Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(18), С. 16820 - 16834
Опубликована: Сен. 5, 2024
bioimaging using shortwave infrared (SWIR) (1000-2000 nm) molecular dyes enables deeper penetration and higher contrast compared to visible near-infrared-I (NIR-I, 700-900 dyes. Developing new SWIR molecules is still quite challenging. This study developed
Язык: Английский
Nature Reviews Clinical Oncology, Год журнала: 2024, Номер 21(6), С. 449 - 467
Опубликована: Май 1, 2024
Язык: Английский
Процитировано
78
Chemical Reviews, Год журнала: 2023, Номер 124(2), С. 554 - 628
Опубликована: Ноя. 22, 2023
In vivo imaging technologies have emerged as a powerful tool for both fundamental research and clinical practice. particular, luminescence in the tissue-transparent near-infrared (NIR, 700–1700 nm) region offers tremendous potential visualizing biological architectures pathophysiological events living subjects with deep tissue penetration high contrast owing to reduced light–tissue interactions of absorption, scattering, autofluorescence. The distinctive quantum effects nanocrystals been harnessed achieve exceptional photophysical properties, establishing them promising category luminescent probes. this comprehensive review, between light tissues, well advantages NIR imaging, are initially elaborated. Subsequently, we focus on achieving improved by optimizing performance nanocrystal fluorophores. ingenious design strategies probes discussed, along their respective biomedical applications versatile modalities. Finally, thought-provoking reflections challenges prospects future translation nanocrystal-based wisely provided.
Язык: Английский
Процитировано
64
Chemical Reviews, Год журнала: 2024, Номер 124(7), С. 4021 - 4078
Опубликована: Март 22, 2024
Fluorescence imaging is one of the most promising approaches to achieve intraoperative assessment tumor/normal tissue margins during cancer surgery. This critical improve patients' prognosis, and therefore various molecular fluorescence probes have been developed for identification lesions Among them, "activatable" that react with cancer-specific biomarker enzymes generate signals great potential high-contrast due their low background high signal amplification by enzymatic turnover. Over past two decades, activatable employing control mechanisms worldwide this purpose. Furthermore, new activities specific types cancers identified, enabling visualization sensitivity specificity. Review focuses on recent advances in design, function characteristics target also discusses future prospects field activity-based diagnostics cancer.
Язык: Английский
Процитировано
33
Nature Nanotechnology, Год журнала: 2023, Номер 19(1), С. 124 - 130
Опубликована: Сен. 11, 2023
Язык: Английский
Процитировано
27
Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(48)
Опубликована: Окт. 2, 2023
An accurate detection of lung metastasis is great significance for making better treatment choices and improving cancer prognosis, but remains a big challenge in clinical practice. In this study, we propose reinventing strategy to develop pH-activatable near-infrared (NIR) fluorescent nanoprobe, pulmonary tracer (denoted as PMT), based on assembly NIR dye IR780 calcium phosphate (CaP). By delicately tuning the intermolecular interactions during process doping content, well synthetic condition probe, fluorescence PMT could be finely adjusted via tumor acidity-triggered disassembly. Notably, selected PMT9 sharply convert subtle pH variations into distinct signal generate high ON/OFF contrast, dramatically reducing background signals. Benefiting from such preferable features, able precisely identify not only sites orthotopic models also metastases mice with remarkable signal-to-background ratio (SBR). This study provides unique turn shortcomings traditional vivo imaging advantages further expand application probe image associated lesions.
Язык: Английский
Процитировано
27
Nano Letters, Год журнала: 2024, Номер 24(20), С. 6131 - 6138
Опубликована: Май 10, 2024
Accurate intraoperative tumor delineation is critical to achieving successful surgical outcomes. However, conventional techniques typically suffer from poor specificity and low sensitivity are time-consuming, which greatly affects decision-making. Here, we report a cascade activatable near-infrared fluorescent (NIRF) probe IR780SS@CaP that can sequentially respond acidity elevated glutathione levels for accurate localization. Compared with nonactivatable single-factor probes, strategy minimize nonspecific activation false positive signals in complicated biological environment, affording superior tumor-to-normal tissue ratio facilitate the of abdominal metastases. Small metastatic lesions were less than 1 mm diameter be precisely identified by completely excised under NIRF imaging guidance. This study could benefit diagnosis image-guided surgery providing real-time information reliable decision support, thus reducing risk both recurrence complications improve patient
Язык: Английский
Процитировано
9
Advanced Materials, Год журнала: 2024, Номер 36(31)
Опубликована: Май 23, 2024
High-performance fluorescent probes stand as indispensable tools in fluorescence-guided imaging, and are crucial for precise delineation of focal tissue while minimizing unnecessary removal healthy tissue. Herein, machine-learning-assisted strategy to investigate the current available xanthene dyes is first proposed, a quantitative prediction model guide rational synthesis novel molecules with desired pH responsivity constructed. Two Si─rhodamine derivatives successfully achieved cathepsin/pH sequentially activated probe Si─rhodamine─cathepsin-pH (SiR─CTS-pH) The results reveal that SiR─CTS-pH exhibits higher signal-to-noise ratio fluorescence compared single or cathepsin-activated probe. Moreover, shows strong differentiation abilities tumor cells tissues accurately discriminates complex hepatocellular carcinoma from normal ones, indicating its significant application potential clinical practice. Therefore, continuous development design superior through broaden path provide more advanced methods researchers.
