Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

Advanced Materials, Год журнала: 2020, Номер 32(47)

Опубликована: Окт. 16, 2020

Ultrasound (US)-triggered sonodynamic therapy (SDT), as a promising noninvasive therapeutic modality, has received ever-increasing attention in recent years. Its specialized chemical agents, named sonosensitizers, are activated by low-intensity US to produce lethal reactive oxygen species (ROS) for oncotherapy. Compared with phototherapeutic strategies, SDT provides many noteworthy opportunities and benefits, such deeper penetration depth, absence of phototoxicity, fewer side effects. Nevertheless, previous studies have also demonstrated its intrinsic limitations. Thanks the facile engineering nature nanotechnology, numerous novel nanoplatforms being applied this emerging field tackle these barriers achieve continuous innovations. In particular, combination other treatment strategies superior efficacy improving anticancer activity relative that monotherapies alone. Therefore, it is necessary summarize nanomaterial-assisted combinational cancer applications. Herein, design principles achieving synergistic effects based on nanomaterial methods highlighted. The ultimate goals stimulate better-quality combined schemes provide innovative ideas perspectives promoting future transformation clinical application.

Язык: Английский

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Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy

Theranostics, Год журнала: 2021, Номер 12(1), С. 434 - 458

Опубликована: Дек. 15, 2021

Cancer immunotherapy has made tremendous clinical progress in advanced-stage malignancies. However, patients with various tumors exhibit a low response rate to because of powerful immunosuppressive tumor microenvironment (TME) and insufficient immunogenicity tumors. Photodynamic therapy (PDT) can not only directly kill cells, but also elicit immunogenic cell death (ICD), providing antitumor immunity. Unfortunately, limitations from the inherent nature complex TME significantly reduce efficiency PDT. Recently, smart nanomedicine-based strategies could subtly modulate pharmacokinetics therapeutic compounds optimize both PDT immunotherapy, resulting an improved effect. Here, emerging nanomedicines for PDT-driven cancer are reviewed, including hypoxia-reversed nanomedicines, nanosized metal-organic frameworks, subcellular targeted nanoparticles (NPs). Moreover, we highlight synergistic nanotherapeutics used amplify immune responses combined against Lastly, challenges future expectations field discussed.

Язык: Английский

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Endoplasmic Reticulum Targeting to Amplify Immunogenic Cell Death for Cancer Immunotherapy

Nano Letters, Год журнала: 2020, Номер 20(3), С. 1928 - 1933

Опубликована: Фев. 19, 2020

Immunogenic cell death (ICD) elicited by photodynamic therapy (PDT) is mediated through generation of reactive oxygen species (ROS) that induce endoplasmic reticulum (ER) stress. However, the half-life ROS very short and intracellular diffusion depth limited, which impairs ER localization thus limits stress induction. To solve problem, we synthesized reduction-sensitive Ds-sP NPs (PEG-s-s-1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] nanoparticles) loaded with an efficient ER-targeting photosensitizer TCPP-TER (4,4',4″,4'″-(porphyrin-5,10,15,20-tetrayl)tetrakis(N-(2-((4-methylphenyl)sulfonamido)ethyl)benzamide). The resulting Ds-sP/TCPP-TER could selectively accumulate in locally generate under near-infrared (NIR) laser irradiation, induced stress, amplified ICD, activated immune cells, leading to augmented immunotherapy effect. This study presents a novel ICD amplifying, PDT strategy can effectively eradicate primary tumors NIR exposure, as well distant abscopal

Язык: Английский

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The fast-growing field of photo-driven theranostics based on aggregation-induced emission

Chemical Society Reviews, Год журнала: 2022, Номер 51(6), С. 1983 - 2030

Опубликована: Янв. 1, 2022

This review summarized the progression of AIEgen-based photo-driven theranostics emphasizing on design strategies for efficient photosensitization, photothermal conversion and multimodal functionalities by adjusting excited energy dissipation.

