Materials,
Год журнала:
2021,
Номер
14(10), С. 2647 - 2647
Опубликована: Май 18, 2021
Porous
tantalum
(Ta)
is
a
promising
biomaterial
and
has
been
applied
in
orthopedics
dentistry
for
nearly
two
decades.
The
high
porosity
interconnected
pore
structure
of
porous
Ta
promise
fine
bone
ingrowth
new
formation
within
the
inner
space,
which
further
guarantee
rapid
osteointegration
bone-implant
stability
long
term.
wettability
surface
energy
that
can
facilitate
adherence,
proliferation
mineralization
osteoblasts.
Meanwhile,
low
elastic
modulus
friction
coefficient
allow
it
to
effectively
avoid
stress
shield
effect,
minimize
marginal
loss
ensure
primary
stability.
Accordingly,
satisfactory
clinical
application
Ta-based
implants
or
prostheses
mainly
derived
from
its
excellent
biological
mechanical
properties.
With
advent
additive
manufacturing,
personalized
have
shown
their
value
treatment
individual
patients
who
need
specially
designed
prosthesis.
In
addition,
many
modification
methods
introduced
enhance
bioactivity
antibacterial
property
with
vitro
vivo
research
results.
any
case,
choosing
suitable
great
importance
surgical
success
after
insertion.
Journal of Science Advanced Materials and Devices,
Год журнала:
2020,
Номер
5(1), С. 1 - 9
Опубликована: Фев. 7, 2020
Globally,
bone
fractures
due
to
osteoporosis
occur
every
20
s
in
people
aged
over
50
years.
The
significant
healthcare
costs
required
manage
this
problem
are
further
exacerbated
by
the
long
healing
times
experienced
with
current
treatment
practices.
Novel
approaches
such
as
tissue
engineering,
is
using
biomaterial
scaffolds
stimulate
and
guide
regeneration
of
damaged
that
cannot
heal
spontaneously.
Scaffolds
provide
a
three-dimensional
network
mimics
extra
cellular
micro-environment
supporting
viability,
attachment,
growth
migration
cells
whilst
maintaining
structure
regenerated
vivo.
osteogenic
capability
scaffold
influenced
interconnections
between
pores
which
facilitate
cell
distribution,
integration
host
capillary
ingrowth.
Hence,
preparation
applicable
pore
size
interconnectivity
issue
engineering.
To
be
effective
however
vivo,
must
also
cope
requirements
for
physiological
mechanical
loading.
This
review
focuses
on
relationship
porosity
subsequent
osteogenesis,
vascularisation
degradation
during
regeneration.
Bioactive Materials,
Год журнала:
2021,
Номер
6(11), С. 4110 - 4140
Опубликована: Апрель 22, 2021
Bone-tissue
defects
affect
millions
of
people
worldwide.
Despite
being
common
treatment
approaches,
autologous
and
allogeneic
bone
grafting
have
not
achieved
the
ideal
therapeutic
effect.
This
has
prompted
researchers
to
explore
novel
bone-regeneration
methods.
In
recent
decades,
development
tissue
engineering
(BTE)
scaffolds
been
leading
forefront
this
field.
As
provided
deep
insights
into
physiology
bone-healing
mechanism,
various
biomimicking
bioinspired
BTE
reported.
Now
it
is
necessary
review
progress
natural
healing
which
will
provide
more
valuable
enlightenments
for
in
work
details
physiological
microenvironment
tissue,
process,
biomolecules
involved
therein.
Next,
according
delivery
bioactive
factors
based
on
elaborates
biomimetic
design
a
scaffold,
highlighting
designing
biology
providing
rationale
next-generation
that
conform
regeneration.
Chemical Society Reviews,
Год журнала:
2020,
Номер
49(15), С. 5178 - 5224
Опубликована: Янв. 1, 2020
Biomedical
scientists
use
chemistry-driven
processes
found
in
nature
as
an
inspiration
to
design
biomaterials
promising
diagnostic
tools,
therapeutic
solutions,
or
tissue
substitutes.
Acta Biomaterialia,
Год журнала:
2019,
Номер
97, С. 637 - 656
Опубликована: Авг. 5, 2019
A
broad
range
of
synthetic
trabecular-like
metallic
lattices
are
3D
printed,
to
study
the
extra
design
freedom
conferred
by
this
new
manufacturing
process.
The
aim
is
propose
conceptual
types
implant
structures
for
superior
bio-mechanical
matching
and
osseo-integration:
bone.
target
designs
printed
in
Ti-6Al-4V
alloy
using
a
laser-bed
Systematic
evaluation
then
carried
out:
(i)
their
accuracy
characterised
at
high
spatial
resolution
computed
X-ray
tomography,
assess
robustness
with
respect
original
geometrical
intent
(ii)
mechanical
properties
–
stiffness
strength
experimentally
measured,
evaluated,
compared.
Finally,
knowledge
synthesised
framework
allow
construction
so-called
maps,
define
processing
conditions
bone
tailored
substitutes,
focus
on
spine
fusion
devices.
criteria
emphasise
stiffness-matching,
preferred
pore
structure
in-growth,
manufacturability
device
choice
inherent
materials
which
needed
durable
implants.