Язык: Английский
Процитировано
9
Theranostics, Год журнала: 2024, Номер 14(2), С. 819 - 829
Опубликована: Янв. 1, 2024
Purpose: Lower-grade gliomas (LGGs) are a group of infiltrative growing glial brain tumors characterized by intricate intratumoral heterogeneity and subtle visual appearance differences from non-tumor tissue, which can lead to errors in pathologic tissue sampling.Although 5-ALA fluorescence has been an essential method for visualizing during surgery, its effectiveness is limited the case LGGs due low sensitivity.Therefore, we developed novel PET/NIR dual-modality image probe targeting gastrin-releasing peptide receptor (GRPR) glioma cells enhance tumor visualization improve accuracy sampling.Methods: A prospective, non-randomized, single-center feasibility clinical trial (NCT 03407781) was conducted referral center October 21, 2016, August 17, 2018.Consecutive enrollment included patients suspected having considered suitable candidates surgical removal.Group 1 comprised ten who underwent preoperative 68 Ga-IRDye800CW-BBN PET/MRI assessment followed intraoperative fluorescence-guided surgery.Group 2 42 IRDye800CW-BBN surgery.The primary endpoints were predictive value PET imaging sensitivity specificity sampling.Results: Thirty-nine in-depth analysis endpoints, with 25 (64.1%)exhibiting visible fluorescence, while 14 (35.9%) did not.The positive uptake exhibited greater predicting compared MRI enhancement (100% [10/10] vs. 87.2%
Язык: Английский
Процитировано
8
Frontiers in Immunology, Год журнала: 2025, Номер 15
Опубликована: Янв. 10, 2025
Prostate-Specific Membrane Antigen (PSMA) is a highly expressed and structurally unique target specific to prostate cancer (PCa). Diagnostic therapeutic approaches in nuclear medicine, coupling PSMA ligands with radionuclides, have shown significant clinical success. PSMA-PET/CT effectively identifies tumors metastatic lymph nodes for imaging purposes, while 177Lu-PSMA-617 (Pluvicto) has received FDA approval treating castration-resistant PCa (mCRPC). Despite their success, radionuclide-based diagnostic methods face limitations such as high costs side effects. Recently, near-infrared (NIR) fluorescence phototherapy advanced significantly biomedical applications. It's benefits, deep tissue penetration, real-time precision, minimal effects, driven broader adoption, especially fluorescence-guided surgery (FGS). This review suggests combining NIR dyes enable targeted, high-resolution superior signal-to-background ratios, facilitating precise FGS. techniques can also aid pathological diagnosis ex vivo specimens. Furthermore, photosensitizers allows localized photothermal (PTT) or photodynamic therapy (PDT) under irradiation, producing heat reactive oxygen species (ROS) treat PCa. aims extend the success of targeting by exploring advances NIR-based FGS phototherapy, presenting promising new approach.
Язык: Английский
Процитировано
1
Military Medical Research, Год журнала: 2025, Номер 12(1)
Опубликована: Фев. 11, 2025
Abstract Cancer recurrence, driven by the phenomenon of tumor dormancy, presents a formidable challenge in oncology. Dormant cancer cells have ability to evade detection and treatment, leading relapse. This review emphasizes urgent need comprehend dormancy its implications for recurrence. Despite notable advancements, significant gaps remain our understanding mechanisms underlying lack reliable biomarkers predicting provides comprehensive analysis cellular, angiogenic, immunological aspects dormancy. It highlights current therapeutic strategies targeting dormant cells, particularly combination therapies immunotherapies, which hold promise preventing By elucidating these proposing innovative research methodologies, this aims deepen ultimately facilitating development more effective recurrence improving patient outcomes.
Язык: Английский
Процитировано
1