Bioengineering & Translational Medicine,
Год журнала:
2022,
Номер
7(2)
Опубликована: Янв. 29, 2022
Abstract
Musculoskeletal
defects
are
an
enormous
healthcare
burden
and
source
of
pain
disability
for
individuals.
With
aging
population,
the
proportion
individuals
living
with
these
medical
indications
will
increase.
Simultaneously,
there
is
pressure
on
providers
to
efficient
solutions,
which
cheaper
less
invasive
than
conventional
technology.
This
has
led
increased
research
focus
hydrogels
as
highly
biocompatible
biomaterials
that
can
be
delivered
through
minimally
procedures.
review
discuss
how
designed
clinical
translation,
particularly
in
context
new
European
Medical
Device
Regulation
(MDR).
We
then
do
a
deep
dive
into
clinically
used
hydrogel
solutions
have
been
commercially
approved
or
undergone
trials
Europe
United
States.
therapeutic
mechanism
limitations
products.
Due
vast
application
areas
hydrogels,
this
work
focuses
only
treatments
cartilage,
bone,
nucleus
pulposus.
Lastly,
main
steps
toward
translation
devices
outlined.
suggest
framework
academics
assist
small
medium
MedTech
enterprises
conducting
initial
investigation
post‐market
follow‐up
required
MDR.
It
evident
successful
governed
by
acquiring
high‐quality
pre‐clinical
data
confirming
device
action
safety.
Advanced Healthcare Materials,
Год журнала:
2022,
Номер
12(9)
Опубликована: Дек. 13, 2022
Bone
tissue
engineering
(BTE)
is
a
topic
of
interest
for
the
last
decade,
and
advances
in
materials,
processing
techniques,
understanding
bone
healing
pathways
have
opened
new
avenues
research.
The
dual
responsibility
BTE
scaffolds
providing
load-bearing
capability
interaction
with
local
extracellular
matrix
to
promote
challenge
synthetic
scaffolds.
This
article
describes
usage
multi-materials
hierarchical
structures
mimic
structure
natural
tissues
function
as
bioactive
first
part
this
literature
review
physiology
responses
interactions
at
different
stages
repair.
following
section
reviews
available
on
biomaterials
used
followed
by
some
multi-material
approaches.
next
discusses
impact
scaffold's
structural
features
necessity
distribution
scaffold
structure.
Finally,
highlights
emerging
trends
developments
that
can
inspire
strategies
truly
develop
generation
MedComm,
Год журнала:
2021,
Номер
2(2), С. 123 - 144
Опубликована: Апрель 8, 2021
Abstract
As
promising
biodegradable
materials
with
nontoxic
degradation
products,
magnesium
(Mg)
and
its
alloys
have
received
more
attention
in
the
biomedical
field
very
recently.
Having
excellent
biocompatibility
unique
mechanical
properties,
magnesium‐based
currently
cover
a
broad
range
of
applications
field.
The
use
Mg‐based
devices
eliminates
need
for
biomaterial
removal
surgery
after
healing
process
reduces
adverse
effects
induced
by
implantation
permanent
biomaterials.
However,
high
corrosion
rate
implants
leads
to
unexpected
degradation,
structural
failure,
hydrogen
evolution,
alkalization,
cytotoxicity.
To
overcome
these
limitations,
alloying
Mg
suitable
elements
surface
treatment
come
highly
recommended.
In
this
area,
open
questions
remain
on
behavior
biomaterials
human
body
different
factors
that
resulted
challenges.
addition
that,
many
techniques
are
yet
be
verified
turn
challenges
into
opportunities.
Accordingly,
article
aims
review
major
opportunities
minimize
development
novel
made
alloys.
Experimental and Therapeutic Medicine,
Год журнала:
2021,
Номер
22(5)
Опубликована: Сен. 17, 2021
Biocompatibility
is
one
of
the
mandatory
requirements
for
clinical
use
biomaterials
in
orthopedics.
It
refers
to
ability
a
biomaterial
perform
its
function
without
eliciting
toxic
or
injurious
effects
on
biological
systems
but
producing
an
appropriate
host
response
specific
case.
Today,
biocompatibility
concept
includes
not
only
bio‑inertia,
also
biofunctionality
and
biostability.
High
functional
properties
are
highly
desirable
new
biomaterials.
The
chemical,
mechanical,
structural
biomaterials,
their
interaction
with
environment
even
methodology
assessment
can
influence
biocompatibility.
evaluation
broad
spectrum
in
vitro
vivo
tests
related
cytocompatibility,
genotoxicity,
sensitization,
irritation,
acute
chronic
toxicity,
hemocompatibility,
reproductive
developmental
toxicitity,
carcinogenicity,
implantation
degradation
as
specified
different
international
standards.
A
brief
review
main
assays
used
testing
orthopedic
presented.
In
addition,
issues
overviewed.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(10), С. 4175 - 4198
Опубликована: Янв. 1, 2022
Polyphenolic
materials
are
a
class
of
fascinating
and
versatile
bioinspired
for
biointerfacial
engineering.
In
particular,
due
to
the
presence
active
chemical
groups,
series
unique
physicochemical
properties
become
accessible
tunable
as-prepared
polyphenolic
platforms,
which
could
delicately
regulate
cell
activities
via
cell-material
contact-dependent
interactions.
More
interestingly,
polyphenols
also
affect
behaviors
contact-independent
manner,
arise
their
intrinsically
functional
characteristics
(e.g.,
antioxidant
photothermal
behaviors).
As
such,
comprehensive
understanding
on
relationship
between
material
desired
biomedical
applications,
as
well
underlying
mechanism
at
cellular
molecular
level
would
provide
design
principles
accelerate
lab-to-clinic
translation
platforms.
this
review,
we
firstly
give
brief
overview
hallmarks
governed
by
surrounding
cues,
followed
introduction
engineering
strategies.
Subsequently,
detailed
discussion
cell-polyphenols
interfacial
interaction
was
carefully
provided.
Lastly,
applications
were
elaborated.
We
believe
that
review
guidances
rational
multifunctional
extend
application
window.
