликована: Авг. 20, 2024
Cognitive
impairment
is
projected
to
affect
a
preponderant
proportion
of
the
aging
population.
Lifelong
dietary
habits
have
been
hypothesized
play
role
in
preventing
cognitive
decline.
Among
most
studied
components,
fish
consumptionhas
extensively
for
its
potential
effects
on
human
brain.
Nutrients,
Год журнала:
2024,
Номер
16(11), С. 1589 - 1589
Опубликована: Май 23, 2024
The
rhizomes
of
Acorus
tatarinowii
Schott
and
gramineus
Solander
are
widely
used
for
treating
amnesia
in
traditional
Chinese
medicine.
In
contrast,
their
leaves
usually
discarded
without
medicinal
properties
being
known.
Here,
we
found
that
the
hot
water
extract
improved
cognition
tau
pathology
model
mice
frontotemporal
dementia,
similar
to
or
even
better
than
rhizomes.
To
explore
optimal
method
processing,
made
three
preparations
from
dried
leaves:
extract,
extraction
residue,
non-extracted
simple
crush
powder.
Among
them,
powder
had
strongest
effect
on
tauopathy
mice.
also
ameliorated
Aβ
α-synuclein
pathologies
restored
mouse
models
Alzheimer’s
disease
dementia
with
Lewy
bodies.
These
findings
suggest
potential
tatarinowii/gramineus
as
a
dietary
source
prevention
reveal
crushing
is
way
maximize
efficacy.
World Journal of Psychiatry,
Год журнала:
2025,
Номер
15(2)
Опубликована: Янв. 14, 2025
BACKGROUND
Body
composition
analysis
(BCA)
is
primarily
used
in
the
management
of
conditions
such
as
obesity
and
endocrine
disorders.
However,
its
potential
providing
nutritional
guidance
for
patients
with
Alzheimer’s
disease
(AD)
remains
relatively
unexplored.
AIM
To
explore
clinical
efficacy
BCA-based
dietary
nutrition
scheme
on
bone
metabolism
AD
patients.
METHODS
This
retrospective
study
included
96
complicated
by
osteoporosis
who
were
admitted
to
The
Third
Hospital
Quzhou
between
January
2023
December
2024.
Based
data
from
previous
similar
studies,
randomly
assigned
either
a
routine
diet
(RD)
group
(n
=
48)
or
personalized
(PN)
48).
RD
received
conventional
guidance,
while
PN
individualized
intervention
measures
based
human
BCA.
period
lasted
12
weeks.
Bone
mineral
density
(BMD),
body
mass
index
(BMI),
muscle
mass,
content,
osteocalcin,
25-hydroxyvitamin
D,
procollagen
type
I
N-terminal
propeptide
(PINP),
beta
C-terminal
telopeptide
collagen
(β-CTX),
serum
calcium
measured
compared
two
groups
before
weeks
after
intervention.
RESULTS
No
significant
differences
observed
terms
age,
sex,
height,
BMI,
other
baseline
(P
>
0.05).
In
both
groups,
BMI
did
not
show
changes
0.05),
whereas
content
significantly
increased
<
After
intervention,
differ
that
group,
but
higher
proportion
had
T
score
-1
mini-mental
state
examination
(MMSE)
was
MMSE
than
post-intervention
pre-intervention
levels
Before
calcium,
PINP,
β-CTX,
D
different
exhibited
well
lower
PINP
higher,
β-CTX
CONCLUSION
regimen
plays
crucial
role
improving
BMD
metabolism,
effects
surpass
those
strategies.
findings
this
provide
strong
evidence
