Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 20, 2025
Язык: Английский
Natural Product Reports, Год журнала: 2022, Номер 39(6), С. 1122 - 1171
Опубликована: Янв. 1, 2022
A comprehensive review of 1407 new MNPs including turbinmicin, a potent antifungal lead isolated from marine bacterium.
Язык: Английский
Процитировано
219
Marine Drugs, Год журнала: 2021, Номер 19(10), С. 530 - 530
Опубликована: Сен. 23, 2021
The prevalence of antimicrobial resistance reduces the effectiveness drugs in preventing and treating infectious diseases caused by pathogenic organisms, such as bacteria, fungi, viruses. Because burgeoning growth microbes with antimicrobial-resistant traits, there is a dire need to identify develop novel effective agents treat infections from strains. marine environment rich ecological biodiversity can be regarded an untapped resource for prospecting bioactive compounds. Therefore, exploring plays significant role drug development biomedical research. Several earlier scientific investigations have proven that bacterial diversity represents emerging source structurally unique agents. There are several reports on secondary metabolites, many pharmacologically enormous promise developing combat microbial drug-resistant pathogens. In this review, we attempt summarize published articles last twenty-five years (1996–2020) metabolites bacteria evolved environments, sediment, water, fauna, flora.
Язык: Английский
Процитировано
110
Molecules, Год журнала: 2022, Номер 27(5), С. 1643 - 1643
Опубликована: Март 2, 2022
This review describes the recent Food and Drug Administration (FDA)-approved drugs (in year 2021) containing at least one halogen atom (covalently bound). The structures proposed throughout this work are grouped according to their therapeutical use. Their synthesis is presented as well. number of halogenated molecules that reaching market regularly preserved, 14 50 approved by FDA in last contain halogens. underlines emergent role halogens and, particular, fluorine chlorine preparation for treatment several diseases such viral infections, types cancer, cardiovascular disease, multiple sclerosis, migraine inflammatory vasculitis.
Язык: Английский
Процитировано
100
Fortschritte der Chemie Organischer Naturstoffe/Fortschritte der Chemie organischer Naturstoffe/Progress in the chemistry of organic natural products, Год журнала: 2023, Номер unknown, С. 1 - 546
Опубликована: Янв. 1, 2023
Язык: Английский
Процитировано
50
Food Production Processing and Nutrition, Год журнала: 2023, Номер 5(1)
Опубликована: Март 20, 2023
Abstract Green seaweed, as the most abundant species of macroseaweeds, is an important marine biological resource. It a rich source several amino acids, fatty and dietary fibers, well polysaccharides, polyphenols, pigments, other active substances, which have crucial roles in various processes such antioxidant activity, immunoregulation, anti-inflammatory response. In recent years, attention to resources has accelerated exploration utilization green seaweeds for greater economic value. This paper elaborates on main nutrients substances present different provides review their activities applications high-value utilization. Graphical abstract
Язык: Английский
Процитировано
48
Natural Products and Bioprospecting, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 24, 2025
Abstract Marine natural products have long been recognized as a vast and diverse source of bioactive compounds with potential therapeutic applications, particularly in oncology. This review provides an updated overview the significant advances made discovery development marine-derived anticancer drugs between 2019 2023. With focus on recent research findings, explores rich biodiversity marine organisms, including sponges, corals, algae, microorganisms, which yielded numerous exhibiting promising properties. Emphasizing multifaceted mechanisms action, discusses molecular targets pathways targeted by these compounds, such cell cycle regulation, apoptosis induction, angiogenesis inhibition, modulation signaling pathways. Additionally, highlights innovative strategies employed isolation, structural elucidation, chemical modification to enhance their potency, selectivity, pharmacological Furthermore, it addresses challenges opportunities associated drugs, issues related supply, sustainability, synthesis, clinical translation. Finally, underscores immense valuable reservoir novel agents advocates for continued exploration exploitation environment address unmet medical needs cancer therapy Graphical
Язык: Английский
Процитировано
4
Antioxidants, Год журнала: 2021, Номер 10(9), С. 1431 - 1431
Опубликована: Сен. 8, 2021
Reactive oxygen species (ROS) attack biological molecules, such as lipids, proteins, enzymes, DNA, and RNA, causing cellular tissue damage. Hence, the disturbance of antioxidant homeostasis can lead to oxidative stress onset a plethora diseases. Macroalgae, growing in stressful conditions under intense exposure UV radiation, have developed protective mechanisms been recognized an important source secondary metabolites macromolecules with activity. In parallel, fact that many algae be cultivated coastal areas ensures provision sufficient quantities fine chemicals biopolymers for commercial utilization, rendering them viable antioxidants. This review focuses on progress made concerning discovery compounds derived from marine macroalgae, covering literature up December 2020. The present report presents potential biogenetic origin 301 macroalgal metabolites, categorized according their chemical classes, highlighting antioxidative action when known.
Язык: Английский
Процитировано
76
RSC Advances, Год журнала: 2021, Номер 11(50), С. 31339 - 31363
Опубликована: Янв. 1, 2021
Since its first report in December 2019, the novel coronavirus virus, SARS-CoV-2, has caused an unprecedented global health crisis and economic loss imposing a tremendous burden on worldwide finance, healthcare system, even daily life. Even with introduction of different preventive vaccines, there is still dire need for effective antiviral therapeutics. Nature been considered as historical trove drug discovery development, particularly cases crises. Herein, comprehensive
Язык: Английский
Процитировано
72
Biotechnology Advances, Год журнала: 2021, Номер 54, С. 107871 - 107871
Опубликована: Ноя. 19, 2021
Язык: Английский
Процитировано
70
Natural Product Reports, Год журнала: 2021, Номер 39(1), С. 7 - 19
Опубликована: Окт. 16, 2021
Covering: 1877 to 2020A key challenge in natural products research is the selection of biodiversity yield novel chemistry. Recently, marine microorganisms have become a preferred source. But how are microorganism compared those reported from terrestrial microbes? Cluster analysis chemical fingerprints and molecular scaffold 55 817 compounds microorganisms, macro-organisms showed that 76.7% isolated closely related microorganisms. Only 14.3% unique when macro-organism also considered. Studies targeting specific understudied microbial phyla result higher likelihood finding compounds, whereas depth geographic location collection little influence. We recommend targeted strain isolation, incorporating early use genomic sequencing guide selection, innovation culture media cultivation techniques application cheminformatics tools focus on product diversity, rather than dereplication known compounds.
Язык: Английский
Процитировано
65