Язык: Английский

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Recent advances in smart stimuli-responsive biomaterials for bone therapeutics and regeneration

Bone Research, Год журнала: 2022, Номер 10(1)

Опубликована: Фев. 23, 2022

Abstract Bone defects combined with tumors, infections, or other bone diseases are challenging in clinical practice. Autologous and allogeneic grafts two main traditional remedies, but they can cause a series of complications. To address this problem, researchers have constructed various implantable biomaterials. However, the original pathological microenvironment defects, such as residual severe infection, diseases, could further affect regeneration. Thus, rational design versatile biomaterials integrated therapy regeneration functions is great demand. Many strategies been applied to fabricate smart stimuli-responsive materials for regeneration, stimuli related external physical triggers endogenous disease microenvironments involving multiple strategies. Typical include light irradiation, electric magnetic fields, ultrasound, mechanical stimuli. These transform internal atomic packing arrangements cell fate, thus enhancing tissue In addition strategy, some specific microenvironments, excess reactive oxygen species mild acidity pH reduction enzymes secreted by bacteria electronegative potential defect sites, be used biochemical activate Herein, we summarize discuss construction therapeutic regenerative functions. The mechanisms, applications, existing limitations newly designed also clarified.

Язык: Английский

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Cancer nanomedicine

Nature reviews. Cancer, Год журнала: 2022, Номер 22(10), С. 550 - 556

Опубликована: Авг. 8, 2022

Язык: Английский

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Multifunctional metal–organic framework heterostructures for enhanced cancer therapy

Chemical Society Reviews, Год журнала: 2020, Номер 50(2), С. 1188 - 1218

Опубликована: Дек. 7, 2020

We review the general principle of design and functional modulation nanoscaled MOF heterostructures, biomedical applications in enhanced therapy.

Язык: Английский

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Electromagnetic Nanomedicines for Combinational Cancer Immunotherapy

Angewandte Chemie International Edition, Год журнала: 2020, Номер 60(23), С. 12682 - 12705

Опубликована: Июль 16, 2020

Immunotherapy that harnesses the power of immune system to eliminate malignant cells has offered an effective approach for cancer treatment. However, limited patient response rates and potential immune-related adverse events exist as two major issues immunotherapy. In parallel, a variety electromagnetic nanomaterials generate heat and/or reactive oxygen species triggered by energy have been applied magnetic hyperthermia therapy, sonodynamic photothermal photodynamic radiotherapy, which ability induce immunogenic cell death. This review summarizes recent development nanomedicines in combinational The mechanisms reprogramming immunosuppressive tumor microenvironment sensitizing tumors immunotherapy are highlighted. Furthermore, challenges perspectives discussed.

Язык: Английский

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Phage-Guided Targeting, Discriminative Imaging, and Synergistic Killing of Bacteria by AIE Bioconjugates

Journal of the American Chemical Society, Год журнала: 2020, Номер 142(8), С. 3959 - 3969

Опубликована: Янв. 30, 2020

New agents with particular specificity toward targeted bacteria and superefficacy in antibacterial activity are urgently needed facing the crisis of worldwide antibiotic resistance. Herein, a novel strategy by equipping bacteriophage (PAP) photodynamic inactivation (PDI)-active AIEgens (luminogens aggregation-induced emission property) was presented to generate type AIE–PAP bioconjugate superior capability for both imaging synergistic killing certain species bacteria. The targeting ability inherited from enabled bioconjugates specifically recognize host preserved infection phage itself. Meanwhile, AIE characteristic empowered them monitoring functionality, real-time tracking their interactions targets therefore realized via convenient fluorescence imaging. More importantly, PDI-active could serve as powerful situ photosensitizers producing high-efficiency reactive oxygen (ROS) under white light irradiation. As result, selective antibiotic-sensitive multi-drug-resistant (MDR) were successfully achieved vitro vivo tests excellent biocompatibility. This AIE–phage integrated would diversify existing pool inspire development promising drug candidates future.

Язык: Английский

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Nanotechnology for Boosting Cancer Immunotherapy and Remodeling Tumor Microenvironment: The Horizons in Cancer Treatment

ACS Nano, Год журнала: 2021, Номер 15(8), С. 12567 - 12603

Опубликована: Авг. 2, 2021

Immunotherapy that harnesses the human immune system to fight cancer has received widespread attention and become a mainstream strategy for treatment. Cancer immunotherapy not only eliminates primary tumors but also treats metastasis recurrence, representing major advantage over traditional treatments. Recently with development of nanotechnology, there exists much work applying nanomaterials on basis their excellent physiochemical properties, such as efficient tissue-specific delivery function, huge specific surface area, controllable chemistry. Consequently, nanotechnology holds significant potential in improving efficacy immunotherapy. Nanotechnology-based mainly manifests its inhibitory effect via two different approaches: one is produce an effective anti-tumor response during tumorigenesis, other enhance tumor defense ability by modulating suppression mechanism microenvironment. With success immunotherapy, understanding interaction between smart nanomedicine provided vigorous vitality This review highlights application, progress, prospect process immunoediting discusses several engineering methods improve efficiency

Язык: Английский

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