Examples
use
such
maps
given
devices,
emphasising
osseo-integration
We
present
bio-engineering
methodology
biomedical
produced
additive
manufacturing,
addresses
some
critical
points
currently
existing
porous
materials.
Amongst
others:
feasibility
elastic
bone,
(iii)
sensible
pores
sizes
osseointegration.
This
has
inspired
novel
latticed
improving
intervertebral
In
fundamental
form,
these
here
fabricated
tested.
When
integrated
into
medical
concepts
could
offer
outcomes.
Japanese Dental Science Review,
Год журнала:
2018,
Номер
55(1), С. 26 - 32
Опубликована: Сен. 28, 2018
Bone
deficits
of
the
jaws
are
often
attributed
to
accidents,
surgical
removal
benign
lesions
or
malignant
neoplasms,
congenital
abnormalities,
periodontal
inflammation,
tooth
abscess
extraction
and
finally
jaw
atrophy
due
advanced
age
general
disease.
These
bone
defects
require
rehabilitation
for
a
variety
reasons,
e.g.
maintaining
normal
anatomic
outline,
eliminating
empty
space,
aesthetic
restoration
placing
dental
implants.
Today,
several
techniques
have
been
developed
eliminate
these
deformities
including
grafting,
guided
regeneration,
distraction
osteogenesis,
use
growth
factors
stem
cells.
grafts
consist
materials
natural
synthetic
origin,
implanted
into
defect
site,
documented
possess
healing
properties.
Currently,
restorative
with
different
characteristics
available,
possesing
Despite
years
effort
‘perfect’
reconstruction
material
has
not
yet
developed,
further
is
required
make
this
objective
feasible.
The
aim
article
provide
contemporary
comprehensive
overview
grafting
that
can
be
applied
in
dentoalveolar
reconstruction,
discussing
their
properties,
advantages
disadvantages,
enlightening
present
future
perspectives
field
regeneration.
Biomolecules,
Год журнала:
2019,
Номер
9(11), С. 750 - 750
Опубликована: Ноя. 19, 2019
This
review
focuses
on
a
somewhat
unexplored
strand
of
regenerative
medicine,
that
is
in
situ
tissue
engineering.
In
this
approach
manufactured
scaffolds
are
implanted
the
injured
region
for
regeneration
within
patient.
The
scaffold
designed
to
attract
cells
required
volume
subsequently
proliferate,
differentiate,
and
as
consequence
develop
which
time
will
degrade
leaving
just
regenerated
tissue.
highlights
wealth
information
available
from
studies
ex-situ
engineering
about
selection
materials
scaffolds.
It
clear
there
great
opportunities
use
additive
manufacturing
prepare
complex
personalized
we
speculate
by
building
knowledge
technology,
development
could
rapidly
increase.
Ex-situ
handicapped
need
bioreactor
where
conditions,
however
optimized,
may
not
be
optimum
accelerated
growth
maintenance
cell
function.
We
identify
both
methodologies
prospect
has
created
much
promise
but
delivered
little
outside
scope
laboratory-based
experiments.
propose
design
selected
remain
at
heart
developments
field
predictive
modelling
can
used
optimization
Acta Biomaterialia,
Год журнала:
2020,
Номер
109, С. 1 - 20
Опубликована: Апрель 6, 2020
The
growing
interest
in
multi-functional
metallic
biomaterials
for
bone
substitutes
challenges
the
current
additive
manufacturing
(AM,
=3D
printing)
technologies.
It
is
foreseeable
that
advances
multi-material
AM
will
not
only
allow
complex
geometrical
designs,
but
also
improve
their
multi-functionalities
by
tuning
types
or
compositions
of
underlying
base
materials,
thereby
presenting
unprecedented
opportunities
advanced
orthopedic
treatments.
technologies
are
yet
to
be
extensively
explored
fabrication
biomaterials,
especially
substitutes.
aim
this
review
present
viable
options
state-of-the-art
Ti-,
Mg-,
and
Fe-based
used
as
starts
with
a
brief
tissue
engineering,
design
requirements,
highlight
advantages
using
over
conventional
methods.
Five
suitable
metal
3D
printing
compared
against
requirements
AM.
Of
these
technologies,
extrusion-based
shown
have
greatest
potential
meet
biomaterials.
Finally,
recent
progress
including
utilization
reviewed
so
identify
knowledge
gaps
propose
directions
further
research
development
applicable
Addressing
critical
defect
requires
assistance
porous
As
one
most
technology
challenged
its
viability
This
article
reviews
how
been
can
Progress
on
manufacturing,
discussed
direct
future
advancing
additively
manufactured
Journal of Materials Chemistry B,
Год журнала:
2019,
Номер
7(26), С. 4088 - 4117
Опубликована: Янв. 1, 2019
Additively
manufactured
(AM,
=3D
printed)
porous
metallic
biomaterials
with
topologically
ordered
unit
cells
have
created
a
lot
of
excitement
and
are
currently
receiving
attention
given
their
great
potential
for
improving
bone
tissue
regeneration
preventing
implant-associated
infections.
