Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Авг. 8, 2022
Ginseng
(
Panax
ginseng
)
is
a
perennial
herbaceous
plant
belonging
to
genus
of
Araliaceae.
Ginsenosides
are
kind
important
compounds
in
and
minor
ginsenosides
secondary
metabolic
derivatives
ginsenosides.
Studies
have
shown
that
many
pharmacological
effects,
such
as
antioxidant,
anti-tumor,
anti-platelet
aggregation,
neuroprotective
effects.
However,
the
therapeutic
effects
limited
due
poor
solubility
water,
short
half-life,
targeting
accuracy.
In
recent
years,
improve
application
efficiency,
research
on
nanocrystallization
attracted
extensive
attention
from
researchers.
This
review
focuses
classification,
preparation
methods,
action
mechanisms
ginsenoside
nanoparticles,
well
existing
problems
future
direction
relevant
research,
which
provides
reference
for
in-depth
nanoparticles.
Cancers,
Год журнала:
2020,
Номер
12(1), С. 113 - 113
Опубликована: Янв. 1, 2020
Piceatannol
(PIC)
is
known
to
have
anticancer
activity,
which
has
been
attributed
its
ability
block
the
proliferation
of
cancer
cells
via
suppression
NF-kB
signaling
pathway.
However,
effect
on
hypoxia-inducible
factor
(HIF)
not
well
in
cancer.
In
this
study,
PIC
was
loaded
into
bovine
serum
albumin
(BSA)
by
desolvation
method
as
PIC-BSA
nanoparticles
(NPs).
These
were
assessed
for
vitro
cytotoxicity,
migration,
invasion,
and
colony
formation
studies
levels
p65
HIF-1α.
Our
results
indicate
that
NPs
more
effective
downregulating
expression
nuclear
HIF-1α
colon
compared
free
PIC.
We
also
observed
a
significant
reduction
inflammation
induced
chemical
colitis
mice
NPs.
Furthermore,
tumor
size
number
tumors
murine
model
colitis-associated
colorectal
cancer,
when
treated
with
The
overall
PIC,
formulated
NPs,
enhances
therpautice
potential.
work
could
prompt
further
research
using
natural
agents
nanoparticels
possiable
human
clinical
trails.
This
lead
development
new
line
safe
therapeutics
patients.
RSC Advances,
Год журнала:
2024,
Номер
14(11), С. 7338 - 7349
Опубликована: Янв. 1, 2024
Schematic
representation
of
synthesis
process
Folic
Acid
(FA)
conjugated
Bovine
Serum
Albumin
(BSA)
nanoparticles
for
the
delivery
Fisetin
(FST)
and
its
application
cancer
treatment.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2022,
Номер
63(25), С. 7238 - 7268
Опубликована: Март 3, 2022
Enriched
products
with
bioactive
compounds
(BCs)
show
the
capacity
to
produce
a
wide
range
of
possible
health
effects.
Most
BCs
are
essentially
hydrophobic
and
sensitive
environmental
factors;
so,
encapsulation
becomes
strategy
solve
these
problems.
Many
globular
proteins
have
intrinsic
ability
bind,
protect,
encapsulate,
introduce
into
nutraceutical
or
pharmaceutical
matrices.
Among
them,
albumins
as
human
serum
albumin
(HSA),
bovine
(BSA),
ovalbumin
(OVA)
α-lactalbumin
(ALA)
widely
abundant,
available,
applied
in
many
industrial
sectors,
becoming
promissory
materials
encapsulate
BCs.
Therefore,
this
review
focuses
on
researches
about
main
groups
natural
origin
(namely
phenolic
compounds,
lipids,
vitamins,
carotenoids),
different
types
nanostructures
based
them
fields
application
for
BCs-loaded
systems.
In
context,
(catechins,
quercetin,
chrysin)
most
extensively
studied
encapsulated
albumin-based
nanocarriers.
Other
subgroups
stilbenes
curcuminoids.
Regarding
lipids
vitamins;
terpenes,
carotenoids
(β-carotene),
xanthophylls
(astaxanthin)
considered.
The
areas
related
their
antitumor,
anti-inflammatory,
antioxidant
properties.
Finally,
BSA
is
used
produced
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
25(1), С. 37 - 37
Опубликована: Дек. 19, 2023
Due
to
the
specificity
of
their
structure,
protein
systems
are
adapted
carry
various
ligands.
The
structure
many
proteins
potentially
allows
for
two
types
immobilization
a
therapeutic
agent,
either
on
outer
surface
or
within
structure.
existence
active
sites
in
BSA’s
so-called
Sudlow
I
and
II,
was
confirmed.
conducted
research
involved
determining
effectiveness
BSA
as
potential
carrier
5-fluorouracil
(5FU).
is
broad-spectrum
anticancer
drug
targeting
solid
tumors.
carried
out
estimate
physicochemical
properties
system
using
complementary
measurement
techniques.
optimization
complex
formation
conditions
made
it
possible
obtain
significant
correlations
between
form
effective
localization
substance
molecule.
presence
amino
groups
5FU
contributes
deprotonation
molecule
at
high
pH
values
(pH
>
8)
transition
anionic
(AN1
AN3).
To
investigate
binding
affinity
tautomeric
with
BSA,
UV-vis
absorption,
fluorescence
quenching,
zeta
potential,
QCM-D,
CD
spectroscopic
studies
were
performed.
experimental
supported
by
molecular
dynamics
(MD)
simulations
docking.
confirm
location
tautomers
inside
its
surface.
